Endometrial Scratch Trial
A Multicentre Randomised Controlled Trial of Induced Endometrial Scratch in Women Undergoing First Time IN Vitro Fertilisation (IVF)
The Endometrial Scratch trial is a randomised controlled trial aiming to assess the effectiveness of local endometrial trauma (also known as “endometrial scratch”) on In Vitro Fertilisation (IVF). The trial is no longer looking for new participants - we completed data analysis in mid-2020, with the results of the trial released at the ESHRE conference in July 2020 (see https://www.eshre.eu/ESHRE2020/Media/2020-Press-releases/Metwally). We are currently writing up the trial for publication.
Over 1000 women have been recruited across the UK to be randomised to either receive the endometrial scratch intervention followed by “usual” IVF, or to just receive “usual” IVF. The pregnancy rates in each group will be analysed to assess if the endometrial scratch has a positive effect.
For more information, please contact Robin Chatters on 01142222969 or r.chatters@sheffield.ac.uk
Project Team, Participating Sites and Useful Documents
- Project Team
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Name Role Site Contact Chief Investigator Sheffield Teaching Hospitals mmetwally@nhs.net
01142 268092
Trial Manager The University of Sheffield R.chatters@sheffield.ac.uk
0114 2222969
Clare Pye RN
Lead Research Nurse Sheffield Teaching Hospitals Clare.Pye@sth.nhs.uk
0114 2268194
Sub Study Investigator Sheffield Hallam University s.m.laird@shu.ac.uk
Data Management Team The University of Sheffield endo-scratch-dm-group@sheffield.ac.uk Senior Statistician The University of Sheffield s.j.walters@sheffield.ac.uk
0114 222 0730
Statistician The University of Sheffield m.dimairo@sheffield.ac.uk
0114 222 5204
Health Economics The University of Sheffield t.a.young@sheffield.ac.uk
0114 222 0837
CTRU Advice The University of Sheffield 0114 222 0870
Kerry Wilson
Trial Support Officer The University of Sheffield kerry.wilson@sheffield.ac.uk
0114 222 0867
Kate Brian
PPI Lead Lamiya Mohiyiddeen
Clinical Advice Manchester University Hospitals lamiya.mohiyiddeen@cmft.nhs.uk
Clinical Advice University of Southampton y.cheong@soton.ac.uk - Participating Sites
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Site Principal Investigator Vidya Tamhankar Tarek Gelbaya Lamiya Mohiyiddeen Dr Meenakshi Choudhary Dr. Ying Cheong Mugdha Kulkarni Dr Mohar Goswami Mr Isaac Evbuomwan Mr Phillip Harris Mr Andrew Drakeley Mr Nick Raine Fenning Tim Childs Dr Madhurima Rajkhowa Dr Sarah Martins Da Silva Dr. Priya Bhide Jan Grace - Useful documents