Melatonin for Anxiety prior to General anaesthesia In Children (MAGIC)
A Multicentre, Parallel Randomised Controlled Trial of Melatonin versus Midazolam in the Premedication of Anxious Children Attending for Elective Dental, Ophthalmologic or Ear, Nose and Throat Surgery Under General Anaesthesia.
Anxiety ahead of general anaesthesia is common, with up to 50% of children displaying manifestations of distress-behaviour at the point of anaesthetic induction.
Midazolam, the current standard premedication given to an anxious child ahead of surgery has been shown to be effective, although there are numerous adverse effects which make the medication less than ideal. Melatonin offers many potential benefits over Midazolam.
MAGIC aims to compare the effectiveness and side effects of Melatonin versus Midazolam premedication, and to determine whether Melatonin offers sufficient benefit to warrant change in standard NHS practice.
This study is in start up. Recruitment updates will be released soon.
News updates will be released soon.
This project is funded by the National Institute for Health Research Health Technology Assessment (NIHR HTA) Programme (project number 16/80/08). Any views or opinions expressed are those of the authors and do not necessarily reflect those of the HTA programme, NIHR, NHS or the Department of Health.
Sheffield Teaching Hospitals NHS Foundation Trust