Melatonin for Anxiety prior to General anaesthesia In Children (MAGIC)
A Multicentre, Parallel Randomised Controlled Trial of Melatonin versus Midazolam in the Premedication of Anxious Children Attending for Elective Dental, Ophthalmologic or Ear, Nose and Throat Surgery Under General Anaesthesia.
Anxiety ahead of general anaesthesia is common, with up to 50% of children displaying manifestations of distress-behaviour at the point of anaesthetic induction.
Midazolam, the current standard premedication given to an anxious child ahead of surgery has been shown to be effective, although there are numerous adverse effects which make the medication less than ideal. Melatonin offers many potential benefits over Midazolam.
MAGIC aims to compare the effectiveness and side effects of Melatonin versus Midazolam premedication, and to determine whether Melatonin offers sufficient benefit to warrant change in standard NHS practice.
2ND APRIL 2020
78 patients have been recruited and randomised to the trial.
Message from Professor Chris Deery (Chief Investigator): “It is very exciting to be getting going with the Trial at last. We have a great team and as you can imagine since being awarded the funding a lot of work has already been done".
2ND JANUARY 2020
17 Sites are now open to recruitment:
COVID-19 Update May 2020
The current COVID-19 coronavirus pandemic has lead to numerous pressures and changes, both for the NHS and research, the most recent of which included the cancellation of all routine elective surgeries within the UK and the prioritisation of COVID-19 studies.
Many sites have chosen to halt recruitment to the MAGIC trial already. In light of these extraordinary circumstances, we have decided to pause recruitment to the MAGIC trial until further notice.
This project is funded by the National Institute for Health Research Health Technology Assessment (NIHR HTA) Programme (project number 16/80/08). Any views or opinions expressed are those of the authors and do not necessarily reflect those of the HTA programme, NIHR, NHS or the Department of Health.
Sheffield Teaching Hospitals NHS Foundation Trust
|Professor Chris Deery||Chief Investigator||School of Clinical Dentistryemail@example.com|
|Dr Robert Bolt||Co-Investigator||School of Clinical Dentistryfirstname.lastname@example.org|
|Dr Ayman Eissa||Lead Anaesthetist||Sheffield Children's Hospitalemail@example.com|
|Katie Biggs||Study Lead||CTRU, University of Sheffieldfirstname.lastname@example.org|
|Marie Hyslop||Study Manager||CTRU, University of Sheffieldemail@example.com|
|Elena Sheldon||Research Assistant||CTRU, University of Sheffieldfirstname.lastname@example.org|
|Louise Turner||Trial Support Officer||CTRU, University of Sheffieldemail@example.com|
|Nikki Totton||Statistician||CTRU, University of Sheffieldfirstname.lastname@example.org|
|Esther Herbert||Statistician||CTRU, University of Sheffieldemail@example.com|
|Amanda Loban||Data Management||CTRU, University of Sheffieldfirstname.lastname@example.org|
|Tracey Young||Health Economist||HEDS, University of Sheffieldemail@example.com|