Cindy Cooper BSc. (Pharmacology & Physiology), Ph.D. (Neuropharmacology)Photo of Cindy Cooper

Director, Clinical Trials Research Unit/Professor of Health Services Research and Clinical Trials

Clinical Trials Research Unit, ScHARR
The University of Sheffield
Regent Court
30 Regent Street
S1 4DA

Room: 2026, Regent Court
Tel: +44 (0)114 22 20743
Fax: +44 (0)114 22 20749

 Email :


Rebecca Swift
Working pattern: Tuesday-Friday 9.30am-4.00pm
Tel: +44 (0)114 22 22988



Professor Cindy Cooper is Director of the University of Sheffield Clinical Trials Research Unit (CTRU) based at ScHARR. After graduating in Pharmacology and Physiology from the University of Manchester and completing a PhD in neuropharmacology at the University of Nottingham, she worked at Sheffield and West Yorkshire Health Authorities in clinical audit and health needs assessment. She joined ScHARR in 1996 to establish the North Trent Research Office, to provide support to local NHS organisations to develop research strategy and increase research income. She has been involved in health services research and clinical trials for over twenty years and has held the position of Professor of Health Services Research and Clinical Trials since January 2014.

Cindy established the CTRU in 2006. The focus of the CTRU is the design and implementation of clinical trials of complex health interventions including trials of investigational medicinal products and devices. The aim of the CTRU is to support and enhance academic health research in the University of Sheffield in collaboration with NHS investigators throughout South Yorkshire and to develop a portfolio of academic work and publications.

Cindy was Chair of the NIHR Yorkshire & Humber Regional Funding Committee for Research for Patient Benefit between 2009 and 2012 and is currently a member of the Programme Grant for Applied Research Committee. Her research interests include trials methodology (particularly relating to pilot trials and recruitment and retention), psycho-social aspects of long term conditions and evaluation of complex interventions particularly psychotherapeutic interventions.

Research Interests

  • Trials methodology, particularly pilot (external and internal) and feasibility studies
  • Psycho-social aspects of long term conditions
  • Health technology evaluation
  • Evaluation of psychotherapeutic interventions
  • Public and patient involvement in research

Teaching Interests

Co-ordinator for the Randomised Controlled Trials in Health and Social Care module of the MSc in Clinical Research

My teaching interests lie in RCT methodology,and
Getting Funded for Research

I am interested in supervising research students in areas such as RCT methodology, evaluation of health technologies, particularly psychotherapeutic interventions and psychosocial aspects of chronic conditions.

Professional Activities

  • Director of the Clinical Trials Research Unit
  • Chair of University Health Research Governance Committee 2011-
  • Member of the NIHR CTU Directors Executive Group
  • Trial Management Group member for Journeying through Dementia, CACTUS, ACUTE, ASPECT, I-Socialise and OPTION DM trials
  • Member of the York Trials Unit Strategic Advisory Group
  • Member of the Programme Grant for Applied Research Committee

Current Projects

  • CACTUS (Clinical and cost effectiveness of aphasia computer therapy compared with usual stimulation or attention control long term post stroke. HTA 2013-2018. £1.7 million.
  • Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus (OPTION-DM) trial. HTA Project: 15/35/03. £2.9 million 01/06/2016 to: 31/08/2019 .
  • The ACUTE (Ambulance CPAP: Use, Treatment effect and Economics) feasibility study: A pilot randomised controlled trial of prehospital CPAP for acute respiratory failure. HTA: 15/08/40, 2016-1019. £378,285
  • ASPECT A non inferiority randomised controlled trial comparing the clinical and cost effectiveness of single session treatment with multi-session CBT in children with specific phobias. HTA 15/38/04 . 2016-2020.£1.4 million
  • NIHR CTU Support Funding £350,000 per annum
  • Journeying through Dementia is a large-scale research study that aims to find out whether attending a 12-week community programme has a positive impact on the quality of life for people who are living with the early stages of dementia.
  • The COMMEND project (NIHR HTA 16/81/010) includes two phases. Phase 1 will adapt ACT for people with MND and test the acceptability and feasibility of the adapted ACT intervention and whether it is possible to conduct a larger study.
  • High CALS
  • MSS 3

Please click here  for a full list of Cindy Cooper's publications.

Journal articles

Conference proceedings papers

  • Thomas SA, Drummond A, Lincoln NB, Palmer R, dasnair R, Latimer N, Hackney G, Hatton R, Walters S, Mandefield L , Cooper C et al (2017) Behavioural activation therapy for depression after stroke (BEADS): a feasibility randomised controlled pilot trial of a psychological intervention for post-stroke depression. INTERNATIONAL JOURNAL OF STROKE, Vol. 12 (pp 15-15) RIS download Bibtex download
  • Harrison M, Palmer R & Cooper C (2017) Identifying barriers and enablers of adherence to self-directed aphasia computer therapy: a patient and carer perspective. INTERNATIONAL JOURNAL OF STROKE, Vol. 12 (pp 23-23) RIS download Bibtex download
  • Harrison M, Palmer R & Cooper C (2016) Defining and measuring the components of a complex neuro-rehabilitation intervention for aphasia. INTERNATIONAL JOURNAL OF STROKE, Vol. 11 (pp S19-S19) RIS download Bibtex download
  • Elphick H, Horspool M, Davis S, Bradburn M, Norman P, Shephard N, Cooper C, Smithson WH, Boote J, Loban A , Franklin M et al (2016) LATE-BREAKING ABSTRACT: PLEASANT: Preventing and lessening exacerbations of asthma in school-age children associated with a new term (pp oa1993) RIS download Bibtex download
  • Dimairo M, Stevely A, Todd S, Julious S, Nicholl J, Hind D & Cooper C (2015) Investigation of the shortcomings of the consort 2010 statement for the reporting of group sequential randomised controlled trials. Trials, Vol. 16(Suppl 2) (pp o53) View this article in WRRO RIS download Bibtex download
  • Dimairo M, Stevely A, Julious S, Todd S, Cooper C, Hind D & Nicholl J (2015) Differential reporting of group sequential RCTs: shortcomings ofthe CONSORT 2010 statement. CPS 11: Group Sequential Methods and Interim Analysis. ARLINGTON, VIRGINIA, USA, 17 May 2015 - 20 May 2015. RIS download Bibtex download
  • Hind D, Roberts C, Sprange K, Gossage-Worrall R, Cooper C & Walters S (2013) Methodological, planning and implementation challenges for rcts evaluating group interventions. Trials, Vol. 14(Suppl 1) (pp o124) RIS download Bibtex download
  • Rose A, Cooper CL, Hind D, O'Cathain A, Parry GD, Martin L, Issac CL & Sharrack B (2008) How appropriate is cognitive behavioural therapy computer software for the treatment of depression in people with multiple sclerosis?. MULTIPLE SCLEROSIS JOURNAL, Vol. 14 (pp S263-S264) RIS download Bibtex download
  • Cooper CL, Hind D, O'Cathain A, Parry GD, Isaac CL, Rose A & Sharrack B (2008) The acceptability of cognitive behavioural therapy software for the treatment of depression in people with multiple sclerosis. J EPIDEMIOL COMMUN H, Vol. 62 (pp A12-A13) RIS download Bibtex download
  • Cooper C, Palace J, Pickin M, Boggild M, Nichol J & Monitoring Study Consortium (2004) The multiple sclerosis monitoring study: Progress to date. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 75(8) (pp 1214-1214) RIS download Bibtex download


  • Palmer R, Cooper C, Enderby P, Brady M, Julious S, Bowen A, Latimer N, Gossage-Worrall R, Cross E & Harrison M (2018) Big CACTUS study protocol v5.0 31may17. RIS download Bibtex download