Cindy Cooper BSc. (Pharmacology & Physiology), Ph.D. (Neuropharmacology)
Director, Clinical Trials Research Unit/Professor of Health Services Research and Clinical Trials
Clinical Trials Research Unit, ScHARR
The University of Sheffield
30 Regent Street
Room: 2026, Regent Court
Tel: +44 (0)114 22 20743
Fax: +44 (0)114 22 20749
Email : firstname.lastname@example.org
Working pattern: Tuesday-Friday 9.30am-4.00pm
Tel: +44 (0)114 22 22988
Professor Cindy Cooper is Director of the University of Sheffield Clinical Trials Research Unit (CTRU) based at ScHARR. After graduating in Pharmacology and Physiology from the University of Manchester and completing a PhD in neuropharmacology at the University of Nottingham, she worked at Sheffield and West Yorkshire Health Authorities in clinical audit and health needs assessment. She joined ScHARR in 1996 to establish the North Trent Research Office, to provide support to local NHS organisations to develop research strategy and increase research income. She has been involved in health services research and clinical trials for over twenty years and has held the position of Professor of Health Services Research and Clinical Trials since January 2014.
Cindy established the CTRU in 2006. The focus of the CTRU is the design and implementation of clinical trials of complex health interventions including trials of investigational medicinal products and devices. The aim of the CTRU is to support and enhance academic health research in the University of Sheffield in collaboration with NHS investigators throughout South Yorkshire and to develop a portfolio of academic work and publications.
Cindy was Chair of the NIHR Yorkshire & Humber Regional Funding Committee for Research for Patient Benefit between 2009 and 2012 and is currently a member of the Programme Grant for Applied Research Committee. Her research interests include trials methodology (particularly relating to pilot trials and recruitment and retention), psycho-social aspects of long term conditions and evaluation of complex interventions particularly psychotherapeutic interventions.
- Trials methodology, particularly pilot (external and internal) and feasibility studies
- Psycho-social aspects of long term conditions
- Health technology evaluation
- Evaluation of psychotherapeutic interventions
- Public and patient involvement in research
Co-ordinator for the Randomised Controlled Trials in Health and Social Care module of the MSc in Clinical Research.
I am interested in supervising research students in areas such as RCT methodology, evaluation of health technologies, particularly psychotherapeutic interventions and psychosocial aspects of chronic conditions.
- Director of the Clinical Trials Research Unit
- Chair of University Health Research Governance Committee 2011 - 2019
- Member of the NIHR CTU Directors Executive Group 2015 -
- Trial Management Group member for Journeying through Dementia, CACTUS, ACUTE, ASPECT, I-Socialise and OPTION DM trials
- Member of the York Trials Unit Strategic Advisory Group
- Member of the UKCRC CTU Directors Meeting
- Member of the NIHR Clinical Trials Unit Standing Advisory Committee 2016 -
- Member of the Sheffield Teaching Hospital Foundation Trust Research Innovation and Education Committee 2016-2019
- Member of the Programme Grant for Applied Research Assessment Panel D 20170-
- Chair of the Trial Steering COmmittee for the York University lead, HTA Funded:-ACTIVE (articular type C pilon fracture Trial Internal vs External Fixation) Trial. 2017 -
- Chair of the Trial Steering COmmittee for the York University lead, NIHR Programme Grant Funde: MODS (Multi-morbidity in OLder Adults with Depression Study) 2019 -
- CACTUS (Clinical and cost effectiveness of aphasia computer therapy compared with usual stimulation or attention control long term post stroke. HTA 2013-2018. £1.7 million.
- OPTION DM Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus (OPTION-DM) trial. HTA Project: 15/35/03. £2.9 million 01/06/2016 to: 31/08/2019 .
- The ACUTE (Ambulance CPAP: Use, Treatment effect and Economics) feasibility study: A pilot randomised controlled trial of prehospital CPAP for acute respiratory failure. HTA: 15/08/40, 2016-1019. £378,285
- ASPECT A non inferiority randomised controlled trial comparing the clinical and cost effectiveness of single session treatment with multi-session CBT in children with specific phobias. HTA 15/38/04 . 2016-2020.£1.4 million
- NIHR CTU Support Funding £350,000 per annum
- Journeying through Dementia is a large-scale research study that aims to find out whether attending a 12-week community programme has a positive impact on the quality of life for people who are living with the early stages of dementia.
- The COMMEND project (NIHR HTA 16/81/010) includes two phases. Phase 1 will adapt ACT for people with MND and test the acceptability and feasibility of the adapted ACT intervention and whether it is possible to conduct a larger study.
- High CALS. A programme to develop and evaluate a complex intervention to achieve a high calorie diet in ALS (HighCALS) 42 months 02/04/2018 - 01/03/2024. NIHR PGfAR £1,871,107.00 (IA 6% - £112,266.42. CI - C McDermott
- MSS 3. NIHR HS&DR Funded RCT - MSS3: Multiple Symptoms Study 3: pragmatic trial of a community based clinic for patients with persistent (medically unexplained) physical symptoms. Co-I.UoS allocation - £898,732.57.
- MATTS. Major Trauma Triage Tool Study. NIHR HTA funded. CI- Dr Gordon Fuller
- I-SOCIALISE Investigating SOcial Competence and Isolation in children with Autism taking part in LEGO-based therapy clubs In School Environments (I-SOCIALISE), NIHR PHR Funded
- A study of target effect sizes in randomised controlled trials published in the Health Technology Assessment journal.. Trials, 19. View this article in WRRO
- Are pilot trials useful for predicting randomisation and attrition rates in definitive studies: A review of publicly funded trials. Clinical Trials, 15(2), 189-196. View this article in WRRO
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ, 356. View this article in WRRO
- Use of MRI in the diagnosis of fetal brain abnormalities in utero (MERIDIAN): a multicentre, prospective cohort study. The Lancet, 389(10068), 538-546. View this article in WRRO
- The second Randomised Evaluation of the Effectiveness, cost-effectiveness and Acceptability of Computerised Therapy (REEACT-2) trial: does the provision of telephone support enhance the effectiveness of computer-delivered cognitive behaviour therapy? A randomised controlled trial.. Health Technology Assessment, 20(89), 1-64. View this article in WRRO
- Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable. Statistical Methods in Medical Research, 25(3), 1057-1073. View this article in WRRO
- Safety and efficacy of diaphragm pacing in patients with respiratory insufficiency due to amyotrophic lateral sclerosis (DiPALS): a multicentre, open-label, randomised controlled trial. The Lancet Neurology, 14(9), 883-892. View this article in WRRO
- A rapid review indicated higher recruitment rates in treatment trials than in prevention trials. Journal of Clinical Epidemiology, 68(3), 347-354. View this article in WRRO
- Cognitive behavioural intervention for adults with anxiety complications of asthma: prospective randomised trial.. Respir Med, 106(6), 802-810.
- Computerised cognitive behavioural therapy for the treatment of depression in people with multiple sclerosis: external pilot trial.. Trials, 12, 259. View this article in WRRO