Munya Dimairo BSc (Hons) (Statistics), MSc (Medical Statistics), PhD (Medical Statistics)

Research FellowPhoto of Munya Dimairo

Clinical Trials Research Unit, ScHARR
University of Sheffield
Regent Court, 30 Regent Street
S1 4DA

Office: 3.10 Innovation Centre

Tel: +44 (0) 114 222 5204
Fax: +44 (0) 114 222 0870




My vast research interests are in innovative clinical trials statistical methodology. I joined the University of Sheffield in 2009 and have been involved in the design, monitoring, modelling and analysis of clinical trials within the Sheffield CTRU. I have also been providing statistical advice in research design for grant applications for researchers through the NIHR-RDS for Yorkshire and the Humber region as a Medical Statistician. Prior to this, I have worked in TB and HIV related research as a statistician and in data management responsible for Smear Negative and TB Diagnostic studies at the Biomedical Research and Training Institute under DETECTB Project.

I graduated with a BSc (Hons) in Statistics from the University of Zimbabwe, an MSc in Medical Statistics from the London School of Hygiene and Tropical Medicine funded by Wellcome Trust and a PhD in Medical Statistics from the University of Sheffield funded by NIHR as part of a Doctoral Research Fellowship (DRF-2012-05-182). My PhD investigated “The Utility of Adaptive Designs in Publicly Funded Confirmatory Trials” ( I am involved in proposal development, clinical trials statistical support of a number of trials within the Sheffield CTU, and research on innovative statistical methods to improve efficiency in the design and conduct of clinical trials. I am currently leading two adaptive designs projects: the development of a CONSORT extension to enhance the reporting of adaptive clinical trials in collaboration with international researchers, CONSORT Executive Group, and MRC HTMR Adaptive Designs Working Group (The ACE Project); and the development of an online practical educational platform on adaptive designs (The PANDA project).

I am based in the Design, Trials & Statistics (DTS) section within ScHARR.

Research Interests

  • Clinical trials methodology
  • Adaptive designs, especially group sequential methods and treatment selection in multi-arm trials
  • Transparency and reporting of adaptive trials
  • Statistical issues around the application of a stepped wedge trial design
  • Diagnostic accuracy studies
  • Hierarchical or Multilevel modelling
  • Multiple imputation techniques in dealing with missing data
  • Bayesian inference in small clinical trials

Research Grants and Awards

  • NIHR CTU Support Funding: Practical Adaptive & Novel Designs and Analysis (PANDA) Toolkit (The PANDA project). Lead Investigator in collaboration with University of Sheffield colleagues, Cardiff University, Lancaster University, University College London, and the University of Western Australia (££98,886).
  • NIHR CTU Support Funding: The development of a CONSORT guidance tailored for adaptive clinical trials (The ACE Project). Lead Investigator in collaboration with the MRC HTMR Adaptive Designs Working Group, CONSORT Group and international researchers (£50,000)
  • NIHR Doctoral Research Fellowship (DRF-2012-05-182): Utility of adaptive designs in publicly funded trials; PI: Dimairo M; Co-applicants and supervisors: Prof Julious SA, Prof Nicholl J and Prof Todd SC. £206,221
  • Wellcome Trust: Masters Fellowship in Public Health and Tropical Medicine at LSHTM; PI: Dimairo M; Co-applicants and supervisors; Corbett EL and Fielding K. £75,919
  • NIHR RfPB: Can Physiotherapy effectively treat patients with Lumbar Radicular Syndrome secondary to MRI demonstrable disc prolapse? A preliminary randomised trial of patients awaiting lumbar micro-discectomy. Co-Principal Investigators; Newsome R and Reddington M; Co Investigators: Breakwell L, Chiverton N, Cole A, Boote J, Dimairo M. £197,129
  • CLAHRC South Yorkshire: Nutritional Rehabilitation in Stable Chronic Obstructive Pulmonary Disease (COPD) - A randomised controlled pilot trial. Kyi M, Parker S, Dimairo M. £28,170

Professional Activities

  • Reviewer of grant proposals for publicly funding bodies (NIHR and MRC)
  • Trials Associate Editor
  • Independent TSC and DMEC Trial Statistician
  • Independent reviewer for a number of journals including BMJ, BMJ Open, The Lancet, The Lancet Infectious Diseases, Trials, and Pilot and Feasibility Studies
  • Member of the MRC HTMR ADWG
  • Advisory board member of The Bill & Melinda Gates Foundation on adaptive trials in low- and middle-income countries (LMIC)

Current and Previous Trials

The PANDA Project: Practical Adaptive & Novel Designs and Analysis Toolkit

The ACE Project: Adaptive Designs CONSORT Extension

Big CACTUS: A study to assess the clinical and cost effectiveness of aphasia computer treatment versus usual stimulation or attention control long term post stroke (CACTUS)

Endometrial Scratch: The Endometrial Scratch Trial

OPTION-DM: Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus trial

REPOSE: The Relative Effectiveness of Pumps over MDI and Structured Education for Type-1 Diabetes

Booster Trial: A randomised controlled trial and cost-effectiveness evaluation of 'booster' interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods

CACTUS: Evaluating the cost effectiveness of computer therapy compared with usual stimulation for people with long standing aphasia: a pilot study

CoSMoS: CBT Software for the treatment of depression in people with MS

Key Publications

Please click here to view a full list of Munya Dimairo's publications

Journal articles

Conference proceedings papers


  • Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D , Nicholl J et al (2017) Journeying through the development of a consensus-driven adaptive designs reporting guidance. Global Forum on Bioethics in Research. View this article in WRRO RIS download Bibtex download
  • Candlish J, Teare D, Cohen J, Dimairo M, Flight L, Mandefield L & Walters S (2017) Methods to analyse partially nested randomised controlled trials. RIS download Bibtex download

Theses / Dissertations

  • Dimairo M (2016) The Utility of Adaptive Designs in Publicly Funded Confirmatory Trials. RIS download Bibtex download