Munya Dimairo BSc (Hons) (Statistics), MSc (Medical Statistics), PhD (Medical Statistics)

Research FellowPhoto of Munya Dimairo

Clinical Trials Research Unit, ScHARR
University of Sheffield
Regent Court, 30 Regent Street
Sheffield
S1 4DA

Office: 3.10 Innovation Centre

Tel: +44 (0) 114 222 5204
Fax: +44 (0) 114 222 0870

Email: m.dimairo@sheffield.ac.uk

ORCiD: orcid.org/0000-0002-9311-6920

Biography

My vast research interests are in innovative clinical trials statistical methodology. I joined the University of Sheffield in 2009 and have been involved in the design, monitoring, modelling and analysis of clinical trials within the Sheffield CTRU. I have also been providing statistical advice in research design for grant applications for researchers through the NIHR-RDS for Yorkshire and the Humber region as a Medical Statistician. Prior to this, I have worked in TB and HIV related research as a statistician and in data management responsible for Smear Negative and TB Diagnostic studies at the Biomedical Research and Training Institute under DETECTB Project.

I graduated with a BSc (Hons) in Statistics from the University of Zimbabwe, an MSc in Medical Statistics from the London School of Hygiene and Tropical Medicine funded by Wellcome Trust and a PhD in Medical Statistics from the University of Sheffield funded by NIHR as part of a Doctoral Research Fellowship (DRF-2012-05-182). My PhD investigated “The Utility of Adaptive Designs in Publicly Funded Confirmatory Trials” (http://etheses.whiterose.ac.uk/13981/). I am involved in proposal development, clinical trials statistical support of a number of trials within the Sheffield CTU, and research on innovative statistical methods to improve efficiency in the design and conduct of clinical trials. I am currently leading the development of a CONSORT extension to enhance the reporting of adaptive clinical trials in collaboration with international researchers, CONSORT Executive Group, and MRC HTMR Adaptive Designs Working Group (The ACE Project).

I am based in the Design, Trials & Statistics (DTS) section within ScHARR.

Research Interests

  • Clinical trials methodology
  • Adaptive designs, especially group sequential methods and treatment selection in multi-arm trials
  • Transparency and reporting of adaptive trials
  • Statistical issues around the application of a stepped wedge trial design
  • Diagnostic accuracy studies
  • Hierarchical or Multilevel modelling
  • Multiple imputation techniques in dealing with missing data
  • Bayesian inference in small clinical trials

Research Grants and Awards

  • NIHR CTU Support Funding: The development of a CONSORT guidance tailored for adaptive clinical trials (The ACE Project). Lead Investigator in collaboration with the MRC HTMR Adaptive Designs Working Group, CONSORT Group and international researchers (£50,000)
  • NIHR Doctoral Research Fellowship (DRF-2012-05-182): Utility of adaptive designs in publicly funded trials; PI: Dimairo M; Co-applicants and supervisors: Prof Julious SA, Prof Nicholl J and Prof Todd SC. £206,221
  • Wellcome Trust: Masters Fellowship in Public Health and Tropical Medicine at LSHTM; PI: Dimairo M; Co-applicants and supervisors; Corbett EL and Fielding K. £75,919
  • NIHR RfPB: Can Physiotherapy effectively treat patients with Lumbar Radicular Syndrome secondary to MRI demonstrable disc prolapse? A preliminary randomised trial of patients awaiting lumbar micro-discectomy. Co-Principal Investigators; Newsome R and Reddington M; Co Investigators: Breakwell L, Chiverton N, Cole A, Boote J, Dimairo M. £197,129
  • CLAHRC South Yorkshire: Nutritional Rehabilitation in Stable Chronic Obstructive Pulmonary Disease (COPD) - A randomised controlled pilot trial. Kyi M, Parker S, Dimairo M. £28,170

Professional Activities

  • Reviewer of grant proposals for publicly funding bodies (NIHR and MRC)
  • Trials Associate Editor
  • Independent TSC and DMEC Trial Statistician
  • Independent reviewer for a number of journals including BMJ, BMJ Open, The Lancet, The Lancet Infectious Diseases, Trials, and Pilot and Feasibility Studies
  • Member of the MRC HTMR ADWG
  • Member of the SCHARR Staff Development Group

Current and Previous Trials

The ACE Project: Adaptive Designs CONSORT Extension

Big CACTUS: A study to assess the clinical and cost effectiveness of aphasia computer treatment versus usual stimulation or attention control long term post stroke (CACTUS)

Endometrial Scratch: The Endometrial Scratch Trial

OPTION-DM: Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus trial

REPOSE: The Relative Effectiveness of Pumps over MDI and Structured Education for Type-1 Diabetes

Booster Trial: A randomised controlled trial and cost-effectiveness evaluation of 'booster' interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods

CACTUS: Evaluating the cost effectiveness of computer therapy compared with usual stimulation for people with long standing aphasia: a pilot study

CoSMoS: CBT Software for the treatment of depression in people with MS

Key Publications

Please click here to view a full list of Munya Dimairo's publications

Journal articles

Conference proceedings papers

  • Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D, Hamasaki T, Proschan M, Scott J, Walton M, Ando Y, Biggs K, Pallmann P & Coates E (2017) Journeying through the development of an adaptive designs reporting guidance: findings from Delphi process. CEN ISBS Vienna 2017 (pp 94-94), 28 August 2017 - 1 September 2017. RIS download Bibtex download
  • Dimairo M, Todd S, Julious S, Jaki T, Wason J, Mander A, Hind D, Weir C, Koenig F, Altman D, Nicholl J, Hamasaki T, Proschan M, Scott J, Walton M, Ando Y, Biggs K, Pallmann P & Coates E (2017) Journeying through the development of an adaptive designs reporting guidance: preliminary findings. Evidence Live 2017 (pp 42-43), 21 June 2017 - 22 June 2017. RIS download Bibtex download
  • Dimairo M, Stevely A, Todd S, Julious S, Nicholl J, Hind D & Cooper C (2015) Investigation of the shortcomings of the consort 2010 statement for the reporting of group sequential randomised controlled trials. 3rd International Clinical Trials Methodology Conference, Vol. 16(Supp 2) (pp 71-71). Glasgow, UK, 16 November 2015 - 17 November 2015. View this article in WRRO RIS download Bibtex download
  • Dimairo M, Julious S, Todd S & Nicholl J (2015) Meandering journey towards routine trial adaptation: survey results on barriers to use of adaptive designs in confirmatory trials. 3rd International Clinical Trials Methodology Conference, Vol. 16(Supp 2) (pp 45-45). Glasgow, UK, 16 November 2015 - 17 November 2015. View this article in WRRO RIS download Bibtex download
  • Dimairo M, Stevely A, Julious S, Todd S, Cooper C, Hind D & Nicholl J (2015) Differential reporting of group sequential RCTs: shortcomings ofthe CONSORT 2010 statement. CPS 11: Group Sequential Methods and Interim Analysis. ARLINGTON, VIRGINIA, USA, 17 May 2015 - 20 May 2015. RIS download Bibtex download
  • Dimairo M, Bradburn M & Walters SJ (2011) Sample size determination through power simulation; practical lessons from a stepped wedge cluster randomised trial (SW CRT).. Trials, Vol. 12 Suppl 1 (pp A26) RIS download Bibtex download
  • Dimairo M, Mativenga S, Dauya E, Mungofa S, Makamure B, Mason P, Mangwanya D, Walley J & Corbett EL (2009) The Fate of Sputum Smear-negative TB Suspects Managed by Routine Clinical Services in Harare, Zimbabwe. 16th Conference on Retroviruses and Opportunistic Infections, Vol. 17(2). Montreal; Canada RIS download Bibtex download
  • MacPherson P, Dimairo M, Bandason T, Zezai A, Munyati S, Mungofa S, Rusikaniko S, Fielding K, Mason P & Corbett EL () Risk Factors and Timing of Mortality in HIV+ Smear-negative TB Suspects: 12-Month Cohort Study in Harare, Zimbabwe. 18th Conference on Retroviruses and Opportunistic Infections, Montreal. Boston, USA, 27 February 2011 - 2 March 2011. RIS download Bibtex download

Posters

  • Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D, Nicholl J, Hamasaki T, Proschan M, Scott J, Walton M, Ando Y, Biggs K, Pallmann P & Coates E (2017) Journeying through the development of a consensus-driven adaptive designs reporting guidance. Global Forum on Bioethics in Research. View this article in WRRO RIS download Bibtex download
  • Candlish J, Teare D, Cohen J, Dimairo M, Flight L, Mandefield L & Walters S (2017) Methods to analyse partially nested randomised controlled trials. RIS download Bibtex download

Theses / Dissertations

  • Dimairo M (2016) The Utility of Adaptive Designs in Publicly Funded Confirmatory Trials. RIS download Bibtex download