Munya Dimairo BSc (Hons) (Statistics), MSc (Medical Statistics), PhD (Medical Statistics)
Clinical Trials Research Unit, ScHARR
University of Sheffield
Regent Court, 30 Regent Street
Office: 3.10 Innovation Centre
Tel: +44 (0) 114 222 5204
Fax: +44 (0) 114 222 0870
My vast research interests are in innovative clinical trials statistical methodology. I joined the University of Sheffield in 2009 and have been involved in the design, monitoring, modelling and analysis of clinical trials within the Sheffield CTRU. I have also been providing statistical advice in research design for grant applications for researchers through the NIHR-RDS for Yorkshire and the Humber region as a Medical Statistician. Prior to this, I have worked in TB and HIV related research as a statistician and in data management responsible for Smear Negative and TB Diagnostic studies at the Biomedical Research and Training Institute under DETECTB Project.
I graduated with a BSc (Hons) in Statistics from the University of Zimbabwe, an MSc in Medical Statistics from the London School of Hygiene and Tropical Medicine funded by Wellcome Trust and a PhD in Medical Statistics from the University of Sheffield funded by NIHR as part of a Doctoral Research Fellowship (DRF-2012-05-182). My PhD investigated “The Utility of Adaptive Designs in Publicly Funded Confirmatory Trials” (http://etheses.whiterose.ac.uk/13981/). I am involved in proposal development, clinical trials statistical support of a number of trials within the Sheffield CTU, and research on innovative statistical methods to improve efficiency in the design and conduct of clinical trials. I am currently leading two adaptive designs projects: the development of a CONSORT extension to enhance the reporting of adaptive clinical trials in collaboration with international researchers, CONSORT Executive Group, and MRC HTMR Adaptive Designs Working Group (The ACE Project); and the development of an online practical educational platform on adaptive designs (The PANDA project).
I am based in the Design, Trials & Statistics (DTS) section within ScHARR.
- Clinical trials methodology
- Adaptive designs, especially group sequential methods and treatment selection in multi-arm trials
- Transparency and reporting of adaptive trials
- Statistical issues around the application of a stepped wedge trial design
- Diagnostic accuracy studies
- Hierarchical or Multilevel modelling
- Multiple imputation techniques in dealing with missing data
- Bayesian inference in small clinical trials
Research Grants and Awards
- NIHR CTU Support Funding: Practical Adaptive & Novel Designs and Analysis (PANDA) Toolkit (The PANDA project). Lead Investigator in collaboration with University of Sheffield colleagues, Cardiff University, Lancaster University, University College London, and the University of Western Australia (££98,886).
- NIHR CTU Support Funding: The development of a CONSORT guidance tailored for adaptive clinical trials (The ACE Project). Lead Investigator in collaboration with the MRC HTMR Adaptive Designs Working Group, CONSORT Group and international researchers (£50,000)
- NIHR Doctoral Research Fellowship (DRF-2012-05-182): Utility of adaptive designs in publicly funded trials; PI: Dimairo M; Co-applicants and supervisors: Prof Julious SA, Prof Nicholl J and Prof Todd SC. £206,221
- Wellcome Trust: Masters Fellowship in Public Health and Tropical Medicine at LSHTM; PI: Dimairo M; Co-applicants and supervisors; Corbett EL and Fielding K. £75,919
- NIHR RfPB: Can Physiotherapy effectively treat patients with Lumbar Radicular Syndrome secondary to MRI demonstrable disc prolapse? A preliminary randomised trial of patients awaiting lumbar micro-discectomy. Co-Principal Investigators; Newsome R and Reddington M; Co Investigators: Breakwell L, Chiverton N, Cole A, Boote J, Dimairo M. £197,129
- CLAHRC South Yorkshire: Nutritional Rehabilitation in Stable Chronic Obstructive Pulmonary Disease (COPD) - A randomised controlled pilot trial. Kyi M, Parker S, Dimairo M. £28,170
- Reviewer of grant proposals for publicly funding bodies (NIHR and MRC)
- Trials Associate Editor
- Independent TSC and DMEC Trial Statistician
- Independent reviewer for a number of journals including BMJ, BMJ Open, The Lancet, The Lancet Infectious Diseases, Trials, and Pilot and Feasibility Studies
- Member of the MRC HTMR ADWG
- Advisory board member of The Bill & Melinda Gates Foundation on adaptive trials in low- and middle-income countries (LMIC)
Current and Previous Trials
The PANDA Project: Practical Adaptive & Novel Designs and Analysis Toolkit
The ACE Project: Adaptive Designs CONSORT Extension
Big CACTUS: A study to assess the clinical and cost effectiveness of aphasia computer treatment versus usual stimulation or attention control long term post stroke (CACTUS)
Endometrial Scratch: The Endometrial Scratch Trial
OPTION-DM: Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus trial
REPOSE: The Relative Effectiveness of Pumps over MDI and Structured Education for Type-1 Diabetes
Booster Trial: A randomised controlled trial and cost-effectiveness evaluation of 'booster' interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods
CACTUS: Evaluating the cost effectiveness of computer therapy compared with usual stimulation for people with long standing aphasia: a pilot study
CoSMoS: CBT Software for the treatment of depression in people with MS
- Palmer R, Dimairo M, Cooper C, Enderby P, Brady M, Bowen A, Latimer N, Julious S, Cross E, Alshreef A , Harrison M et al (2019) Self-managed, computerised speech and language therapy for patients with chronic aphasia post-stroke compared with usual care or attention control (Big CACTUS) : a multicentre, single-blinded, randomised controlled trial. The Lancet Neurology, 18(9), 821-833. View this article in WRRO
- Grayling MJ, Dimairo M, Mander AP & Jaki TF (2019) A review of perspectives on the use of randomization in phase II oncology trials. JNCI: Journal of the National Cancer Institute. View this article in WRRO
- Pandor A, Kaltenthaler E, Martyn-St James M, Wong R, Cooper K, Dimairo M, O’Cathain A, Campbell F & Booth A (2019) Delphi consensus reached to produce a decision tool for SelecTing Approaches forRapid Reviews (STARR). Journal of Clinical Epidemiology. View this article in WRRO
- Dimairo M, Coates E, Pallmann P, Todd S, Julious SA, Jaki T, Wason J, Mander AP, Weir CJ, Koenig F , Walton MK et al (2018) Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design. BMC Medicine, 16. View this article in WRRO
- Candlish J, Teare MD, Dimairo M, Flight L, Mandefield L & Walters SJ (2018) Appropriate statistical methods for analysing partially nested randomised controlled trials with continuous outcomes: a simulation study.. BMC Medical Research Methodology, 18(1), 105-105. View this article in WRRO
- Pallmann P, Bedding AW, Choodari-Oskooei B, Dimairo M, Flight L, Hampson LV, Holmes J, Mander AP, Odondi L, Sydes MR , Villar SS et al (2018) Adaptive designs in clinical trials: why use them, and how to run and report them. BMC Medicine, 16. View this article in WRRO
- Heller S, White D, Lee E, Lawton J, Pollard D, Waugh N, Amiel S, Barnard K, Beckwith A, Brennan A , Campbell M et al (2017) A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial. Health Technology Assessment, 21(20), 1-278. View this article in WRRO
- Heller S, Amiel S, Campbell M, Choudhary P, Cooper C, Dimairo M, Elliott J, Hammond P, Lee E, Lindsay R , Waugh N et al (2017) Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). BMJ, 356. View this article in WRRO
- Avery KNL, Williamson PR, Gamble C, Francischetto EOC, Metcalfe C, Davidson P, Williams H, Blazeby JM, Blencowe N, Bugge C , Campbell M et al (2017) Informing efficient randomised controlled trials: Exploration of challenges in developing progression criteria for internal pilot studies. BMJ Open, 7(e013537). View this article in WRRO
- Flight L, Allison A, Dimairo M, Lee E, Mandefield L & Walters SJ (2016) Recommendations for the analysis of individually randomised controlled trials with clustering in one arm – a case of continuous outcomes. BMC Medical Research Methodology, 16. View this article in WRRO
- Hatfield I, Allison A, Flight L, Julious SA & Dimairo M (2016) Adaptive designs undertaken in clinical research: a review of registered clinical trials. Trials, 17(1). View this article in WRRO
- Dimairo M, Boote J, Julious SA, Nicholl JP & Todd S (2015) Missing steps in a staircase: a qualitative study of the perspectives of key stakeholders on the use of adaptive designs in confirmatory trials. Trials, 16(1). View this article in WRRO
- Dimairo M, Julious SA, Todd S, Nicholl JP & Boote J (2015) Cross-sector surveys assessing perceptions of key stakeholders towards barriers, concerns and facilitators to the appropriate use of adaptive designs in confirmatory trials. Trials, 16(1). View this article in WRRO
- Teare M, Dimairo M, Shephard N, Hayman A, Whitehead A & Walters S (2014) Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study. Trials, 15(1), 264-264. View this article in WRRO
- Goyder E, Hind D, Breckon J, Dimairo M, Minton J, Everson-Hock E, Read S, Copeland R, Crank H, Horspool K , Humphreys L et al (2014) A randomised controlled trial and cost-effectiveness evaluation of 'booster' interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods.. Health Technol Assess, 18(13), 1-210.
- MacPherson P, Dimairo M, Bandason T, Zezai A, Munyati SS, Butterworth AE, Mungofa S, Rusakaniko S, Fielding K, Mason PR & Corbett EL (2011) Risk factors for mortality in smear-negative tuberculosis suspects: A cohort study in Harare, Zimbabwe. International Journal of Tuberculosis and Lung Disease, 15(10), 1390-1396.
- Lowe S, Ferrand RA, Morris-Jones R, Salisbury J, Mangeya N, Dimairo M, Miller RF & Corbett EL (2010) Skin disease among human immunodeficiency virus-infected adolescents in Zimbabwe: a strong indicator of underlying HIV infection.. Pediatr Infect Dis J, 29(4), 346-351.
- Dimairo M, MacPherson P, Bandason T, Zezai A, Munyati SS, Butterworth AE, Mungofa S, Rusikaniko S, Fielding K, Mason PR & Corbett EL (2010) The risk and timing of tuberculosis diagnosed in smear-negative TB suspects: A 12 month cohort study in Harare, Zimbabwe. PLoS ONE, 5(7). View this article in WRRO
- Mutetwa R, Boehme C, Dimairo M, Bandason T, Munyati SS, Mangwanya D, Mungofa S, Butterworth AE, Mason PR & Corbett EL (2009) Diagnostic accuracy of commercial urinary lipoarabinomannan detection in African tuberculosis suspects and patients.. Int J Tuberc Lung Dis, 13(10), 1253-1259.
- Stevely A, Dimairo M, Todd S, Julious SA, Nicholl J, Hind D & Cooper CL () An Investigation of the Shortcomings of the CONSORT 2010 Statement for the Reporting of Group Sequential Randomised Controlled Trials: A Methodological Systematic Review. PLOS ONE, 10(11), e0141104-e0141104. View this article in WRRO
Conference proceedings papers
- Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D , Hamasaki T et al (2017) Journeying through the development of an adaptive designs reporting guidance: findings from Delphi process. CEN ISBS Vienna 2017 (pp 94-94), 28 August 2017 - 1 September 2017.
- Dimairo M, Todd S, Julious S, Jaki T, Wason J, Mander A, Hind D, Weir C, Koenig F, Altman D , Nicholl J et al (2017) Journeying through the development of an adaptive designs reporting guidance: preliminary findings. Evidence Live 2017 (pp 42-43), 21 June 2017 - 22 June 2017.
- Dimairo M, Stevely A, Todd S, Julious S, Nicholl J, Hind D & Cooper C (2015) Investigation of the shortcomings of the consort 2010 statement for the reporting of group sequential randomised controlled trials. Trials, Vol. 16(S2) View this article in WRRO
- Dimairo M, Julious S, Todd S & Nicholl J (2015) Meandering journey towards routine trial adaptation: survey results on barriers to use of adaptive designs in confirmatory trials. Trials, Vol. 16(S2) View this article in WRRO
- Dimairo M, Stevely A, Julious S, Todd S, Cooper C, Hind D & Nicholl J (2015) Differential reporting of group sequential RCTs: shortcomings ofthe CONSORT 2010 statement. CPS 11: Group Sequential Methods and Interim Analysis. ARLINGTON, VIRGINIA, USA, 17 May 2015 - 20 May 2015.
- Dimairo M, Bradburn M & Walters SJ (2011) Sample size determination through power simulation; practical lessons from a stepped wedge cluster randomised trial (SW CRT).. Trials, Vol. 12 Suppl 1 (pp A26)
- Dimairo M, Mativenga S, Dauya E, Mungofa S, Makamure B, Mason P, Mangwanya D, Walley J & Corbett EL (2009) The Fate of Sputum Smear-negative TB Suspects Managed by Routine Clinical Services in Harare, Zimbabwe. 16th Conference on Retroviruses and Opportunistic Infections, Vol. 17(2). Montreal; Canada
- MacPherson P, Dimairo M, Bandason T, Zezai A, Munyati S, Mungofa S, Rusikaniko S, Fielding K, Mason P & Corbett EL () Risk Factors and Timing of Mortality in HIV+ Smear-negative TB Suspects: 12-Month Cohort Study in Harare, Zimbabwe. 18th Conference on Retroviruses and Opportunistic Infections, Montreal. Boston, USA, 27 February 2011 - 2 March 2011.
- Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D , Nicholl J et al Development of a CONSORT Extension for adaptive clinical trials.
- Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D , Nicholl J et al (2017) Journeying through the development of a consensus-driven adaptive designs reporting guidance. Global Forum on Bioethics in Research. View this article in WRRO
- Candlish J, Teare D, Cohen J, Dimairo M, Flight L, Mandefield L & Walters S (2017) Methods to analyse partially nested randomised controlled trials.