Professor Stephen Walters BSc, PGCE, MSc, PhD, CStat.
Professor of Medical Statistics and Clinical Trials
The University of Sheffield
30 Regent Street
Tel: (+44) (0)114 222 0730
Fax: (+44) (0)114 272 4095
Working pattern: Tuesday and Wednesday – 9:30am to 4.00pm, Thursday 9:30am to 3:30pm
Tel: +44 (0)114 2222988
Fax: +44 (0)114 2220870
I graduated with a degree in Mathematics and Economics. This was followed by a PGCE and an MSc in Medical Statistics and Information Technology. My PhD involved using computer intensive statistical methods for estimating sample sizes and analysing quality of life outcomes. I joined ScHARR in January 1995. I was promoted to Senior Lecturer in 2003; Reader in 2008 and to a Personal Chair in 2009. I was appointed Director of the Design, Trials and Statistics section in ScHARR in August 2012.
I am a Chartered Statistician with over 22 years’ experience of health services research and technology assessment. The main focus of my research has been in the design, analysis and reporting of trials of complex interventions; and the design, assessment, analysis and interpretation of patient reported outcomes in clinical trials. I work with clinicians from a variety of backgrounds to develop pragmatic clinical trial designs to capture the effectiveness and cost-effectiveness of a variety of health technologies. I have been co-investigator for more than 15 RCTs of non-pharmaceutical interventions.
I have co-authored over 270 publications (including 161 in refereed journals and 4 books, with over 21,000 copies sold). The majority of my peer-reviewed journal articles have been applied research, with the emphasis on the evaluation of new services. I have been a co-applicant, statistical advisor and collaborator on over 50 health services research projects.
My research interests are
- Design, Analysis and Interpretation of studies with Health Related Quality of Life (HRQoL) outcome measures. See 'Quality of life outcomes in clinical trials and health care evaluation: a practical guide to analysis and interpretation'.
- Computer intensive methods – the bootstrap.
- Health Services Research and Technology Assessment.
- Cluster RCTs and clustering by health professional in individually randomised trials.
- Study design and sample size determination.
I have developed several courses on teaching medical statistics to medical and health science students, clinicians and allied health professionals. I have also co-authored three textbooks: 'Medical Statistics: A Textbook for the Health Sciences' ; 'How to Display Data' and 'How to Design, Analyse and Report Cluster Randomised Trials in Medicine and Health Related Research'.
I co-ordinate and teach on HAR6035 `An Introduction to Statistics and Critical Appraisal´ module on the Master of Public Health programme and contribute to the distance learning version (HAR6042). I also teach on several other courses including: HAR674 Randomised Controlled Trials; MAS6061 Epidemiology; MAS6062 Further Clinical Trials.
- Member of the NIHR Health Technology Assessment Clinical Evaluation and Trials Board.
- Independent statistician member on several data and safety monitoring committees.
- Member of the Editorial Board for the journal of Health and Quality of Life Outcomes.
- Member of the Irish Health Research Board.
- NIHR Yorkshire and Humber Research Design Services. Co-applicant (PI: Professor Wendy Baird). 2013-2018 £5,250,000
- NIHR PGFaR Bridging the age gap in breast cancer. Improving outcomes for older women. Co-applicant (PI: Dr L. Wyld, Prof. M. Read). 2012-2017 £1,705,273
- ACtiF Development and evaluation of an intervention to support Adherence to treatment in adults with Cystic Fibrosis. Co-applicant. (PI: Dr M Wildman). 2014-2019. £1,981,622
- NIHR HTA Scratch A multi-centre RCT of Induced Endometrial Trauma in Women undergoing first time IVF. Co-applicant. (PI: Mr M Metwally). 2015-2020 £1,347,586
- NIHR HTA JtD Journeying Through Dementia; RCT of clinical and cost-effectiveness. 2015-2019. Co-applicant. (PI: Professor Gail Mountain). £1,964,310
- PRACTICE Post-Exacerbation Rehabilitation and ExerCise Training. Co-applicant. (PI: Dr R Hughes). 2015-2016. £361,988.
- BEADS Behavioural Activation Therapy after Stroke (BEADS). a feasibility randomised controlled trial of a psychological intervention for post-stroke depression. Co-applicant. (PI: Dr S Thomas). 2014-2017. £430,583
- VASCULAR The Design, Development, Commissioning and Evaluation of Patient Focused Vascular Services. Co-applicant. (PI: Prof J Michaels). 2013-2018. £1,866,367
- NIHR Research methods Fellowships and Internships NIHR-RMFI. Co-applicant. (PI: Professor Jon Nicholl).2015-2017. £87,376
- PREeMPT Is it feasible to conduct a randomised controlled trial of pre transplant exercise (pre-habilitation) for multiple myeloma patients awaiting autologous stem cell transplantation (PREempt). Co-applicant. (PI: Professor Sue Mawson). 2016-2020. £179,361
Stephen Walters is based in the Design, Trials & Statistics Section.
- Campbell MJ & Walters SJ (2014) How to Design, Analyse and Report Cluster Randomised Trials in Medicine and Health Related Research. John Wiley & Sons Ltd..
- Walters SJ, Henriques-Cadby IBDA, Bortolami O, Flight L, Hind D, Jacques RM, Knox C, Nadin B, Rothwell J, Surtees M & Julious SA (2017) Recruitment and retention of participants in randomised controlled trials: a review of trials funded and published by the United Kingdom Health Technology Assessment Programme. BMJ OPEN, 7(3). View this article in WRRO
- Flight L, Allison A, Dimairo M, Lee E, Mandefield L & Walters SJ (2016) Recommendations for the analysis of individually randomised controlled trials with clustering in one arm – a case of continuous outcomes. BMC Medical Research Methodology, 16. View this article in WRRO
- Thomas SA, Coates E, das Nair R, Lincoln NB, Cooper C, Palmer R, Walters SJ, Latimer NR, England TJ, Mandefield L, Chater T, Callaghan P & Drummond AER (2016) Behavioural Activation Therapy for Depression after Stroke (BEADS): a study protocol for a feasibility randomised controlled pilot trial of a psychological intervention for post-stroke depression. Pilot and Feasibility Studies, 2(1). View this article in WRRO
- Littlewood C, Bateman M, Brown K, Bury J, Mawson S, May S & Walters S (2016) A self-managed single exercise programme versus usual physiotherapy treatment for rotator cuff tendinopathy: a randomised controlled trial (the SELF study). Clinical Rehabilitation, 30(7), 686-696. View this article in WRRO
- Hoo ZH, Curley R, Campbell MJ, Walters SJ, Hind D & Wildman MJ (2016) Accurate reporting of adherence to inhaled therapies in adults with cystic fibrosis: methods to calculate normative adherence. Patient Preference and Adherence, 887-900. View this article in WRRO
- Relton C, Strong M, Renfrew M, Thomas K, Burrows J, Whelan B, Whitford H, Scott E, Fox-Rushby J, Anokye N, Sanghera S, Johnson M, Easton S & Walters S (2016) Cluster randomised controlled trial of a financial incentive for mothers to improve breast feeding in areas with low breastfeeding rates: the NOSH study protocol. BMJ Open, 6. View this article in WRRO
- Adiotomre E, Summers L, Allison A, Walters SJ, Digby M, Broadley P, Lang I & Offiah AC (2016) Diagnosis of vertebral fractures in children: is a simplified algorithm-based qualitative technique reliable?. Pediatric Radiology, 46(5), 680-688. View this article in WRRO
- (2015) Gastrostomy in patients with amyotrophic lateral sclerosis (ProGas): a prospective cohort study. The Lancet Neurology, 14(7), 702-709. View this article in WRRO
- Julious SA & Walters SJ (2014) Estimating effect sizes for health-related quality of life outcomes.. Stat Methods Med Res, 23(5), 430-439.
- Teare M, Dimairo M, Shephard N, Hayman A, Whitehead A & Walters S (2014) Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study. Trials, 15(1), 264-264. View this article in WRRO