A Multicentre Randomised Controlled Trial of Induced Endometrial Scratch in Women Undergoing First Time
IN Vitro Fertilisation (IVF)

Endometrial Scratchscratch logo

The Endometrial Scratch Trial completed recruitment in October 2018. We are therefore no longer looking for new participants. Data is currently being collected and analysed, with findings being released in mid-2020. Findings will be made available on this website.

What is the research about?

Taking a small amount of tissue from the lining of the womb (endometrium) can sometimes improve the chance of achieving a pregnancy in women who have previously had several unsuccessful attempts at In Vitro Fertilisation (IVF) or Intra-cytoplasmic sperm injection (ICSI). This procedure has been named “Endometrial Scratch” (ES). It is not known exactly why performing an Endometrial Scratch may be beneficial, but it is thought that the process of “scratching” the lining of the womb may release certain chemicals that are important in helping the fertilised egg (embryo) stick to the lining of the womb (implantation).

The use of Endometrial Scratch has not yet been fully tested in women who are about to have IVF/ICSI for the first time, but similar trials have used the same technique in women undergoing IVF/ICSI for the second or subsequent time, with beneficial results. If found to be beneficial then it could be used to improve the chance of achieving a pregnancy for a large group of women without the need for repeated IVF attempts.