A Multicentre Randomised Controlled Trial of Induced Endometrial Scratch in Women Undergoing First Time
IN Vitro Fertilisation (IVF)
What is the research about?
Taking a small amount of tissue from the lining of the womb (endometrium) can sometimes improve the chance of achieving a pregnancy in women who have previously had several unsuccessful attempts at In Vitro Fertilisation (IVF) or Intra-cytoplasmic sperm injection (ICSI). This procedure has been named “Endometrial Scratch” (ES). It is not known exactly why performing an Endometrial Scratch may be beneficial, but it is thought that the process of “scratching” the lining of the womb may release certain chemicals that are important in helping the fertilised egg (embryo) stick to the lining of the womb (implantation).
The use of Endometrial Scratch has not yet been fully tested in women who are about to have IVF/ICSI for the first time, but similar trials have used the same technique in women undergoing IVF/ICSI for the second or subsequent time, with beneficial results. If found to be beneficial then it could be used to improve the chance of achieving a pregnancy for a large group of women without the need for repeated IVF attempts.
Why have I been chosen and what are the possible benefits?
Women invited to participate will be having In Vitro Fertilisation (IVF) or Intra-cytoplasmic sperm injection (ICSI) for the first time. Taking part in this trial may or may not improve the chances of achieving a pregnancy. However, information from this trial may help doctors understand if there is any benefit to offering this procedure to women having first time IVF/ICSI on achieving a pregnancy in the future.
What does participating in this research involve?
The following film describes what it is like to be part of the trial and what participation will involve:
What do I do if I am interested in participating?
If you are interested in participating in the trial, you will need to be receiving IVF from one of the Fertility Units that are participating in the study:
If you are interested in participating in the trial, please discuss it with a member of your fertility team at your next routine appointment.
|Sheffield Teaching Hospitals||Vidya Tamhankar|
|University Hospital of Leicester||Tarek Gelbaya|
|Manchester University Hospitals (No longer recruiting new participants to the trial)||Lamiya Mohiyiddeen|
|The Newcastle upon Tyne Hospitals||Dr Meenakshi Choudhary|
|The University hospital Southampton (No longer recruiting new participants to the trial)||Ying Cheong|
|The Leeds Teaching Hospitals||Mugdha Kulkarni|
|South Tees Hospital NHS Trust (No longer recruiting new participants to the trial)||Dr Mohar Goswami|
|Gateshead Health NHS Foundation Trust||Mr Isaac Evbuomwan|
|Wrightington, Wigan and Leigh NHS Foundation Trust||Mr Phillip Harris|
|The Hewitt Fertility Centre||Mr Andrew Drakeley|
|Nurture Fertility (No longer recruiting new participants to the trial)||Mr Nick Raine Fenning|
|Oxford Fertility||Tim Childs|
|Birmingham Women’s Fertility Centre||Dr Madhurima Rajkhowa|
|NHS Tayside||Dr Sarah Martins Da Silva|
|Homerton University Hospital||Dr. Priya Bhide|
|Guys and St Thomas||Jan Grace|