Professor Claire Lewis

Clinical Medicine, School of Medicine and Population Health

Professor of Molecular & Cellular Pathology

Research Director, Weston Park Cancer Centre

Visiting Professor, Leiden University, The Netherlands

claire.lewis@sheffield.ac.uk
+44 114 215 9012

Floor E, The Medical School

Full contact details

Professor Claire Lewis
Clinical Medicine, School of Medicine and Population Health
Floor E
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

For enquiries, please contact - iicd-om-operational@sheffield.ac.uk

After completing my DPhil (PhD) in the Department of Physiology, Anatomy and Genetics in Oxford in 1986, I held two postdoctoral positions and a Lectureship in the Medical School there before moving to join the Medical School in Sheffield in 1996.

I currently hold a Personal Chair in Molecular & Cellular Pathology and head a team of pre and postdoctoral scientists in the Academic Unit of Inflammation and Tumour Targeting.

I was awarded a DSc by Oxford University in 2006 for my contribution to the field of tumour inflammation research.

Research interests

Our research is focused mainly on the role of inflammatory cells called macrophages in tumour progression and responses to conventional anti-cancer treatments like chemotherapy and irradiation.

We have also developed ways of using these cells to target therapeutic genes and viruses to tumours. Our work was reported in the national press (http://www.bbc.co.uk/news/health-20795977,) and is mainly funded by grants from Breast Cancer Now, Prostate Cancer UK, The European Union, Cancer Research UK and Team Verrico.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Al-Janabi H & Lewis CE (2021) Macrophage Regulation of the Development of Castration-Resistant Prostate Cancer. Cancer Research, 81(21), 5399-5400.
Boussommier-Calleja A, Atiyas Y, Haase K, Headley M, Lewis C & Kamm RD (2019) The effects of monocytes on tumor cell extravasation in a 3D vascularized microfluidic model. Biomaterials, 198, 180-193. View this article in WRRO
Keklikoglou I, Cianciaruso C, Güç E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A, Ferraro GB, Baer C , Cassará A et al (2018) Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models. Nature Cell Biology, 21(-), 190-202. View this article in WRRO
Yang M, McKay D, Pollard JW & Lewis CE (2018) Diverse functions of macrophages in different tumor microenvironments. Cancer Research, 78(19), 5492-5503. View this article in WRRO

All publications

Books

Staton C, Lewis CE & Bicknell R (2007) Angiogenesis Assays: A Critical Appraisal of Current Techniques. Wiley-Blackwell.

Journal articles

Humphries MP, Bingham V, Abdullah Sidi F, Craig S, Lara B, El-daly H, O'Doherty N, Maxwell P, Lewis C, McQuaid S , Lyness J et al (2023) Technical note on the exploration of COVID-19 in autopsy material. Journal of Clinical Pathology, 76(6), 418-423.
Kwan A, Howard F, Winder N, Atkinson E, Jailani A, Patel PB, Allen R, Ottewell PD, Shaw GC, Conner J , Wilson C et al (2022) Macrophage delivered HSV1716 is active against triple negative breast cancer. Future Pharmacology, 2(4), 444-459. View this article in WRRO
Iscaro A, Jones C, Forbes N, Mughal A, Howard FN, Al Janabi H, Demiral S, Perrie Y, Essand M, Weglarz A , Cruz LJ et al (2021) Targeting circulating monocytes with CCL2-loaded liposomes armed with an oncolytic adenovirus. Nanomedicine: Nanotechnology, Biology and Medicine, 102506-102506.
Juncker-Jensen A, Stavrou N, Moamin M, Nagy M, Allen R, Cox A & Lewis C (2021) 828 Quantifying perivascular immune cells in the stroma of human triple negative breast tumors using deep learning spatial analytics. Journal for ImmunoTherapy of Cancer, 9(Suppl 2), A867-A867.
Al-Janabi H & Lewis CE (2021) Macrophage Regulation of the Development of Castration-Resistant Prostate Cancer. Cancer Research, 81(21), 5399-5400.
Greene C, O'Doherty E, Abdullahi Sidi F, Bingham V, Fisher NC, Humphries MP, Craig SG, Harewood L, McQuaid S, Lewis C & James J (2021) The Potential of Digital Image Analysis to Determine Tumor Cell Content in Biobanked Formalin-Fixed, Paraffin-Embedded Tissue Samples. Biopreservation and Biobanking, 19(4), 324-331.
Kwan A, Winder N, Atkinson E, Al-Janabi H, Allen RJ, Hughes R, Moamin M, Louie R, Evans D, Hutchinson M , Capper D et al (2021) Macrophages Mediate the Antitumor Effects of the Oncolytic Virus HSV1716 in Mammary Tumors. Molecular Cancer Therapeutics, 20(3), 589-601.
Rohwer N, Jumpertz S, Erdem M, Egners A, Warzecha KT, Fragoulis A, Kühl AA, Kramann R, Neuss S, Rudolph I , Endermann T et al (2019) Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis.. Oncogene. View this article in WRRO
Boussommier-Calleja A, Atiyas Y, Haase K, Headley M, Lewis C & Kamm RD (2019) The effects of monocytes on tumor cell extravasation in a 3D vascularized microfluidic model. Biomaterials, 198, 180-193. View this article in WRRO
Keklikoglou I, Cianciaruso C, Güç E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A, Ferraro GB, Baer C , Cassará A et al (2018) Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models. Nature Cell Biology, 21(-), 190-202. View this article in WRRO
Yang M, McKay D, Pollard JW & Lewis CE (2018) Diverse functions of macrophages in different tumor microenvironments. Cancer Research, 78(19), 5492-5503. View this article in WRRO
Lewis C, McQuaid S, Clark P, Murray P, McGuigan T, Greene C, Coulter B, Mills K & James J (2018) The Northern Ireland Biobank: A Cancer Focused Repository of Science. Open Journal of Bioresources, 5.
Lapenna A, De Palma M & Lewis CE (2018) Perivascular macrophages in health and disease. Nature Reviews Immunology, 18(11), 689-702. View this article in WRRO
Bingham V, McIlreavey L, Greene C, O’Doherty E, Clarke R, Craig S, Salto-Tellez M, McQuaid S, Lewis C & James J (2017) RNAscope in situ hybridization confirms mRNA integrity in formalin-fixed, paraffin-embedded cancer tissue samples. Oncotarget, 8(55), 93392-93403.
Reid J, Briggs J, Carlisle S, Scott D & Lewis C (2017) Enhancing utility and understanding of evidence based practice through undergraduate nurse education. BMC Nursing, 16(1).
Lewis C, McQuaid S, Hamilton PW, Salto-Tellez M, McArt D & James JA (2016) Building a ‘Repository of Science’: The importance of integrating biobanks within molecular pathology programmes. European Journal of Cancer, 67, 191-199.
Lewis C, Reid J, McLernon Z, Ingham R & Traynor M (2016) The impact of a simulated intervention on attitudes of undergraduate nursing and medical students towards end of life care provision. BMC Palliative Care, 15(1).
Lewis CE, Harney AS & Pollard JW (2016) The Multifaceted Role of Perivascular Macrophages in Tumors. Cancer Cell, 30(1), 18-25. View this article in WRRO
Hughes R, Qian B-Z, Rowan C, Muthana M, Keklikoglou I, Olson OC, Tazzyman S, Danson S, Addison C, Clemons M , Gonzalez-Angulo AM et al (2015) Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy. Cancer Research, 75(17), 3479-3491.
Muthana M, Kennerley AJ, Hughes R, Faganano E, Richardson J, Paul M, Murdoch C, Wright F, Payne C, Lythgoe MF , Farrow N et al (2015) Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting. Nature Communications, 6(-), ---. View this article in WRRO
Galluzzi L, Vacchelli E, Pedro J-MB-S, Buqué A, Senovilla L, Baracco EE, Bloy N, Castoldi F, Abastado J-P, Agostinis P , Apte RN et al (2015) Classification of current anticancer immunotherapies. Oncotarget, 5(24), 12472-12508. View this article in WRRO
(2014) , 5(24).
Highley JR, Gebril OH, Simpson JE, Wharton SB, Kirby J, O'Brien JT, Barber R, Kalaria RN, Brayne C, Lewis CE , Shaw PJ et al (2014) Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain. Journal of Aging Science, 2(1). View this article in WRRO
Chen Y-Y, Brown NJ, Jones R, Lewis CE, Mujamammi AH, Muthana M, Seed MP & Barker MD (2014) A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice.. Angiogenesis, 17(1), 207-219. View this article in WRRO
De Palma M & Lewis CE (2013) Macrophage Regulation of Tumor Responses to Anticancer Therapies. CANCER CELL, 23(3), 277-286.
Muthana M, Richardson J, Rodrigues S & Lewis C (2013) Construction of Human Monocyte Derived Macrophages Armed with Oncolytic Viruses. BIO-PROTOCOL, 3(13).
Muthana M, Rodrigues S, Chen Y-Y, Welford A, Hughes R, Tazzyman S, Essand M, Morrow F & Lewis CE (2013) Macrophage delivery of an oncolytic virus abolishes tumor regrowth and metastasis after chemotherapy or irradiation.. Cancer Res, 73(2), 490-495.
Gheryani N, Coffelt SB, Gartland A, Rumney RMH, Kiss-Toth E, Lewis CE, Tozer GM, Greaves DR, Dear TN & Miller G (2013) Generation of a novel mouse model for the inducible depletion of macrophages in vivo.. Genesis, 51(1), 41-49.
De Palma M & Lewis CE (2011) CANCER Macrophages limit chemotherapy. NATURE, 472(7343), 303-304.
Abigail WF, Biziato D, Coffelt SB, Nucera S, Fisher M, Pucci F, Serio CD, Naldini L, De Palma M, Tozer GM & Lewis CE (2011) Abstract 2849: Tie2-expressing macrophages (TEM) depletion may enhance the clinical efficacy of combretastatin A-4-phosphate (CA-4-P). Tumor Biology.
Lewis CE & Ferrara N (2011) Multiple effects of angiopoietin-2 blockade on tumors.. Cancer Cell, 19(4), 431-433.
Welford AF, Biziato D, Coffelt SB, Nucera S, Fisher M, Pucci F, Di Serio C, Naldini L, De Palma M, Tozer GM & Lewis CE (2011) TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice.. J Clin Invest, 121(5), 1969-1973.
Coffelt SB, Chen Y-Y, Muthana M, Welford AF, Tal AO, Scholz A, Plate KH, Reiss Y, Murdoch C, De Palma M & Lewis CE (2011) Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion.. J Immunol, 186(7), 4183-4190.
Owen MR, Stamper IJ, Muthana M, Richardson GW, Dobson J, Lewis CE & Byrne HM (2011) Mathematical modeling predicts synergistic antitumor effects of combining a macrophage-based, hypoxia-targeted gene therapy with chemotherapy.. Cancer Res, 71(8), 2826-2837.
Tazzyman S, Barry ST, Ashton S, Wood P, Blakey D, Lewis CE & Murdoch C (2011) Inhibition of neutrophil infiltration into A549 lung tumors in vitro and in vivo using a CXCR2-specific antagonist is associated with reduced tumor growth.. Int J Cancer, 129(4), 847-858.
Muthana M, Giannoudis A, Scott SD, Fang H-Y, Coffelt SB, Morrow FJ, Murdoch C, Burton J, Cross N, Burke B , Mistry R et al (2011) Use of macrophages to target therapeutic adenovirus to human prostate tumors.. Cancer Res, 71(5), 1805-1815.
Krajewska E, Lewis C, Staton C, MacGowan A & MacNeil S (2011) New insights into induction of early-stage neovascularization in an improved tissue-engineered model of psoriasis. Journal of Tissue Engineering and Regenerative Medicine, 5(5), 363-374.
Biswas SK & Lewis CE (2010) NF-κB as a central regulator of macrophage function in tumors.. J Leukoc Biol, 88(5), 877-884.
Coffelt SB, Tal AO, Scholz A, De Palma M, Patel S, Urbich C, Biswas SK, Murdoch C, Plate KH, Reiss Y & Lewis CE (2010) Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions.. Cancer Res, 70(13), 5270-5280.
Coffelt SB, Lewis CE, Naldini L, Brown JM, Ferrara N & De Palma M (2010) Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors.. Am J Pathol, 176(4), 1564-1576.
Krajewska E, Lewis CE, Chen Y-Y, Welford A, Tazzyman S & Staton CA (2010) A novel fragment derived from the beta chain of human fibrinogen, beta43-63, is a potent inhibitor of activated endothelial cells in vitro and in vivo.. Br J Cancer, 102(3), 594-601. View this article in WRRO
Coffelt SB, Hughes R & Lewis CE (2009) Tumor-associated macrophages: effectors of angiogenesis and tumor progression.. Biochim Biophys Acta, 1796(1), 11-18.
Fang H-Y, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, Johnson RS, Imityaz HZ, Simon MC, Fredlund E , Greten FR et al (2009) Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia.. Blood, 114(4), 844-859.
Tazzyman S, Lewis CE & Murdoch C (2009) Neutrophils: key mediators of tumour angiogenesis.. Int J Exp Pathol, 90(3), 222-231.
Hagemann T, Biswas SK, Lawrence T, Sica A & Lewis CE (2009) Regulation of macrophage function in tumors: the multifaceted role of NF-kappa B. BLOOD, 113(14), 3139-3146.
Ryan RM, Green J, Williams PJ, Tazzyman S, Hunt S, Harmey JH, Kehoe SC & Lewis CE (2009) Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors.. Gene Ther, 16(3), 329-339.
Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R , Kalaria RN et al (2009) Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways.. Stroke, 40(2), 369-375.
Murdoch C, Muthana M, Coffelt SB & Lewis CE (2008) The role of myeloid cells in the promotion of tumour angiogenesis.. Nat Rev Cancer, 8(8), 618-631.
Larsen M, Tazzyman S, Lund EL, Junker N, Lewis CE, Kristjansen PEG & Murdoch C (2008) Hypoxia-induced secretion of macrophage migration-inhibitory factor from MCF-7 breast cancer cells is regulated in a hypoxia-inducible factor-independent manner. CANCER LETT, 265(2), 239-249.
Muthana M, Scott SD, Farrow N, Morrow F, Murdoch C, Grubb S, Brown N, Dobson J & Lewis CE (2008) A novel magnetic approach to enhance the efficacy of cell-based gene therapies.. Gene Ther, 15(12), 902-910.
Biswas SK, Sica A & Lewis CE (2008) Plasticity of macrophage function during tumor progression: Regulation by distinct molecular mechanisms. J IMMUNOL, 180(4), 2011-2017.
Elbarghati L, Murdoch C & Lewis CE (2008) Effects of hypoxia on transcription factor expression in human monocytes and macrophages.. Immunobiology, 213(9-10), 899-908.
Pahler JC, Tazzyman S, Erez N, Chen YY, Murdoch C, Nozawa H, Lewis CE & Hanahan D (2008) Plasticity in tumor-promoting inflammation: Impairment of macrophage recruitment evokes a compensatory neutrophil response. Neoplasia, 10(4), 329-339.
Lewis C (2008) Research alert: Gene therapy - Microscopic magnets attached to human cells offer hope for cancer treatment. Biomedical Materials(JUNE), 10.
Simpson JE, Ince PG, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN , Brayne C et al (2007) Microglial activation in white matter lesions and nonlesional white matter of ageing brains.. Neuropathol Appl Neurobiol, 33(6), 670-683.
De Palma M, Murdoch C, Venneri MA, Naldin L & Lewis CE (2007) Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications. TRENDS IMMUNOL, 28(12), 519-524.
Staton CA, Lewis C & Bicknell R (2007) Preface. Angiogenesis Assays: A Critical Appraisal of Current Techniques.
Lewis CE, De Palma M & Naldini L (2007) Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2.. Cancer Res, 67(18), 8429-8432.
Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C , Shaw PJ et al (2007) White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses.. Neuropathol Appl Neurobiol, 33(4), 410-419.
Webb SD, Owen MR, Byrne HM, Murdoch C & Lewis CE (2007) Macrophage-based anti-cancer therapy: Modelling different modes of tumour targeting. B MATH BIOL, 69(5), 1747-1776.
Murdoch C, Tazzyman S, Webster S & Lewis CE (2007) Expression of Tie-2 by human monocytes and their responses to angiopoietin-2.. J Immunol, 178(11), 7405-7411.
Staton CA, Stribbling SM, García-Echeverría C, Bury JP, Tazzyman S, Lewis CE & Brown NJ (2007) Identification of key residues involved in mediating the in vivo anti-tumor/anti-endothelial activity of Alphastatin.. J Thromb Haemost, 5(4), 846-854.
Lewis CE & Hughes R (2007) Inflammation and breast cancer. Microenvironmental factors regulating macrophage function in breast tumours: hypoxia and angiopoietin-2.. Breast Cancer Res, 9(3), 209. View this article in WRRO
Lin EY, Li J-F, Gnatovskiy L, Deng Y, Zhu L, Grzesik DA, Qian H, Xue X-N & Pollard JW (2006) Macrophages Regulate the Angiogenic Switch in a Mouse Model of Breast Cancer. Cancer Research, 66(23), 11238-11246.
Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB , Shaw PJ et al (2006) White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury.. Stroke, 37(6), 1391-1398.
MacRae EJ, Giannoudis A, Ryan R, Brown NJ, Hamdy FC, Maitland N & Lewis CE (2006) Gene therapy for prostate cancer: current strategies and new cell-based approaches.. Prostate, 66(5), 470-494.
Bingle L, Lewis CE, Corke KP, Reed MWR & Brown NJ (2006) Macrophages promote angiogenesis in human breast tumour spheroids in vivo.. Br J Cancer, 94(1), 101-107. View this article in WRRO
Lewis CE & Pollard JW (2006) Distinct role of macrophages in different tumor microenvironments.. Cancer Res, 66(2), 605-612.
Brockington A, Wharton SB, Fernando M, Gelsthorpe CH, Baxter L, Ince PG, Lewis CE & Shaw PJ (2006) Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis.. J Neuropathol Exp Neurol, 65(1), 26-36.
Ryan RM, Green J & Lewis CE (2006) Use of bacteria in anti-cancer therapies.. Bioessays, 28(1), 84-94.
Murdoch C & Lewis CE (2005) Macrophage migration and gene expression in response to tumor hypoxia.. Int J Cancer, 117(5), 701-708.
Murdoch C, Muthana M & Lewis CE (2005) Hypoxia regulates macrophage functions in inflammation.. J Immunol, 175(10), 6257-6263.
Lewis C & Murdoch C (2005) Macrophage Responses to Hypoxia. The American Journal of Pathology, 167(3), 627-635.
Brockington A, Kirby J, Eggitt D, Schofield E, Morris C, Lewis CE, Ince PG & Shaw PJ (2005) Screening of the regulatory and coding regions of vascular endothelial growth factor in amyotrophic lateral sclerosis. NEUROGENETICS, 6(2), 101-104.
Staton CA & Lewis CE (2005) Angiogenesis inhibitors found within the haemostasis pathway.. J Cell Mol Med, 9(2), 286-302.
Franks SJ, Byrne HM, Underwood JCE & Lewis CE (2005) Biological inferences from a mathematical model of comedo ductal carcinoma in situ of the breast.. J Theor Biol, 232(4), 523-543.
Murdoch C, Giannoudis A & Lewis CE (2004) Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.. Blood, 104(8), 2224-2234.
Brockington A, Lewis C, Wharton S & Shaw PJ (2004) Vascular endothelial growth factor and the nervous system. Neuropathology and Applied Neurobiology, 30(5), 427-446.
Staton CA, Stribbling SM, Tazzyman S, Hughes R, Brown NJ & Lewis CE (2004) Current methods for assaying angiogenesis in vitro and in vivo.. Int J Exp Pathol, 85(5), 233-248.
Stribbling SM, Bury JP, Corke KP, Lewis CE & Brown NJ (2004) PC41 THE IN VIVO EFFICACY OF THE ANTIANGIOGENIC PEPTIDE ALPHASTATIN. Microcirculation, 11(6), 552-553.
Staton CA, Brown NJ, Rodgers G, Corke KP, Tazzyman S, Underwood JCE & Lewis CE (2004) OC9 ALPHASTATIN, A 24-AMINO ACID FRAGMENT OF FIBRINOGEN IS A NOVEL ANTI-ANGIOGENIC AND ANTI-VASCULAR AGENT. Microcirculation, 11(6), 531-532.
Ameri K, Lewis CE, Raida M, Sowter H, Hai TW & Harris AL (2004) Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells. BLOOD, 103(5), 1876-1882.
Owen MR, Byrne HM & Lewis CE (2004) Mathematical modelling of the use of macrophages as vehicles for drug delivery to hypoxic tumour sites. J THEOR BIOL, 226(4), 377-391.
Staton CA, Brown NJ, Rodgers GR, Corke KP, Tazzyman S, Underwood JCE & Lewis CE (2004) Alphastatin, a 24-amino acid fragment of human fibrinogen, is a potent new inhibitor of activated endothelial cells in vitro and in vivo.. Blood, 103(2), 601-606.
Peters CL, Morris CJ, Mapp PI, Blake DR, Lewis CE & Winrow VR (2004) The transcription factors hypoxia-inducible factor 1 alpha and Ets-1 colocalize in the hypoxic synovium of inflamed joints in adjuvant-induced arthritis. ARTHRITIS RHEUM, 50(1), 291-296.
Daly ME, Makris A, Reed M & Lewis CE (2003) Hemostatic regulators of tumor angiogenesis: a source of antiangiogenic agents for cancer treatment?. J Natl Cancer Inst, 95(22), 1660-1673.
Franks SJ, Byrne HM, King JR, Underwood JCE & Lewis CE (2003) Modelling the early growth of ductal carcinoma in situ of the breast. J MATH BIOL, 47(5), 424-452.
Burke B, Giannoudis A, Corke KP, Gill D, Wells M, Ziegler-Heitbrock L & Lewis CE (2003) Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy.. Am J Pathol, 163(4), 1233-1243.
Staton CA, Brown NJ & Lewis CE (2003) The role of fibrinogen and related fragments in tumour angiogenesis and metastasis.. Expert Opin Biol Ther, 3(7), 1105-1120.
Franks SJ, Byrne HM, Mudhar HS, Underwood JCE & Lewis CE (2003) Mathematical modelling of comedo ductal carcinoma in situ of the breast. MATH MED BIOL, 20(3), 277-308.
Breward CJW, Byrne HM & Lewis CE (2003) A multiphase model describing vascular tumour growth. B MATH BIOL, 65(4), 609-640.
Ameri K, Burke B, Lewis CE & Harris AL (2002) Regulation of a rat VL30 element in human breast cancer cells in hypoxia and anoxia: role of HIF-1.. Br J Cancer, 87(10), 1173-1181. View this article in WRRO
Baluch CJ, Burke B, Corke K, Wells M, Smith J, Tidy J, Coleman R & Lewis CE (2002) Expression of hypoxia inducible factor-1 in metastatic tumour's in ovarian cancer: link with p53 expression and relevance to hypoxia-targeted gene therapies for disseminated disease. J PATHOL, 198, 5A-5A.
Burke B, Sumner S, Maitland N & Lewis CE (2002) Macrophages in gene therapy: cellular delivery vehicles and in vivo targets. J LEUKOCYTE BIOL, 72(3), 417-428.
Breward CJW, Byrne HM & Lewis CE (2002) The role of cell-cell interactions in a two-phase model for avascular tumour growth. J MATH BIOL, 45(2), 125-152.
Brown NJ, Staton CA, Rodgers GR, Corke KP, Underwood JCE & Lewis CE (2002) Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model.. Br J Cancer, 86(11), 1813-1816. View this article in WRRO
Bingle L, Brown NJ & Lewis CE (2002) The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies.. J Pathol, 196(3), 254-265.
Burke B, Tang N, Corke KP, Tazzyman D, Ameri K, Wells M & Lewis CE (2002) Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy.. J Pathol, 196(2), 204-212.
Kelly CE, Leek RD, Byrne HM, Cox SM, Harris AL & Lewis CE (2002) Modelling macrophage infiltration into avascular tumours. Journal of Theoretical Medicine, 4(1), 21-39.
Crowther M, Brown NJ, Bishop ET & Lewis CE (2001) Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors.. J Leukoc Biol, 70(4), 478-490.
Breward CJW, Byrne HM & Lewis CE (2001) Modelling the interactions between tumour cells and a blood vessel in a microenvironment within a vascular tumour. EUR J APPL MATH, 12, 529-556. View this article in WRRO
Hehlgans T, Seitz C, Lewis C & Männel DN (2001) Hypoxic Upregulation of TNF Receptor Type 2 Expression Involves NF-IL-6 and Is Independent of HIF-1 or HIF-2. Journal of Interferon & Cytokine Research, 21(9), 757-762.
Burton JL, Wells JM, Corke KP, Maitland NJ, Harndy FC & Lewis CE (2001) Hypoxic macrophages accumulate in avascular, hypoxic areas of prostate cancer and benign prostatic hyperplasia.. J PATHOL, 195, 33A-33A.
Hollander AP, Corke KP, Freemont AJ & Lewis CE (2001) Expression of hypoxia-inducible factor la by macrophages in the rheumatoid synovium - Implications for targeting of therapeutic genes to the inflamed joint. ARTHRITIS RHEUM, 44(7), 1540-1544.
Donovan D, Brown NJ, Bishop ET & Lewis CE (2001) Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo.. Angiogenesis, 4(2), 113-121.
Bootle-Wilbraham CA, Tazzyman S, Thompson WD, Stirk CM & Lewis CE (2001) Fibrin fragment E stimulates the proliferation, migration and differentiation of human microvascular endothelial cells in vitro.. Angiogenesis, 4(4), 269-275.
Gammack D, Byrne HM & Lewis CE (2001) Estimating the selective advantage of mutant p53 tumour cells to repeated rounds of hypoxia. B MATH BIOL, 63(1), 135-166.
Lewis JS, Landers RJ, Underwood JC, Harris AL & Lewis CE (2000) Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas.. J Pathol, 192(2), 150-158.
Bootle-Wilbraham CA, Tazzyman S, Marshall JM & Lewis CE (2000) Fibrinogen E-fragment inhibits the migration and tubule formation of human dermal microvascular endothelial cells in vitro.. Cancer Res, 60(17), 4719-4724.
Ferreux E, Lewis CE, Perrett CW & Wells M (2000) The role of p53 gene status in modulating the effects of hypoxia on human epithelial ovarian cancer cells. J PATHOL, 192, 10A-10A.
Landers RJ, Underwood JCE, Evans CA, Lawry J, Leek RD, Harris AL & Lewis CE (2000) Macrophage expression of urokinase receptors correlates with macrophage infiltration and angiogenesis in invasive carcinoma of the breast: Regulation by hypoxia. J PATHOL, 192, 20A-20A.
Burton JL, Wells JM, Corke KP, Maitland N, Hamdy FC & Lewis CE (2000) Macrophages accumulate in avascular, hypoxic areas of prostate tumours: implications for targeted therapeutic gene delivery to such sites.. J PATHOL, 192, 8A-8A.
Ameri K, Lewis CE, Burke B & Harris AL (2000) Characterisation of hypoxia responsive element activity under anoxia in breast cancer cells: Role of HIF-1 and ATF-4. BRIT J CANCER, 83, 11-11.
Leek RD, Hunt NC, Landers RJ, Lewis CE, Royds JA & Harris AL (2000) Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. J PATHOL, 190(4), 430-436.
Griffiths L, Binley K, Iqball S, Kan O, Maxwell P, Ratcliffe P, Lewis C, Harris A, Kingsman S & Naylor S (2000) The macrophage – a novel system to deliver gene therapy to pathological hypoxia. Gene Therapy, 7(3), 255-262.
Lewis JS, Lee JA, Underwood JC, Harris AL & Lewis CE (1999) Macrophage responses to hypoxia: relevance to disease mechanisms.. J Leukoc Biol, 66(6), 889-900.
Leek RD, Landers RJ, Harris AL & Lewis CE (1999) Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. BRIT J CANCER, 79(5-6), 991-995. View this article in WRRO
Lewis JS, Landers RJ, Underwood JCE, Harris AL & Lewis CE (1999) Expression of vascular endothelial growth factor by macrophages is upregulated in poorly vascularised areas of breast carcinomas. J PATHOL, 189, 13A-13A.
Ferreux E, Wells M, Perrett CP & Lewis CE (1999) Regulation of angiogenesis in ovarian cancer: role of p53, vascular endothelial growth factor and hypoxia.. J PATHOL, 189, 16A-16A.
Kingsman SM, Griffiths L, Binley K, Iqball S, Kan O, Maxwell P, Lewis C, Harris A & Naylor S (1999) The Macrophage-Exploiting Hypoxia With Cell Based Delivery of GDEPT. Nature Biotechnology, 17(S4), 38-38.
Zhang L, Scott PAE, Turley H, Leek R, Lewis CE, Gatter KC, Harris AL, Mackenzie IZ, Rees MCP & Bicknell R (1998) Validation of anti-vascular endothelial growth factor (anti-VEGF) antibodies for immunohistochemical localization of VEGF in tissue sections: Expression of VEGF in the human endometrium. J PATHOL, 185(4), 402-408.
Landers RJ, Leek RD, Fox SB, Ng F, Harris AL & Lewis CE (1998) Association of tumour necrosis factor and its receptors with thymidine phosphorylase expression and metastasis in human breast cancer. J PATHOL, 182, A16-A16.
Leek RD, Landers R, Fox SB, Ng F, Harris AL & Lewis CE (1998) Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma. BRIT J CANCER, 77(12), 2246-2251. View this article in WRRO
Royds JA, Dower SK, Qwarnstrom EE & Lewis CE (1998) Response of tumour cells to hypoxia: role of p53 and NFkB.. Mol Pathol, 51(2), 55-61.
Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J & Harris AL (1996) Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Research, 56(20), 4625-4629.
CAMPBELL AP, SMITHSON J, LEWIS C, KETTLEWELL MGW, MORTENSEN N, JEWELL DP & McGEE JO (1996) ALTERED EXPRESSION OF TGFα AND TGFβ1 IN THE MUCOSA OF THE FUNCTIONING PELVIC ILEAL POUCH. The Journal of Pathology, 180(4), 407-414.
Bromley L, McCarthy SP, Stickland JE, Lewis CE & McGee JO (1994) Non-isotopic in situ detection of mRNA for interleukin-4 in archival human tissue. Journal of Immunological Methods, 167(1-2), 47-54.
O'Sullivan C & Lewis CE (1994) Tumour-associated leucocytes: Friends or foes in breast carcinoma. The Journal of Pathology, 172(3), 229-235.
Leek RD, Harris AL & Lewis CE (1994) Cytokine networks in solid human tumors: regulation of angiogenesis. Journal of Leukocyte Biology, 56(4), 423-435.
Pusztai L, Clover LM, Cooper K, Starkey PM, Lewis CE & McGee J (1994) Expression of tumour necrosis factor α and its receptors in carcinoma of the breast. British Journal of Cancer, 70(2), 289-292.
O'Sullivan C, Lewis CE, McGee JO & Harris AL (1993) Secretion of epidermal growth factor by macrophages associated with breast carcinoma. The Lancet, 342(8864), 148-149.
Pusztai L, Lewis CE, Lorenzen J & McGee JO (1993) Growth factors: Regulation of normal and neoplastic growth. The Journal of Pathology, 169(2), 191-201.
Pusztai L, Lewis CE & McGee J (1993) Growth arrest of the breast cancer cell line, T47D, by TNF α; cell cycle specificity and signal transduction. British Journal of Cancer, 67(2), 290-296.
Pusztai L, Lewis CE & McGee JO (1993) Epidermal growth factor, insulin-like growth factor-1 and basic fibroblast growth factor modulate the cytostatic effect of tumour necrosis factor-α on the breast cancer cell line, T47D. Cytokine, 5(2), 169-172.
BAIGRIE R (1992) Effect of major surgery on the release of interferon gamma by peripheral blood mononuclear cells: An investigation at the single cell level using the reverse haemolytic plaque assay. Cytokine, 4(1), 63-65.
Lewis CE, McCracken D, Ling R, Richards PS, McCarthy SR & McGee JO (1991) Cytokine Release by Single, Immunophenotyped Human Cells: Use of the Reverse Hemolytic Plaque Assay. Immunological Reviews, 119(1), 23-39.
Lorenzen J, Lewis CE, McCracken D, Horak E, Greenall M & McGee J (1991) Human tumour-associated NK cells secrete increased amounts of interferon-γ and interleukin-4. British Journal of Cancer, 64(3), 457-462.
Lewis CE (1991) Detecting cytokine production at the single-cell level. Cytokine, 3(3), 184-188.
Lewis CE, Ramshaw AL, Lorenzen J & McGee JO (1991) Basic fibroblast growth factor and interleukins 4 and 6 stimulate the release of IFN-γ by individual NK cells. Cellular Immunology, 132(1), 158-167.
Lewis CE, McCarthy SP, Richards PS, Lorenzen J, Horak E & O'D McGee J (1990) Measurement of cytokine release by human cells A quantitative analysis at the single cell level using the reverse haemolytic plaque assay. Journal of Immunological Methods, 127(1), 51-59.
Lewis CE, McCarthy SP, Lorenzen J & McGee O'D. J (1990) Differential effects of LPS, IFN-γ and TNFα on the secretion of lysozyme by individual human mononuclear phagocytes: Relationship to cell maturity. Immunology, 69(3), 402-408.
McCarthy SP, Lewis CE & McGee JO (1990) Effects of ethanol on human monocyte/macrophage lysozyme storage and release. Journal of Hepatology, 10(1), 90-98.
Lewis CE, Mccarthy SP, Lorenzen J & Mcgee JOD (1989) Heterogeneity among human mononuclear phagocytes in their secretion of lysozyme, interleukin 1 and type-β transforming growth factor: a quantitative analysis at the single-cell level. European Journal of Immunology, 19(11), 2037-2043.
Lewis CE, Richards PSM & Morris JF (1989) Heterogeneity of responses to LH-releasing hormone and phorbol ester among rat gonadotrophs: a study using a reverse haemolytic plaque assay for LH. Journal of Molecular Endocrinology, 2(1), 55-63.
Lewis CE, Clark A, Ashcroft SJH, Cooper GJS & Morris JF (1988) Calcitonin gene-related peptide and somatostatin inhibit insulin release from individual rat B cells. Molecular and Cellular Endocrinology, 57(1-2), 41-49.
Cooper GJS, Willis AC, Reid KBM, Clark A, Baker CA, Turner RC, Lewis CE, Morris JF, Howland K & Rothbard JB (1987) DIABETES-ASSOCIATED PEPTIDE. The Lancet, 330(8565), 966-966.
Clark A, Lewis CE, Willis AC, Cooper GJS, Morris JF, Reid KBM & Turner RC (1987) ISLET AMYLOID FORMED FROM DIABETES-ASSOCIATED PEPTIDE MAY BE PATHOGENIC IN TYPE-2 DIABETES. The Lancet, 330(8553), 231-234.
Lewis CE, Megson A, Morris JF & Charlton HM (1986) Multiple injections of LH-releasing hormone into hypogonadal (hpg) mice induce the appearance of two morphologically distinct populations of gonadotrophs. Journal of Endocrinology, 111(3), 483-NP.
Lewis CE, Morris JF, Fink G & Johnson M (1986) Changes in the granule population of gonadotrophs of hypogonadal (hpg) and normal female mice associated with the priming effect of LH-releasing hormone in vitro. Journal of Endocrinology, 109(1), 35-NP.
Lewis CE, Fink G, Dow RC & Morris JF (1986) Hyperprolactinemia Induced by Pituitary Isografts Suppresses the Priming Effect of LH-Releasing Hormone in Normal and Hypogonadal Mice. Neuroendocrinology, 43(5), 584-589.
Lewis CE, Morris JF & Fink G (1985) The role of microfilaments in the priming effect of LH-releasing hormone: an ultrastructural study using cytochalasin B. Journal of Endocrinology, 106(2), 211-NP.

Chapters

Staton CA & Lewis CE (2006) Alphastatin: a pluripotent inhibitor of activated endothelial cells In Siemann DW (Ed.), Vascular-targeted therapies in oncology (pp. 205-220). Wiley-Blackwell

Conference proceedings papers

Al-janabi H, Pu X, Muthana M, Wang N, Crespo M, Gurel B, De Bono J, Brown JE & Lewis CE (2021) Abstract 2797: Changes in the phenotype of macrophages and CD8+ T Cells in the perivascular niche of prostate tumours following androgen deprivation. Tumor Biology
Moamin MR, Allen RJ, Stavrou N, Nagy M, Juncker-Jensen A & Lewis CE (2021) Abstract 2720: Perivascular accumulation of immunosuppressive cells in the stroma of human triple negative breast carcinomas: implications for immunotherapy. Tumor Biology
Al-Janabi H, Pu X, Muthana M, Wang N, Crespo M, Gurel B, De Bono J, Brown JE & Lewis CE (2021) Changes in the phenotype of macrophages and CD8+T Cells in the perivascular niche of prostate tumours following androgen deprivation.. CANCER RESEARCH, Vol. 81(13)
Moamin MR, Allen RJ, Stavrou N, Nagy M, Juncker-Jensen A & Lewis CE (2021) Perivascular accumulation of immunosuppressive cells in the stroma of human triple negative breast carcinomas: implications for immunotherapy.. CANCER RESEARCH, Vol. 81(13)
Pu X, AL-Janabi H, Wang N, Muthana M, Brown J & Lewis C (2019) Abstract LB-136: Targeting perivascular macrophages to prevent castration resistance in men with high-risk, localized prostate cancer. Tumor Biology
Pu X, AL-Janabi H, Wang N, Muthana M, Brown J & Lewis C (2019) Abstract LB-136: Targeting perivascular macrophages to prevent castration resistance in men with high-risk, localized prostate cancer. Tumor Biology
Tazzyman S, Muthana M, Harrison J, Lewis C, Conner J & Chantry A (2015) Development of a Trojan horse oncolytic virus for treatment of myeloma.. Journal of Clinical Oncology, Vol. 33(15_suppl) (pp e14035-e14035)
Muthana M, Giannoudis A, Scott SD, Burke B, Mistry R, Hamdy F, Brown N, Maitland N & Lewis CE (2006) Engineering macrophages to synthesize recombinant adenoviruses in hypoxic areas of human prostate tumors. CANCER RESEARCH, Vol. 66(8)
Lewis CE, Leek R, Harris A & McGee JO (1995) Cytokine regulation of angiogenesis in breast cancer: the role of tumor-associated macrophages. Journal of Leukocyte Biology, Vol. 57(5) (pp 747-751)

Preprints

Rohwer N, Jumpertz S, Erdem M, Egners A, Warzecha KT, Fragoulis A, Kühl AA, Kramann R, Neuss S, Rudolph I , Endermann T et al () Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis, Cold Spring Harbor Laboratory.

Research group

Members of the AUITT

Professor Claire Lewis
Dr Munitta Muthana (Senior Lecturer)
Dr Mohammed Ridha (Postdoc)
Dr Haider Al-Janabi (Postdoc)
Dr Jenny Down (Postdoc)
Dr Xuan Pu (Postdoc)
Dr Faith Howard (Postdoc)
Dr Amy Kwan (Clinical Research Fellow & PhD Student)
Christine Hospach (ECR & PhD Student)
Richard Allen (PhD Student)
Areej Alghamdi (PhD Student)
Natalie Winder (PhD Student)
Rita Dey (SHU Placement Student)

Teaching interests

Acute and chronic inflammation
Angiogenesis in human diseases
Cancer

Professional activities and memberships

Journals

Member of the Editorial Board, Frontiers in Immunology.
Member of the Editorial Board, Cancer Research.
Member of the Editorial Board, Cancers.
Member of the Editorial Board, Journal of Clinical Investigation Insight.
Member of the Editorial Board, OncoImmunology.
Member of the Editorial Board, International Journal of Cancer.
Associate Editor, International Journal of Experimental Pathology.

Grant Awarding Bodies

Member, MRC Molecular & Cellular Medicines Board (2018-2022).
Member, PCUK Research Advisory Committee (2019-2022).
Member, Quinquennial Review Panel, MRC Human Immunology Unit, Oxford, Nov. 2016.
Member, Quinquennial Review Panel, Breast Cancer Now Manchester Research Unit, Feb. 2016.
Member, Senior Investigator Awards Committee, The Wellcome Trust, (2013).
Member of 3 Scientific Advisory Boards: ‘Cancer Immunotherapy’, Tumour Inflammation’ and ‘Metastasis’ for the Cancer Section of EU Framework 7 (2007- present).
Member, International Science Evaluation Panel (for biology, medicine and health), The Research Council, Norway (2011).
Member, AACR Basic Cancer Research Grants Scientific Review Committee (2010).
Chair, BBSRC Review Panel in Interdisciplinary Research (2005).
MRC College of Experts - Molecular and Cellular Medicine Board, (2004-current).
EPSRC Peer Review College (2006-2009).
Member, Scientific Advisory Board, Breast Cancer Campaign (1999-2002)