Dr Hugo Penny

MBBS, MRCP, PhD.

Clinical Medicine, School of Medicine and Population Health

NIHR Clinical Lecturer in Gastroenterology

h.penny@sheffield.ac.uk
+44 114 271 2271

Royal Hallamshire Hospital

Full contact details

Dr Hugo Penny
Clinical Medicine, School of Medicine and Population Health
Royal Hallamshire Hospital
Glossop Road
Sheffield
S10 2JF

Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

I completed my undergraduate medical training at King’s College London in 2012, after which I moved to Sheffield for foundation training, and subsequently completed an Academic Clinical Fellowship alongside core medical training in South Yorkshire. I moved to Manchester to undertake a Wellcome Trust PhD Fellowship in Immunology in the lab of Dr Matthew Hepworth (University of Manchester) and then returned to Sheffield to complete my specialist training in Gastroenterology. In 2021 I was awarded an NIHR Academic Clinical Lectureship at the University of Sheffield to undertake research alongside my clinical training. My research focuses on clinical and translational aspects of small bowel diseases such as coeliac disease and other chronic enteropathies.

Qualifications

MBBS, King’s College London, 2012
PhD, University of Manchester, 2020
MRCP(UK), (Gastroenterology), Royal College of Physicians

Research interests: My research interests are focused on clinical and translational aspects of diseases of the small bowel including coeliac disease, and other chronic enteropathies. I am also interested in fundamental and mechanistic immunology of the GI tract, including the cross-talk between the immune system and commensal microbiota.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Penny HA, Domingues RG, Krauss MZ, Melo-Gonzalez F, Lawson MAE, Dickson S, Parkinson J, Hurry M, Purse C, Jegham E , Godinho-Silva C et al (2022) Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism. Science Immunology, 7(75).
Penny HA, Raju SA, Lau MS, Marks LJS, Baggus EMR, Bai JC, Bassotti G, Bontkes HJ, Carroccio A, Danciu M , Derakhshan MH et al (2021) Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts. Gut, 70(5), 876-883. View this article in WRRO
Penny HA, Baggus EMR, Rej A, Snowden JA & Sanders DS (2020) Non-responsive coeliac disease : a comprehensive review from the NHS England national centre for refractory coeliac disease. Nutrients, 12(1). View this article in WRRO

Chapters

Penny HA, Chetcuti Zammat S, Sidhu R & Sanders DS (2022) The Role of Endoscopy in Refractory Coeliac Disease, Refractory Celiac Disease (pp. 51-62). Springer International Publishing

All publications

Journal articles

Shiha MG, Schiepatti A, Maimaris S, Nandi N, Penny HA & Sanders DS (2024) Clinical outcomes of potential coeliac disease: a systematic review and meta-analysis. Gut, gutjnl-2024.
Shiha MG, Oka P, Nandi N, Ingham K, Raju SA, Penny HA, Elli L, Sanders DS & Sidhu R (2024) Role of capsule endoscopy and double-balloon enteroscopy in the management of adult patients with coeliac disease and persisting symptoms. Digestive and Liver Disease.
Shiha MG, Nandi N, Oka P, Raju SA, Penny HA, Hopper AD, Elli L & Sanders DS (2023) Narrow-band imaging for optical diagnosis of duodenal villous atrophy in patients with suspected coeliac disease: A systematic review and meta-analysis. Digestive and Liver Disease.
Rej A & Penny HA (2023) Current evidence for dietary therapies in irritable bowel syndrome. Current Opinion in Gastroenterology, 39(3), 219-226.
Shiha MG, Raju SA, Sidhu R & Penny HA (2023) The debate in the diagnosis of coeliac disease – time to go ‘no-biopsy’?. Current Opinion in Gastroenterology, 39(3), 192-199.
Penny HA, Domingues RG, Krauss MZ, Melo-Gonzalez F, Lawson MAE, Dickson S, Parkinson J, Hurry M, Purse C, Jegham E , Godinho-Silva C et al (2022) Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism. Science Immunology, 7(75).
Penny HA, Rej A, Baggus EMR, Coleman SH, Ward R, Wild G, Bouma G, Trott N, Snowden JA, Wright J , Cross SS et al (2022) Non-responsive and refractory coeliac disease : experience from the NHS England National Centre. Nutrients, 14(13). View this article in WRRO
Taylor MA, Blanshard RJ, Naylor G, Penny HA, Mooney PD & Sanders DS (2021) Do gastroenterologists have medical inertia towards coeliac disease? A UK multicentre secondary care study. BMJ Open Gastroenterology, 8(1). View this article in WRRO
Penny HA, Raju SA, Lau MS, Marks LJS, Baggus EMR, Bai JC, Bassotti G, Bontkes HJ, Carroccio A, Danciu M , Derakhshan MH et al (2021) Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts. Gut, 70(5), 876-883. View this article in WRRO
Penny HA, Raju SA & Sanders DS (2020) Progress in the serology-based diagnosis and management of adult celiac disease. Expert Review of Gastroenterology & Hepatology, 14(3), 147-154.
Penny HA, Baggus EMR, Rej A, Snowden JA & Sanders DS (2020) Non-responsive coeliac disease : a comprehensive review from the NHS England national centre for refractory coeliac disease. Nutrients, 12(1). View this article in WRRO
Baggus EMR, Hadjivassiliou M, Cross S, Penny H, Urwin H, Watson S, Woodward JM & Sanders DS (2020) How to manage adult coeliac disease: perspective from the NHS England Rare Diseases Collaborative Network for Non-Responsive and Refractory Coeliac Disease. Frontline Gastroenterology, 11(3), 235-242.
Adu-Tei S, Penny HA, El-Fekhi M, Ruse C & Sanders DS (2019) Healthcare professionals' attitudes towards PEG tube feeding in advanced dementia: time to engage with a wide clinical audience?. Minerva Gastroenterologica e Dietologica, 65(3).
Raju SA, Mooney PD, Kodali K, Toh C, Kusumawidjaja D, Hersey N, Penny H, Kurien M & Sanders DS (2018) First UK data for CT angiography in persisting upper GI bleeding. Frontline Gastroenterology, 9(4), 331-332. View this article in WRRO
Penny HA, Hodge SH & Hepworth MR (2018) Orchestration of intestinal homeostasis and tolerance by group 3 innate lymphoid cells. Seminars in Immunopathology, 40(4), 357-370.
Penny HA, Aziz I, Ferrar M, Atkinson J, Hoggard N, Hadjivassiliou M, West JN & Sanders DS (2016) Is there a relationship between gluten sensitivity and postural tachycardia syndrome?. European Journal of Gastroenterology & Hepatology, 28(12), 1383-1387.
Penny HA, Mooney PD, Burden M, Patel N, Johnston AJ, Wong SH, Teare J & Sanders DS (2016) High definition endoscopy with or without I-Scan increases the detection of celiac disease during routine endoscopy. Digestive and Liver Disease, 48(6), 644-649.
Penny HA, Kurien M, Wong E, Ahmed R, Ejenavi E, Lau M, Romaya C, Gohar F, Dear KL, Kapur K , Hoeroldt B et al (2016) Changing trends in the UK management of upper GI bleeding: is there evidence of reduced UK training experience?. Frontline Gastroenterology, 7(1), 67-72.
Penny HA, Leeds JS, Kurien M, Averginos A, Hopper AD, Hadjivassiliou M, Tesfaye S & Sanders DS (2015) The relationship between inflammatory bowel disease and type 1 diabetes mellitus: a study of relative prevalence in comparison with population controls. Journal of Gastrointestinal and Liver Diseases, 24(1), 125-126. View this article in WRRO
Kurien M, Penny H & Sanders DS (2015) Impact of direct drug delivery via gastric access devices. Expert Opinion on Drug Delivery, 12(3), 455-463.
McGregor R, Li G, Penny H, Lombardi G, Afzali B & Goldsmith DJ (2014) Vitamin D in Renal Transplantation – from Biological Mechanisms to Clinical Benefits. American Journal of Transplantation, 14(6), 1259-1270.
Penny H, Leckström D & Goldsmith D (2013) The Janus faces of ESAs: caveat Chimaera!. International Urology and Nephrology, 45(3), 761-767.
Penny H, Frame S, Dickinson F & Goldsmith D (2012) How Well Do Renal Transplant Patients “Cover-Up”? Seasonal Vitamin D Variation in Long-Term Renal Transplant Survivors. Transplantation Journal, 94(10S), 877-878.
Penny H, Frame S, Dickinson F, Garrett G, Young AR, Sarkany R, Chitalia N, Hampson G & Goldsmith D (2012) Determinants of vitamin D status in long‐term renal transplant patients. Clinical Transplantation, 26(6).
Heymann EP, Penny H & Goldsmith DJA (2012) Vascular and Arterial Calcification in Peritoneal Dialysis Patients – State-of-the-Art 2012, 189-194.
Shiha MG, Bowker-Howell FJ, Harper AM, Elwenspoek MMC, Penny HA, Banks J & Sanders DS () Exploring the views of primary and secondary care physicians on the no-biopsy diagnosis of coeliac disease in adults: a qualitative interview study. Frontline Gastroenterology, flgastro-2024.
Shiha MG, Hadjisavvas N, Sanders DS & Penny HA () Optimising the Diagnosis of Adult Coeliac Disease: Current Evidence and Future Directions. British Journal of Hospital Medicine, 1-21.
Shiha MG, Penny HA & Sanders DS () Is There a Need to Undertake Conventional Gastroscopy and Biopsy When Making the Diagnosis of Coeliac Disease in Adults?. Journal of Clinical Gastroenterology, 57(2), 139-142.
Raju SA, Sanders DS & Penny HA () Coeliac Disease and Probiotics: Clinicians Need to Provide the Evidence Base for this Unmet Need. Journal of Gastrointestinal and Liver Diseases, 30(4), 423-426.
Ziff OJ, Penny H, Frame S, Cronin A & Goldsmith D () Impact of seasonality on the dynamics of native Vitamin D repletion in long-term renal transplant patients. Clinical Kidney Journal, sfw136-sfw136.

Chapters

Schinnerling K, Penny HA, Soto JA & Melo-Gonzalez F (2023) Immune Responses at Host Barriers and Their Importance in Systemic Autoimmune Diseases, Advances in Experimental Medicine and Biology (pp. 3-24). Springer Nature Switzerland
Penny HA, Chetcuti Zammat S, Sidhu R & Sanders DS (2022) The Role of Endoscopy in Refractory Coeliac Disease, Refractory Celiac Disease (pp. 51-62). Springer International Publishing
Penny HA, Schiepatti A & Sanders DS (2022) Nonresponsive and complicated coeliac disease, Coeliac Disease and Gluten-Related Disorders (pp. 87-100). Elsevier

Preprints

Blanshard RJ, Naylor G, Taylor MA, Penny HA, Mooney PD & Sanders DS (2020) Does Clinical Nihilism affect the diagnostic approach for patients with undiagnosed adult coeliac disease? A UK Multicentre study, Cold Spring Harbor Laboratory.