Dr Jon Wood

Journal articles

• Eachus H, Ryu S, Placzek M & Wood J (2022) Zebrafish as a model to investigate the CRH axis and interactions with DISC1. Current Opinion in Endocrine and Metabolic Research, 100383-100383.
• Lorente Pons A, Higginbottom A, Cooper‐Knock J, Alrafiah A, Alofi E, Kirby J, Shaw PJ, Wood JD & Highley JR (2020) Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis. The Journal of Pathology. View this article in WRRO
• Eachus H, Bright C, Cunliffe VT, Placzek M, Wood JD & Watt PJ (2017) Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function. Human Molecular Genetics, 26(11), 1992-2005. View this article in WRRO
• Highley JR, Pons AL, Cooper‐Knock J, Wharton SB, Ince PG, Shaw PJ, Wood J & Kirby J (2016) Motor neurone disease/amyotrophic lateral sclerosis associated with intermediate‐length CAG repeat expansions in Ataxin‐2 does not have 1C2‐positive polyglutamine inclusions. Neuropathology and Applied Neurobiology, 42(4), 377-389. View this article in WRRO
• Seytanoglu A, Alsomali NI, Valori CF, McGown A, Kim HR, Ning K, Ramesh T, Sharrack B, Wood JD & Azzouz M (2016) Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo. Neuroscience, 322, 287-297. View this article in WRRO
• Wood JD, cunliffe VT, Roy S & Boyd PB (2015) Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): implications for mental illness. Biology Open. View this article in WRRO
• Fullstone G, Wood J, Holcombe M & Battaglia G (2015) Modelling the Transport of Nanoparticles under Blood Flow using an Agent-based Approach. Scientific Reports, 5(1). View this article in WRRO
• Butler R, Wood JD, Landers JA & Cunliffe VT (2010) Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia.. Dis Model Mech, 3(11-12), 743-751.
• Wood JD, Bonath F, Kumar S, Ross CA & Cunliffe VT (2009) Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain.. Hum Mol Genet, 18(3), 391-404.
• Sato T, Miura M, Yamada M, Yoshida T, Wood JD, Yazawa I, Masuda M, Suzuki T, Shin RM, Yau HJ , Liu FC et al (2009) Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice. Human Molecular Genetics, 18(4), 723-736.
• Kasher PR, De Vos KJ, Wharton SB, Manser C, Bennett EJ, Bingley M, Wood JD, Milner R, McDermott CJ, Miller CCJ , Shaw PJ et al (2009) Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.. J Neurochem, 110(1), 34-44.
• Wood JD, Landers JA, Bingley M, McDermott CJ, Thomas-McArthur V, Gleadall LJ, Shaw PJ & Cunliffe VT (2006) The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo.. Hum Mol Genet, 15(18), 2763-2771.
• Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA , Copeland NG et al (2006) Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin. Neurobiology of Disease, 21(2), 381-391.
• Wood JD, Beaujeux TP & Shaw PJ (2003) Protein aggregation in motor neurone disorders.. Neuropathol Appl Neurobiol, 29(6), 529-545.
• McDermott CJ, Grierson AJ, Wood JD, Bingley M, Wharton SB, Bushby KMD & Shaw PJ (2003) Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation.. Ann Neurol, 54(6), 748-759.
• Wharton SB, McDermott CJ, Grierson AJ, Wood JD, Gelsthorpe C, Ince PG & Shaw PJ (2003) The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene.. J Neuropathol Exp Neurol, 62(11), 1166-1177.
• Nucifora FC, Ellerby LM, Wellington CL, Wood JD, Herring WJ, Sawa A, Hayden MR, Dawson VL, Dawson TM & Ross CA (2003) Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity. J BIOL CHEM, 278(15), 13047-13055.
• Igarashi S, Morita H, Bennett KM, Tanaka Y, Engelender S, Peters MF, Cooper JK, Wood JD, Sawa A & Ross CA (2003) Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation.. Neuroreport, 14(4), 565-568.
• Beaujeux TP, Schofield EL, Shaw PJ & Wood JD (2002) SOD1 aggregation in familial amyotrophic lateral sclerosis (FALS). Biochemical Society Transactions, 30(3), A85-A85.
• Galinier R, Gout E, Lortat-Jacob H, Wood JD & Chroboczek J (2002) Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. Biochemistry, 41(48), 14299-14305.
• Schilling G, Jinnah HA, Gonzales V, Coonfield ML, Kim Y, Wood JD, Price DL, Li XJ, Jenkins N, Copeland N , Moran T et al (2001) Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA.. Neurobiol Dis, 8(3), 405-418.
• Yamada M, Wood JD, Shimohata T, Hayashi S, Tsuji S, Ross CA & Takahashi H (2001) Widespread occurrence of intranuclear atrophin-1 accumulation in the central nervous system neurons of patients with dentatorubral-pallidoluysian atrophy.. Ann Neurol, 49(1), 14-23.
• Xu J, Paquet M, Lau AG, Wood JD, Ross CA & Hall RA (2001) β1-Adrenergic Receptor Association with the Synaptic Scaffolding Protein Membrane-associated Guanylate Kinase Inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 AND PSD-95. Journal of Biological Chemistry, 276(44), 41310-41317.
• Wood JD, Nucifora FC, Duan K, Zhang C, Wang J, Kim Y, Schilling G, Sacchi N, Liu JM & Ross CA (2000) Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription.. J Cell Biol, 150(5), 939-948.
• Wu X, Hepner K, Castelino-Prabhu S, Do D, Kaye MB, Yuan X-J, Wood J, Ross C, Sawyers CL & Whang YE (2000) Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Proc Natl Acad Sci U S A, 97(8), 4233-4238.
• Schilling G, Wood JD, Duan K, Slunt HH, Gonzales V, Yamada M, Cooper JK, Margolis RL, Jenkins NA, Copeland NG , Takahashi H et al (1999) Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA.. Neuron, 24(1), 275-286.
• Ross CA, Wood JD, Schilling G, Peters MF, Nucifora FC, Cooper JK, Sharp AH, Margolis RL & Borchelt DR (1999) Polyglutamine pathogenesis.. Philos Trans R Soc Lond B Biol Sci, 354(1386), 1005-1011.
• Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA & Salvesen GS (1999) Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity. J Biol Chem, 274, 8730-8736.
• Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH & Ross CA (1998) Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.. Mol Cell Neurosci, 11(3), 149-160.
• Singhrao SK, Thomas P, Wood JD, MacMillan JC, Neal JW, Harper PS & Jones AL (1998) Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases.. Exp Neurol, 150(2), 213-222.
• Boutell JM, Wood JD, Harper PS & Jones AL (1998) Huntingtin interacts with cystathionine beta-synthase.. Hum Mol Genet, 7(3), 371-378.
• Ross CA, Margolis RL, Becher MW, Wood JD, Engelender S, Cooper JK & Sharp AH (1998) Pathogenesis of neurodegenerative diseases associated with expanded glutamine repeats: new answers, new questions.. Prog Brain Res, 117, 397-419.
• Ross CA, Becher MW, Colomer V, Engelender S, Wood JD & Sharp AH (1997) Huntington's disease and dentatorubral-pallidoluysian atrophy: proteins, pathogenesis and pathology.. Brain Pathol, 7(3), 1003-1016.
• Jones AL, Wood JD & Harper PS (1997) Huntington disease: advances in molecular and cell biology.. J Inherit Metab Dis, 20(2), 125-138.
• Jones SA, O'Donnell VB, Wood JD, Broughton JP, Hughes EJ & Jones OT (1996) Expression of phagocyte NADPH oxidase components in human endothelial cells.. Am J Physiol, 271(4 Pt 2), H1626-H1634.
• Jones OTG & Wood JD (1996) Oxidant Production by Human B Lymphocytes: Detection of Activity and Identification of Components Involved. Methods, 9(3), 619-627.
• Wood JD, MacMillan JC, Harper PS, Lowenstein PR & Jones AL (1996) Partial characterisation of murine huntingtin and apparent variations in the subcellular localisation of huntingtin in human, mouse and rat brain.. Hum Mol Genet, 5(4), 481-487.
• Jones SA, Wood JD, Coffey MJ & Jones OT (1994) The functional expression of p47-phox and p67-phox may contribute to the generation of superoxide by an NADPH oxidase-like system in human fibroblasts.. FEBS Lett, 355(2), 178-182.
• Wood JD & Wood PM (1992) Homology between cellobiose oxidase from Phanerochaete chrysosporium and other proteins.. Biochem Soc Trans, 20(2), 109S.
• Wood JD & Wood PM (1992) Evidence that cellobiose:quinone oxidoreductase from Phanerochaete chrysosporium is a breakdown product of cellobiose oxidase.. Biochim Biophys Acta, 1119(1), 90-96.

Chapters

• Ross CA, Ellerby LM, Wood JD & Nucifora Jr. FC (2005) Dentatorubral-pallidoluysian atrophy (DRPLA): model for Huntingdon's disease and other polyglutamine diseases In Beal MF, Lang AE & Ludolph AC (Ed.), Neurodegenerative Diseases (pp. 861-870). Cambridge University Press
• Ross CA, Margolis RL, Becher MW, Wood JD, Engelender S & Sharp AH (1998) Pathogenesis of Polyglutamine Neurodegenerative Diseases:Towards a Unifying Mechanism In Wells RD, Warren ST & Sarmiento M (Ed.), Genetic instabilities and hereditary neurological diseases (pp. 761-776). Academic Press

Conference proceedings papers

• (2016) Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 June - 1 July 2016. The Journal of Pathology, Vol. 240 (pp S1-S48) View this article in WRRO
• Lorente-Pons A, Wood JD, Shaw PJ, Ince PG, Cooper-Knock J, Ramachandran A, Kirby J & Highley JR (2016) Investigating the mechanisms underlying oligodendrocyte dysfunction in C9ORF72 ALS. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42(S1) (pp 28-28), 2 March 2016 - 4 March 2016. View this article in WRRO
• Lorente-Pons A, Wood JD, Shaw PJ, Ince PG, Cooper-Knock J, Ramachandran A, Kirby J & Highley JR (2015) Investigating the mechanisms underlying oligodendrocyte dysfunction in C9ORF72 ALS. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 26-27)
• Almansoori K, Valori C, Furley A, Chandran J, Wood J & Azzouz M (2014) The mRNA exporter GLE1 is essential for embryonic development. FEBS Journal, Vol. 281(Suppl 1) (pp 644-645)
• Alsomali N, Seytanoglu A, Valori C, Kim HR, Ning K, Ramesh T, Sharrack B, Wood JD & Azzouz M (2014) Deficiency in Gle1, an mRNA export mediator, inhibits Schwann cell development in the zebrafish embryo. FEBS JOURNAL, Vol. 281 (pp 771-771)