Professor Stephen B Wharton
Neuroscience, School of Medicine and Population Health
Professor and Honorary Consultant in Neuropathology
s.wharton@sheffield.ac.uk
Sheffield Institute for Translational Neuroscience (SITraN)
Full contact details
Professor Stephen B Wharton
Neuroscience, School of Medicine and Population Health
Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
Sheffield
S10 2HQ
Neuroscience, School of Medicine and Population Health
Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
Sheffield
S10 2HQ
- Profile
-
- 2014 - present: Professor in Neuropathology, Sheffield University
- 2001-2014: Senior Lecturer / Reader in Neuropathology, Sheffield University
- 1997 - 2001: Senior lecturer / honorary consultant in Neuropathology, Edinburgh University
- 1994 – 1997: Senior registrar in Neuropathology, Addenbrookes Hospital, Cambridge
- Qualifications
-
- PhD (by publications), University of Sheffield, 2013
- FRCPath awarded 2005
- MRCPath in Neuropathology 1997
- DipRCPath Histopathology 1995
- MSc University of Cambridge 1995
- MBBS London University 1988
- BSc (Hons) University of London 1985
- Research interests
-
Professor Wharton’s research interest are focused on the cellular and molecular pathology of dementia and brain ageing. His major areas of interest are in:
- Understanding the pathological basis of dementia through the Cognitive Function and Ageing Study (www.cfas.ac.uk) which takes a population-based approach to the neuropathology of dementia.
- Investigating the cellular and molecular pathology of astrocytes, neurones and endothelium as components of the neurovascular unit in brain ageing and in the pathogenesis of dementia.
- The pathogenesis of white matter pathology in brain ageing and its contribution to dementia.
- The pathology of motor neurone diseases and tissue banking in collaboration with Prof Ince and Prof Shaw.
External collaborations
- Prof Fiona Matthews (University of Newcastle) and Prof Carol Brayne (University of Cambridge). The Cognitive Function and Ageing Study.
- Prof Raj Kalaria (University of Newcastle). Post-stroke dementia.
- Publications
-
Journal articles
- Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection. Alzheimer’s Research & Therapy, 15.
- Harmonization of neuropathology measures and characterization of neuropathological burden across population‐based autopsy samples. Alzheimer's & Dementia, 18(S5).
- Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development. Cell Reports, 40(5), 111162-111162.
- Differential perivascular microglial activation in the deep white matter in vascular dementia developed post‐stroke. Brain Pathology.
- Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts. Acta Neuropathologica, 144(1), 27-44.
- Transcriptomic profiling reveals discrete poststroke dementia neuronal and gliovascular signatures. Translational Stroke Research.
- Astrocytic C–X–C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity. Journal of Neuroinflammation, 18(1).
- Biological and methodological complexities of beta‐amyloid peptide; implications for Alzheimer’s disease research. Journal of Neurochemistry.
- Dementia in the older population is associated with neocortex content of serum amyloid P component. Brain Communications, 3(4).
- Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function. European Journal of Neuroscience. View this article in WRRO
- Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to alzheimer’s and small vessel disease pathologies. Brain Pathology, 31(3). View this article in WRRO
- Advanced molecular pathology for rare tumours: A national feasibility study and model for centralised medulloblastoma diagnostics.. Neuropathol Appl Neurobiol.
- Prevalence and factors associated with poor performance in the 5‐chair stand test: findings from the Cognitive Function and Ageing Study II and proposed Newcastle protocol for use in the assessment of sarcopenia. Journal of Cachexia, Sarcopenia and Muscle, 12(2), 308-318.
- Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain. Acta Neuropathologica Communications, 9(1).
- A Parkinson’s disease-relevant mitochondrial and neuronal morphology high-throughput screening assay in LUHMES cells. Bio-protocol, 11(1). View this article in WRRO
- MBRS-60. THE ACTIONABLE GENOMIC LANDSCAPE OF RELAPSED MEDULLOBLASTOMA IS DEFINED BY MAINTENANCE AND ACQUISITION OF DRIVER EVENTS. Neuro-Oncology, 22(Supplement_3), iii408-iii408.
- MBRS-44. TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE ARE ASSOCIATED WITH TUMOUR BIOLOGY AT DIAGNOSIS AND UPFRONT THERAPY: A COHORT STUDY. Neuro-Oncology, 22(Supplement_3), iii405-iii406.
- The association between polygenic hazard scores and clinical markers of Alzheimer’s disease following stratification for
APOE
genotype. Alzheimer's & Dementia, 16(S4).
- MBRS-60. THE ACTIONABLE GENOMIC LANDSCAPE OF RELAPSED MEDULLOBLASTOMA IS DEFINED BY MAINTENANCE AND ACQUISITION OF DRIVER EVENTS. Neuro-oncology, 22(Suppl 3), iii408-iii408.
- MBRS-44. TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE ARE ASSOCIATED WITH TUMOUR BIOLOGY AT DIAGNOSIS AND UPFRONT THERAPY: A COHORT STUDY. Neuro-oncology, 22(Suppl 3), iii405-iii406.
- Transcriptomic analysis of human astrocytes in vitro reveals hypoxia-induced mitochondrial dysfunction, modulation of metabolism, and dysregulation of the immune response. International Journal of Molecular Sciences, 21(21).
- Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response. International Journal of Molecular Sciences, 21(21).
- Time, pattern, and outcome of medulloblastoma relapse and their association with tumour biology at diagnosis and therapy: a multicentre cohort study. The Lancet Child & Adolescent Health.
- The Association between Polygenic Hazard and Markers of Alzheimer’s Disease Following Stratification for APOE Genotype. Current Alzheimer Research, 17.
- The molecular landscape and associated clinical experience in infant medulloblastoma: prognostic significance of second‐generation subtypes. Neuropathology and Applied Neurobiology.
- Demonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia. Acta Neuropathologica Communications, 8(1). View this article in WRRO
- Advanced Glycation End Product Formation in Human Cerebral Cortex Increases With Alzheimer-Type Neuropathologic Changes but Is Not Independently Associated With Dementia in a Population-Derived Aging Brain Cohort. Journal of Neuropathology & Experimental Neurology, 79(9), 950-958.
- Enhanced cerebral blood volume under normobaric hyperoxia in the J20-hAPP mouse model of Alzheimer’s disease. Scientific Reports, 10(1). View this article in WRRO
- A case of multiple sclerosis—like relapsing remitting encephalomyelitis following allogeneic hematopoietic stem cell transplantation and a review of the published literature. Frontiers in Immunology, 11. View this article in WRRO
- Histological characterization of interneurons in Alzheimer's disease reveals a loss of somatostatin interneurons in the temporal cortex. Neuropathology. View this article in WRRO
- Neuropathological correlates of cumulative benzodiazepine and anticholinergic drug use. Journal of Alzheimer's Disease. View this article in WRRO
- NDRG2 expression correlates with neurofibrillary tangles and microglial pathology in the ageing brain. International Journal of Molecular Sciences, 21(1). View this article in WRRO
- Changing prevalence and treatment of depression among older people over two decades. The British Journal of Psychiatry, 216(1), 49-54.
- Epidemiological pathology of Aβ deposition in the ageing brain in CFAS : addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches. Acta Neuropathologica Communications, 7(1), 1-12. View this article in WRRO
- Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical.. Journal of Cerebral Blood Flow and Metabolism. View this article in WRRO
- Neutrophil-derived microvesicle induced dysfunction of brain microvascular endothelial cells in vitro. International Journal of Molecular Sciences, 20(20). View this article in WRRO
- O4-02-02: WHAT ARE THE EFFECTS OF BENZODIAZEPINE AND ANTICHOLINERGIC DRUG USE ON THE BRAIN: A NEUROPATHOLOGICAL STUDY. Alzheimer's & Dementia, 15, P1232-P1232.
- Age-associated mRNA and miRNA expression changes in the blood-brain barrier. International Journal of Molecular Sciences, 20(12). View this article in WRRO
- Expression of p16 and p21 in the frontal association cortex of ALS/MND brains suggest neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease. Neuropathology and Applied Neurobiology. View this article in WRRO
- The time course of recognition memory impairment and glial pathology in the hAPP-J20 mouse model of Alzheimer’s disease. Journal of Alzheimer's disease : JAD. View this article in WRRO
- Combined FUS+ Basophilic Inclusion Body Disease and Atypical Tauopathy Presenting with an ALS/MND-plus Phenotype.. Neuropathology and Applied Neurobiology. View this article in WRRO
- Metallothionein‐I/II expression associates with the astrocyte DNA damage response and not Alzheimer‐type pathology in the aging brain. Glia, 66(11), 2316-2323. View this article in WRRO
- Pituitary apoplexy secondary to metastatic breast carcinoma into a gonadotroph cell adenoma of the pituitary.. British Journal of Neurosurgery. View this article in WRRO
- Loss of IGF1R in human astrocytes alters complex I activity and support for neurons.. Neuroscience, 390, 46-59. View this article in WRRO
- Proteomic and cellular localisation studies suggest non-tight junction cytoplasmic and nuclear roles for occludin in astrocytes. European Journal of Neuroscience, 47(12), 1444-1456. View this article in WRRO
- S5-01-01: AGEING AND NEUROIMMUNOLOGY: WHITE MATTER PATHOLOGY. Alzheimer's & Dementia, 14(7S_Part_31), P1624-P1624.
- P4-059: NEUTROPHIL-DERIVED MICROVESICLE-INDUCED BLOOD BRAIN BARRIER DYSFUNCTION: A POTENTIAL MECHANISM LINKING SYSTEMIC INFLAMMATION AND DEMENTIA. Alzheimer's & Dementia, 14(7S_Part_27), P1455-P1455.
- MBCL-30. SUBGROUP-DIRECTED CLINICAL AND MOLECULAR STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA. Neuro-Oncology, 20(suppl_2), i123-i123.
- MBCL-30. SUBGROUP-DIRECTED CLINICAL AND MOLECULAR STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA.. Neuro-oncology, 20(Suppl 2), i123-i123.
- Age‐associated changes in the blood‐brain barrier: comparative studies in human and mouse. Neuropathology and Applied Neurobiology, 44(3), 328-340. View this article in WRRO
- Genomic Analysis, Surgical Treatment and Outcomes of Lower-Grade Gliomas in a Single Institution.. Neuro-oncology, 20(Suppl 1), i20-i20.
- Immuno-Laser-Capture Microdissection for the Isolation of Enriched Glial Populations from Frozen Post-Mortem Human Brain, 273-284.
- Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease. Neuropathology and Applied Neurobiology, 43(7), 553-570. View this article in WRRO
- Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS). The Lancet. View this article in WRRO
- Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study. The Lancet Oncology, 18(7), 958-971. View this article in WRRO
- Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). Journal of Neuropathology and Experimental Neurology, 76(7), 605-619. View this article in WRRO
- Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role. Neuropathology and Applied Neurobiology, 43(4), 281-298. View this article in WRRO
- Intracerebral Masson's Tumor—Slow-Filling Vascular Lesion Demonstrated by Indocyanine Green Video Angiography. World Neurosurgery. View this article in WRRO
- Low grade glioma: An Update for Radiologists.. British Journal of Radiology. View this article in WRRO
- Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role. Journal of Neuroimmunology, 299, 139-146. View this article in WRRO
- Microinfarcts in an older population-representative brain donor cohort (MRC CFAS): Prevalence, relation to dementia and mobility, and implications for the evaluation of cerebral Small Vessel Disease.. Neuropathol Appl Neurobiol. View this article in WRRO
- Post-mortem assessment in vascular dementia: Advances and aspirations. BMC Medicine, 14(1). View this article in WRRO
- Expression microdissection isolation of enriched cell populations
from archival brain tissue. Journal of Neuroscience Methods, 268, 125-130. View this article in WRRO
- Motor neurone disease/amyotrophic lateral sclerosis associated with intermediate‐length CAG repeat expansions in Ataxin‐2 does not have 1C2‐positive polyglutamine inclusions. Neuropathology and Applied Neurobiology, 42(4), 377-389. View this article in WRRO
- A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II. Nature Communications, 7, 11398-11398. View this article in WRRO
- A wolf in sheep's clothing. Practical Neurology, 16(2), 153-156.
- Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study. Acta Neuropathologica Communications, 4(1). View this article in WRRO
- Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology. Neuropathology and Applied Neurobiology, 42(2), 167-179. View this article in WRRO
- Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathologica, 131(1), 87-102. View this article in WRRO
- Mitochondrial pathology in progressive cerebellar ataxia. Cerebellum & Ataxias, 2. View this article in WRRO
- Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Molecular Brain, 8(1). View this article in WRRO
- The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neuroscience Letters, 609, 11-17. View this article in WRRO
- Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain. Brain Pathology, 25(5), 565-574. View this article in WRRO
- Precortical Phase of Alzheimer's Disease (AD)-Related Tau Cytoskeletal Pathology. Brain Pathology, 26(3), 371-386.
- Erratum to: Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium. Journal of Neural Transmission, 122(7), 973-974.
- Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy. Acta Neuropathologica, 130(1), 63-75. View this article in WRRO
- Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium. Journal of Neural Transmission, 122(7), 957-972.
- A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort. Neuropathology and Applied Neurobiology, 41(4), 483-496. View this article in WRRO
- Xanthogranulomatous hypophysitis: a rare and often mistaken pituitary lesion. Endocrinology, Diabetes & Metabolism Case Reports, 2015. View this article in WRRO
- Age-Associated White Matter Lesions: The MRC Cognitive Function and Ageing Study. Brain Pathology, 25(1), 35-43.
- Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease. Cancer Cell, 27(1), 72-84.
- Intermediate length C9orf72 expansion in an ALS patient without classical C9orf72 neuropathology. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16(3-4), 249-251. View this article in WRRO
- Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.. Neuropathol Appl Neurobiol, 40(6), 670-685.
- Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.. Brain, 137(Pt 7), 2040-2051. View this article in WRRO
- Alpha-synuclein mRNA expression in oligodendrocytes in MSA. GLIA. View this article in WRRO
- DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort.. Neuropathol Appl Neurobiol, 40(7), 802-814.
- TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.. Acta Neuropathol, 127(3), 407-418. View this article in WRRO
- Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds.. Neuropathol Appl Neurobiol, 40(3), 258-269. View this article in WRRO
- Neuro-ophthalmological complications of chronic inflammatory demyelinating polyradiculoneuropathy. Neuro-Ophthalmology, 37(4), 146-156.
- The Effect of SOD1 Mutation on Cellular Bioenergetic Profile and Viability in Response to Oxidative Stress and Influence of Mutation-Type.. Plos One, 6(8), e68256-e68256. View this article in WRRO
- Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain.. Neuropathol Appl Neurobiol, 39(7), 788-799.
- From molecule to clinic and community for neurodegeneration: Research to bridge translational gaps. Journal of Alzheimer's Disease, 33(SUPPL. 1).
- Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity.. Acta Neuropathol, 125(1), 95-109. View this article in WRRO
- The need to unify neuropathological assessments of vascular alterations in the ageing brain. Multicentre survey by the BrainNet Europe consortium.. Experimental Gerontology, 47(11), 825-833.
- The epidemiological neuropathology of dementia and the implications for drug development. Neurodegenerative Disease Management, 2(5), 471-482.
- Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort.. Dement Geriatr Cogn Disord, 34(1), 15-24.
- Isolation of enriched glial populations from post-mortem human CNS material by immuno-laser capture microdissection.. J Neurosci Methods, 208(2), 108-113.
- Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72.. Brain, 135(Pt 3), 751-764.
- From molecule to clinic and community for neurodegeneration: Research to bridge translational gaps. Advances in Alzheimer's Disease, 3, 385-396.
- Impact of Less Common and "Disregarded" Neurodegenerative Pathologies on Dementia Burden in a Population-Based Cohort. JOURNAL OF ALZHEIMERS DISEASE, 28(2), 485-493.
- Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology.. Acta Neuropathol, 122(6), 657-671.
- Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype. NEUROBIOL AGING, 32(10), 1795-1807.
- Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: a study in the MRC-CFAS population neuropathology cohort.. Neurosci Lett, 505(1), 25-30.
- P3-156: Microarray analysis of the astrocyte transcriptome in the aging brain: Relationship to Alzheimer's pathology and APOE genotype. Alzheimer's & Dementia, 7, S566-S566.
- P3-282: Less common and “disregarded” pathologies in late onset dementia: what are we missing?. Alzheimer's & Dementia, 7, S606-S607.
- PRESENILIN-1 MUTATION ASSOCIATED WITH AMNESIA, ATAXIA, AND MEDIAL TEMPORAL LOBE T2 SIGNAL CHANGES. NEUROLOGY, 76(16), 1435-1436.
- Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience.. J Alzheimers Dis, 25(2), 359-372.
- Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis.. Brain, 134(Pt 2), 506-517. View this article in WRRO
- Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort. Neuroscience Letters, 505(1), 25-30.
- Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain.. Neurosci Lett, 486(3), 246-251.
- Sensory ganglionopathy due to gluten sensitivity.. Neurology, 75(11), 1003-1008.
- Intracranial non-Langerhans cell histiocytosis presenting as an isolated intraparenchymal lesion.. Pediatr Radiol, 40 Suppl 1, S145-S149.
- Broad clinical phenotypes associated with TAR-DNA binding protein (TARDBP) mutations in amyotrophic lateral sclerosis.. Neurogenetics, 11(2), 217-225. View this article in WRRO
- Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain.. Neurobiol Aging, 31(4), 578-590.
- Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.. Neuropathol Appl Neurobiol, 36(1), 25-40.
- Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain. Neuroscience Letters, 486(3), 246-251.
- Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).. PLoS One, 5(3), e9872. View this article in WRRO
- Epidemiological Pathology of Dementia: Attributable-Risks at Death in the Medical Research Council Cognitive Function and Ageing Study. PLOS MED, 6(11). View this article in WRRO
- Antibody-negative neuromyelitis optica with heavy B-cell infiltration.. APMIS, 117(10), 768-772.
- Age, Neuropathology, and Dementia. NEW ENGL J MED, 360(22), 2302-2309.
- Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study.. Brain, 132(Pt 5), 1324-1334.
- Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium. ACTA NEUROPATHOL, 117(3), 309-320.
- Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways.. Stroke, 40(2), 369-375.
- Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review. BMC NEUROL, 9. View this article in WRRO
- Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia.. Dement Geriatr Cogn Disord, 27(5), 465-473.
- Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.. J Neurochem, 110(1), 34-44.
- Staging of neurofibrillary pathology in Alzheimer's disease: A study of the BrainNet Europe consortium. BRAIN PATHOL, 18(4), 484-496. View this article in WRRO
- Low grade gliomas. Can we predict tumour behaviour from imaging features?. Neuroradiology Journal, 21(SUPPL. 1), 47-66.
- Microglial activation in white matter lesions and nonlesional white matter of ageing brains.. Neuropathol Appl Neurobiol, 33(6), 670-683.
- White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses.. Neuropathol Appl Neurobiol, 33(4), 410-419.
- Myopathy associated with gluten sensitivity.. Muscle Nerve, 35(4), 443-450.
- A brief history of tau: the evolving view of the microtubule-associated protein tau in neurodegenerative diseases.. Clin Neuropathol, 26(2), 43-58.
- Subtypes of oligodendroglioma defined by 1p,19q deletions, differ in the proportion of apoptotic cells but not in replication-licensed non-proliferating cells.. Acta Neuropathol, 113(2), 119-127.
- Fatal spontaneous thrombosis of a cerebral arteriovenous malformation in a young patient with a rare heterozygous prothrombin gene mutation. Case report.. J Neurosurg, 106(2 Suppl), 143-146.
- Neuropathy associated with gluten sensitivity.. J Neurol Neurosurg Psychiatry, 77(11), 1262-1266.
- White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury.. Stroke, 37(6), 1391-1398.
- Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis.. J Neuropathol Exp Neurol, 65(1), 26-36.
- Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis. MUSCLE NERVE, 32(4), 541-544.
- Extra-cranial metastasis of glioblastoma multiforme presenting as acute parotitis.. Br J Neurosurg, 19(4), 348-351.
- Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the ageing human hippocampus increases with the burden of Alzheimer-type pathology.. Neurosci Lett, 383(1-2), 33-38.
- Discovery of a perinecrotic 60 kDa MDM2 isoform within glioma spheroids and glioblastoma biopsy material. NEUROPATH APPL NEURO, 31(2), 191-202.
- Progressive loss of motor neuron function in wasted mice: Effects of a spontaneous null mutation in the gene for the eEF1A2 translation factor. J NEUROPATH EXP NEUR, 64(4), 295-303.
- A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas. CLIN CANCER RES, 11(1), 217-225.
- Vascular endothelial growth factor and the nervous system.. Neuropathol Appl Neurobiol, 30(5), 427-446.
- DNA replication licensing and cell cycle kinetics of oligodendroglial tumours.. Br J Cancer, 91(2), 262-269. View this article in WRRO
- Morphological changes and stress responses in neurons in cerebral cortex infiltrated by diffuse astrocytoma. NEUROPATHOLOGY, 23(4), 262-270.
- Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation.. Ann Neurol, 54(6), 748-759.
- The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene.. J Neuropathol Exp Neurol, 62(11), 1166-1177.
- Comparative genomic hybridization and pathological findings in atypical teratoid/rhabdoid tumour of the central nervous system.. Neuropathol Appl Neurobiol, 29(3), 254-261.
- Corticospinal tract degeneration in the progressive muscular atrophy variant of ALS.. Neurology, 60(8), 1252-1258.
- Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways.. J Biol Chem, 278(8), 6371-6383.
- Greenfield's neuropathology (7th edn). David I Graham, Peter L Lantos (eds). Arnold, London, 2002. No of pages: 2330. ISBN: 0340742313. The Journal of Pathology, 199(2), 271-271.
- Proliferation and death of conditionally immortalized neural cells from murine neocortex: p53 alters the ability of neuron-like cells to re-enter the cell cycle. Brain Research, 965(1-2), 57-66.
- Glioma tumourgenicity is decreased by iNOS knockout: experimental studies using the C6 striatal implantation glioma model. BRIT J NEUROSURG, 16(6), 567-572.
- Highly unsaturated fatty acid induced tumor regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology. PROSTAG LEUKOTR ESS, 67(5), 283-292.
- Manganese: elemental defence for a life with oxygen. Trends in Microbiology, 10(11), 496-501.
- Orbital nodular-granuloma annulare in a juvenile diabetic. EYE, 16(5), 670-673.
- Anaplastic progression in low grade glioneural neoplasms. ACTA NEUROPATHOL, 104(2), 215-215.
- Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis - Reply. CLIN NEUROPATHOL, 21(4), 195-196.
- Microtubule-associated protein 2 (MAP-2) is expressed in low and high grade diffuse astrocytomas. J CLIN NEUROSCI, 9(2), 165-169.
- Foreign body reaction with delayed extrusion of ganciclovir implant in a patient with immune recovery vitritis syndrome.. Am J Ophthalmol, 133(1), 147-149.
- Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma.. Prostaglandins Leukot Essent Fatty Acids, 66(1), 19-29.
- Heme oxygenase (HO) isoforms in experimental C6 glioma: an immunocytochemical study.. Br J Neurosurg, 15(5), 416-418.
- Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis.. Clin Neuropathol, 20(5), 212-218.
- The development of necrosis and apoptosis in glioma: experimental findings using spheroid culture systems.. Neuropathol Appl Neurobiol, 27(4), 291-304.
- Replicative Mcm2 protein as a novel proliferation marker in oligodendrogliomas and its relationship to Ki67 labelling index, histological grade and prognosis.. Neuropathol Appl Neurobiol, 27(4), 305-313.
- Conjunctival myxoma, Zollinger-Ellison syndrome and abnormal thickening of the inter-atrial septum: a case report and review of the literature.. Eye (Lond), 15(Pt 3), 309-312.
- Perfluorodecalin-induced intravitreal inflammation.. Retina, 21(3), 247-251.
- The significance of intratumoural neurones and neuronal differentiation in diffuse gliomas: a case series.. Acta Neuropathol, 100(6), 695-700.
- Expression of poly(ADP-ribose) polymerase and distribution of poly(ADP-ribosyl)ation in glioblastoma and in a glioma multicellular tumour spheroid model.. Neuropathol Appl Neurobiol, 26(6), 528-535.
- Metastases from glomus jugulare tumours. The Journal of Laryngology & Otology, 114(1), 17-23.
- Glomus jugulare tumour with metastases to cervical lymph nodes. The Journal of Laryngology & Otology, 114(1), 67-69.
- Spontaneous acute scleritis and scleral necrosis in choroidal malignant melanoma. EYE, 13, 793-795.
- Effects of N-6 essential fatty acids on glioma invasion and growth: experimental studies with glioma spheroids in collagen gels.. J Neurosurg, 91(6), 989-996.
- Angiotropic large B-cell lymphoma with clinical features resembling subacute combined degeneration of the cord.. Clin Neurol Neurosurg, 101(4), 275-279.
- Expression of Bcl-2 and Bax in oligodendrogliomas and their relationship to apoptosis.. Neuropathol Appl Neurobiol, 25(5), 400-407.
- Corneal epithelial toxic effects and inflammatory response to perfluorocarbon liquid.. Arch Ophthalmol, 117(10), 1411-1413.
- Intraocular metastases of cutaneous malignant melanoma: a case report and review of the literature.. Eye (Lond), 13 ( Pt 2), 247-250.
- Systemic metastases of glioblastoma multiforme. CLIN ONCOL-UK, 11(3), 205-207.
- Apoptosis in human primary brain tumours.. Br J Neurosurg, 12(6), 539-546.
- Expression of neuronal markers in oligodendrogliomas: an immunohistochemical study.. Neuropathol Appl Neurobiol, 24(4), 302-308.
- Proliferation and cell death in oligodendrogliomas. NEUROPATH APPL NEURO, 24(1), 21-28.
- The natural history of a recurrent central neurocytoma-like tumor.. Clin Neuropathol, 17(3), 136-140.
- Chondrosarcoma of the petrous apex. Dilemmas in diagnosis and treatment. The Journal of Laryngology & Otology, 111(4), 368-371.
- Paravertebral muscles in disease of the cervical spine.. Journal of Neurology, Neurosurgery & Psychiatry, 61(5), 461-465.
- Experimental herpes simplex virus type 1 (HSV-1) infection of the spinal cord and dorsal root ganglia. Neuropathology and Applied Neurobiology, 21(3), 228-237.
- Insights into the Pathological Basis of Dementia from Population Based Neuropathology Studies. Neuropathology and Applied Neurobiology.
- Atypical
TDP ‐43 protein expression in anALS pedigree carrying a p.Y374X truncation mutation in TARDBP. Brain Pathology.
- RNA-Seq Profiling of Neutrophil-Derived Microvesicles in Alzheimer’s Disease Patients Identifies a miRNA Signature That May Impact Blood–Brain Barrier Integrity. International Journal of Molecular Sciences, 23(11), 5913-5913.
- Emergence and maintenance of actionable genetic drivers at medulloblastoma relapse. Neuro-Oncology.
- Assessment of Neurovascular Coupling & Cortical Spreading Depression in Mixed Models of Atherosclerosis & Alzheimer’s Disease.
- Neurovascular Function in a Novel Model of Experimental Atherosclerosis.
- The time course of recognition memory impairment and glial pathology in the hAPP-J20 mouse model of Alzheimer's disease..
- Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical.
- Variable presentation of xanthogranulomatous hypophysitis: a case series. Endocrine Abstracts.
- A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment. PLoS ONE, 10(2). View this article in WRRO
- Assessment of neurovascular coupling
and cortical spreading depression in
mixed mouse models of atherosclerosis
and Alzheimer’s disease. eLife.
Chapters
- Motor neuron disorders In Love S, Budka H, Ironside JW & Perry A (Ed.), Greenfield's Neuropathology (pp. 817-848). Boca Raton: CRC Press.
- Chapter 5 Cytopathology of the motor neuron (pp. 89-119).
- Chapter 2 Pathology of Motor Neuron Disorders, Motor Neuron Disorders (pp. 17-49). Elsevier
Conference proceedings papers
- The miRNA profile of neutrophil-derived microvesicles may impact blood-brain barrier integrity in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
- Characterising the astrocyte response to oligomeric and fibrillary A beta 1-42 in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
- Demystifying the gluten brain: Understanding the origin of gluten-related neurological disorders. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
- Microarray approach to identifying the role of microglia in the pathogenesis of age-associated deep-subcortical white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 48
- What happens to cells of the brain in people who develop dementia after stroke?. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 8-8)
- The effect of systemic atherosclerosis on the neurovascular unit. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 21-21)
- Effects of Type 2 Diabetes on Neuronal and Associated Neurovascular Unit Transcriptomes. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 8-8)
- Characterising the varying astrocyte response to oligomeric and fibrillar A beta(1-42). NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 47 (pp 18-19)
- Transcriptomic profile of the blood-brain barrier in age-associated white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 46-46)
- 121st Meeting of the British Neuropathological Society UCL Great Ormond Street Institute of Child Health, London. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 14-15)
- Characterising the varying astrocyte response to oligomeric and fibrillar A beta. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 46 (pp 25-25)
- Multiple sclerosis-like CNS inflammation following allogeneic haematopoietic stem cell transplantation treated with a 'domino' autologous haematopoietic stem cell transplantation. NEUROLOGY, Vol. 94(15)
- TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE ARE ASSOCIATED WITH TUMOUR BIOLOGY AT DIAGNOSIS AND UPFRONT THERAPY: A COHORT STUDY. NEURO-ONCOLOGY, Vol. 22 (pp 405-406)
- THE ACTIONABLE GENOMIC LANDSCAPE OF RELAPSED MEDULLOBLASTOMA IS DEFINED BY MAINTENANCE AND ACQUISITION OF DRIVER EVENTS. NEURO-ONCOLOGY, Vol. 22 (pp 408-408)
- The Molecular Landscape and Clinical Experience in Infant Medulloblastoma. PEDIATRIC BLOOD & CANCER, Vol. 66 (pp S4-S4)
- A microarray analysis approach to identify mechanisms underlying the pathogenesis of age-associated periventricular white matter lesions. GLIA, Vol. 67 (pp E300-E300)
- SUBGROUP-DIRECTED CLINICAL AND MOLECULAR STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA. NEURO-ONCOLOGY, Vol. 20 (pp 123-123)
- Hypoxia-induced changes in astrocytes and their role in the formation of age-associated white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 17-18)
- Advanced glycosylated end products in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 12-12)
- Identification of miRNA and mRNA regulatory networks in the ageing blood-brain barrier: Comparative gene expression studies in human and mouse. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 36-36)
- Genomic Analysis, Surgical Treatment and Outcomes of Lower-Grade Gliomas in a Single Institution. Neuro-Oncology, Vol. 20(suppl_1) (pp i20-i20)
- GENOMIC ANALYSIS, SURGICAL TREATMENT AND OUTCOMES OF LOWER-GRADE GLIOMAS IN A SINGLE INSTITUTION. NEURO-ONCOLOGY, Vol. 19 (pp 238-238)
- Time, Pattern and Outcome of Medulloblastoma Relapse is Biology and Therapy-Dependent. PEDIATRIC BLOOD & CANCER, Vol. 64 (pp S13-S14)
- SUBGROUP-DIRECTED STRATIFICATION OF DISEASE RISK IN INFANT MEDULLOBLASTOMA. NEURO-ONCOLOGY, Vol. 19 (pp 39-39)
- TIME, PATTERN AND OUTCOME OF MEDULLOBLASTOMA RELAPSE IS BIOLOGY AND THERAPY-DEPENDENT. NEURO-ONCOLOGY, Vol. 19 (pp 41-41)
- Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 43 (pp 43-43)
- Early cellular changes and cognitive decline in an Alzheimer's mouse model. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 43 (pp 42-43)
- CENTRALISED MOLECULAR PATHOLOGY FOR RARE TUMOURS: A NATIONAL FEASIBILITY STUDY OF REAL-TIME MEDULLOBLASTOMA DIAGNOSTICS. NEURO-ONCOLOGY, Vol. 18 (pp 115-115)
- SUBGROUP-DIRECTED STRATIFICATION OF RISK IN INFANT MEDULLOBLASTOMA. NEURO-ONCOLOGY, Vol. 18 (pp 111-111)
- Impairment of IGF1 signalling in human astrocytes and it's effect on astrocyte support for neurons. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 51-52)
- Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 27-28)
- Establishment of national real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma (MB). NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 19-20)
- Microinfarcts, Small Vessel Disease and Dementia in the population-representative CFAS brain donor cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 22-23)
- A reduced astrocyte response to beta-amyloid plaques in the ageing brain associates with dementia and cognitive impairment. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 30-31) View this article in WRRO
- Neuronal senescence as a contributor to neurodegeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 32-32)
- Abstract LB-201: MYC and TP53 defects interact at medulloblastoma relapse to define rapidly progressive disease and can be targeted therapeutically. Tumor Biology
- AMYOTROPHIC LATERAL SCLEROSIS ASSOCIATED WITH AN INTERMEDIATE LENGTH GGGGCC REPEAT EXPANSION HAS DISTINCT NEUROPATHOLOGY COMPARED TO PATIENTS WITH LARGER EXPANSIONS. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.130-e4)
- Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 33-34)
- A neuronal DNA damage response is detected at low Braak stages and correlates with cognitive impairment in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 31-32)
- A pathological basis for the association of parkinsonism and amyotrophic lateral sclerosis. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 51-51)
- A national feasibility study of real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 20-20)
- Oxidative stress and DNA damage in cerebral white matter lesions of the ageing human brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 36-37)
- Evidence for an ischemic origin of deep brain 'microbleeds'. CEREBROVASCULAR DISEASES, Vol. 35 (pp 42-42)
- Microarray analysis of the astrocyte transcriptome in normal appearing white matter in multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY, Vol. 253(1-2) (pp 54-54)
- A NATIONAL FEASIBILITY STUDY OF REAL-TIME CENTRAL PATHOLOGY REVIEW AND MOLECULAR DIAGNOSTICS FOR MEDULLOBLASTOMA. NEURO-ONCOLOGY, Vol. 14 (pp 44-44)
- MOTOR NEURONES SUBTYPES RESISTANT TO DEGENERATION IN AMYOTROPHIC LATERAL SCLEROSIS SHOW DISTINCT SYNAPTIC CHARACTERISTICS ACROSS SPECIES. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83(3)
- SEMI-AUTOMATED VOLUMETRIC ANALYSIS OF LOW-GRADE GLIOMAS. NEURO-ONCOLOGY, Vol. 13 (pp 140-140)
- Oxidative nucleic acid damage in motor neuron disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 36-36)
- A feasibility study of real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma in the United Kingdom. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 18-19)
- Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 33-33)
- The development of the National Brain and CNS Tumour Registry. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 19-19)
- Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. BRAIN PATHOLOGY, Vol. 20 (pp 46-46)
- ESTABLISHMENT OF REAL-TIME CENTRALISED PATHOLOGY REVIEW (CPR) AND MOLECULAR DIAGNOSTICS FOR MEDULLOBLASTOMA IN THE UNITED KINGDOM. NEURO-ONCOLOGY, Vol. 12 (pp 6-6)
- ESTABLISHMENT OF REAL-TIME CENTRALISED PATHOLOGY REVIEW (CPR) AND MOLECULAR DIAGNOSTICS FOR MEDULLOBLASTOMA IN THE UNITED KINGDOM. NEURO-ONCOLOGY, Vol. 12(6) (pp II58-II58)
- Presenilin 1 S170P Mutation with a Limbic Encephalitis like Presentation. NEUROLOGY, Vol. 74(9) (pp A244-A244)
- BIOPSY PROVEN ATAXIC VARIANT EARLY ONSET ALZHEIMER'S DISEASE WITH A LIMBIC ENCEPHALITIS LIKE PRESENTATION. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 80(11)
- Evidence of an astrocytic DNA damage response to oxidative stress in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 35 (pp 18-19)
- Variation in 4R and 3R tau isoforms in the ageing population. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 35 (pp 19-19)
- Reproducibility in the assessment of Alzheimer's disease and Lewy body disease-related pathologies: a study by Brain Net Europe. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 35 (pp 12-13)
- DNA oxidative damage and repair mechanisms in astrocytes, and their relationship to Alzheimer-type pathology in the ageing brain. JOURNAL OF NEURAL TRANSMISSION, Vol. 115(12) (pp 1727-1727)
- Variation in 4R and 3R Tau isoforms in the ageing population. JOURNAL OF NEURAL TRANSMISSION, Vol. 115(12) (pp 1725-1726)
- Optic neuropathy and cerebellar degeneration. JOURNAL OF NEUROIMMUNOLOGY, Vol. 197(2) (pp 175-175)
- Characterisation of astrocytes in relation to Alzheimer-type pathology in the ageing brain using a population-based neuropathology cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 31-31)
- Age effects on the relationship between pathology and cognitive impairment in a population cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 10-10)
- Population variation in tau pathology in the MRC-CFAS neuropathology cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 10-11)
- Microarray gene expression analysis of deep subcortical lesions in the ageing brain reveals changes in multiple functional pathways. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 30-31)
- Population variation in tau pathology in the aged hippocampus in the MRC-CFAS neuropathology cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 263-263)
- Extra-motor manifestations of motor neurone disease and the role of TDP43 in ALS variants. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 264-265)
- Axonal number and myelin sheath degeneration in MRI hyperintense white matter lesions in the aging brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 266-267)
- Microarray gene expression profiling of deep subcortical lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 254-255)
- Microglial activation in white matter of the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 255-255)
- Cytogenetic subtypes of oligodendroglioma differ in their apoptotic index, while the population of replication-licensed, non-proliferating cells is higher in anaplastic tumors but does not differ according to 1p,19q status. NEURO-ONCOLOGY, Vol. 8(4) (pp 459-459)
- FISH for the detection of 1p and 19q deletions in oligodendrogioma paraffin wax sections - A retrospective study of 55 cases. JOURNAL OF MEDICAL GENETICS, Vol. 43 (pp S101-S101)
- Molecular markers of tissue hypoxia and glial pathology associated with incidental white matter lesions in the ageing brain. BRAIN PATHOLOGY, Vol. 16 (pp S92-S92)
- New pathological findings from the MRC-cognitive function and ageing study (CFAS) neuropathology cohort. BRAIN PATHOLOGY, Vol. 16 (pp S127-S127)
- Molecular markers of tissue hypoxia are associated with deep subcortical white matter lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 32(2) (pp 224-224)
- Glial cell pathology of periventricular and deep white matter lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 32(2) (pp 224-225)
- The Pattern of AQP4 Expression in the Ageing Human Brain and in Cerebral Amyloid Angiopathy. International Journal of Molecular Sciences, Vol. 21(4) (pp 1225-1225)
Datasets
Preprints
- Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease, Research Square Platform LLC.
- Assessment of Alzheimer-related Pathologies of Dementia Using Machine Learning Feature Selection, Research Square.
- Assessment of Alzheimer-related Pathologies of Dementia Using Machine Learning Feature Selection, medRxiv.
- Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease, Cold Spring Harbor Laboratory.
- Medulloblastoma Group 3 and 4 Tumors Comprise a Clinically and Biologically Significant Expression Continuum Reflecting Human Cerebellar Development, Cold Spring Harbor Laboratory.
- Astrocytic C-X-C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity, Cold Spring Harbor Laboratory.
- Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer’s Disease, Cold Spring Harbor Laboratory.
- Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection. Alzheimer’s Research & Therapy, 15.
- Research group
-
Current PhD students:
- Hemant Mistry
- Monica Gaugnelli
- Martyna Matuszyk
Research team:
- Dr Rachel Waller
- Dr Irina Vacquez Villasenor
- Grants
-
Current funding sources
- Alzheimer’s Society
- Alzheimer’s Research UK
- Professional activities and memberships
-
Editorial activities
- Consulting editor, Neuropathology and Applied Neurobiology (2014-)
- Editor-in-Chief, Neuropathology and Applied Neurobiology (2007-13)
- Associate editor (for reviews), Histopathology (2003-2006)
- Current editorial board membership – Neuropathology Applied Neurobiology
External professional activities – current and recent
- Member of the Alzheimer’s Research UK Grant Review Board 2016-
- Chief of panel of examiners in neuropathology for the Royal College of Pathologists (2018-)
- Examiner in neuropathology for the Royal College of Pathologists (2005-)
- Member British Neuropathological Society Academic Affairs Committee (2018-).
Membership of associations and societies - current
- International Society for Neuropathology
- British Neuropathological Society
- British Medical Association
- Current projects
Defective nutrient signalling and dementia: an epidemiological neuropathology approach.
Funded by the Alzheimer’s Society, this project examines the effects of diabetes on the brain. Diabetes is a major risk factor for dementia and Alzheimer’s disease, but the mechanisms by which it contributes to cognitive decline are unclear.
We seek to define the contribution of diabetes and related metabolic changes to dementia, and to identify novel mechanisms by which it damages different key cell types within the brain; the nerve cells, the cells that line brain blood vessels and the astrocyte, which supports and integrates the functions of the other two types.
Using autopsy-brain samples from the Cognitive Function and Ageing Study (CFAS), we plan to investigate the relationship of diabetes to dementia and to Alzheimer’s pathology and vascular pathology. The CFAS brain-donation cohort, held in Sheffield, is from a population (rather than clinic) based sample of over 65yr olds; its unselected nature means that it is ideal for examining interactions between pathologies and relationships to dementia in an unbiased way.
Cells in the brain and elsewhere are able to sense changes to nutrients, such as glucose, with specialised signalling pathways. Alterations in these pathways may impair the ability of nerve cells to function, so we are examining the impact of diabetes on them.
We use methods that allow us to examine overall changes in the activities of genes in cells to identify new mechanisms by which diabetes impairs different brain cell-types. Obesity and diabetes are increasing problems. This proposal will better define how they contribute to dementia.
Neuronal Senescence as a Contributory Mechanism to Dementia
Funded by Alzheimer's Research UK, this project aims to study the contribution of neuronal senescence to dementia. Markers of dementia, such as tangles and plaques that characterise Alzheimer’s, do not explain all dementia, and treatments aimed at them have been unsuccessful. This suggests other processes contribute to dementia.
Senescent cells, sometimes called zombie cells, are persistently damaged cells, often because of damage to their DNA, which carries all the instructions for the cell. These cells remain alive, but they do not carry out their normal functions. Additionally, they produce factors that damage nearby cells and cause inflammation. Zombie cells are described in other tissues and diseases, and there are drug treatments aimed at them. However, their role in dementia is not understood. Using brain tissue samples from the Cognitive Function and Ageing Study, we plan to identify senescent nerve cells in the brain and determine how they relate to dementia.
To determine how senescence causes damage, we will isolate nerve cells with and without markers of senescence from the same cases, and investigate effects on the cells by determining differences in the gene messages present. This will provide greater understanding of how senescence contributes to dementia and identify specific ways in which senescence affects nerve cells, which may lead us to new approaches to target zombie cells.
A Cellular Pathology and Gene Expression Approach to Understand the Basis of Progressive Dementia Occurring After Stroke.
This work is funded by the Alzheimer’s Society and is a collaboration with Prof Kalaria at the University of Newcastle. Around a quarter of stroke survivors develop progressive dementia after more than 3-6 months, and with more stroke survivors, post stroke dementia is an increasing problem. We aim to identify cell mechanisms that can cause post-stroke dementia.
We are using brain tissue donated to the Cognitive Function After Stroke Study (CogFAST), which includes individuals with and without dementia after stroke. Previous work showed that the front of the brain is particularly affected, with leakiness of small blood vessels in the white matter. This can damage the processes or wires of nerve cells that pass through this area.
We are isolating different cell types in this area and using methods to examine changes in the patterns of gene expression in these cells. This has the potential to identify new mechanisms that contribute to a stroke survivor developing dementia, and which might lead to new treatments.
Cholesterol Dysregulation in the Neurovascular Unit as an Early Contributor to Neuronal Dysfunction in Alzheimer’s Disease.
This is a PhD studentship funded by Alzheimer’s Research UK.
Variation in Astrocyte Responses to Different Molecular Pathologies and the Effect on Neuroprotection.
This is a PhD studentship funded by the Alzheimer’s Society.
The Effects of Systemic Atherosclerosis on the Brain Neurovascular Unit.
A collaboration with Prof Sheila Francis in Cardiovascular Sciences, this PhD studentship is funded by Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico
Additional Collaborations.
Work on the role of neuroinflammation in dementia, with Dr Julie Simpson, and on Gene Based Therapies for Frontotemporal dementia (ARUK-funded) with Prof Mimoun Azzouz.