First Evans lab paper accepted for publication in Current Biology
The paper is titled: Draper/CED-1 mediates an ancient damage response to control inflammatory blood cell migration in vivo.
The work describes how Src42A>Draper>Shark signalling regulates macrophage migration to wounds in Drosophila embryos.
This pathway is very similar to the Src family kinase>immune cell receptor>Syk signalling used by vertebrate immune cells and therefore this work suggests that our ability to discriminate between self/non-self may have evolved from an ancient pathway used to regulate activation of innate immune cells in response to damage.
Draper/CED-1 Mediates an Ancient Damage Response to Control Inflammatory Blood Cell Migration In Vivo.
Curr Biol. 2015 May 28. pii: S0960-9822(15)00488-1. doi: 10.1016/j.cub.2015.04.037. [Epub ahead of print]
Evans IR1, Rodrigues FS2, Armitage EL3, Wood W4.
The University’s four flagship institutes bring together our key strengths to tackle global issues, turning interdisciplinary and translational research into real-world solutions.