4 June 2015

First Evans lab paper accepted for publication in Current Biology

The Evans lab have had their first paper accepted for publication in Current Biology.

A grey placeholder image with a cross through the middle.

The paper is titled: Draper/CED-1 mediates an ancient damage response to control inflammatory blood cell migration in vivo.

The work describes how Src42A>Draper>Shark signalling regulates macrophage migration to wounds in Drosophila embryos.

This pathway is very similar to the Src family kinase>immune cell receptor>Syk signalling used by vertebrate immune cells and therefore this work suggests that our ability to discriminate between self/non-self may have evolved from an ancient pathway used to regulate activation of innate immune cells in response to damage.

PubMed:

Draper/CED-1 Mediates an Ancient Damage Response to Control Inflammatory Blood Cell Migration In Vivo.

Curr Biol. 2015 May 28. pii: S0960-9822(15)00488-1. doi: 10.1016/j.cub.2015.04.037. [Epub ahead of print]
Evans IR1, Rodrigues FS2, Armitage EL3, Wood W4.

Flagship institutes

The University’s four flagship institutes bring together our key strengths to tackle global issues, turning interdisciplinary and translational research into real-world solutions.