First Evans lab paper accepted for publication in Current Biology

The Evans lab have had their first paper accepted for publication in Current Biology.

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The paper is titled: Draper/CED-1 mediates an ancient damage response to control inflammatory blood cell migration in vivo.

The work describes how Src42A>Draper>Shark signalling regulates macrophage migration to wounds in Drosophila embryos.

This pathway is very similar to the Src family kinase>immune cell receptor>Syk signalling used by vertebrate immune cells and therefore this work suggests that our ability to discriminate between self/non-self may have evolved from an ancient pathway used to regulate activation of innate immune cells in response to damage.


Draper/CED-1 Mediates an Ancient Damage Response to Control Inflammatory Blood Cell Migration In Vivo.

Curr Biol. 2015 May 28. pii: S0960-9822(15)00488-1. doi: 10.1016/j.cub.2015.04.037. [Epub ahead of print]
Evans IR1, Rodrigues FS2, Armitage EL3, Wood W4.

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