Member Publications
Recent publications from members of the Bateson Centre.

Publications
Journal articles
- C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons. Life Science Alliance, 5(9), e202101276-e202101276.
- Management Of Acute Adrenal Insufficiency Related Adverse Events In Children With Congenital Adrenal Hyperplasia - Results Of An International Survey Of Specialist Centres. Hormone Research in Paediatrics.
- MO015: The Interaction of Gender and Genotype in the Development of Polycystic Liver Disease in ADPKD. Nephrology Dialysis Transplantation, 37(Supplement_3).
- FC029: A Multivariate Model Identifies Genotype, Hypertension and Kidney Length as Independent Baseline Predictors of Disease Progression in a Longitudinal Autosomal Dominant Polycystic Kidney Disease Patient Cohort. Nephrology Dialysis Transplantation, 37(Supplement_3).
- MO030: Familial clustering of a rare UMOD variant in undiagnosed hereditary nephropathy suggests the presence of a common ancestral founder mutation. Nephrology Dialysis Transplantation, 37(Supplement_3).
- MO012: Development of an Accurate Automated Segmentation Algorithm to Measure Total Kidney Volume in ADPKD Suitable for Clinical Application (The Cystvas Study). Nephrology Dialysis Transplantation, 37(Supplement_3).
- Amino acid availability is not essential for lifespan extension by dietary restriction in the fly.. Journals of Gerontology, Series A.
- Can ketogenic dietary interventions slow disease progression in ADPKD : what we know and what we don't. Clinical Kidney Journal.
- SMN-deficient cells exhibit increased ribosomal DNA damage. Life Science Alliance, 5(8), e202101145-e202101145.
- Investigation and management of Wilson's disease: a practical guide from the British Association for the Study of the Liver. The Lancet Gastroenterology & Hepatology.
- Reply to Benjamin Davies, Keith Kowalczyk RE: Zachary Klaassen, Emily Vertosick, Andrew J. Vickers, et al. Optimal Dissemination of Scientific Manuscripts via Social Media: A Prospective Trial Comparing Visual Abstracts Versus Key Figures in Consecutive Original Manuscripts. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2022.01.041. European Urology.
- Treatment of congenital adrenal hyperplasia in children aged 0-3 years: A retrospective multicenter analysis of salt supplementation, glucocorticoid and mineralocorticoid medication, growth and blood pressure. European Journal of Endocrinology.
- Loss of function of the neural cell adhesion molecule NrCAM regulates differentiation, proliferation and neurogenesis in early postnatal hypothalamic tanycytes. Frontiers in Neuroscience, 16.
- From WEDA to EDTA to ERA: 60 years of supporting European Nephrology and counting.. Nephrol Dial Transplant.
- Measuring patient compliance with remote monitoring following discharge from hospital after major surgery (DREAMPath): protocol for a prospective observational study. JMIR Research Protocols, 11(4).
- The Amoebal Model for Macropinocytosis, 41-59.
- Müller glia maintain their regenerative potential despite degeneration in the aged zebrafish retina. Aging Cell.
- Author Correction: STORM imaging reveals the spatial arrangement of transition zone components and IFT particles at the ciliary base in Tetrahymena. Scientific Reports, 12(1).
- Neural crest-derived stem cells (NCSCs) obtained from dental-related stem cells (DRSCs) : a literature review on current knowledge and directions toward translational applications. International Journal of Molecular Sciences, 23(5). View this article in WRRO
- Defective repair of topoisomerase I induced chromosomal damage in Huntington’s disease. Cellular and Molecular Life Sciences, 79(3). View this article in WRRO
- DASL-HiCaP: Darolutamide augments standard therapy for localized very high-risk cancer of the prostate (ANZUP1801). a randomized phase 3 double-blind, placebo-controlled trial of adding darolutamide to androgen deprivation therapy and definitive or salvage radiation.. Journal of Clinical Oncology, 40(6_suppl), TPS284-TPS284.
- A phase 3, randomized, open-label, multicenter, global study of the efficacy and safety of durvalumab (D) + tremelimumab (T) + enfortumab vedotin (EV) or D + EV for neoadjuvant treatment in cisplatin-ineligible muscle-invasive bladder cancer (MIBC) (VOLGA).. Journal of Clinical Oncology, 40(6_suppl), TPS579-TPS579.
- Real-world evidence from a single U.K. cancer center for atezolizumab in second-line setting in advanced urothelial cancer: Moving beyond clinical trials.. Journal of Clinical Oncology, 40(6_suppl), 461-461.
- Zebrafish vascular quantification: a tool for quantification of three-dimensional zebrafish cerebrovascular architecture by automated image analysis. Development, 149(3).
- Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 399(10325), 665-676. View this article in WRRO
- Individualized everolimus treatment for tuberous sclerosis-related angiomyolipoma promotes treatment adherence and response. Clinical Kidney Journal. View this article in WRRO
- A bacterial endosymbiont of the fungus Rhizopus microsporus drives phagocyte evasion and opportunistic virulence. Current Biology.
- Adhesion-regulated junction slippage controls cell intercalation dynamics in an Apposed-Cortex Adhesion Model. PLoS Computational Biology, 18(1).
- The cross-talk between EGFR and E-Cadherin. Frontiers in Cell and Developmental Biology, 9. View this article in WRRO
- Single-cell analysis of early chick hypothalamic development reveals that hypothalamic cells are induced from prethalamic-like progenitors. Cell Reports, 38(3). View this article in WRRO
- Shaping axial identity during human pluripotent stem cell differentiation to neural crest cells.. Biochem Soc Trans.
- Impact of circ-0000221 in the pathogenesis of hepatocellular via modulation of miR-661–PTPN11 mRNA axis. Pharmaceutics, 14(1).
- Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 399(10320), 143-151. View this article in WRRO
- Optimal Dissemination of Scientific Manuscripts via Social Media: A Prospective Trial Comparing Visual Abstracts Versus Key Figures in Consecutive Original Manuscripts Published in European Urology. European Urology.
- B-cell depletion abrogates immune mediated cytopenia and rejection of cord blood transplantation in Hurler syndrome. Bone Marrow Transplantation, 57(1), 38-42.
- SARS‐CoV‐2 infection and venous thromboembolism after surgery: an international prospective cohort study. Anaesthesia, 77(1), 28-39.
- Genome-wide meta-analysis identifies novel genes associated with recurrence and progression in non–muscle-invasive bladder cancer. European Urology Oncology, 5(1), 70-83.
- Zebrafish as a tractable model of human cardiovascular disease. British Journal of Pharmacology, 179(5), 900-917. View this article in WRRO
- Metformin induces lactate accumulation and accelerates renal cyst progression in Pkd1-deficient mice. Human Molecular Genetics. View this article in WRRO
- Androgen elevation accelerates reproductive senescence in three-spined stickleback. Frontiers in Cell and Developmental Biology, 9. View this article in WRRO
- Monoallelic IFT140 pathogenic variants are an important cause of the autosomal dominant polycystic kidney-spectrum phenotype. The American Journal of Human Genetics.
- Compensatory variability in network parameters enhances memory performance in the Drosophila mushroom body. Proceedings of the National Academy of Sciences, 118(49). View this article in WRRO
- Editorial: Neutrophil functions in host immunity, inflammation and tissue repair. Frontiers in Immunology, 12.
- Tetraspanin Cd9b and Cxcl12a/Cxcr4b have a synergistic effect on the control of collective cell migration. PLoS ONE, 16(11). View this article in WRRO
- Moving the research forward : the best of British biology using the tractable model system Dictyostelium discoideum. Cells, 10(11).
- Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics. Proceedings of the National Academy of Sciences, 118(44), e2106022118-e2106022118.
- The broad phenotypic spectrum of 17α-hydroxylase/17,20-lyase (CYP17A1) deficiency : a case series. European Journal of Endocrinology, 185(5), 729-741.
- Defining factors associated with high-quality surgery following radical cystectomy : analysis of the British Association of Urological Surgeons cystectomy audit. European Urology Open Science, 33, 1-10.
- Scientists on the Spot: A matter of blood flow. Cardiovascular Research, 117(12), e162-e163.
- Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition. Nature Reviews Molecular Cell Biology, 22(12), 834-834.
- Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.. Lancet Oncol.
- A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance. Life Science Alliance, 4(10), e202000966-e202000966.
- Xenon ventilation MRI in difficult asthma; initial experience in a clinical setting. European Respiratory Journal, 7(3). View this article in WRRO
- Lamb1a regulates atrial growth by limiting second heart field addition during zebrafish heart development.. Development.
- Radical cystectomy in England from 2013 to 2019 on 12,644 patients : an analysis of national trends and comparison of surgical approaches using Hospital Episode Statistics data. BJUI Compass, 2(5), 338-347.
- Commensal bacteria augment Staphylococcus aureus infection by inactivation of phagocyte-derived reactive oxygen species. PLoS Pathogens, 17(9).
- USP11 controls R-loops by regulating senataxin proteostasis. Nature Communications, 12. View this article in WRRO
- Peptide hormone analysis in diagnosis and treatment of Differences of Sex Development: joint position paper of EU COST Action ‘DSDnet’ and European Reference Network on Rare Endocrine Conditions.
- The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics. eLife, 10.
- PD59-10 FACTORS ASSOCIATED WITH HIGH-QUALITY SURGERY FOLLOWING RADICAL CYSTECTOMY: ANALYSIS OF THE BRITISH ASSOCIATION OF UROLOGICAL SURGEONS (BAUS) CYSTECTOMY AUDIT. Journal of Urology, 206(Supplement 3).
- TAMEing ADPKD with metformin : safe and effective?. Kidney International, 100(3), 513-515.
- In vitro generation of posterior motor neurons from human pluripotent stem cells. Current Protocols, 1(9).
- The GLP-1 receptor agonist, liraglutide, fails to slow disease progression in SOD1G93A and TDP-43Q331K transgenic mouse models of ALS. Scientific Reports, 11. View this article in WRRO
- An Nphp1 knockout mouse model targeting exon 2–20 demonstrates characteristic phenotypes of human Nephronophthisis. Human Molecular Genetics.
- The Scottish Bladder Cancer Quality Performance Indicators Influencing Outcomes, Prognosis, and Surveillance (Scot BC Quality OPS) Clinical Project. European Urology Focus.
- Dynamic Rac1 inhibition by CYRI helps cells drink, but stops them from driving.. J Cell Biol, 220(9).
- Prostate-specific Antigen Testing as Part of a Risk-Adapted Early Detection Strategy for Prostate Cancer: European Association of Urology Position and Recommendations for 2021. European Urology.
- Effects of pre‐operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study. Anaesthesia, 76(11), 1454-1464.
- Mesenchymal-to-epithelial transitions require tissue-specific interactions with distinct laminins. Journal of Cell Biology, 220(8). View this article in WRRO
- The effect of absent blood flow on the zebrafish cerebral and trunk vasculature. Vascular Biology, 3(1), 1-16.
- Pioneer neutrophils release chromatin within in vivo swarms. eLife, 10. View this article in WRRO
- Apurinic/Apyrimidinic Endonuclease 2 (APE2): An ancillary enzyme for contextual base excision repair mechanisms to preserve genome stability. Biochimie, 190, 70-90.
- The European Urology Commitment to Gender Equity and Diversity: Expanding Cognitive Diversity through Inclusivity at the Podium. European Urology.
- CISPLATIN RESISTANCE IN HPV-POSITIVE AND HPV-NEGATIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 132(1), e15-e15.
- Progress towards therapies for disease modification in Parkinson's disease. The Lancet Neurology, 20(7), 559-572.
- Interactions and feedbacks in E-cadherin transcriptional regulation. Frontiers in Cell and Developmental Biology, 9.
- Hypoxia-induced SETX links replication stress with the unfolded protein response. Nature Communications, 12(1). View this article in WRRO
- Adipose-derived stem cells protect motor neurons and reduce glial activation in both in vitro and in vivo models of ALS. Molecular Therapy — Methods & Clinical Development, 21, 413-433. View this article in WRRO
- Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart. Cardiovascular Research, 117(10), 2161-2174.
- Resilience of the Internal Mammary Artery to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs. Arteriosclerosis, Thrombosis, & Vascular Biology, 41(8), 2237-2251.
- Erratum to: The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics. Cardiovascular Research, 117(9), 2107-2107.
- Modelling of epithelial growth, fission and lumen formation during embryonic thyroid development : a combination of computational and experimental approaches. Frontiers in Endocrinology, 12.
- Neuroanatomical and cognitive correlates of visual hallucinations in Parkinson’s disease and dementia with Lewy bodies: Voxel-based morphometry and neuropsychological meta-analysis. Neuroscience & Biobehavioral Reviews.
- Cognitive correlates and baseline predictors of future development of visual hallucinations in dementia with Lewy bodies. Cortex.
- Using a remote monitoring kit to predict re-admissions for patients discharged following radical cystectomy. European Urology, 79, S1385-S1385.
- Defining factors associated with high-quality surgery following radical cystectomy: Analysis of the British Association of Urological Surgeons (BAUS) cystectomy audit. European Urology, 79, S1151-S1151.
- Gonadectomy in conditions affecting sex development: a registry-based cohort study. European Journal of Endocrinology, 184(6), 791-801.
- Generating enteric nervous system progenitors from human pluripotent stem cells. Current Protocols, 1(6).
- Dna homeostasis and senescence: lessons from the naked mole rat. International Journal of Molecular Sciences, 22(11).
- Interrenal development and function in zebrafish. Molecular and Cellular Endocrinology, 535, 111372-111372.
- MO023FLANK PAIN HAS A MAJOR NEGATIVE IMPACT ON HEALTH-RELATED QUALITY OF LIFE IN ADPKD: THE CYSTIC I STUDY. Nephrology Dialysis Transplantation, 36(Supplement_1).
- Society for Endocrinology UK Guidance On The Initial Evaluation Of A Suspected Difference or Disorder Of Sex Development (DSD) (Revised 2021).. Clin Endocrinol (Oxf).
- Genetic analysis of pediatric primary adrenal insufficiency of unknown etiology: 25 years’ experience in the UK. Journal of the Endocrine Society.
- Sensitive high-throughput assays for tumour burden reveal the response of a Drosophila melanogaster model of colorectal cancer to standard chemotherapies. International Journal of Molecular Sciences, 22(10). View this article in WRRO
- High temperature drives topoisomerase mediated chromosomal break repair pathway choice. Cancers, 13(10). View this article in WRRO
- Reply to Trey Durdin, Alvin Goh, and Eugene Pietzak. Can an Imaging-guided Pathway Replace the Current Paradigm for Muscle-invasive Bladder Cancer? Eur Urol. In press. https://doi.org/10.1016/j.eururo.2021.03.018. European Urology.
- Seven challenges in the multiscale modeling of multicellular tissues. WIREs Mechanisms of Disease. View this article in WRRO
- Neural cell adhesion molecule (NCAM-1) is required for ventricular conduction system development.. Development. View this article in WRRO
- Quality of Life in Children and Young People With Congenital Adrenal Hyperplasia in the United Kingdom - Nationwide Multicentre Assessment. Journal of the Endocrine Society, 5(Suppl 1), a720-a720.
- Health Status of Children and Young Persons With Congenital Adrenal Hyperplasia in the United Kingdom: Results of a Multi-Center Cohort Study. Journal of the Endocrine Society, 5(Suppl 1), a717-a717.
- Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 397(10285), 1637-1645. View this article in WRRO
- Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. The Lancet, 397(10289), 2049-2059. View this article in WRRO
- Prehabilitation Exercise Before Urologic Cancer Surgery: A Systematic and Interdisciplinary Review. European Urology.
- Identification of functionally distinct macrophage subpopulations in Drosophila. Elife, 10. View this article in WRRO
- Correction: Effect of sports massage on performance and recovery: a systematic review and meta-analysis. BMJ Open Sport & Exercise Medicine, 7(2), e000614corr1-e000614corr1.
- Applying the adverse outcome pathway concept to questions in anaesthetic neurotoxicity. British Journal of Anaesthesia.
- STORM imaging reveals the spatial arrangement of transition zone components and IFT particles at the ciliary base in Tetrahymena. Scientific Reports, 11(1).
- The epidermal growth factor ligand Spitz modulates macrophage efferocytosis, wound responses and migration dynamics during Drosophila embryogenesis. Frontiers in Cell and Developmental Biology, 9.
- Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study. The Journal of Thoracic and Cardiovascular Surgery, 162(2), e355-e372.
- Excitatory granule neuron precursors orchestrate laminar localization and differentiation of cerebellar inhibitory interneuron subtypes. Cell Reports, 34(13). View this article in WRRO
- Drug repurposing in autosomal dominant polycystic kidney disease: back to the future with pioglitazone. Clinical Kidney Journal. View this article in WRRO
- PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons. Scientific Reports, 11(1).
- The adhesion GPCR Adgrg6 (Gpr126): Insights from the zebrafish model.. Genesis, e23417.
- Identification of a novel series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity. JCI Insight.
- Cerebrovascular development: mechanisms and experimental approaches.. Cell Mol Life Sci.
- Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study. Anaesthesia, 76(6), 748-758.
- The ECM as a driver of heart development and repair. Development, 148(5), dev191320-dev191320.
- Targeting mechanisms in cognitive training for neurodegenerative diseases. Neural Regeneration Research, 16(3), 500-500.
- Comparing an Imaging-guided Pathway with the Standard Pathway for Staging Muscle-invasive Bladder Cancer: Preliminary Data from the BladderPath Study. European Urology.
- Olfactory rod cells : a rare cell type in the larval zebrafish olfactory epithelium with a large actin-rich apical projection. Frontiers in Physiology, 12(1).
- Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development. Cardiovascular Research.
- A phase III, randomized, open-label, multicenter, global study of efficacy and safety of durvalumab in combination with gemcitabine plus cisplatin for neoadjuvant treatment followed by durvalumab alone for adjuvant treatment in muscle-invasive bladder cancer (NIAGARA).. Journal of Clinical Oncology, 39(6_suppl), TPS505-TPS505.
- DASL-HiCaP: Darolutamide augments standard therapy for localized very high-risk cancer of the prostate (ANZUP1801)—A randomized phase III double-blind, placebo-controlled trial of adding darolutamide to androgen deprivation therapy and definitive or salvage radiation.. Journal of Clinical Oncology, 39(6_suppl), TPS266-TPS266.
- Updated outcomes of POUT: A phase III randomized trial of peri-operative chemotherapy versus surveillance in upper tract urothelial cancer (UTUC).. Journal of Clinical Oncology, 39(6_suppl), 455-455.
- Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling.. Cardiovasc Res.
- Exploiting multiple timescales in hierarchical echo state networks. Frontiers in Applied Mathematics and Statistics, 6. View this article in WRRO
- Understanding axial progenitor biology in vivo and in vitro.. Development, 148(4).
- Human-specific staphylococcal virulence factors enhance pathogenicity in a humanised zebrafish C5a receptor model.. J Cell Sci.
- Quality of life after bladder cancer: a cross-sectional survey of patient-reported outcomes. European Urology. View this article in WRRO
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).. Autophagy. View this article in WRRO
- Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 397(10274), 605-612. View this article in WRRO
- Hereditary haemorrhagic telangiectasia, an inherited vascular disorder in need of improved evidence-based pharmaceutical interventions. Genes, 12(2).
- Plasma neurofilament light as a biomarker of neurological involvement in Wilson's disease. Movement Disorders, 36(2), 503-508. View this article in WRRO
- Bio-tribology of Vascular Devices: A Review of Tissue/Device Friction Research. Biotribology, 100169-100169.
- Endothelial NADPH oxidase 4 protects against angiotensin II‐induced cardiac fibrosis and inflammation. ESC Heart Failure. View this article in WRRO
- Adrenal insufficiency. The Lancet, 397(10274), 613-629.
- Phase I trial of DNA methyltransferase inhibitor guadecitabine combined with cisplatin and gemcitabine for solid malignancies including urothelial carcinoma (SPIRE). Clinical Cancer Research. View this article in WRRO
- International practice of corticosteroid replacement therapy in congenital adrenal hyperplasia - data from the I-CAH registry. European Journal of Endocrinology.
- Integrative microRNA and gene expression analysis identifies new epigenetically regulated microRNAs mediating taxane resistance in ovarian cancer. Scientific Reports, 11(1).
- Men’s experiences of radiotherapy treatment for localized prostate cancer and its long-term treatment side effects: a longitudinal qualitative study. Cancer Causes & Control, 32(3), 261-269.
- Dirty fish versus squeaky clean mice: dissecting interspecies differences between animal models of interferonopathy. Frontiers in Immunology, 11. View this article in WRRO
- Coronavirus-associated kidney outcomes in COVID-19, SARS, and MERS: a meta-analysis and systematic review. Renal Failure, 43(1), 1-15.
- Methods to Generate and Assay for Distinct Stages of Cancer Metastasis in Adult Drosophila melanogaster, 161-170.
- Tdp1 protects from topoisomerase 1–mediated chromosomal breaks in adult zebrafish but is dispensable during larval development. Science Advances, 7(5), eabc4165-eabc4165.
- Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Neuron, 109(3), 448-460.e4.
- Metabolic signature of articular cartilage following mechanical injury: An integrated transcriptomics and metabolomics analysis. Frontiers in Molecular Biosciences, 7. View this article in WRRO
- Radical cystectomy against intravesical BCG for high-risk high-grade nonmuscle invasive bladder cancer: results from the randomized controlled BRAVO-feasibility study. Journal of Clinical Oncology. View this article in WRRO
- Circulating BMP9 protects the pulmonary endothelium during inflammation-induced lung injury in mice. American Journal of Respiratory and Critical Care Medicine.
- The relationship between longevity and diet is genotype dependent and sensitive to desiccation in Drosophila melanogaster. The Journal of Experimental Biology, 223(23). View this article in WRRO
- The controversial role of fibrosis in Autosomal Dominant Polycystic Kidney Disease. International Journal of Molecular Sciences, 21(23). View this article in WRRO
- Multiple network properties overcome random connectivity to enable stereotypic sensory responses. Nature Communications, 11(1), ---. View this article in WRRO
- Analysis tools to quantify dissemination of pathology in zebrafish larvae. Scientific Reports, 10(1). View this article in WRRO
- Re: Helena Vila-Reyes, G. Joel DeCastro, and James M. McKiernan’s Letter to the Editor re: Yunjin Bai, Yubo Yang, and Yin Tang’s Letter to the Editor re: Andrea Necchi, Marco Bandini, Giuseppina Calareso, et al. Multiparametric Magnetic Resonance Imaging as a Noninvasive Assessment of Tumor Response to Neoadjuvant Pembrolizumab in Muscle-invasive Bladder Cancer: Preliminary Findings from the PURE-01 Study. Eur Urol 2020; 77:636–43. Eur Urol 2020;77:e158: Can mpMRI Replace Conventional Transurethral Resection of Bladder Cancer? Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.08.006. European Urology.
- Tribbles-1 expression and its function to control inflammatory cytokines, including interleukin-8 levels are regulated by miRNAs in macrophages and prostate cancer cells. Frontiers in Immunology, 11.
- Biallelic inheritance of hypomorphic PKD1 variants is highly prevalent in very early onset polycystic kidney disease. Genetics in Medicine.
- Shear stress : the dark energy of atherosclerotic plaques. Cardiovascular Research. View this article in WRRO
- 11β-Hydroxylase loss disrupts steroidogenesis and reproductive function in zebrafish. Journal of Endocrinology, 247(2), 197-212. View this article in WRRO
- Telemedicine and smart working: Spanish adaptation of the European Association of Urology recommendations. Actas Urológicas Españolas (English Edition), 44(10), 644-652.
- Peptide hormone analysis in diagnosis and treatment of differences of sex development: Joint position paper of EU COST action ‘DSDnet’ and european reference network on rare endocrine conditions.
- Occupational bladder cancer: A cross section survey of previous employments, tasks and exposures matched to cancer phenotypes. PLoS ONE, 15(10). View this article in WRRO
- Parental experience of prophylactic antibiotics. Archives of Disease in Childhood. View this article in WRRO
- Corrigendum to 'Diagnostic Performance of Vesical Imaging Reporting and Data System for the Prediction of Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis' [European Urology Oncology 3 (2020) 306-315].. Eur Urol Oncol.
- The cardiac complications of COVID-19; many publications, multiple uncertainties. Vascular Biology.
- Role of unfolded proteins in lung disease. Thorax.
- Systematic review and meta-analysis of vesical imaging-reporting and data system (VI-RADS) inter-observer reliability : an added value for muscle invasive bladder cancer detection. Cancers, 12(10).
- Epithelial–mesenchymal plasticity : emerging parallels between tissue morphogenesis and cancer metastasis. Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1809). View this article in WRRO
- Arf6 determines tissue architecture by stabilizing intercellular adhesion. Philosophical Transactions B: Biological Sciences, 375(1809). View this article in WRRO
- Of mitogens and morphogens : modelling Sonic Hedgehog mechanisms in vertebrate development. Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1809). View this article in WRRO
- Contemporary morphogenesis: Contemporary morphogenesis. Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1809).
- ‘A sword of Damocles’ : patient and caregiver beliefs, attitudes and perspectives on presymptomatic testing for autosomal dominant polycystic kidney disease: a focus group study. BMJ Open, 10(10).
- Integration of JAK/STAT receptor/ligand trafficking, signalling and gene expression in Drosophila melanogaster cells. Journal of Cell Science, 133.
- Corrigendum to ‘Diagnostic Performance of Vesical Imaging Reporting and Data System for the Prediction of Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis’ [European Urology Oncology 3 (2020) 306-315]. European Urology Oncology, 3(6), 811-811.
- The ProtecT randomised trial cost-effectiveness analysis comparing active monitoring, surgery, or radiotherapy for prostate cancer. British Journal of Cancer, 123(7), 1063-1070.
- MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly. eLife, 9.
- Localized inhibition in the Drosophila mushroom body. eLife, 9.
- NF-κB inhibition prevents acute shear stress-induced inflammation in the saphenous vein graft endothelium. Scientific Reports, 10(1).
- TELEMEDICINA Y TRABAJO INTELIGENTE: ADAPTACIÓN AL ESPAÑOL DE LAS RECOMENDACIONES DE LA ASOCIACIÓN EUROPEA DE UROLOGÍA. Actas Urológicas Españolas.
- Strategies adopted by men to deal with uncertainty and anxiety when following an active surveillance/monitoring protocol for localised prostate cancer and implications for care: a longitudinal qualitative study embedded within the ProtecT trial. BMJ Open, 10(9).
- 694TiP DASL-HiCaP: Darolutamide augments standard therapy for localised very high-risk cancer of the prostate (ANZUP1801). A randomised phase III double-blind, placebo-controlled trial of adding darolutamide to androgen deprivation therapy and definitive or salvage radiation. Annals of Oncology, 31, S548-S549.
- The Impact of the COVID-19 Pandemic on Genitourinary Cancer Care: Re-envisioning the Future. European Urology.
- Diabetic atherosclerosis: is there a role for the hypoxia-inducible factors?. Bioscience Reports, 40(8).
- Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signaling. JCI Insight, 5(16).
- Overexposure to apoptosis via disrupted glial specification perturbs Drosophila macrophage function and reveals roles of the CNS during injury. Cell Death & Disease, 11(8). View this article in WRRO
- A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ‐aminobutyric acidergic anticonvulsant. Epilepsia. View this article in WRRO
- Retinoic Acid Accelerates the Specification of Enteric Neural Progenitors from In-Vitro-Derived Neural Crest. Stem Cell Reports.
- Establishing a core outcome set for autosomal dominant polycystic kidney disease : report of the Standardized Outcomes in Nephrology–Polycystic Kidney Disease (SONG-PKD) consensus workshop. American Journal of Kidney Diseases.
- Active monitoring, radical prostatectomy and radical radiotherapy in PSA-detected clinically localised prostate cancer : the ProtecT three-arm RCT. Health Technology Assessment, 24(37), 1-175.
- Survey of the Impact of COVID-19 on Oncologists’ Decision Making in Cancer. JCO Global Oncology(6), 1248-1257.
- Post-translational modifications of the polycystin proteins. Cellular Signalling, 72.
- Reply to Gianluca Giannarini, Vincenzo Ficarra, and Claudio Valotto’s Letter to the Editor re: Stephen B. Williams, Marcus G.K. Cumberbatch, Ashish M. Kamat, et al. Reporting Radical Cystectomy Outcomes Following Implementation of Enhanced Recovery After Surgery Protocols: A Systematic Review and Individual Patient Data Meta-analysis. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.06.039. European Urology.
- An international cohort study of autosomal dominant tubulointerstitial kidney disease due to REN mutations identifies distinct clinical subtypes. Kidney International. View this article in WRRO
- Ursodeoxycholic acid as a novel disease-modifying treatment for Parkinson’s disease: protocol for a two-centre, randomised, double-blind, placebo-controlled trial, The 'UP' study. BMJ Open, 10(8).
- Deletion of cftr leads to an excessive neutrophilic response and defective tissue repair in a zebrafish model of sterile inflammation. Frontiers in Immunology, 11(1). View this article in WRRO
- If it’s not one thing, HIF’s another : immunoregulation by hypoxia inducible factors in disease. The FEBS Journal. View this article in WRRO
- Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature, 584(7819), E2-E2.
- Best Practices to Optimise Quality and Outcomes of Transurethral Resection of Bladder Tumours. European Urology Oncology.
- Interplay between actomyosin and E-cadherin dynamics regulates cell shape in the Drosophila embryonic epidermis.. Journal of Cell Science. View this article in WRRO
- A novel method for measuring absolute coronary blood flow & microvascular resistance in patients with ischaemic heart disease. Cardiovascular Research. View this article in WRRO
- Establishment and neural differentiation of neural crest-derived stem cells
(NCSCs) from human dental pulp in serum-free conditions. Stem Cells Translational Medicine. View this article in WRRO
- Erratum to ‘Ten-year Mortality, Disease Progression, and Treatment-related Side Effects in Men with Localised Prostate Cancer from the ProtecT Randomised Controlled Trial According to Treatment Received’ [European Urology 77 (2020) 320–330]. European Urology, 78(3), e139-e143.
- Reporting Radical Cystectomy Outcomes Following Implementation of Enhanced Recovery After Surgery Protocols: A Systematic Review and Individual Patient Data Meta-analysis. European Urology, 78(5), 719-730.
- Cellular signaling in PKD: foreword. Cellular Signalling, 71. View this article in WRRO
- Radical cystectomy (open, laparoscopic and robotic) in 12625 patients in England: National trends and peri-operative outcomes from Hospital Episode Statistics data. European Urology Open Science, 19, e2281-e2282.
- Reporting radical cystectomy outcomes following implementation of Enhanced Recovery after Surgery (ERAS) protocols: A systematic review and individual patient data meta-analysis. European Urology Open Science, 19, e2280-e2280.
- Comparison of wearable device measured mobility with patient-reported mobility during peri-operative recovery following radical cystectomy. European Urology Open Science, 19, e1999-e1999.
- Meta-analysis of six genome-wide association studies identifies novel loci associated with recurrence and progression of non-muscle invasive bladder cancer. European Urology Open Science, 19, e1369-e1369.
- Replacing TURBT with mpMRI for staging MIBC: Pilot data from the BladderPath trial. European Urology Open Science, 19, e824-e825.
- Open science and open publishing: A new paradigm for the European urology family. European Urology Open Science, 19, 1-2. View this article in WRRO
- Mechanisms underlying homeostatic plasticity in the Drosophila mushroom body in vivo. Proceedings of the National Academy of Sciences. View this article in WRRO
- Toward engineering biosystems with emergent collective functions. Frontiers in Bioengineering and Biotechnology, 8. View this article in WRRO
- Coupled differentiation and division of embryonic stem cells inferred from clonal snapshots. Physical Biology. View this article in WRRO
- Polymersomes eradicating intracellular bacteria. ACS Nano. View this article in WRRO
- Neutrophils use selective autophagy receptor Sqstm1/p62 to target Staphylococcus aureus for degradation in vivo in zebrafish. Autophagy. View this article in WRRO
- Toll-like receptor 9 and the inflammatory response to surgical trauma and cardiopulmonary bypass. Journal of Cardiothoracic Surgery, 15.
- Coordinated ras and rac activity shapes macropinocytic cups and enables phagocytosis of geometrically diverse bacteria. Current Biology, 30. View this article in WRRO
- Guidelines and definitions for research on epithelial-mesenchymal transition. Nature Reviews Molecular Cell Biology, 21(6), 341-352.
- Macrophage polarisation associated with atherosclerosis differentially affects their capacity to handle lipid. Atherosclerosis. View this article in WRRO
- Nucleosides rescue replication-mediated genome instability of human pluripotent stem cells. Stem Cell Reports, 14(6), 1009-1017. View this article in WRRO
- Developing novel host-based therapies targeting microbicidal responses in macrophages and neutrophils to combat bacterial antimicrobial resistance. Frontiers in Immunology, 11. View this article in WRRO
- The Impact of Centralised Services on Metric Reflecting High-quality Performance: Outcomes from 1110 Consecutive Radical Cystectomies at a Single Centre. European Urology Focus.
- Molecular Characterization of Upper Tract Urothelial Carcinoma in the Era of Next-generation Sequencing: A Systematic Review of the Current Literature. European Urology, 78(2), 209-220.
- Safety and immunogenicity of novel 5T4 viral vectored vaccination regimens in early stage prostate cancer: a phase I clinical trial. Journal for ImmunoTherapy of Cancer, 8(1), e000928-e000928.
- SO092REDUCED QUALITY OF LIFE IN ADPKD PATIENTS WITH CKD STAGE 1-3: THE CYSTIC I QUALITY OF LIFE STUDY. Nephrology Dialysis Transplantation, 35(Supplement_3).
- Transcriptional and post-transcriptional regulation of checkpoint genes on the tumour side of the immunological synapse. Heredity.
- Blood vessel occlusion by Cryptococcus neoformans is a mechanism for haemorrhagic dissemination of infection. PLOS Pathogens, 18(4), e1010389-e1010389.
- Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines. Human Molecular Genetics.
- A zebrafish reporter line reveals immune and neuronal expression of endogenous retrovirus. Disease Models & Mechanisms.
- Interpretation and actionability of genetic variants in cardiomyopathies: a position statement from the European Society of Cardiology Council on cardiovascular genomics. European Heart Journal.
- Roscovitine Worsens Mycobacterium abscessus Infection by Reducing DUOX2-Mediated Neutrophil Response. American Journal of Respiratory Cell and Molecular Biology.
- Gene of the month: NKX3.1. Journal of Clinical Pathology.
- GCH1 deficiency activates brain innate immune response and impairs tyrosine hydroxylase homeostasis. The Journal of Neuroscience.
- An update on the use of tolvaptan for autosomal dominant polycystic kidney disease: consensus statement on behalf of the ERA Working Group on Inherited Kidney Disorders, the European Rare Kidney Disease Reference Network and Polycystic Kidney Disease International. Nephrology Dialysis Transplantation.
- Carbon Monoxide Releasing Molecule A1 Reduces Myocardial Damage After Acute Myocardial Infarction in a Porcine Model. Journal of Cardiovascular Pharmacology, 78(5), e656-e661.
- Quantifying endothelial cell proliferation in the zebrafish embryo. F1000Research, 10, 1032-1032.
- Wilson’s disease: update on pathogenesis, biomarkers and treatments. Journal of Neurology, Neurosurgery & Psychiatry.
- Surgical Practice in Girls with Congenital Adrenal Hyperplasia: An International Registry Study. Sexual Development, 1-7.
- Neuroimaging correlates of brain injury in Wilson’s disease: a multimodal, whole-brain MRI study. Brain.
- Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score. British Journal of Surgery.
- The development of the C‐PAT: a concise tool to assess the quality of care in the cystectomy pathway. BJU International.
- Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia. Frontiers in Cell and Developmental Biology, 9.
- Bladder cancer: shedding light on the most promising investigational drugs in clinical trials. Expert Opinion on Investigational Drugs.
- Zoledronate extends healthspan and survival via the mevalonate pathway in a FOXO-dependent manner. The Journals of Gerontology: Series A.
- The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study. BJU International.
- Nrf2-Keap-1 imbalance under acute shear stress induces inflammatory response in venous endothelial cells. Perfusion, 026765912110125-026765912110125.
- Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction. PLOS Pathogens, 17(3), e1009468-e1009468.
- THE YEAR IN BASIC VASCULAR BIOLOGY RESEARCH: FROM MECHANORECEPTORS AND NETS TO SMARTPHONE DATA AND OMICS. Cardiovascular Research.
- Robustness of the microtubule network self-organization in epithelia. eLife, 10.
- Epithelial-Mesenchymal Transition (EMT) as a Therapeutic Target. Cells Tissues Organs, 1-26.
- The role of regulated necrosis in endocrine diseases. Nature Reviews Endocrinology.
- Altered Macrophage Polarization Induces Experimental Pulmonary Hypertension and Is Observed in Patients With Pulmonary Arterial Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology.
- Correction: 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLOS Pathogens, 16(11), e1009058-e1009058.
- Evaluation of the anti-inflammatory effects of synthesised tanshinone I and isotanshinone I analogues in zebrafish. PLOS ONE, 15(10), e0240231-e0240231.
- Real-World Estimates of Adrenal Insufficiency–Related Adverse Events in Children With Congenital Adrenal Hyperplasia. The Journal of Clinical Endocrinology & Metabolism.
- Contemporary rationale for non-invasive imaging of adverse coronary plaque features to identify the vulnerable patient: a Position Paper from the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology and the European Association of Cardiovascular Imaging. European Heart Journal - Cardiovascular Imaging.
- Neurological letter from Bangladesh. Practical Neurology.
- Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. Cardiovascular Research.
- The great host‐pathogen war:
UK
cellular microbiology meeting 2020. Cellular Microbiology.
Chapters
- A Workflow to Track and Analyze Endothelial Migration During Vascular Development in Zebrafish Embryos Using Lightsheet Microscopy, Methods in Molecular Biology (pp. 19-28). Springer US
- Prostate Cancer, Basic Urological Sciences (pp. 208-217). CRC Press
- Urothelial and Urethral Cancer, Basic Urological Sciences (pp. 189-207). CRC Press
- Genetics of Congenital Adrenal Hyperplasia, Oxford Textbook of Endocrinology and Diabetes 3e (pp. 931-941). Oxford University Press
- C. elegans as a Potential Model for Acute Seizure-Like Activity, Neuromethods (pp. 233-248). Springer US
Conference proceedings papers
- Abstract 2512: BRCA1 and BRCA2 mutations and its clinical relevance among egyptian breast cancer women. Molecular and Cellular Biology/Genetics
- A c-REL drives atherosclerosis at sites of disturbed blood flow. Young investigators award
- BS30 Light sheet imaging to analyse the spatial distribution of proteins in atherosclerotic plaques. Basic science
- BS11 Inhibition of VEGF signalling mitigates the hereditary haemorrhagic telangiectasia-like phenotype in endoglin mutant zebrafish. Basic science
- BS15 Using zebrafish embryos to identify genes that regulate endothelial proliferation. Basic science