Member Publications
Recent publications from members of the Bateson Centre.

Publications
Journal articles
- Balancing SHH and BMP/FGF10 to specify tuberal hypothalamic neurons and glia. Developmental Biology.
- Circulating tumor DNA (ctDNA) in patients with muscle-invasive bladder cancer (MIBC) who received perioperative durvalumab (D) in NIAGARA.. Journal of Clinical Oncology, 43(16_suppl), 4503-4503.
- ADP-ribosylation of NuMA promotes DNA single-strand break repair and transcription. Cell Reports, 44(6), 115737-115737.
- EPS7.09Verapamil limits inflammatory damage by reducing epithelial calcium activity in preclinical models of cystic fibrosis. Journal of Cystic Fibrosis, 24, S62-S62.
- Peto’s paradox’s relevance is off the scale. Aging, 17.
- Modelling adrenal steroid profiles to inform monitoring guidance in congenital adrenal hyperplasia. eBioMedicine, 116, 105749-105749.
- Subtypes and Sequencing in Bladder Cancer: Powering Personalised Treatment or Extraneous Information?. European Urology.
- PD37-09 THE FIRST REPORT OF DISEASE-FREE SURVIVAL ANALYSES FROM THE NIAGARA TRIAL OF PERIOPERATIVE DURVALUMAB PLUS NEOADJUVANT CHEMOTHERAPY IN MUSCLE-INVASIVE BLADDER CANCER. Journal of Urology, 213(5S).
- MP08-02 INVESTIGATING THE RELATIONSHIP BETWEEN CARDIOPULMONARY EXERCISE METRICS AND POST-OPERATIVE OUTCOMES IN RADICAL CYSTECTOMY: INSIGHTS FROM THE IROC PHASE 3 TRIAL. Journal of Urology, 213(5S).
- Erratum: Randomized Comparison of Magnetic Resonance Imaging Versus Transurethral Resection for Staging New Bladder Cancers: Results From the Prospective BladderPath Trial. Journal of Clinical Oncology, 43(15), 1847-1847.
- Abstract 2600: A human stem cell model of neuroblastoma reveals candidate drivers of tumorigenesis on chromosome 17q. Cancer Research, 85(8_Supplement_1), 2600-2600.
- Treatment Selection and Prioritization for the EJS ACT-PD MAMS Trial Platform.. Movement disorders : official journal of the Movement Disorder Society.
- No evidence for a trade-off between reproduction and survival in a meta-analysis across birds. eLife, 12. View this article in WRRO
- No evidence for a trade-off between reproduction and survival in a meta-analysis across birds. eLife.
- The Lancet Commission on rethinking coronary artery disease: moving from ischaemia to atheroma. The Lancet, 405(10486), 1264-1312.
- Curcumin-mediated NRF2 induction limits inflammatory damage in, preclinical models of cystic fibrosis. Biomedicine & Pharmacotherapy, 186, 117957-117957.
- Insights from ADPedKD, ERKReg and RaDaR registries provide a multi-national perspective on the presentation of childhood autosomal dominant polycystic kidney disease in high- and middle-income countries. Kidney International.
- Local anaesthetic transperineal biopsy versus transrectal prostate biopsy in prostate cancer detection (TRANSLATE): a multicentre, randomised, controlled trial. The Lancet Oncology.
- Commentary: Tolvaptan for Autosomal Dominant Polycystic Kidney Disease (ADPKD) - an update. BMC Nephrology, 26(1). View this article in WRRO
- Protocol for a randomised phase 3 trial evaluating the role of Finasteride in Active Surveillance for men with low and intermediate-risk prostate cancer: the FINESSE Study.. BMJ Open, 15(2), e096431.
- A phase Ib window of opportunity study of atezolizumab administered intravesically or direct injection in patients undergoing radical cystectomy for bladder cancer: Results of the single dose cohorts.. Journal of Clinical Oncology, 43(5_suppl), 773-773.
- Additional efficacy and safety outcomes and an exploratory analysis of the impact of pathological complete response (pCR) on long-term outcomes from NIAGARA.. Journal of Clinical Oncology, 43(5_suppl), 659-659.
- KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of autosomal dominant polycystic kidney disease (ADPKD): executive summary. Kidney International, 107(2), 234-254. View this article in WRRO
- KDIGO 2025 Clinical Practice Guideline for the Evaluation, Management, and Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD). Kidney International, 107(2), S1-S239.
- morphoHeart: a quantitative tool for integrated 3D morphometric analyses of heart and ECM during embryonic development. PLOS Biology, 23(1). View this article in WRRO
- Development of TAR-200: A novel targeted releasing system designed to provide sustained delivery of gemcitabine for patients with bladder cancer. Urologic Oncology: Seminars and Original Investigations.
- Randomized Comparison of Magnetic Resonance Imaging Versus Transurethral Resection for Staging New Bladder Cancers: Results From the Prospective BladderPath Trial.. J Clin Oncol, JCO2302398.
- Heritability and age-dependent changes in genetic variation of telomere length in a wild house sparrow population. Evolution Letters, 9(2), 209-220. View this article in WRRO
- Clinical Spectrum and Prognosis of Atypical Autosomal Dominant Polycystic Kidney Disease Caused by Monoallelic Pathogenic Variants of IFT140. American Journal of Kidney Diseases.
- Increasing Life Expectancy in Patients with Genitourinary Malignancies: Impact of Treatment Burden on Disease Management and Quality of Life. European Urology.
- The Fat-Dachsous planar polarity pathway competes with hinge contraction to orient polarized cell behaviors during Drosophila wing morphogenesis. Current Biology.
- Addressing the challenges of integrating digital health technologies to measure patient-centred outcomes in clinical registries. The Lancet Digital Health.
- Insights into the human cDNA: A descriptive study using library screening in yeast. Journal of Genetic Engineering and Biotechnology, 22(4), 100427-100427.
- MT41 The Diagnostic Accuracy of Ultrasound and Genetic Tests for the Diagnosis of Autosomal Dominant Polycystic Kidney Disease: A Systematic Mapping Review. Value in Health, 27(12), S493-S493.
- Enhanced Recovery After Surgery for patients undergoing Radical Cystectomy: surgeons’ perspectives and recommendations ten years after its implementation. European Journal of Surgical Oncology, 109543-109543.
- Tetracycline and Oxacillin Act Synergistically on Biofilms and Display Increased Efficacy In Vivo Against Staphylococcus aureus. Current Microbiology, 81(12).
- A novel therapeutic pathway to the human cochlear nerve. Scientific Reports, 14. View this article in WRRO
- The Drosophila adult midgut progenitor cells arise from asymmetric divisions of neuroblast-like cells. Developmental Cell.
- COVID-19 diagnosis, vaccination during pregnancy, and adverse pregnancy outcomes of 865,654 women in England and Wales: a population-based cohort study. The Lancet Regional Health - Europe, 45, 101037-101037.
- ANKHD1 Has a Cytoprotective Role in Stressed Kidney Cells. Journal of the American Society of Nephrology, 35(10S).
- 540P Assessing the effect of chronic nitrate supplementation on muscle mass and physical function outcomes. Neuromuscular Disorders, 43, 104441.131-104441.131.
- Peroxisomal import stress activates integrated stress response and inhibits ribosome biogenesis. PNAS Nexus, 3(10). View this article in WRRO
- FGFR Inhibition in Urothelial Carcinoma. European Urology.
- Perioperative durvalumab with neoadjuvant chemotherapy in operable bladder cancer. New England Journal of Medicine, 391(19), 1773-1786. View this article in WRRO
- EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake.. Circ Res.
- LBA5 A randomized phase III trial of neoadjuvant durvalumab plus chemotherapy followed by radical cystectomy and adjuvant durvalumab in muscle-invasive bladder cancer (NIAGARA). Annals of Oncology, 35, S1271-S1271.
- Pharmacological inhibition of ENT1 enhances the impact of specific dietary fats on energy metabolism gene expression. Proceedings of the National Academy of Sciences, 121(36).
- Mating proximity blinds threat perception. Nature, 634(8034), 635-643. View this article in WRRO
- Adult telomere length is positively correlated with survival and lifetime reproductive success in a wild passerine. Molecular Ecology, 33(15). View this article in WRRO
- A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts. The Lancet Digital Health, 6(7), e507-e519.
- Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle. Development, 151(13), dev202482.
- The DNA repair kinase ATM regulates CD13 expression and cell migration. Frontiers in Cell and Developmental Biology, 12. View this article in WRRO
- Sensory encoding and memory in the mushroom body: signals, noise, and variability. Learning & Memory, 31(5). View this article in WRRO
- The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers. BJU International, 134(3), 484-500.
- Use of gene expression patterns to identify unique molecular subtypes in muscle invasive bladder cancer: GUSTO.. Journal of Clinical Oncology, 42(16_suppl), TPS4621-TPS4621.
- P207 The longitudinal assessment of anti-virulence gene expression in Pseudomonas aeruginosa grown in cystic fibrosis sputum mimics. Journal of Cystic Fibrosis, 23, S132-S133.
- WS16.04 When cystic fibrosis triggers a protective immunity against tuberculosis: loss of CFTR confers resistance to Mycobacterium marinum infections in cystic fibrosis zebrafish models. Journal of Cystic Fibrosis, 23, S30-S30.
- #2695 A Polycystin-1-Bicaudal C1 complex regulates focal adhesion function through integrin beta-1, F-actin organisation and local translation in HKE cells. Nephrology Dialysis Transplantation, 39(Supplement_1).
- Stakeholder perspectives on contributors to delayed and inaccurate diagnosis of cardiovascular disease and their implications for digital health technologies: a UK-based qualitative study. BMJ Open, 14(5), e080445-e080445.
- Macrophage transplantation rescues RNASET2-deficient leukodystrophy by replacing deficient microglia in a zebrafish model. Proceedings of the National Academy of Sciences, 121(21).
- Decision Regret Regarding Treatment Choices 1 Year After a New Diagnosis of Bladder Cancer. European Urology.
- PD36-04 REMOTE DIGITAL SURVEILLANCE AND MACHINE LEARNING MODELLING TO PREDICT SURVIVAL FOLLOWING RADICAL CYSTECTOMY FOR BLADDER CANCER—A SECONDARY OUTCOME ANALYSIS OF THE IROC TRIAL. Journal of Urology, 211(5S).
- Relocating coincidence detection for associative learning.. J Physiol, 602(9), 1877-1878.
- Dietary restriction extends lifespan across different temperatures in the fly. Functional Ecology. View this article in WRRO
- Case report: Effectiveness of low-dose methotrexate monotherapy in post-essential thrombocythemia myelofibrosis. Frontiers in Medicine, 11. View this article in WRRO
- Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs. Cell Reports, 43(4), 114073-114073.
- Chronic kidney disease and the global public health agenda: an international consensus. Nature Reviews Nephrology, 1-13.
- The mechanical influence of densification on epithelial architecture. PLOS Computational Biology, 20(4), e1012001-e1012001.
- Effects of rare kidney diseases on kidney failure: a longitudinal analysis of the UK National Registry of Rare Kidney Diseases (RaDaR) cohort. The Lancet, S0140-6736(23)02843.
- What can we learn about fish neutrophil and macrophage response to immune challenge from studies in zebrafish. Fish & Shellfish Immunology, 148, 109490-109490.
- Telomere length is an epigenetic trait – Implications for the use of telomerase-deficient organisms to model human disease. Disease Models & Mechanisms, 17(3).
- Fabrication and characterisation of random and aligned electrospun scaffolds to investigate hypothalamic stem/progenitor cell behaviour. Engineered Regeneration, 5(1), 11-20.
- UPDATED EFFICACY AND SAFETY OF ORAL ERDAFITINIB IN PATIENTS WITH BACILLUS CALMETTE-GUÉRIN–UNRESPONSIVE, HIGH-RISK NON-MUSCLE–INVASIVE BLADDER CANCER WITH FGFR3/2 ALTERATIONS IN THOR-2 COHORT 2. Urologic Oncology: Seminars and Original Investigations, 42, S53-S53.
- Digital remote monitoring and Machine Learning (ML) modeling to predict survival following radical cystectomy for bladder cancer – a secondary outcome analysis of the iROC trial. European Urology, 85, S929-S930.
- SunRISe-3: TAR-200 plus cetrelimab or TAR-200 versus intravesical Bacillus Calmette–Guérin in patients with BCG-naive high-risk non–muscle-invasive bladder cancer. European Urology, 85, S1505-S1505.
- Clinical Application of Bladder MRI and Vesical Imaging-Reporting And Data System. European Urology, 85, S1874-S1875.
- Gene of the month: the uroplakins. Journal of Clinical Pathology, 77(5), 291-296.
- Global analysis of urinary extracellular vesicle small RNAs in autosomal dominant polycystic kidney disease. The Journal of Gene Medicine, 26(2), e3674.
- The people behind the papers – Fay Cooper and Anestis Tsakiridis. Development, 151(3).
- Verification of molecular subtyping of bladder cancer in the GUSTO clinical trial. The Journal of Pathology: Clinical Research, 10(2). View this article in WRRO
- INVEST: A phase Ib window of opportunity study of atezolizumab administered either intravesically or direct tumour injection in patients with bladder cancer prior to radical cystectomy.. Journal of Clinical Oncology, 42(4_suppl), TPS710-TPS710.
- Thromboembolic events associated with neoadjuvant chemotherapy for muscle invasive cancer of the bladder.. Journal of Clinical Oncology, 42(4_suppl), 586-586.
- Real world outcomes for maintenance avelumab treatment in locally advanced/metastatic urothelial cancer after platinum-based chemotherapy.. Journal of Clinical Oncology, 42(4_suppl), 584-584.
- Combining genotype with height-adjusted kidney length predicts rapid progression of ADPKD. Nephrology Dialysis Transplantation, 39(6), 956-966. View this article in WRRO
- Chromosomal single-strand break repair and neurological disease: implications on transcription and emerging genomic tools. DNA Repair, 103629-103629.
- Abstract A023: High glucose increases DNA damage and elevates the expression of multiple DDR genes. Cancer Research, 84(1_Supplement), A023-A023.
- Liver transplant recipients with polycystic liver disease have longer waiting times but better long-term clinical outcomes than those with liver disease due to other causes: a retrospective cross-sectional study. PLOS ONE, 19(1). View this article in WRRO
- Corrigendum to “An Artificial Intelligence Generated Automated Algorithm to Measure Total Kidney Volume in ADPKD” [Kidney International Reports Volume 9, Issue 2, February 2024, Pages 249-256]. Kidney International Reports.
- Description and Cross-Sectional Analyses of 25,880 Adults and Children in the UK National Registry of Rare Kidney Diseases Cohort. Kidney International Reports.
- Interruptions in bladder cancer care during the COVID-19 public health emergency. Urologic Oncology: Seminars and Original Investigations.
- A Methodology for the Enzymatic Isolation of Embryonic Hypothalamus Tissue and Its Acute or Post-Culture Analysis by Multiplex Hybridisation Chain Reaction. BIO-PROTOCOL, 13(23).
- The pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo. Molecular Metabolism, 78, 101829-101829.
- An interview with Marysia Placzek. Development, 150(23).
- Boosting and broadening recruitment to UK cancer trials: towards a blueprint for action. BMJ Oncology, 2(1), e000092-e000092.
- Cancer-specific glycosylation of CD13 impacts its detection and activity in preclinical cancer tissues. iScience, 26(11), 108219-108219.
- An Artificial Intelligence generated Automated Algorithm to measure Total Kidney Volume in ADPKD. Kidney International Reports.
- Digital Tracking of Patients Undergoing Radical Cystectomy for Bladder Cancer: Daily Step Counts Before and After Surgery Within the iROC Randomised Controlled Trial. European Urology Oncology.
- Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly. Science, 382(6667), 223-230.
- Erdafitinib in BCG-treated high-risk non-muscle-invasive bladder cancer. Annals of Oncology.
- LBA102 THOR-2 cohort 1: Results of erdafitinib (ERDA) vs intravesical chemotherapy (chemo) in patients (pts) with high-risk non–muscle-invasive bladder cancer (HR NMIBC) with select fibroblast growth factor receptor alterations (FGFRALT) who received prior bacillus calmette-guérin (BCG) treatment. Annals of Oncology, 34, S1341-S1342.
- 2407TiP SunRISe-3: TAR-200 plus cetrelimab (CET) or TAR-200 versus intravesical bacillus Calmette-Guérin (BCG) in patients (pts) with BCG-naive high-risk non-muscle-invasive bladder cancer (HR NMIBC). Annals of Oncology, 34, S1224-S1224.
- How could sensor-based measurement of physical activity be used in cardiovascular healthcare?. Sensors, 23(19). View this article in WRRO
- Clinical Trial Highlights: Modulators of Mitochondrial Function. Journal of Parkinson's Disease, 13(6), 851-864.
- Outcome Measures for Disease-Modifying Trials in Parkinson’s Disease: Consensus Paper by the EJS ACT-PD Multi-Arm Multi-Stage Trial Initiative. Journal of Parkinson's Disease, 13(6), 1011-1033.
- Protocol for the YORKSURe prospective multistage study testing the feasibility for early detection of bladder cancer in populations with high disease-specific mortality risk. BMJ Open, 13(9), e076612-e076612.
- insideOutside: an accessible algorithm for classifying interior and exterior points, with applications in embryology. Biology Open, 12(9).
- Biomarkers in congenital adrenal hyperplasia.. Clin Endocrinol (Oxf).
- Evaluating the molecular properties and function of ANKHD1, and Its role in cancer. International Journal of Molecular Sciences, 24(16). View this article in WRRO
- In-silico and in-vitro morphometric analysis of intestinal organoids. PLOS Computational Biology, 19(8). View this article in WRRO
- Corrigendum to “Robot-assisted Radical Cystectomy Versus Open Radical Cystectomy: A Systematic Review and Meta-analysis of Perioperative, Oncological, and Quality of Life Outcomes Using Randomized Controlled Trials” [Eur Urol. 2023;84:393–405]. European Urology, 84(4), e98-e99.
- Neuroscience: Hacking development to understand sensory discrimination. Current Biology, 33(15), R822-R825.
- The potential of innovative trial design for efficiently evaluating repurposed drugs. Nature Reviews Drug Discovery, 22(9), 681-682.
- Diet and Polycystic Kidney Disease: Nutrients, Foods, Dietary Patterns, and Implications for Practice. Seminars in Nephrology, 43(2), 151405-151405.
- Cardiopulmonary exercise testing of patients with metastatic castrate-resistant prostate cancer as screening for vigorous exercise medicine prescription.. JCO Global Oncology, 9(Supplement_1), 80-80.
- Stochasticity explains nongenetic inheritance of lifespan and apparent trade-offs between reproduction and aging. Aging Biology, 1(1), 1-6. View this article in WRRO
- The common PKD1 p.(Ile3167Phe) variant is hypomorphic and associated with very early onset, biallelic polycystic kidney disease. Human Mutation, 2023. View this article in WRRO
- A screen of pharmacologically active compounds to identify modulators of the Adgrg6/Gpr126 signalling pathway in zebrafish embryos. Basic and Clinical Pharmacology and Toxicology, 133(4), 364-377.
- Markers of the ageing macrophage: a systematic review and meta-analysis. Frontiers in Immunology, 14. View this article in WRRO
- Assessing the Response of Biomarkers to Anti-Inflammatory Medications in PIMS-TS by Longitudinal Multilevel Modeling: Real-World Data from a UK Tertiary Center. Pediatric Allergy, Immunology, and Pulmonology, 36(3), 94-103.
- Wearable technology and the cardiovascular system: the future of patient assessment. The Lancet Digital Health, 5(7), e467-e476.
- Cost-effectiveness of robot-assisted radical cystectomy vs open radical cystectomy for patients with bladder cancer. JAMA Network Open, 6(6). View this article in WRRO
- A PI(3,5)P2 reporter reveals PIKfyve activity and dynamics on macropinosomes and phagosomes. Journal of Cell Biology, 222(9).
- Stakeholder-led understanding of the implementation of digital technologies within heart disease diagnosis: a qualitative study protocol. BMJ Open, 13(6), e072952-e072952.
- ANKHD1 promotes pathogenic proliferation in Autosomal Dominant Polycystic Kidney Disease via the Cyclin D1/CDK4 pathway. Journal of Translational Medicine, 23(1).
- Donor embryonic stem cells displace host cells of 8-cell stage chimeras to the extraembryonic lineages by spatial crowding and FGF4 signalling. Development.
- Insights into the health provision for children with congenital adrenal hyperplasia in the UK and implementation of longitudinal collection and analysis of real-world data. Endocrine Abstracts.
- Exploring the role of glucocorticoids and androgens in the regulation of brain immunity using zebrafish models of impaired steroidogenesis. Endocrine Abstracts.
- Hydrocortisone treatment only partially restores systemic dysregulations caused by cortisol deficiency in a 21-hydroxylase deficient zebrafish model. Endocrine Abstracts.
- Thematic analysis of quality of life in a community-based sample of adults living with congenital adrenal hyperplasia reveals a significant unmet medical need. Endocrine Abstracts.
- A zebrafish model of acmsd deficiency does not support a prominent role for ACMSD in Parkinson’s disease. npj Parkinson's Disease, 11(1).
- Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies. Communications Medicine, 5(1).
- Improving the pathway to correct treatment for patients with muscle‐invasive bladder cancer: exploring the myths around the
BladderPath trial. BJU International. - Blood pressure and its associations in 554 children and young people with CAH. European Journal of Endocrinology.
- Cost-effectiveness of de-escalated molecular subtype dependent use of neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer in a Swedish setting. Frontiers in Oncology, 15.
- Expansion of Drosophila haemocytes using a conditional GeneSwitch driver affects larval haemocyte function, but does not modulate adult lifespan or survival after severe infection. Journal of Experimental Biology.
- Exploring Stakeholder Perspectives on the Barriers and Facilitators of Implementing Digital Technologies for Heart Disease Diagnosis: Qualitative Study. JMIR Cardio, 9, e66464-e66464.
- Rare disease gene association discovery in the 100,000 Genomes Project. Nature, 1-9.
- Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathways. Cardiovascular Research.
- Cerebrovascular ageing: how zebrafish can contribute to solving the puzzle. Frontiers in Physiology, 16.
- The significance of isolated de novo red patches in the bladder in patients referred with suspected urinary tract cancer: Results from the IDENTIFY study. BJUI Compass.
- Home Urine Dipstick Screening for Bladder and Kidney Cancer in High-Risk Populations in England: A Microsimulation Study of Long-Term Impact and Cost-Effectiveness. PharmacoEconomics.
- Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation. Scientific Reports, 14(1).
- Parkinson’s families project: a UK-wide study of early onset and familial Parkinson’s disease. npj Parkinson's Disease, 10(1).
- Understanding the long‐term impact of the COVID‐19 pandemic on non‐muscle‐invasive bladder cancer outcomes: 12‐Month follow‐up data from the international, prospective COVIDSurg Cancer study. BJUI Compass.
- Real‐word outcomes for high‐risk non‐muscle‐invasive bladder cancer: screened patients for the
BRAVO trial. BJU International. - Control of tuberal hypothalamic development and its implications in metabolic disorders. Nature Reviews Endocrinology.
- Second generation lethality in RNAseH2a knockout zebrafish. Nucleic Acids Research.
- Temporal Trends In Acute Adrenal Insufficiency Events In Children With Congenital Adrenal Hyperplasia During 2019-2022. Journal of the Endocrine Society.
- National audit of patient reported experience of radical cystectomy for bladder cancer pathways. BJUI Compass.
- Controversy in mechanotransduction: the role of endothelial cell-cell junctions in fluid shear stress sensing. Journal of Cell Science.
- Genomic landscape of hepatocellular carcinoma in Egyptian patients by whole exome sequencing. BMC Medical Genomics, 17(1).
- Image directed redesign of bladder cancer treatment pathways: the BladderPath RCT. Health Technology Assessment, 1-65.
- Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight. Nature Reviews Cardiology.
- Exploring the role of E. faecalis enterococcal polysaccharide antigen (
EPA ) and lipoproteins in evasion of phagocytosis. Molecular Microbiology. - Hypoxia‐Responsive Prodrug of ATR Inhibitor, AZD6738, Selectively Eradicates Treatment‐Resistant Cancer Cells. Advanced Science.
- Making cups and rings: the ‘stalled-wave’ model for macropinocytosis. Biochemical Society Transactions.
- Blood Transfusion, Radical Cystectomy, and Cancer Recurrence: A New Look at an Old Story. Comment on Ladner et al. Perioperative Blood Transfusion Is Associated with Worse Survival in Patients Undergoing Radical Cystectomy after Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer. Soc. Int. Urol. J. 2024, 5, 202–213. Société Internationale d’Urologie Journal, 5(3), 244-246.
- Tribbles1 is host protective during in vivo mycobacterial infection. eLife, 13.
- Human enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissue. Gut, gutjnl-2023.
- A comparative study of different antiviral treatment protocols in HCV related cryoglobulinemic vasculitis. Scientific Reports, 14(1), 11840.
- Polygenic Risk Scores Validated in Patient‐Derived Cells Stratify for Mitochondrial Subtypes of Parkinson's Disease. Annals of Neurology.
- A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations. Nature Communications, 15(1).
- Experimental evolution of
Staphylococcus aureus
in macrophages: dissection of a conditional adaptive trait promoting intracellular survival. mBio.
- Clinical Characteristics and Kidney Outcomes in Chinese Patients with Autosomal Dominant Polycystic Kidney Disease. Kidney360.
- Service evaluation suggests variation in clinical care provision in adults with congenital adrenal hyperplasia in the UK and Ireland. Clinical Endocrinology.
- National service evaluation of the quality of care for children and young people with congenital adrenal hyperplasia in the United Kingdom: survey responses from patients and clinicians. Hormone Research in Paediatrics.
- ASXL3‐related disorder: Molecular phenotyping and comprehensive review providing insights into disease mechanism. Clinical Genetics.
- HYDROchlorothiazide versus placebo to PROTECT polycystic kidney disease patients and improve their quality of life: study protocol and rationale for the HYDRO-PROTECT randomized controlled trial. Trials, 25(1).
- Improved Disease-Free Survival With Adjuvant Chemotherapy After Nephroureterectomy for Upper Tract Urothelial Cancer: Final Results of the POUT Trial. Journal of Clinical Oncology.
- Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Nature Communications, 15(1).
- Correction to “A
p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo”. Aging Cell. - Notch signalling influences cell fate decisions and HOX gene induction in axial progenitors. Development.
- Macrophage subpopulation identity in Drosophila is modulated by apoptotic cell clearance and related signalling pathways. Frontiers in Immunology, 14.
- Multimodal assessment of mitochondrial function in Parkinson's disease. Brain.
- Clinical application of bladder MRI and the Vesical Imaging-Reporting And Data System. Nature Reviews Urology.
- Quality of life after a diagnosis of Bladder Cancer: Longitudinal survey over the first year. BJU International.
- Emerging strategies to target virulence in
Pseudomonas aeruginosa
respiratory infections. Critical Reviews in Microbiology, 1-16.
- London calling: The 5th
UK Cellular Microbiology Network Meeting. Molecular Microbiology. - Functional Follow-Up After Cystectomy and Urinary Diversion: A Narrative Review. JU Open Plus, 1(11).
- An international study of the association between local health care resources and acute adrenal insufficiency events in children with congenital adrenal hyperplasia. Endocrine Abstracts.
- Association of newborn screening of congenital adrenal hyperplasia with outcomes in the first 90 days of life: a multi-centre I-CAH registry analysis of contemporary practice. Endocrine Abstracts.
- Service evaluation suggests variation in clinical care provision in adults with congenital adrenal hyperplasia in the UK and Ireland. Endocrine Abstracts.
- CaHASE2: Current clinical practice and future research. Endocrine Abstracts.
- Accurate staging of chick embryonic tissues via deep learning of salient features. Development.
- Oncological Surveillance After Radical Cystectomy: a Narrative Review of the Enhanced Recovery After Surgery Cystectomy Committee. JU Open Plus, 1(10).
- Fgf signalling triggers an intrinsic mesodermal timer that determines the duration of limb patterning. Nature Communications, 14(1).
- The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function. Nature Communications, 14(1).
- Long‐term health consequences of congenital adrenal hyperplasia. Clinical Endocrinology.
- Blood Pressure in Children with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. Hormone Research in Paediatrics, 1-11.
- Investigating Metabolic and Molecular Ecological Evolution of Opportunistic Pulmonary Fungal Coinfections: Protocol for a Laboratory-Based Cross-Sectional Study. JMIR Research Protocols, 12, e48014-e48014.
- Journey of a thousand miles: from ‘Manpo-Kei’ to the first steps-based physical activity recommendations. British Journal of Sports Medicine.
- Device-based measurement of physical activity in cardiovascular healthcare: possibilities and challenges. British Journal of Sports Medicine.
- Potential impact of wearables on physical activity guidelines and interventions: opportunities and challenges. British Journal of Sports Medicine.
- Glucocorticoid Receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain. Disease Models & Mechanisms.
- Identification of renal cyst cells of type I Nephronophthisis by single-nucleus RNA sequencing. Frontiers in Cell and Developmental Biology, 11, 1192935.
- Quality of Life in Children and Young People With Congenital Adrenal Hyperplasia—UK Nationwide Multicenter Assessment. The Journal of Clinical Endocrinology & Metabolism.
- Using the Non-Adoption, Abandonment, Scale-Up, Spread, and Sustainability (NASSS) Framework to Identify Barriers and Facilitators for the Implementation of Digital Twins in Cardiovascular Medicine. Sensors, 23(14), 6333-6333.
- Diagnosis, treatment, and survival from kidney cancer: real‐world
NHS England data between 2013‐2019. BJU International. - PLA2G12A as a Novel Biomarker for Colorectal Cancer with Prognostic Relevance. International Journal of Molecular Sciences, 24(13), 10889-10889.
Chapters
- Development of the semicircular canals and otolithic organs of the vertebrate inner ear In Whitfield T (Ed.), Current Topics in Developmental Biology Elsevier
- Adult zebrafish as a vertebrate model of ageing, Zebrafish (pp. 159-181). CABI
- Light-Sheet Microscopy Enables Three-Dimensional Fluorescence Imaging and Live Imaging of Satellite Cells on Skeletal Muscle Fibers, Methods in Molecular Biology Springer US
- Disorders of the Adrenal Gland in Children and Adolescents, Endocrinology (pp. 115-184). Springer International Publishing
- Organizing activities of axial mesoderm, Current Topics in Developmental Biology (pp. 83-123). Elsevier
- Cardiac construction—Recent advances in morphological and transcriptional modeling of early heart development, Current Topics in Developmental Biology Elsevier
Conference proceedings papers
- I026 Screening for mitochondrial therapeutics in Huntington’s disease using patient-derived cells. I: Experimental therapeutics – preclinical (pp A152.1-A152)
Preprints
- Type I interferon responses contribute to immune protection against mycobacterial infection, eLife Sciences Publications, Ltd.
- Type I interferon responses contribute to immune protection against mycobacterial infection, eLife Sciences Publications, Ltd.
- TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques, Cold Spring Harbor Laboratory.
- Polycystin-1 acts as an atypical adhesion GPCR that responds to novel Wnt signaling and mechanical stimuli, Cold Spring Harbor Laboratory.
- Telomerase reverse transcriptase is required for resistance to mycobacterial infection, Cold Spring Harbor Laboratory.
- Examining the genetic and phenotypic correlation between survival and fecundity in a wild bird, Cold Spring Harbor Laboratory.
- Artificial Intelligence Remote Patient Monitoring (AI RPM) for predicting overall survival for patients undergoing radical cystectomy for bladder cancer: an exploratory analysis of the prospective trial iROC (Preprint), JMIR Publications Inc..
- Dietary restriction is evolutionary conserved on the phenotypic and mechanistic level, Cold Spring Harbor Laboratory.
- Mechanical fracturing of the extracellular matrix patterns the vertebrate heart, Cold Spring Harbor Laboratory.
- The optimal clutch size revisited: separating individual quality from the parental survival costs of reproduction, eLife Sciences Publications, Ltd.
- Integrating Natural Language Processing to Assess Effect of Loneliness and Social isolation on Cognitive Decline in Dementia: A Retrospective Cohort Analysis, Cold Spring Harbor Laboratory.
- Resolving forebrain developmental organisation by analysis of differential growth patterns, Cold Spring Harbor Laboratory.
- E-cadherin endocytosis promotes non-canonical EGFR:STAT signalling to induce cell death and inhibit heterochromatinisation, Cold Spring Harbor Laboratory.
- Donor embryonic stem cells impede host epiblast specification in 8-cell stage chimeras by crowding and FGF4 signalling, Cold Spring Harbor Laboratory.
- Paired and solitary ionocytes in the zebrafish olfactory epithelium, Cold Spring Harbor Laboratory.
- A role for class I PAKs in the regulation of the excitability of the actin cytoskeleton., Cold Spring Harbor Laboratory.
- The optimal clutch size revisited: separating individual quality from the parental survival costs of reproduction, eLife Sciences Publications, Ltd.
- Expansion ofDrosophilahaemocytes using a conditionalGeneSwitchdriver affects larval haemocyte function, but does not modulate adult lifespan or survival from infection, Cold Spring Harbor Laboratory.
- BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD, Cold Spring Harbor Laboratory.
- Separating the genetic and environmental drivers of body temperature during the development of endothermy in an altricial bird, Cold Spring Harbor Laboratory.
- Type I interferon responses contribute to immune protection against mycobacterial infection, Cold Spring Harbor Laboratory.
- Exploring the role ofE. faecalisEnterococcal Polysaccharide Antigen (EPA) and lipoproteins in evasion of phagocytosis, Cold Spring Harbor Laboratory.
- The optimal clutch size revisited: separating individual quality from the parental survival costs of reproduction, eLife Sciences Publications, Ltd.
- The optimal clutch size revisited: separating individual quality from the parental survival costs of reproduction, eLife Sciences Publications, Ltd.
- Exploring the role of E. faecalis Enterococcal Polysaccharide Antigen (EPA) and lipoproteins in evasion of phagocytosis, Authorea, Inc..
- Biallelic mutations in SUPV3L1 cause an inherited neurodevelopmental disorder with variable leukodystrophy due to aberrant mitochondrial double stranded RNA processing, Research Square Platform LLC.
- Mating proximity blinds threat perception., Cold Spring Harbor Laboratory.
- Curcumin-mediated NRF2 induction limits inflammatory damage in preclinical models of cystic fibrosis, Cold Spring Harbor Laboratory.
- Pulses of Class I PI3kinase activity identify the release and recapture of prey from neutrophil phagosomes, Cold Spring Harbor Laboratory.
- Senataxin modulates resistance to cisplatin through an R-loop mediated mechanism in HPV-associated Head and Neck Squamous Cell Carcinoma, Cold Spring Harbor Laboratory.
- morphoHeart: a novel quantitative tool to perform integrated 3D morphometric analyses of heart and ECM morphology during embryonic development, Cold Spring Harbor Laboratory.
- Rare disease gene association discovery from burden analysis of the 100,000 Genomes Project data, Cold Spring Harbor Laboratory.
- EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake, Cold Spring Harbor Laboratory.
- Macrophage transplantation rescues RNASET2-deficient leukodystrophy by replacing deficient microglia in a zebrafish model, Cold Spring Harbor Laboratory.
- Human enteric nervous system progenitor transplantation restores functional responses in Hirschsprung Disease patient-derived tissue, Cold Spring Harbor Laboratory.
- Oncogenic RAS drives rapid onset cellular plasticity and elicits a tumour-promoting neutrophil response at the inception of preneoplastic development, Cold Spring Harbor Laboratory.
- Candida albicanssuppression of neutrophil reactive nitrogen species is rescued by host Hif-1αin vivo, Cold Spring Harbor Laboratory.
- Dietary restriction extends lifespan across different temperatures in the fly, Cold Spring Harbor Laboratory.
- Stakeholder perspectives on contributors to delayed and inaccurate diagnosis of cardiovascular disease: a UK-based qualitative study, Cold Spring Harbor Laboratory.
- Ageing-related defects in macrophage function are driven byMYCandUSF1transcriptional programmes, Cold Spring Harbor Laboratory.
- Macrophage subpopulation identity inDrosophilais modulated by apoptotic cell clearance and related signalling pathways, Cold Spring Harbor Laboratory.
- Tribbles1 and Cop1 cooperate to protect the host during in vivo mycobacterial infection, Cold Spring Harbor Laboratory.
- Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle, Cold Spring Harbor Laboratory.
- Candida albicanscells lacking AP-2 have defective hyphae and are avirulent despite increased host uptake and intracellular proliferation in macrophages, Cold Spring Harbor Laboratory.
- Determining the importance of the stringent response for methicillin-resistantStaphylococcus aureusvirulence using a zebrafish model of infection, Cold Spring Harbor Laboratory.
- WITHDRAWN: Biallelic mutation ofSUPV3L1causes an inherited leukodystrophy-associated neurodevelopmental disorder due to aberrant mitochondrial double stranded RNA processing, Cold Spring Harbor Laboratory.