Member Publications
Recent publications from members of the Bateson Centre.
Publications
Journal articles
- Insights into the human cDNA: A descriptive study using library screening in yeast. Journal of Genetic Engineering and Biotechnology, 22(4), 100427-100427.
- Tetracycline and Oxacillin Act Synergistically on Biofilms and Display Increased Efficacy In Vivo Against Staphylococcus aureus. Current Microbiology, 81(12).
- The Drosophila adult midgut progenitor cells arise from asymmetric divisions of neuroblast-like cells. Developmental Cell.
- 6437 Analysis of 17-OH-progesterone (17OHP) and androstenedione (A4) profiles to rationalise biochemical monitoring of CAH patients. Journal of the Endocrine Society, 8(Supplement_1). View this article in WRRO
- COVID-19 diagnosis, vaccination during pregnancy, and adverse pregnancy outcomes of 865,654 women in England and Wales: a population-based cohort study. The Lancet Regional Health - Europe, 45, 101037-101037.
- 540P Assessing the effect of chronic nitrate supplementation on muscle mass and physical function outcomes. Neuromuscular Disorders, 43, 104441.131-104441.131.
- FGFR Inhibition in Urothelial Carcinoma. European Urology.
- EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake.. Circ Res.
- LBA5 A randomized phase III trial of neoadjuvant durvalumab plus chemotherapy followed by radical cystectomy and adjuvant durvalumab in muscle-invasive bladder cancer (NIAGARA). Annals of Oncology, 35, S1271-S1271.
- Pharmacological inhibition of ENT1 enhances the impact of specific dietary fats on energy metabolism gene expression. Proceedings of the National Academy of Sciences, 121(36).
- Adult telomere length is positively correlated with survival and lifetime reproductive success in a wild passerine. Molecular Ecology. View this article in WRRO
- A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts. The Lancet Digital Health, 6(7), e507-e519.
- Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle. Development, 151(13), dev202482.
- The DNA repair kinase ATM regulates CD13 expression and cell migration. Frontiers in Cell and Developmental Biology, 12. View this article in WRRO
- Sensory encoding and memory in the mushroom body: signals, noise, and variability. Learning & Memory, 31(5), a053825-a053825.
- The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers. BJU International, 134(3), 484-500.
- Use of gene expression patterns to identify unique molecular subtypes in muscle invasive bladder cancer: GUSTO.. Journal of Clinical Oncology, 42(16_suppl), TPS4621-TPS4621.
- P207 The longitudinal assessment of anti-virulence gene expression in Pseudomonas aeruginosa grown in cystic fibrosis sputum mimics. Journal of Cystic Fibrosis, 23, S132-S133.
- WS16.04 When cystic fibrosis triggers a protective immunity against tuberculosis: loss of CFTR confers resistance to Mycobacterium marinum infections in cystic fibrosis zebrafish models. Journal of Cystic Fibrosis, 23, S30-S30.
- #2695 A Polycystin-1-Bicaudal C1 complex regulates focal adhesion function through integrin beta-1, F-actin organisation and local translation in HKE cells. Nephrology Dialysis Transplantation, 39(Supplement_1).
- #2613 Clinical spectrum and prognosis of the atypical polycystic kidney disease caused by monoallelic loss-of-function IFT140 variants. Nephrology Dialysis Transplantation, 39(Supplement_1).
- Stakeholder perspectives on contributors to delayed and inaccurate diagnosis of cardiovascular disease and their implications for digital health technologies: a UK-based qualitative study. BMJ Open, 14(5), e080445-e080445.
- Macrophage transplantation rescues RNASET2-deficient leukodystrophy by replacing deficient microglia in a zebrafish model. Proceedings of the National Academy of Sciences, 121(21).
- Decision Regret Regarding Treatment Choices 1 Year After a New Diagnosis of Bladder Cancer. European Urology.
- PD36-04 REMOTE DIGITAL SURVEILLANCE AND MACHINE LEARNING MODELLING TO PREDICT SURVIVAL FOLLOWING RADICAL CYSTECTOMY FOR BLADDER CANCER—A SECONDARY OUTCOME ANALYSIS OF THE IROC TRIAL. Journal of Urology, 211(5S).
- Relocating coincidence detection for associative learning.. J Physiol, 602(9), 1877-1878.
- Dietary restriction extends lifespan across different temperatures in the fly. Functional Ecology. View this article in WRRO
- Case report: Effectiveness of low-dose methotrexate monotherapy in post-essential thrombocythemia myelofibrosis. Frontiers in Medicine, 11. View this article in WRRO
- Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs. Cell Reports, 43(4). View this article in WRRO
- Chronic kidney disease and the global public health agenda: an international consensus. Nature Reviews Nephrology, 1-13.
- The mechanical influence of densification on epithelial architecture. PLOS Computational Biology, 20(4), e1012001-e1012001.
- Effects of rare kidney diseases on kidney failure: a longitudinal analysis of the UK National Registry of Rare Kidney Diseases (RaDaR) cohort. The Lancet, S0140-6736(23)02843.
- What can we learn about fish neutrophil and macrophage response to immune challenge from studies in zebrafish. Fish & Shellfish Immunology, 148, 109490-109490.
- Telomere length is an epigenetic trait – Implications for the use of telomerase-deficient organisms to model human disease. Disease Models & Mechanisms, 17(3).
- Fabrication and characterisation of random and aligned electrospun scaffolds to investigate hypothalamic stem/progenitor cell behaviour. Engineered Regeneration, 5(1), 11-20.
- UPDATED EFFICACY AND SAFETY OF ORAL ERDAFITINIB IN PATIENTS WITH BACILLUS CALMETTE-GUÉRIN–UNRESPONSIVE, HIGH-RISK NON-MUSCLE–INVASIVE BLADDER CANCER WITH FGFR3/2 ALTERATIONS IN THOR-2 COHORT 2. Urologic Oncology: Seminars and Original Investigations, 42, S53-S53.
- Digital remote monitoring and Machine Learning (ML) modeling to predict survival following radical cystectomy for bladder cancer – a secondary outcome analysis of the iROC trial. European Urology, 85, S929-S930.
- SunRISe-3: TAR-200 plus cetrelimab or TAR-200 versus intravesical Bacillus Calmette–Guérin in patients with BCG-naive high-risk non–muscle-invasive bladder cancer. European Urology, 85, S1505-S1505.
- Clinical Application of Bladder MRI and Vesical Imaging-Reporting And Data System. European Urology, 85, S1874-S1875.
- Gene of the month: the uroplakins. Journal of Clinical Pathology, 77(5), 291-296.
- Global analysis of urinary extracellular vesicle small RNAs in autosomal dominant polycystic kidney disease. The Journal of Gene Medicine, 26(2), e3674.
- The people behind the papers – Fay Cooper and Anestis Tsakiridis. Development, 151(3).
- Verification of molecular subtyping of bladder cancer in the GUSTO clinical trial. The Journal of Pathology: Clinical Research, 10(2). View this article in WRRO
- INVEST: A phase Ib window of opportunity study of atezolizumab administered either intravesically or direct tumour injection in patients with bladder cancer prior to radical cystectomy.. Journal of Clinical Oncology, 42(4_suppl), TPS710-TPS710.
- Thromboembolic events associated with neoadjuvant chemotherapy for muscle invasive cancer of the bladder.. Journal of Clinical Oncology, 42(4_suppl), 586-586.
- Real world outcomes for maintenance avelumab treatment in locally advanced/metastatic urothelial cancer after platinum-based chemotherapy.. Journal of Clinical Oncology, 42(4_suppl), 584-584.
- Combining genotype with height-adjusted kidney length predicts rapid progression of ADPKD. Nephrology Dialysis Transplantation. View this article in WRRO
- Chromosomal single-strand break repair and neurological disease: implications on transcription and emerging genomic tools. DNA Repair, 103629-103629.
- Abstract A023: High glucose increases DNA damage and elevates the expression of multiple DDR genes. Cancer Research, 84(1_Supplement), A023-A023.
- Liver transplant recipients with polycystic liver disease have longer waiting times but better long-term clinical outcomes than those with liver disease due to other causes: a retrospective cross-sectional study. PLOS ONE, 19(1). View this article in WRRO
- Corrigendum to “An Artificial Intelligence Generated Automated Algorithm to Measure Total Kidney Volume in ADPKD” [Kidney International Reports Volume 9, Issue 2, February 2024, Pages 249-256]. Kidney International Reports.
- Description and Cross-Sectional Analyses of 25,880 Adults and Children in the UK National Registry of Rare Kidney Diseases Cohort. Kidney International Reports.
- Interruptions in bladder cancer care during the COVID-19 public health emergency. Urologic Oncology: Seminars and Original Investigations.
- A Methodology for the Enzymatic Isolation of Embryonic Hypothalamus Tissue and Its Acute or Post-Culture Analysis by Multiplex Hybridisation Chain Reaction. BIO-PROTOCOL, 13(23).
- The pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo. Molecular Metabolism, 78, 101829-101829.
- An interview with Marysia Placzek. Development, 150(23).
- Boosting and broadening recruitment to UK cancer trials: towards a blueprint for action. BMJ Oncology, 2(1), e000092-e000092.
- Cancer-specific glycosylation of CD13 impacts its detection and activity in preclinical cancer tissues. iScience, 26(11), 108219-108219.
- An Artificial Intelligence generated Automated Algorithm to measure Total Kidney Volume in ADPKD. Kidney International Reports.
- Digital Tracking of Patients Undergoing Radical Cystectomy for Bladder Cancer: Daily Step Counts Before and After Surgery Within the iROC Randomised Controlled Trial. European Urology Oncology.
- Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly. Science, 382(6667), 223-230.
- Erdafitinib in BCG-treated high-risk non-muscle-invasive bladder cancer. Annals of Oncology.
- LBA102 THOR-2 cohort 1: Results of erdafitinib (ERDA) vs intravesical chemotherapy (chemo) in patients (pts) with high-risk non–muscle-invasive bladder cancer (HR NMIBC) with select fibroblast growth factor receptor alterations (FGFRALT) who received prior bacillus calmette-guérin (BCG) treatment. Annals of Oncology, 34, S1341-S1342.
- 2407TiP SunRISe-3: TAR-200 plus cetrelimab (CET) or TAR-200 versus intravesical bacillus Calmette-Guérin (BCG) in patients (pts) with BCG-naive high-risk non-muscle-invasive bladder cancer (HR NMIBC). Annals of Oncology, 34, S1224-S1224.
- How could sensor-based measurement of physical activity be used in cardiovascular healthcare?. Sensors, 23(19). View this article in WRRO
- Clinical Trial Highlights: Modulators of Mitochondrial Function. Journal of Parkinson's Disease, 13(6), 851-864.
- Outcome Measures for Disease-Modifying Trials in Parkinson’s Disease: Consensus Paper by the EJS ACT-PD Multi-Arm Multi-Stage Trial Initiative. Journal of Parkinson's Disease, 13(6), 1011-1033.
- Protocol for the YORKSURe prospective multistage study testing the feasibility for early detection of bladder cancer in populations with high disease-specific mortality risk. BMJ Open, 13(9), e076612-e076612.
- insideOutside: an accessible algorithm for classifying interior and exterior points, with applications in embryology. Biology Open, 12(9).
- Biomarkers in congenital adrenal hyperplasia.. Clin Endocrinol (Oxf).
- Evaluating the molecular properties and function of ANKHD1, and Its role in cancer. International Journal of Molecular Sciences, 24(16). View this article in WRRO
- In-silico and in-vitro morphometric analysis of intestinal organoids. PLOS Computational Biology, 19(8). View this article in WRRO
- Corrigendum to “Robot-assisted Radical Cystectomy Versus Open Radical Cystectomy: A Systematic Review and Meta-analysis of Perioperative, Oncological, and Quality of Life Outcomes Using Randomized Controlled Trials” [Eur Urol. 2023;84:393–405]. European Urology, 84(4), e98-e99.
- Neuroscience: Hacking development to understand sensory discrimination. Current Biology, 33(15), R822-R825.
- The potential of innovative trial design for efficiently evaluating repurposed drugs. Nature Reviews Drug Discovery, 22(9), 681-682.
- Diet and Polycystic Kidney Disease: Nutrients, Foods, Dietary Patterns, and Implications for Practice. Seminars in Nephrology, 43(2), 151405-151405.
- Cardiopulmonary exercise testing of patients with metastatic castrate-resistant prostate cancer as screening for vigorous exercise medicine prescription.. JCO Global Oncology, 9(Supplement_1), 80-80.
- Stochasticity explains nongenetic inheritance of lifespan and apparent trade-offs between reproduction and aging. Aging Biology, 1(1), 1-6. View this article in WRRO
- The common PKD1 p.(Ile3167Phe) variant is hypomorphic and associated with very early onset, biallelic polycystic kidney disease. Human Mutation, 2023. View this article in WRRO
- A screen of pharmacologically active compounds to identify modulators of the Adgrg6/Gpr126 signalling pathway in zebrafish embryos. Basic and Clinical Pharmacology and Toxicology, 133(4), 364-377.
- Markers of the ageing macrophage: a systematic review and meta-analysis. Frontiers in Immunology, 14. View this article in WRRO
- Assessing the Response of Biomarkers to Anti-Inflammatory Medications in PIMS-TS by Longitudinal Multilevel Modeling: Real-World Data from a UK Tertiary Center. Pediatric Allergy, Immunology, and Pulmonology, 36(3), 94-103.
- Wearable technology and the cardiovascular system: the future of patient assessment. The Lancet Digital Health, 5(7), e467-e476.
- Cost-effectiveness of robot-assisted radical cystectomy vs open radical cystectomy for patients with bladder cancer. JAMA Network Open, 6(6). View this article in WRRO
- A PI(3,5)P2 reporter reveals PIKfyve activity and dynamics on macropinosomes and phagosomes. Journal of Cell Biology, 222(9).
- Stakeholder-led understanding of the implementation of digital technologies within heart disease diagnosis: a qualitative study protocol. BMJ Open, 13(6), e072952-e072952.
- Formation and closure of macropinocytic cups in Dictyostelium. Current Biology.
- Continuous monitoring of health and mobility indicators in patients with cardiovascular disease: a review of recent technologies. Sensors, 23(12).
- Analysis of the distal urinary tract in larval and adult zebrafish reveals homology to the human system. Disease Models & Mechanisms, dmm.050110.
- P235 Pharmacological activation of NRF2 has protective effects during Mycobacterium abscessus infection by promoting host defences and reducing inflammatory damage in the context of cystic fibrosis. Journal of Cystic Fibrosis, 22, S137-S137.
- Epidemiology of Bladder Cancer in 2023: A Systematic Review of Risk Factors. European Urology, 84(2), 176-190.
- Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins. Molecular Biology of the Cell, 34(8), ar81.
- Robot-assisted Radical Cystectomy Versus Open Radical Cystectomy: A Systematic Review and Meta-analysis of Perioperative, Oncological, and Quality of Life Outcomes Using Randomized Controlled Trials. European Urology, 84(4), 393-405.
- The Mechanical Influence of Densification on Initial Epithelial Architecture.
- An arginase 2 promoter transgenic illuminates immune cell polarisation in zebrafish. Disease Models & Mechanisms, 16(6).
- DLL4 promotes partial endothelial-to-mesenchymal transition at atherosclerosis-prone regions of arteries. Vascular Pharmacology, 150, 107178-107178.
- Nutritional Supplementation for the Prevention of Muscle Atrophy in Older People. Nutrition Today, 58(3), 105-118.
- Patient perspectives on ADPKD. Advances in Kidney Disease and Health, 30(3), 294-302.
- Lifestyle Factors in Patients with Bladder Cancer: A Contemporary Picture of Tobacco Smoking, Electronic Cigarette Use, Body Mass Index, and Levels of Physical Activity. European Urology Focus.
- A p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo. Aging Cell.
- Oxidative DNA damage and repair at non-coding regulatory regions. Trends in Cell Biology.
- Abstract 3542: A stem cell model dissects detrimental effects of neuroblastoma-linked chromosomal aberrations on cell differentiation during neural crest development. Cancer Research, 83(7_Supplement), 3542-3542.
- The importance of reaction norms in dietary restriction and ageing research. Ageing Research Reviews, 87, 101926-101926.
- PD36-12 MEASURING OBJECTIVE RECOVERY OF ACTIVITY LEVELS USING WEARABLE DEVICES FOLLOWING OPEN VS INTRACORPOREAL ROBOTIC CYSTECTOMY: SECONDARY OUTCOMES ANALYSIS OF THE IROC RANDOMIZED TRIAL. Journal of Urology, 209(Supplement 4).
- An Association Study of Germline Variants in Bladder Cancer-Related Genes with the Prognosis of Non-Muscle Invasive Bladder Cancer. Bladder Cancer, 9(1), 59-71.
- Therapeutic targeting of vascular malformation in a zebrafish model of hereditary haemorrhagic telangiectasia. Disease Models & Mechanisms, 16(4).
- Patient-Reported Outcomes 12 Years after Localized Prostate Cancer Treatment. NEJM Evidence, 2(4).
- Hypertension in young adults with autosomal dominant polycystic kidney disease: a case for early screening?. Clinical Kidney Journal.
- The association of urinary epidermal growth factors with ADPKD disease severity and progression. Nephrology Dialysis Transplantation.
- Critical appraisal of decision models used for the economic evaluation of bladder cancer screening and diagnosis: a systematic review. PharmacoEconomics, 41(6), 633-650. View this article in WRRO
- WCN23-0391 THE CLINICAL CHARACTERISTICS AND KIDNEY OUTCOME IN CHINESE PATIENTS WITH TYPICAL AND ATYPICAL POLYCYSTIC KIDNEY DISEASE. Kidney International Reports, 8(3), S244-S245.
- Modelling cancer metastasis in Drosophila melanogaster. Cells, 12(5).
- Protocol for the TRANSLATE prospective, multicentre, randomised clinical trial of prostate biopsy technique. BJU International.
- Phase 2 study of the efficacy and safety of erdafitinib in patients (pts) with bacillus Calmette-Guérin (BCG)-unresponsive, high-risk non–muscle-invasive bladder cancer (HR-NMIBC) with FGFR3/2 alterations (alt) in THOR-2: Cohort 2 interim analysis results.. Journal of Clinical Oncology, 41(6_suppl), 503-503.
- DASL-HiCaP: A randomized, phase 3, double-blind trial of darolutamide with androgen-deprivation therapy and definitive or salvage radiation for localized very high-risk prostate cancer.. Journal of Clinical Oncology, 41(6_suppl), TPS396-TPS396.
- Study EV-104: Phase 1 study of intravesical enfortumab vedotin for treatment of patients with non-muscle invasive bladder cancer (NMIBC)—Trial in progress.. Journal of Clinical Oncology, 41(6_suppl), TPS582-TPS582.
- Factors associated with response to growth hormone in pediatric growth disorders: results of a 5-year registry analysis. Journal of the Endocrine Society, 7(5).
- EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy. Arteriosclerosis, Thrombosis, and Vascular Biology, 43(4), 547-561.
- OVERTURE: A worldwide, prospective, observational study of disease characteristics in patients with ADPKD. Kidney International Reports, 8(5), 989-1001.
- Enhancer trap lines with GFP driven by smad6b and frizzled1 regulatory sequences for the study of epithelial morphogenesis in the developing zebrafish inner ear. Journal of Anatomy. View this article in WRRO
- Elicitation of health state utilities associated with progression from Bacillus Calmette-Guerin (BCG) unresponsive Non-muscle Invasive Bladder Cancer (NMIBC). PharmacoEconomics - Open.
- SpaRCe: Improved Learning of Reservoir Computing Systems Through Sparse Representations.. IEEE Trans Neural Netw Learn Syst, 34(2), 824-838.
- Comparing objective recovery of activity levels using wearable devices in open vs. intracorporeal robotic cystectomy: An analysis of the secondary outcomes of the iROC randomized trial. European Urology, 83, S219-S220.
- A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus. eLife, 12. View this article in WRRO
- Patient Preferences for Treatment of Bacillus Calmette-Guérin–unresponsive Non–muscle-invasive Bladder Cancer: A Cross-country Choice Experiment. European Urology Open Science, 49, 92-99.
- Association Between Antibiotic Prophylaxis Before Cystectomy or Stent Removal and Infection Complications: A Systematic Review. European Urology Focus, 9(4), 631-636.
- Clonal population expansion of Staphylococcus aureus occurs due to escape from a finite number of intraphagocyte niches. Scientific Reports, 13(1), 1-11.
- The current use of the EORTC QLQ-NMIBC24 and QLQ-BLM30 questionnaires for the assessment of health-related quality of life in bladder cancer patients: a systematic review. Quality of Life Research, 32(8), 2127-2135.
- Accuracy of in vivo microCT imaging in assessing the microstructural properties of the mouse tibia subchondral bone. Frontiers in Endocrinology, 13.
- High glucose increases DNA damage and elevates the expression of multiple DDR genes. Genes, 14(1).
- 3α,7-Dihydroxy-14(13→12)abeo-5β,12α(H),13β(H)-cholan-24-oic Acids Display Neuroprotective Properties in Common Forms of Parkinson’s Disease. Biomolecules, 13(1).
- Increased fracture risk in Parkinson's disease – An exploration of mechanisms and consequences for fracture prediction with FRAX. Bone, 168, 116651-116651.
- Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis. Science Translational Medicine, 14(676).
- Venglustat, a novel glucosylceramide synthase inhibitor, in patients at risk of rapidly progressing ADPKD: primary results of a double-blind, placebo-controlled, phase 2/3 randomized clinical trial. American Journal of Kidney Diseases.
- Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation. Frontiers in Cellular Neuroscience, 16.
- Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation. Scientific Reports, 14(1).
- Heritability and age-dependent changes in genetic variation of telomere length in a wild house sparrow population. Evolution Letters.
- Parkinson’s families project: a UK-wide study of early onset and familial Parkinson’s disease. npj Parkinson's Disease, 10(1).
- Understanding the long‐term impact of the COVID‐19 pandemic on non‐muscle‐invasive bladder cancer outcomes: 12‐Month follow‐up data from the international, prospective COVIDSurg Cancer study. BJUI Compass.
- Peroxisomal import stress activates integrated stress response and inhibits ribosome biogenesis. PNAS Nexus.
- Real‐word outcomes for high‐risk non‐muscle‐invasive bladder cancer: screened patients for the
BRAVO trial. BJU International. - Control of tuberal hypothalamic development and its implications in metabolic disorders. Nature Reviews Endocrinology.
- Analysis of real-world data on the care provision of children with congenital adrenal hyperplasia (CAH) in the united kingdom. Endocrine Abstracts.
- Adipokine analysis in relation to the glucocorticoid dose and androgen concentrations in the paediatric CAH-UK cohort. Endocrine Abstracts.
- Glucocorticoid replacement therapy in congenital adrenal hyperplasia and its associations with growth outcomes - real world data analysis from an international cohort of 1500 patients. Endocrine Abstracts.
- Perioperative Durvalumab with Neoadjuvant Chemotherapy in Operable Bladder Cancer. New England Journal of Medicine.
- Second generation lethality in RNAseH2a knockout zebrafish. Nucleic Acids Research.
- Mating proximity blinds threat perception. Nature.
- Temporal Trends In Acute Adrenal Insufficiency Events In Children With Congenital Adrenal Hyperplasia During 2019-2022. Journal of the Endocrine Society.
- National audit of patient reported experience of radical cystectomy for bladder cancer pathways. BJUI Compass.
- Controversy in mechanotransduction: the role of endothelial cell-cell junctions in fluid shear stress sensing. Journal of Cell Science.
- Genomic landscape of hepatocellular carcinoma in Egyptian patients by whole exome sequencing. BMC Medical Genomics, 17(1).
- Image directed redesign of bladder cancer treatment pathways: the BladderPath RCT. Health Technology Assessment, 1-65.
- Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight. Nature Reviews Cardiology.
- Exploring the role of E. faecalis enterococcal polysaccharide antigen (
EPA ) and lipoproteins in evasion of phagocytosis. Molecular Microbiology. - Hypoxia‐Responsive Prodrug of ATR Inhibitor, AZD6738, Selectively Eradicates Treatment‐Resistant Cancer Cells. Advanced Science.
- Making cups and rings: the ‘stalled-wave’ model for macropinocytosis. Biochemical Society Transactions.
- Blood Transfusion, Radical Cystectomy, and Cancer Recurrence: A New Look at an Old Story. Comment on Ladner et al. Perioperative Blood Transfusion Is Associated with Worse Survival in Patients Undergoing Radical Cystectomy after Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer. Soc. Int. Urol. J. 2024, 5, 202–213. Société Internationale d’Urologie Journal, 5(3), 244-246.
- Tribbles1 is host protective during in vivo mycobacterial infection. eLife, 13.
- Human enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissue. Gut, gutjnl-2023.
- A comparative study of different antiviral treatment protocols in HCV related cryoglobulinemic vasculitis. Scientific Reports, 14(1), 11840.
- Polygenic Risk Scores Validated in Patient‐Derived Cells Stratify for Mitochondrial Subtypes of Parkinson's Disease. Annals of Neurology.
- A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations. Nature Communications, 15(1).
- Experimental evolution of Staphylococcus aureus in macrophages: dissection of a conditional adaptive trait promoting intracellular survival. mBio.
- Clinical Characteristics and Kidney Outcomes in Chinese Patients with Autosomal Dominant Polycystic Kidney Disease. Kidney360.
- Service evaluation suggests variation in clinical care provision in adults with congenital adrenal hyperplasia in the UK and Ireland. Clinical Endocrinology.
- National service evaluation of the quality of care for children and young people with congenital adrenal hyperplasia in the United Kingdom: survey responses from patients and clinicians. Hormone Research in Paediatrics.
- ASXL3‐related disorder: Molecular phenotyping and comprehensive review providing insights into disease mechanism. Clinical Genetics.
- HYDROchlorothiazide versus placebo to PROTECT polycystic kidney disease patients and improve their quality of life: study protocol and rationale for the HYDRO-PROTECT randomized controlled trial. Trials, 25(1).
- Improved Disease-Free Survival With Adjuvant Chemotherapy After Nephroureterectomy for Upper Tract Urothelial Cancer: Final Results of the POUT Trial. Journal of Clinical Oncology.
- Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Nature Communications, 15(1).
- Correction to “A
p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo”. Aging Cell. - Notch signalling influences cell fate decisions and HOX gene induction in axial progenitors. Development.
- Macrophage subpopulation identity in Drosophila is modulated by apoptotic cell clearance and related signalling pathways. Frontiers in Immunology, 14.
- Multimodal assessment of mitochondrial function in Parkinson's disease. Brain.
- Clinical application of bladder MRI and the Vesical Imaging-Reporting And Data System. Nature Reviews Urology.
- Quality of life after a diagnosis of Bladder Cancer: Longitudinal survey over the first year. BJU International.
- Emerging strategies to target virulence in Pseudomonas aeruginosa respiratory infections. Critical Reviews in Microbiology, 1-16.
- London calling: The 5th
UK Cellular Microbiology Network Meeting. Molecular Microbiology. - Functional Follow-Up After Cystectomy and Urinary Diversion: A Narrative Review. JU Open Plus, 1(11).
- An international study of the association between local health care resources and acute adrenal insufficiency events in children with congenital adrenal hyperplasia. Endocrine Abstracts.
- Association of newborn screening of congenital adrenal hyperplasia with outcomes in the first 90 days of life: a multi-centre I-CAH registry analysis of contemporary practice. Endocrine Abstracts.
- Service evaluation suggests variation in clinical care provision in adults with congenital adrenal hyperplasia in the UK and Ireland. Endocrine Abstracts.
- CaHASE2: Current clinical practice and future research. Endocrine Abstracts.
- Accurate staging of chick embryonic tissues via deep learning of salient features. Development.
- Oncological Surveillance After Radical Cystectomy: a Narrative Review of the Enhanced Recovery After Surgery Cystectomy Committee. JU Open Plus, 1(10).
- Fgf signalling triggers an intrinsic mesodermal timer that determines the duration of limb patterning. Nature Communications, 14(1).
- The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function. Nature Communications, 14(1).
- Long‐term health consequences of congenital adrenal hyperplasia. Clinical Endocrinology.
- Blood Pressure in Children with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. Hormone Research in Paediatrics, 1-11.
- Investigating Metabolic and Molecular Ecological Evolution of Opportunistic Pulmonary Fungal Coinfections: Protocol for a Laboratory-Based Cross-Sectional Study. JMIR Research Protocols, 12, e48014-e48014.
- Journey of a thousand miles: from ‘Manpo-Kei’ to the first steps-based physical activity recommendations. British Journal of Sports Medicine.
- Device-based measurement of physical activity in cardiovascular healthcare: possibilities and challenges. British Journal of Sports Medicine.
- Potential impact of wearables on physical activity guidelines and interventions: opportunities and challenges. British Journal of Sports Medicine.
- Glucocorticoid Receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain. Disease Models & Mechanisms.
- Identification of renal cyst cells of type I Nephronophthisis by single-nucleus RNA sequencing. Frontiers in Cell and Developmental Biology, 11, 1192935.
- Quality of Life in Children and Young People With Congenital Adrenal Hyperplasia—UK Nationwide Multicenter Assessment. The Journal of Clinical Endocrinology & Metabolism.
- Using the Non-Adoption, Abandonment, Scale-Up, Spread, and Sustainability (NASSS) Framework to Identify Barriers and Facilitators for the Implementation of Digital Twins in Cardiovascular Medicine. Sensors, 23(14), 6333-6333.
- Diagnosis, treatment, and survival from kidney cancer: real‐world
NHS England data between 2013‐2019. BJU International. - PLA2G12A as a Novel Biomarker for Colorectal Cancer with Prognostic Relevance. International Journal of Molecular Sciences, 24(13), 10889-10889.
- Exercise Interventions for the Management of Sarcopenia: Possibilities and Challenges. Physical & Occupational Therapy In Geriatrics, 1-24.
- Barriers and facilitators to the implementation of guidelines in rare diseases: a systematic review. Orphanet Journal of Rare Diseases, 18(1).
- A Double‐Blind, Randomized, Placebo‐Controlled Trial of Ursodeoxycholic Acid (
UDCA) in Parkinson's Disease. Movement Disorders. - A median fin derived from the lateral plate mesoderm and the origin of paired fins. Nature.
- Current policies on early detection of prostate cancer create overdiagnosis and inequity with minimal benefit. BMJ, e071082-e071082.
- Asymmetric Dimethylation of Ribosomal S6 Kinase 2 Regulates Its Cellular Localisation and Pro-Survival Function. International Journal of Molecular Sciences, 24(10), 8806-8806.
- Early‐life telomere length predicts life‐history strategy and reproductive senescence in a threatened wild songbird. Molecular Ecology. View this article in WRRO
- Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet. View this article in WRRO
- Emergency and perioperative management of adrenal insufficiency in children and young people: British Society for Paediatric Endocrinology and Diabetes consensus guidance. Archives of Disease in Childhood.
- Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency. Disease Models & Mechanisms.
- Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer. New England Journal of Medicine.
- Towards a multi-arm multi-stage platform trial of disease modifying approaches in Parkinson’s disease. Brain.
- Activated PI3K Delta Syndrome-1 mutations cause neutrophilia in zebrafish larvae. Disease Models & Mechanisms.
- Charting a Course for Smartphones and Wearables to Transform Population Health Research. Journal of Medical Internet Research, 25, e42449-e42449.
- Diagnosis, treatment and survival from bladder, upper urinary tract and urethral cancers: Real world findings from
NHS England between 2013 and 2019. BJU International. - Properties of non-coding mutation hotspots as urinary biomarkers for bladder cancer detection. Scientific Reports, 13(1).
- Katnip is required to maintain microtubule function and lysosomal delivery to autophagosomes and phagosomes. Molecular Biology of the Cell.
Chapters
- Adult zebrafish as a vertebrate model of ageing, Zebrafish (pp. 159-181). CABI
- Light-Sheet Microscopy Enables Three-Dimensional Fluorescence Imaging and Live Imaging of Satellite Cells on Skeletal Muscle Fibers, Methods in Molecular Biology Springer US
- Disorders of the Adrenal Gland in Children and Adolescents, Endocrinology (pp. 115-184). Springer International Publishing
- Organizing activities of axial mesoderm, Current Topics in Developmental Biology (pp. 83-123). Elsevier
- Cardiac construction—Recent advances in morphological and transcriptional modeling of early heart development, Current Topics in Developmental Biology Elsevier
- Zebrafish Larvae as an Experimental Model of Cryptococcal Meningitis, Methods in Molecular Biology (pp. 47-69). Springer US
- Disorders of the Adrenal Gland in Children and Adolescents, Endocrinology (pp. 1-70). Springer International Publishing
- Muscle-invasive bladder cancer In Pang KH, Catto JWF, Myat A & Haldar S (Ed.), Challenging Cases in Urological Surgery (pp. C12-C12.P147). Oxford University PressOxford
Conference proceedings papers
- I026 Screening for mitochondrial therapeutics in Huntington’s disease using patient-derived cells. I: Experimental therapeutics – preclinical (pp A152.1-A152)
- A Polycystin-1-Bicaudal C1 complex regulates focal adhesion function through integrin beta-1, F-actin organisation and local translation in HKE cells. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 39 (pp I219-I219)
- Trends in glucocorticoid prescribing practice in CAH over the last 6 years (2017-2023). SEXUAL DEVELOPMENT, Vol. 17 (pp 42-45)
- Clinical spectrum and prognosis of the atypical polycystic kidney disease caused by monoallelic loss-of-function IFT140 variants. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 39 (pp I213-I214)
- Fifteen years of exome sequencing involving >800 cases of DSD. What have we learned?. SEXUAL DEVELOPMENT, Vol. 17 (pp 73-75)
- Development of the I-HH registry to develop best practice management for hypogonadotropic hypogonadism. SEXUAL DEVELOPMENT, Vol. 17 (pp 95-96)
- Evidence Driven Care in CAH. SEXUAL DEVELOPMENT, Vol. 17 (pp 12-12)
- Use of gene expression patterns to identify unique molecular subtypes in muscle invasive bladder cancer: GUSTO. JOURNAL OF CLINICAL ONCOLOGY, Vol. 42(16)
- REMOTE DIGITAL SURVEILLANCE AND MACHINE LEARNING MODELLING TO PREDICT SURVIVAL FOLLOWING RADICAL CYSTECTOMY FOR BLADDER CANCER-A SECONDARY OUTCOME ANALYSIS OF THE IROC TRIAL. JOURNAL OF UROLOGY, Vol. 211(5) (pp E793-E794)
- BS1 Polycystin-1 suppresses apoptotic signalling in endothelial cells and protects from atherosclerosis. Basic Science
- BS80 Macrophage ATP8B1 is upregulated with age. Basic Science
- BS45 Transcription factors MYC and USF1 drive chronic macrophage dysfunction in ageing. Basic Science
- BS85 A clinician-led understanding of the implementation of digital technologies within heart disease diagnosis: a qualitative investigation. Basic Science
- Use of Aromatase inhibitors to improve height outcomes in children with Congenital Adrenal Hyperplasia due to 21 hydroxylase deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 142-143)
- Management of congenital adrenal hyperplasia in the first 90 days of life: a multi-centre I-CAH analysis of contemporary practice. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 29-30)
- Acute Adrenal Insufficiency Related Adverse Events In Children With Congenital Adrenal Hyperplasia (CAH): Changes During The Period 2019-2022 In I-CAH. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 136-137)
- MEASURING OBJECTIVE RECOVERY OF ACTIVITY LEVELS USING WEARABLE DEVICES FOLLOWING OPEN VS INTRACORPOREAL ROBOTIC CYSTECTOMY: SECONDARY OUTCOMES ANALYSIS OF THE IROC RANDOMIZED TRIAL. JOURNAL OF UROLOGY, Vol. 209 (pp E985-E985)
- National service evaluation project analysing the quality of care for children and young people with congenital adrenal hyperplasia in the United Kingdom: Data from patients and clinicians. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 418-419)
- The Role of R-loops in the Development of Cisplatin Resistance in Oropharyngeal Squamous Cell Carcinoma (OPSCC). JOURNAL OF PATHOLOGY, Vol. 261(SUPPL1) (pp S62-S62)
- Metabolic effects of cortisol insufficiency are sex-depended in a zebrafish model of 21-hydroxylase deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 135-135)
- The pathophysiologic response of central nervous system due to differently impaired steroidogenesis. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 27-28)
- Pathology Against the Clock: Verification of Gene Expression Subtyping for the GUSTO Clinical Trial. JOURNAL OF PATHOLOGY, Vol. 261(SUPPL1) (pp S49-S49)
- Enhancing neuronal cell network organization and activity using NOA81 and PDMS nanogrooves. TISSUE ENGINEERING PART A, Vol. 29(13-14)
Preprints
- Donor embryonic stem cells impede host epiblast specification in 8-cell stage chimeras by crowding and FGF4 signalling, Cold Spring Harbor Laboratory.
- Paired and solitary ionocytes in the zebrafish olfactory epithelium, Cold Spring Harbor Laboratory.
- A role for class I PAKs in the regulation of the excitability of the actin cytoskeleton., Cold Spring Harbor Laboratory.
- The optimal clutch size revisited: separating individual quality from the parental survival costs of reproduction, eLife Sciences Publications, Ltd.
- Expansion ofDrosophilahaemocytes using a conditionalGeneSwitchdriver affects larval haemocyte function, but does not modulate adult lifespan or survival from infection, Cold Spring Harbor Laboratory.
- BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD, Cold Spring Harbor Laboratory.
- Separating the genetic and environmental drivers of body temperature during the development of endothermy in an altricial bird, Cold Spring Harbor Laboratory.
- Type I interferon responses contribute to immune protection against mycobacterial infection, Cold Spring Harbor Laboratory.
- Exploring the role ofE. faecalisEnterococcal Polysaccharide Antigen (EPA) and lipoproteins in evasion of phagocytosis, Cold Spring Harbor Laboratory.
- The optimal clutch size revisited: separating individual quality from the parental survival costs of reproduction, eLife Sciences Publications, Ltd.
- The optimal clutch size revisited: separating individual quality from the parental survival costs of reproduction, eLife Sciences Publications, Ltd.
- Exploring the role of E. faecalis Enterococcal Polysaccharide Antigen (EPA) and lipoproteins in evasion of phagocytosis, Authorea, Inc..
- Biallelic mutations in SUPV3L1 cause an inherited neurodevelopmental disorder with variable leukodystrophy due to aberrant mitochondrial double stranded RNA processing, Research Square Platform LLC.
- Mating proximity blinds threat perception., Cold Spring Harbor Laboratory.
- Curcumin-mediated NRF2 induction limits inflammatory damage in preclinical models of cystic fibrosis, Cold Spring Harbor Laboratory.
- Pulses of Class I PI3kinase activity identify the release and recapture of prey from neutrophil phagosomes, Cold Spring Harbor Laboratory.
- Senataxin modulates resistance to cisplatin through an R-loop mediated mechanism in HPV-associated Head and Neck Squamous Cell Carcinoma, Cold Spring Harbor Laboratory.
- morphoHeart: a novel quantitative tool to perform integrated 3D morphometric analyses of heart and ECM morphology during embryonic development, Cold Spring Harbor Laboratory.
- Rare disease gene association discovery from burden analysis of the 100,000 Genomes Project data, Cold Spring Harbor Laboratory.
- EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake, Cold Spring Harbor Laboratory.
- Macrophage transplantation rescues RNASET2-deficient leukodystrophy by replacing deficient microglia in a zebrafish model, Cold Spring Harbor Laboratory.
- Human enteric nervous system progenitor transplantation restores functional responses in Hirschsprung Disease patient-derived tissue, Cold Spring Harbor Laboratory.
- Oncogenic RAS drives rapid onset cellular plasticity and elicits a tumour-promoting neutrophil response at the inception of preneoplastic development, Cold Spring Harbor Laboratory.
- Candida albicanssuppression of neutrophil reactive nitrogen species is rescued by host Hif-1αin vivo, Cold Spring Harbor Laboratory.
- Dietary restriction extends lifespan across different temperatures in the fly, Cold Spring Harbor Laboratory.
- Stakeholder perspectives on contributors to delayed and inaccurate diagnosis of cardiovascular disease: a UK-based qualitative study, Cold Spring Harbor Laboratory.
- Ageing-related defects in macrophage function are driven byMYCandUSF1transcriptional programmes, Cold Spring Harbor Laboratory.
- Macrophage subpopulation identity inDrosophilais modulated by apoptotic cell clearance and related signalling pathways, Cold Spring Harbor Laboratory.
- Tribbles1 and Cop1 cooperate to protect the host during in vivo mycobacterial infection, Cold Spring Harbor Laboratory.
- The optimal clutch size revisited: separating individual quality from the costs of reproduction, eLife Sciences Publications, Ltd.
- Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle, Cold Spring Harbor Laboratory.
- Candida albicanscells lacking AP-2 have defective hyphae and are avirulent despite increased host uptake and intracellular proliferation in macrophages, Cold Spring Harbor Laboratory.
- Determining the importance of the stringent response for methicillin-resistantStaphylococcus aureusvirulence using a zebrafish model of infection, Cold Spring Harbor Laboratory.
- WITHDRAWN: Biallelic mutation ofSUPV3L1causes an inherited leukodystrophy-associated neurodevelopmental disorder due to aberrant mitochondrial double stranded RNA processing, Cold Spring Harbor Laboratory.
- Notch signalling influences cell fate decisions and HOX gene induction in axial progenitors, Cold Spring Harbor Laboratory.
- DNA repair and anti-cancer mechanisms in the long-lived bowhead whale, Cold Spring Harbor Laboratory.
- Stochasticity explains non-genetic inheritance of lifespan and apparent trade-offs between reproduction and ageing, Cold Spring Harbor Laboratory.
- Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins, Cold Spring Harbor Laboratory.
- A Stakeholder-Led Understanding of the Implementation of Digital Technologies Within Heart Disease Diagnosis: A Qualitative Study Protocol, Cold Spring Harbor Laboratory.
- Analysis of the Distal Urinary Tract in Larval and Adult Zebrafish Reveals Unrecognized Homology to the Human System, Cold Spring Harbor Laboratory.
- The importance of reaction norms in dietary restriction and ageing research, Cold Spring Harbor Laboratory.