Professor Richard Clayton

PhD

Department of Computer Science

Professor of Computational Physiology

Deputy Head of Department

Member of the Complex Systems Modelling research group

Richard Clayton profile photo
r.h.clayton@sheffield.ac.uk
+44 114 222 1845

Full contact details

Professor Richard Clayton
Department of Computer Science
Regent Court (DCS)
211 Portobello
Sheffield
S1 4DP
Profile

Richard Clayton has a first degree in Applied Physics and Electronics from the University of Durham, and a PhD in Medical Physics from the University in Newcastle upon Tyne. After completing his PhD, Richard continued research at the Freeman Hospital in Newcastle upon Tyne, funded by British Heart Foundation junior and intermediate fellowships.

The main focus of these projects was on understanding the electrical mechanisms that underlie life-threatening disorders of heart rhythm, based on the analysis of data recorded from patients. A move to the University of Leeds, funded by a British Heart Foundation Lectureship enabled Richard to work on developing mechanistic models of cardiac electrophysiology in the human heart.

Richard Clayton was appointed Senior Lecturer in the Department of Computer Science in Sheffield in 2003, promoted to Reader in Computer Science in 2008, and Professor of Computational Physiology in 2014. He is a core member of the INSIGNEO institute for in-silico Medicine, and serves on the INSIGNEO board.

Research interests

Richard Clayton’s research interests are focussed on developing physics-based and mechanistic computational models and simulations as tools to examine the structure and function of human tissues and organs. This theme aligns with the recently established INSIGNEO institute for in-silico medicine in Sheffield.

Richard Clayton has had a long running interest in developing computational models to investigate the mechanisms that initiate and sustain dangerous disorders of heart rhythm in the human heart, and this has been funded through grants and fellowships from the British Heart Foundation.

Recent funding from EPSRC will develop techniques to handle the quantification and propagation of uncertainty within multiscale models of physiology.

Publications

Journal articles

Chapters

  • Clayton RH & Hose DR (2017) Excitation-Contraction in the Heart, Cardiovascular Biomechanics (pp. 107-126). Springer International Publishing RIS download Bibtex download
  • Clayton RH (2013) Partial Differential Equations, Wave Equation, Encyclopedia of Systems Biology (pp. 1638-1640). Springer New York RIS download Bibtex download
  • Clayton R & Nash M (2008) Modelling the mammalian heart. In Grierson C & Hetherington A (Ed.), Practical systems biology (pp. 175-193). Taylor and Francis Group RIS download Bibtex download

Conference proceedings papers

  • Bernjak A, Heller SR & Clayton RH (2019) Can computational modelling explain the dead in bed syndrome?. DIABETOLOGIA, Vol. 62 (pp S46-S46) RIS download Bibtex download
  • Bernjak A, Chow E, Lee J, Iqbal A, Lubina-Solomon A, Walkinshaw E, Macdonald IA, Heller SR, Clayton RH & Sheridan PJ (2017) Pharmacological autonomic blockade during experimental hypoglycaemia exacerbates cardiac repolarisation abnormalities. DIABETOLOGIA, Vol. 60 (pp S74-S74) RIS download Bibtex download
  • Bernjak A, Chow E, Lee J, Iqbal A, Lubina-Solomon A, Walkinshaw E, Heller SR, Clayton RH & Sheridan PJ (2017) Pharmacological Autonomic Blockade Exacerbates Cardiac Repolarization Abnormalities during Experimental Hypoglycemia. DIABETES, Vol. 66 (pp A95-A95) RIS download Bibtex download
  • Chang ETY, Coveney S & Clayton RH (2017) Variance Based Sensitivity Analysis of IKrIKr in a Model of the Human Atrial Action Potential Using Gaussian Process Emulators. Functional Imaging and Modelling of the Heart 2017, Proceedings, Vol. 10263 LNCS (pp 249-259) View this article in WRRO RIS download Bibtex download
  • Chang ETY & Clayton RH (2015) Parameter sensitivity from single atrial cell to tissue: How much does it matter? A simulation and multivariate regression study. 2015 Computing in Cardiology Conference (CinC), 6 September 2015 - 9 September 2015. RIS download Bibtex download
  • Eatock J, Lin YT, Chang ETY, Galla T & Clayton RH (2015) Assessing measures of atrial fibrillation clustering via stochastic models of episode recurrence and disease progression. 2015 Computing in Cardiology Conference (CinC), 6 September 2015 - 9 September 2015. RIS download Bibtex download
  • Chang ETY & Clayton RH (2015) Uncertainty and sensitivity analysis of the Courtemanche-Ramirez-Nattel human atrial cell model using Gaussian Process emulators. 2015 Computing in Cardiology Conference (CinC), 6 September 2015 - 9 September 2015. RIS download Bibtex download
  • Chang ETY & Clayton RH (2014) Parameter sensitivity analysis of a human atrial cell model using multivariate regression. Computing in Cardiology, Vol. 41(January) (pp 521-524) RIS download Bibtex download
  • Malyala S & Clayton RH (2014) The effect of scar tissue on complexity of activation patterns in simulated human ventricular fibrillation. Computing in Cardiology, Vol. 41(January) (pp 1133-1136) RIS download Bibtex download
  • Abbasi M & Clayton R (2014) Formulation of ATP sensitive K+ current and action potential shape in models of human ventricular myocytes. Computing in Cardiology, Vol. 41(January) (pp 201-204) View this article in WRRO RIS download Bibtex download
  • Clayton RH & Malyala S (2013) Clustering of Re-entry Close to Scar Boundaries in Ventricular Tissue during Simulated Ventricular Fibrillation. Computing in Cardiology, Vol. 40 (pp 1131-1134). Barcelona RIS download Bibtex download
  • Clayton RH & Abbasi M (2013) A Comparison of Two Models of Human Ventricular Tissue: Simulated Ischaemia and Re-entry. Computing in Cardiology, Vol. 40 (pp 385-388). Barcelona RIS download Bibtex download
  • Clayton RH, Bradley CP, Nash MP, Mourad A, Hayward M, David P & Peter T (2009) Transient Type II Ventricular Fibrillation During Global Ischemia in the in-situ Human Heart. CIRCULATION, Vol. 120(18) (pp S630-S630) RIS download Bibtex download
  • Skolidis G, Clayton RH & Sanguinetti G (2008) Automatic Classification of Arrhythmic Beats Using Gaussian Processes. COMPUTERS IN CARDIOLOGY 2008, VOLS 1 AND 2 (pp 921-924) RIS download Bibtex download
  • Clayton RH, Bradley CP, Nash MP, Varma S, Mourad A, Paterson DJ, Hayward M & Taggart P (2008) Epicardial Mapping of Ventricular Fibrillation in the Human Heart during Ischaemia and Reperfusion. COMPUTERS IN CARDIOLOGY 2008, VOLS 1 AND 2 (pp 1029-1032) RIS download Bibtex download
  • Nash MP, Mourad A, Bradley CP, Paterson DJ, Clayton RH, Sutton PM, Hayward M & Taggart P (2007) Is human ventricular fibrillation different from experimental models?. CIRCULATION, Vol. 116(16) (pp 278-278) RIS download Bibtex download
  • Nash MP, Mourad A, Bradley CP, Paterson DJ, Clayton RH, Sutton PM, Hayward M & Taggart P (2007) Mobility of epicardial rotors during human ventricular fibrillation. CIRCULATION, Vol. 116(16) (pp 278-278) RIS download Bibtex download
  • Handley JW, Brodfie KW & Clayton RH (2006) Model based visualization of cardiac virtual tissue. Proceedings of the UK e-Science All Hands Meeting 2006 (pp 233-240) RIS download Bibtex download
  • Handley JW, Brodlie KW & Clayton RH (2006) Multi-variate visualization of cardiac virtual tissue. 19TH IEEE INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS, PROCEEDINGS (pp 665-670) RIS download Bibtex download
  • Mourad A, Nash MP, Clayton RH, Bradley CP, Paterson DJ, Sutton PM, Hayward M & Taggart P (2005) Early ventricular fibrillation in the human heart is sustained by a small number of re-entrant sources. CIRCULATION, Vol. 112(17) (pp U131-U131) RIS download Bibtex download
  • Kharche S, Zhang H, Clayton R & Holden AV (2004) Simulation of hypertrophy in rat left ventricular cells. Computers in Cardiology 2004, Vol 31, Vol. 31 (pp 513-516) RIS download Bibtex download
  • Clayton RH, Holden AV & Tong WC (2003) Can endogenous, noise-triggered early after-depolarizations initiate reentry in a modified Luo-Rudy ventricular virtual tissue?. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3835-3843) RIS download Bibtex download
  • Aslanidi OV, Clayton RH, Holden AV, Phillips HK & Ward RJ (2003) Vulnerability to reentry, and drift, stability and breakdown of spiral waves in a linear gradient of G(K) in a Luo-Rudy 1 virtual ventricular tissue. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3865-3871) RIS download Bibtex download
  • Chen M, Tucker JV, Clayton RH & Holden AV (2003) Constructive volume geometry applied to visualization of cardiac anatomy and electrophysiology. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3591-3604) RIS download Bibtex download
  • Clayton RH & Holden AV (2003) Dynamics and interaction of filaments during reentry and fibrillation in mammalian virtual ventricular tissue. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 13(12) (pp 3733-3745) RIS download Bibtex download
  • Chen M, Clayton RH, Holden AV & Tucker JV (2003) Visualising cardiac anatomy using constructive volume geometry. FUNCTIONAL IMAGING AND MODELING OF THE HEART, PROCEEDINGS, Vol. 2674 (pp 30-38) RIS download Bibtex download
  • Clayton RH & Holden AV (2002) Regional differences in action potential duration and stability of re-entry: insights from computational models. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 544 (pp 3P-3P) RIS download Bibtex download
  • Clayton RH, Parkinson K & Holden AV (2002) Re-entry in computational models of ischaemic myocardium. CHAOS SOLITONS & FRACTALS, Vol. 13(8) (pp 1671-1683) RIS download Bibtex download
  • Clayton RH & Holden AV (2002) Simulating the ECG of ventricular tachyarrhythmias. COMPUTERS IN CARDIOLOGY 2002, VOL 29, Vol. 29 (pp 321-324) RIS download Bibtex download
  • Clayton RH & Holden AV (2002) Filament dynamics in a computational model of re-entrant fibrillation in anatomically detailed canine ventricular anatomy. SECOND JOINT EMBS-BMES CONFERENCE 2002, VOLS 1-3, CONFERENCE PROCEEDINGS (pp 1417-1418) RIS download Bibtex download
  • Aslanidi OV, Biktashev VN, Clayton RH & Holden AV (2001) Differential meander of re-entrant spiral waves in mammalian virtual ventricular tissue. JOURNAL OF PHYSIOLOGY-LONDON, Vol. 536 (pp 71P-71P) RIS download Bibtex download
  • Small M, Yu DJ, Harrison RG, Clayton R, Eftestol T, Sunde K & Steen PA (2001) Temporal evolution of nonlinear dynamics in ventricular arrhythmia. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, Vol. 11(10) (pp 2531-2548) RIS download Bibtex download
  • Aslanidi OV, Clayton RH & Holden AV (2001) Re-entry in the Luo-Rudy ventricular tissue model with different models of Ca2+ dynamics. COMPUTERS IN CARDIOLOGY 2001, VOL 28, Vol. 28 (pp 233-236) RIS download Bibtex download
  • Clayton RH & Holden AV (2000) Computational simulation of multiple wavelet re-entry and fibrillatory conduction shows differences in the ECG characteristics of each mechanism. COMPUTERS IN CARDIOLOGY 2000, VOL 27, Vol. 27 (pp 343-346) RIS download Bibtex download
  • Clayton RH, Bailey A, Biktashev VN & Holden AV (1999) Re-entrant arrhythmias in simulations of the Long-QT syndrome. COMPUTERS IN CARDIOLOGY 1999, VOL 26 (pp 121-124) RIS download Bibtex download
  • Clayton RH, Yu DJ, Small M, Biktashev VN, Harrison RG & Holden AV (1999) Linear and nonlinear characteristics of ECG signals produced by simulations of ventricular tachyarrhythmias. COMPUTERS IN CARDIOLOGY 1999, VOL 26 (pp 479-482) RIS download Bibtex download
  • Whittam AM, Clayton RH, Lord SW, McComb JM & Murray A (1998) Computer modelling of heart rate and blood pressure. COMPUTERS IN CARDIOLOGY 1998, VOL 25, Vol. 25 (pp 149-152) RIS download Bibtex download
  • Clayton RH & Murray A (1997) Model based investigation of cardiovascular variability. IEE Colloquium (Digest)(9) RIS download Bibtex download
  • Clayton RH, Lord SW, McComb JM & Murray A (1997) Comparison of autoregressive and Fourier transform based techniques for estimating RR interval spectra. COMPUTERS IN CARDIOLOGY 1997, VOL 24, Vol. 24 (pp 379-382) RIS download Bibtex download
  • Clayton RH, Campbell RWF & Murray A (1997) Time-frequency analysis of human polymorphic ventricular tachycardia. COMPUTERS IN CARDIOLOGY 1997, VOL 24, Vol. 24 (pp 97-100) RIS download Bibtex download
  • Clayton RH, Campbell RWF & Murray A (1996) Relation between intracardiac and surface ECG signals during the onset of human ventricular fibrillation. COMPUTERS IN CARDIOLOGY 1996 (pp 341-344) RIS download Bibtex download
  • Clayton RH, Murray A & Campbell RWF (1995) Frequency analysis of ventricular fibrillation. IEE Colloquium (Digest)(43) RIS download Bibtex download
  • Clayton RH, Bowman AJ, Ford GA & Murray A (1995) Comparison of techniques for estimating baroreflex gain from heart rate and blood pressure spectra. COMPUTERS IN CARDIOLOGY 1995 (pp 301-304) RIS download Bibtex download
  • CLAYTON RH & MURRAY A (1993) ESTIMATION OF THE ECG SIGNAL SPECTRUM DURING VENTRICULAR-FIBRILLATION USING THE FAST FOURIER-TRANSFORM AND MAXIMUM-ENTROPY METHODS. COMPUTERS IN CARDIOLOGY 1993, PROCEEDINGS (pp 867-870) RIS download Bibtex download
  • Clayton RH, Murray A, Whittam AM & Campbell RWF (1992) Automatic recording of ventricular fibrillation. Computers in Cardiology (pp 685-688) RIS download Bibtex download
  • Clayton RH, Murray A & Campbell RWF (1991) Changes in the surface ECG frequency spectrum during the onset of ventricular fibrillation. Computers in Cardiology (pp 515-518) RIS download Bibtex download
  • Abbasi M & Clayton RH () Formulation of ATP sensitive K+ current and action potential shape in models of human ventricular myocytes. Computing in Cardiology, Vol. 41 (pp 201-201). Cambridge, 7 September 2014 - 10 September 2014. RIS download Bibtex download
  • Small M, Yu DJ, Clayton RH, Simonotto J & Harrison RG () Evolution of ventricular fibrillation revealed by first return plots. Computers in Cardiology 2000. Vol.27 (Cat. 00CH37163) RIS download Bibtex download
  • Clayton RH, Murray A & Campbell RWF () Frequency analysis of ventricular fibrillation in three surface ECG leads. Proceedings Computers in Cardiology RIS download Bibtex download
  • Corrado C, Williams S, Sim I, Coveney S, O'Neill M, Wilkinson R, Oakley J, Clayton R & Niederer S () An algorithm to sample an anatomy with uncertainty. 2018 Computing in Cardiology Conference (CinC), Vol. 45. Maastricht, The Netherlands, 23 September 2018 - 26 September 2018. View this article in WRRO RIS download Bibtex download

Working papers

  • Argungu M, Bayram S, Brook B, Chakrabarti B, Clayton RH, Daly DM, Dyson RJ, Holloway C, Manhas V, Naire S , Shearer T et al () Modelling afferent nerve responses to bladder filling. RIS download Bibtex download

Datasets

Grants

Current grants

Previous grants

Professional activities