Regeneration/Gene Therapy


Gene therapy is a medical approach that is used with the purpose of treating and preventing diseases. We use modified viruses to deliver genes into the auditory organ, which is a safe procedure already used in clinical trials for other diseases. Click here to find out more.


Fluorescent image showing the successful application of gene therapy approach in the sensory cells of the auditory organ (magenta).

Adeno-associated viral (AAV) vectors have proven to be an efficient strategy for transferring corrective genes into hair cells of the mammalian auditory organ. Here at Sheffield, we have established a Gene-Therapy Suite that allows us to deliver these corrective genes in vivo into several mouse models of human deafness and age-related hearing loss.


Hearing Research Group surgery suite

Ana surgery

PhD student preparing for surgery