BMedSci Prize - Cardiology Clinical Rotation

Dr Matthew Hughes, BMedSci student in the Department of Infection, Immunity & Cardiovascular Disease has been awarded a prize by the Medical School for someone who has excelled during a cardiology or cardiovascular disease clinical rotation.  His project was looking at carbon monoxide releasing molecules with his supervisors Professor Julian Gunn, Professor Sheila Francis & Dr Janet Chamberlain.

Dr Chamberlain commented " Matthew was a hardworking, diligent student who was a valued member of the CORMS team for the duration of his project.  His award is well-deserved, following his significant effort and the importance of the data which will lead to further investigations in the clinical setting shortly".

Project Overview:

Previous research has shown carbon monoxide (CO) could be cardioprotective at the correct dosages. The Department of Chemistry at the University of Sheffield had developed transition metal carbonyls as CO releasing molecules (CORMs) that offer a way of delivering controlled amounts of CO to tissues under physiological conditions. Using a porcine model, we occluded the Left Anterior Descending artery to invoke a myocardial infarction. We gave an infusion of CORMs to see if it could reduce the infarct size in this clinically relevant model, compared to a placebo infusion, and investigated potential mechanistic pathways. We found that the Ejection Fraction (EF) recovery from immediately post-MI to 7days post-MI was larger with CORM-A1 than in the controls [p=0.011] which has been shown to be associated with a better prognosis.

Personal Reflection:

Matthew Hughes"I was attracted to the BMedSci project as it stood out amongst the crowd of countless bench and data analysis projects by offering a chance to work with animals to produce a large assortment of different samples to handle using different scientific techniques. I got to experience large animal model experiments, lab procedures, medical imaging, data collection and to be involved with research into novel techniques for a very real problem.

Following the research I was awarded with a prize for a student “who has who has excelled during a cardiology or cardiovascular disease clinical rotation”, donated by Dr. Rob Attaran, a previous Sheffield student who is now an assistant professor of Cardiology at Yale in the USA. A big thank you needs to go to the rest of the CORMs team for supporting me through the year and hopefully the data collected can form a basis for others to take forward and expand into a promising new treatment".