University and Mironid collaborate on kidney disease drug discovery

The University of Sheffield has announced a new collaboration with a leader in cell signalling-directed drug development, Mironid Ltd, to identify and develop new molecules for the treatment of kidney disease.

The partnership will focus on advancing Mironid’s proprietary LoAc molecules towards clinical development with the aim of producing new therapies that can improve the health of patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).

ADPKD is a devastating, life-threatening and currently incurable genetic disorder in which kidney cysts progressively form throughout life. It affects around 12.5 million people worldwide, with around 50 per cent requiring treatment for kidney failure by the age of 60.

The cyst formation is driven by excessive generation of the cell signalling molecule cyclic adenosine monophosphate (AMP), and causes a wide range of health problems including abdominal pain, high blood pressure and urinary tract infections, eventually leading to kidney failure.

Albert Ong, Professor of Renal Medicine at the University of Sheffield's Department of Infection, Immunity and Cardiovascular Disease, said: “The University has developed leading edge, translational ADPKD models and expertise in biomarker development and clinical strategies for therapeutics for the disease. Prof Miles Houslay has spent over 30 years investigating the mechanisms of PDE4 biology, and we are very pleased to be working in partnership with his team at Mironid to progress the development of therapeutics for this debilitating disease.”

Dr Neil Wilkie, Director and Chief Operating Officer at Mironid, said: “Professor Ong is a world leading authority on ADPKD and his research at the University of Sheffield focuses on the molecular genetics, cell biology, pathogenesis and therapy for this disease. We are delighted to be working with his team to develop new therapeutics that have the potential to significantly improve the quality of life for patients suffering with ADPKD.”