Dr. Timothy Chico MBChB MRCP MDTim Chico

Reader in Cardiovascular Medicine and Honorary Consultant Cardiologist
Deputy Head of Department

Department:
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Medical School
Beech Hill Road
Sheffield
S10 2RX

Office:
Lab C13a
Firth Court
University of Sheffield
Western Bank
Sheffield
S10 2TF

Tel: +44 (0)114 222 2396
Fax: +44 (0)114 271 1863
Email: t.j.chico@sheffield.ac.uk

Personal Assistant:
Mrs Sarah Jackson
Tel: +44 (0) 114 215 9510
Email: s.l.jackson@sheffield.ac.uk

Biography:

I qualified in Medicine from Leeds Medical School in 1993. After General Medicine training I undertook an MD with Professor David Crossman at the University of Sheffield which sparked my interest in academic cardiology.

I then moved to the US to a postdoctoral fellow post at Genentech in San Francisco with Stuart Bunting, where I became fascinated by mechanisms of vascular development and how these might be induced therapeutically.

I returned to Sheffield to a Clinical Lectureship and was awarded a GSK Clinician Scientist Fellowship to develop the zebrafish as a novel model of arteriogenesis, capitalising on the zebrafish developmental biology programme established by Phil Ingham FRS who was one of my supervisors during this fellowship.

At the end of my clinical training in 2006 I became Senior Clinical Lecturer and Honorary Consultant Cardiologist, working within the MRC Centre for Developmental and Biomedical Genetics directed by Prof Ingham. I became Reader in Cardiovascular Medicine in 2014 and my research group is based in the Bateson Centre located in the old University Buildings of Firth Court, which is a fantastic place to work.

Research Interests:

My group study the influence of blood flow on vascular development and remodelling. We work in the Bateson Centre in Firth Court  and have identified a number of pathways that integrate sensation of blood flow and vascular development. We predominantly use zebrafish as a model, as these allow superb in vivo imaging of blood vessel development. Most recently, we have started to use lightsheet imaging that allows incredibly detailed cellular and subcellular imaging of living embryos during vascular development.

Teaching Interests:

My teaching and other lecture duties cover clinical cardiology, developmental biology, cardiovascular physiology and pathology and the use of non-mammalian models of cardiovascular disease. I also have an interest in the effect of exercise on cardiovascular physiology and health.

Professional Activities:

I am the Treasurer of the British Atherosclerosis Society and am on the British Heart Foundation Projects Grant Committee. I regularly review manuscripts and grants for a range of journals and funders.

Other Activities:

I am a mentor on the University of Sheffield Elite Sports Performance Scheme.

Current Projects:

  • Next generation sequencing of peripheral blood in patients with acute coronary syndromes.
  • Using the zebrafish to study macrophage/endothelial interactions.

Publications:

For key publication see below.  For a full list of publications click here

Journal articles