Dr. Timothy Chico MBChB MRCP MD
Reader in Cardiovascular Medicine and Honorary Consultant Cardiologist
Deputy Head of Department
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Beech Hill Road
University of Sheffield
Tel: +44 (0)114 222 2396
Fax: +44 (0)114 271 1863
I qualified in Medicine from Leeds Medical School in 1993. After General Medicine training I undertook an MD with Professor David Crossman at the University of Sheffield which sparked my interest in academic cardiology.
I then moved to the US to a postdoctoral fellow post at Genentech in San Francisco with Stuart Bunting, where I became fascinated by mechanisms of vascular development and how these might be induced therapeutically.
I returned to Sheffield to a Clinical Lectureship and was awarded a GSK Clinician Scientist Fellowship to develop the zebrafish as a novel model of arteriogenesis, capitalising on the zebrafish developmental biology programme established by Phil Ingham FRS who was one of my supervisors during this fellowship.
At the end of my clinical training in 2006 I became Senior Clinical Lecturer and Honorary Consultant Cardiologist, working within the MRC Centre for Developmental and Biomedical Genetics directed by Prof Ingham. I became Reader in Cardiovascular Medicine in 2014 and my research group is based in the Bateson Centre located in the old University Buildings of Firth Court, which is a fantastic place to work.
My group study the influence of blood flow on vascular development and remodelling. We work in the Bateson Centre in Firth Court and have identified a number of pathways that integrate sensation of blood flow and vascular development. We predominantly use zebrafish as a model, as these allow superb in vivo imaging of blood vessel development. Most recently, we have started to use lightsheet imaging that allows incredibly detailed cellular and subcellular imaging of living embryos during vascular development.
My teaching and other lecture duties cover clinical cardiology, developmental biology, cardiovascular physiology and pathology and the use of non-mammalian models of cardiovascular disease. I also have an interest in the effect of exercise on cardiovascular physiology and health.
I am the Treasurer of the British Atherosclerosis Society and am on the British Heart Foundation Projects Grant Committee. I regularly review manuscripts and grants for a range of journals and funders.
I am a mentor on the University of Sheffield Elite Sports Performance Scheme.
- Next generation sequencing of peripheral blood in patients with acute coronary syndromes.
- Using the zebrafish to study macrophage/endothelial interactions.
For key publication see below. For a full list of publications click here
- Ellam T, Hameed A, ul Haque R, Muthana M, Wilkie M, Francis SE & Chico TJA (2014) Vitamin D deficiency and exogenous vitamin D excess similarly increase diffuse atherosclerotic calcification in apolipoprotein E knockout mice.. PLoS One, 9(2), e88767. View this article in WRRO
- Ellam T, Fotheringham J, Wilkie ME, Francis SE & Chico TJA (2014) Bone mineral metabolism parameters and urinary albumin excretion in a representative US population sample.. PLoS One, 9(2), e88388. View this article in WRRO
- Ogryzko NV, Hoggett EE, Solaymani-Kohal S, Tazzyman S, Chico TJA, Renshaw SA & Wilson HL (2014) Zebrafish tissue injury causes upregulation of interleukin-1 and caspase-dependent amplification of the inflammatory response.. Dis Model Mech, 7(2), 259-264.
- Watson O, Novodvorsky P, Gray C, Rothman AMK, Lawrie A, Crossman DC, Haase A, McMahon K, Gering M, Van Eeden FJM & Chico TJA (2013) Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling.. Cardiovasc Res, 100(2), 252-261. View this article in WRRO
- Gray C, Bratt D, Lees J, daCosta M, Plant K, Watson OJ, Solaymani-Kohal S, Tazzyman S, Serbanovic-Canic J, Crossman DC, Keavney BD, Haase A, McMahon K, Gering M, Roehl H, Evans PC & Chico TJA (2013) Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development.. Arterioscler Thromb Vasc Biol, 33(6), 1257-1263.
- Bourke L, Kirkbride P, Hooper R, Rosario AJ, Chico TJA & Rosario DJ (2013) Endocrine therapy in prostate cancer: Time for reappraisal of risks, benefits and cost-effectiveness?. British Journal of Cancer, 108(1), 9-13. View this article in WRRO
- Quaife NM, Watson O & Chico TJA (2012) Zebrafish: an emerging model of vascular development and remodelling.. Curr Opin Pharmacol, 12(5), 608-614.
- Bourke L, Chico TJA, Albertsen PC, Hamdy FC & Rosario DJ (2012) Cardiovascular risk in androgen suppression: underappreciated, under-researched and unresolved.. Heart, 98(5), 345-348.
- Ellam TJ & Chico TJA (2012) Phosphate: the new cholesterol? The role of the phosphate axis in non-uremic vascular disease.. Atherosclerosis, 220(2), 310-318.
- Ellam T, Wilkie M, Chamberlain J, Crossman D, Eastell R, Francis S & Chico TJA (2011) Dietary phosphate modulates atherogenesis and insulin resistance in apolipoprotein E knockout mice--brief report.. Arterioscler Thromb Vasc Biol, 31(9), 1988-1990.
- Holden BJ, Bratt DG & Chico TJA (2011) Molecular control of vascular development in the zebrafish.. Birth Defects Res C Embryo Today, 93(2), 134-140.
- Gray C, Loynes CA, Whyte MKB, Crossman DC, Renshaw SA & Chico TJA (2011) Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish.. Thromb Haemost, 105(5), 811-819. View this article in WRRO
- Bugeon L, Taylor HB, Progatzky F, Lin MI, Ellis CD, Welsh N, Smith E, Vargesson N, Gray C, Renshaw SA, Chico TJA, Zon LI, Lamb J & Dallman MJ (2011) The NOTCH pathway contributes to cell fate decision in myelopoiesis. Haematologica, 96(12), 1753-1760.
- McLeish JA, Chico TJA, Taylor HB, Tucker C, Donaldson K & Brown SB (2010) Skin exposure to micro- and nano-particles can cause haemostasis in zebrafish larvae. Thrombosis and Haemostasis, 103(4), 797-807.
- Bourke L, Tew GA, Milo M, Crossman DC, Saxton JM & Chico TJA (2010) Study protocol: a randomised controlled trial investigating the effect of exercise training on peripheral blood gene expression in patients with stable angina.. BMC Public Health, 10, 620. View this article in WRRO