Professor Endre Kiss-Toth
Professor of Cell Signalling
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Beech Hill Road
Tel (Personal): +44 (0)114 215 9534
Fax: +44 (0)114 271 1863
HTS Facility: http://www.shef.ac.uk/medicine/research/corefacilities/robotics
I joined the University of Sheffield in 1988 as a postdoctoral researcher and was working on the development and implementation of a novel genetic screening approach. This is based on detecting the bioactivity of proteins, which are transiently overexpressed in mammalian cells. We used this approach to identify novel components of signalling pathways key in innate immunity. I have kept interest and association with this screening platform ever since and have recently been leading research identifying novel inflammatory regulators of macrophages.
In 2000, I was awarded a Career Development Fellowship by the Arthritis Research Campaign (now AR-UK) to characterise the mode of action of a novel family of proteins, tribbles.
In 2002, I joined the Cardiovascular Research Group as a Lecturer and developed my interest in tribbles further, by investigating their biological importance in vascular cells.
I became a Reader in 2013 and a Professor in 2017 with the same overall focus around regulation of innate immune signalling.
My group is interested in identifying novel regulators of inflammatory signal transduction, characterising their basic mechanism of action, as well as validating some of these novel genes as potential drug targets for therapeutic intervention in chronic inflammatory diseases.
Much of our recent work has been focussing on studying the biological importance of the tribbles family of pseudokinases in cell types that are relevant to the development of cardiovascular disease. We have established a global network of collaborators to pursue joint projects that aim to understand the importance of tribbles in cell biology, both in health and disease.
I lecture on technologies and approaches designed to identify novel genes with a particular function. My other main area of teaching involves bioinformatics for molecular biology and functional genomics applications.
- Discovery of novel regulators of inflammatory signalling.
- Defining the molecular mechanism of action for TMEM203, a novel inflammatory signalling regulator.
- Characterisation the biological importance of tribbles proteins in the development of lipid homeostasis, inflammation and metabolic syndromes (http://www.meddium.com/mas/leducqcvgene.mp)
- Regulation of tribbles expression in vascular cells: development of novel anti-atherosclerotic drug targeting strategies.
For key publications see below. For a full list of publications click here.
- Kiss-Toth E, Harlock E, Lath D, Quertermous T & Wilkinson JM (2013) A TNF Variant that Associates with Susceptibility to Musculoskeletal Disease Modulates Thyroid Hormone Receptor Binding to Control Promoter Activation. PLoS ONE, 8(9). View this article in WRRO
- Salazar M, Lorente M, García-Taboada E, Hernández-Tiedra S, Davila D, Francis SE, Guzmán M, Kiss-Toth E & Velasco G (2013) The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action.. Biochim Biophys Acta, 1831(10), 1573-1578.
- Dugast E, Kiss-Toth E, Docherty L, Danger R, Chesneau M, Pichard V, Judor J-P, Pettré S, Conchon S, Soulillou J-P , Brouard S et al (2013) Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells.. J Biol Chem, 288(14), 10051-10060.
- Wyllie DH, Søgaard KC, Holland K, Yaobo X, Bregu M, Hill AVS & Kiss-Toth E (2012) Identification of 34 novel proinflammatory proteins in a genome-wide macrophage functional screen.. PLoS One, 7(7), e42388. View this article in WRRO
- Angyal A & Kiss-Toth E (2012) The tribbles gene family and lipoprotein metabolism.. Curr Opin Lipidol, 23(2), 122-126.
- Kiss-Toth E (2011) Tribbles: 'puzzling' regulators of cell signalling.. Biochem Soc Trans, 39(2), 684-687.
- Zhang XA, Shephard F, Kim HB, Palmer IR, McHarg S, Fowler GJS, O'Neill LAJ, Kiss-Toth E & Qwarnstrom EE (2010) TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappa B (vol 285, pg 7222, 2010). J BIOL CHEM, 285(23), 18122-18122.
- Gilby DC, Sung HY, Winship PR, Goodeve AC, Reilly JT & Kiss-Toth E (2010) Tribbles-1 and -2 are tumour suppressors, down-regulated in human acute myeloid leukaemia.. Immunol Lett, 130(1-2), 115-124.
- Gordon A, Greenfield EM, Eastell R, Kiss-Toth E & Wilkinson JM (2010) Individual susceptibility to periprosthetic osteolysis is associated with altered patterns of innate immune gene expression in response to pro-inflammatory stimuli.. J Orthop Res, 28(9), 1127-1135.
- Eder K, Guan H, Sung HY, Ward J, Angyal A, Janas M, Sarmay G, Duda E, Turner M, Dower SK , Francis SE et al (2008) Tribbles-2 is a novel regulator of inflammatory activation of monocytes.. Int Immunol, 20(12), 1543-1550. View this article in WRRO
- Sung HY, Guan H, Czibula A, King AR, Eder K, Heath E, Suvarna SK, Dower SK, Wilson AG, Francis SE , Crossman DC et al (2007) Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways.. J Biol Chem, 282(25), 18379-18387. View this article in WRRO
- Hegedus Z, Czibula A & Kiss-Toth E (2007) Tribbles: a family of kinase-like proteins with potent signalling regulatory function.. Cell Signal, 19(2), 238-250.
- Hegedus Z, Czibula A & Kiss-Toth E (2006) Tribbles: novel regulators of cell function; evolutionary aspects.. Cell Mol Life Sci, 63(14), 1632-1641.
- Sung HY, Francis SE, Crossman DC & Kiss-Toth E (2006) Regulation of expression and signalling modulator function of mammalian tribbles is cell-type specific.. Immunol Lett, 104(1-2), 171-177.
- Kiss-Toth E, Wyllie DH, Holland K, Marsden L, Jozsa V, Oxley KM, Polgar T, Qwarnstrom EE & Dower SK (2006) Functional mapping and identification of novel regulators for the Toll/Interleukin-1 signalling network by transcription expression cloning.. Cell Signal, 18(2), 202-214.