Professor Endre Kiss-Toth

Professor of Cell Signalling

Department of Infection, Immunity & Cardiovascular DiseaseEndre Kiss-Toth
University of Sheffield
Medical School
Beech Hill Road
S10 2RX

Tel (Personal): +44 (0)114 215 9534
Fax: +44 (0)114 271 1863

HTS Facility:


I joined the University of Sheffield in 1988 as a postdoctoral researcher and was working on the development and implementation of a novel genetic screening approach. This is based on detecting the bioactivity of proteins, which are transiently overexpressed in mammalian cells. We used this approach to identify novel components of signalling pathways key in innate immunity. I have kept interest and association with this screening platform ever since and have recently been leading research identifying novel inflammatory regulators of macrophages.

In 2000, I was awarded a Career Development Fellowship by the Arthritis Research Campaign (now AR-UK) to characterise the mode of action of a novel family of proteins, tribbles.

In 2002, I joined the Cardiovascular Research Group as a Lecturer and developed my interest in tribbles further, by investigating their biological importance in vascular cells.

I became a Reader in 2013 and a Professor in 2017 with the same overall focus around regulation of innate immune signalling.

Research Interests:

My group is interested in identifying novel regulators of inflammatory signal transduction, characterising their basic mechanism of action, as well as validating some of these novel genes as potential drug targets for therapeutic intervention in chronic inflammatory diseases.

Much of our recent work has been focussing on studying the biological importance of the tribbles family of pseudokinases in cell types that are relevant to the development of cardiovascular disease. We have established a global network of collaborators to pursue joint projects that aim to understand the importance of tribbles in cell biology, both in health and disease.

Teaching Interests:

I lecture on technologies and approaches designed to identify novel genes with a particular function. My other main area of teaching involves bioinformatics for molecular biology and functional genomics applications.

Current Projects:

  • Discovery of novel regulators of inflammatory signalling.
  • Defining the molecular mechanism of action for TMEM203, a novel inflammatory signalling regulator.
  • Characterisation the biological importance of tribbles proteins in the development of lipid homeostasis, inflammation and metabolic syndromes (
  • Regulation of tribbles expression in vascular cells: development of novel anti-atherosclerotic drug targeting strategies.


For key publications see below. For a full list of publications click here.

Journal articles