Dr Lynne Prince MSc PhD

Russell FellowLynne Prince

Department of Infection, Immunity & Cardiovascular Disease
L Floor
University of Sheffield
Medical School
Beech Hill Road
Sheffield
S10 2RX
UK

Tel: +44 (0)114 215 9546
Fax: +44 (0)114 271 1863
Email: l.r.prince@sheffield.ac.uk

Biography:

I graduated from Newcastle University in 1997 with a degree in Medical Microbiology and relocated to Sheffield to study for an MSc in pathological sciences (University of Sheffield, 1999). This was followed by my PhD entitled `The Regulation of Neutrophil Apoptosis by Bacterial Products´ (University of Sheffield, 2000-04) under the supervision of Professor Moira Whyte. In 2004 I was awarded a University of Sheffield Russell Research Fellowship to study the molecular mechanisms of neutrophil activation and apoptosis.

Research Interests:

Inflammation and inflammatory diseases such as chronic obstructive pulmonary disease, or rheumatoid arthritis are extremely difficult to treat effectively. During inflammation, inflammatory cells, in particular neutrophils and monocytes, are thought to be key mediators of both tissue damage and perpetuation of further inflammatory signalling. My research focuses on the role of neutrophils during infection and inflammation, and how their inflammatory potential and function is regulated by apoptosis. I also study how the immune response is subverted by pathogens such as Staphylococcus aureus and Haemophilus influenzae, via the Florey Institute for host-pathogen interactions.

Professional Activities:

  • Deputy Chair of School Graduate Research Committee.
  • Post-Graduate Year Tutor for the Medical School and Staff-Student Liaison Committee member.
  • I teach on the MBChB Phase 2a course.
  • Member of the Society for Leukocyte Biology.

Current Projects:

2018-2021 “Do ErbB inhibitors have therapeutic potential in the resolution of inflammatory disease?” Faculty of MDH Studentship (Kimberley Herman) co-supervisor: Prof Steve Renshaw.

2018-2021 “Investigating phagocyte defects in diabetes” IICD/SHIELD studentship (Rebecca Dowey) lead supervisor Prof Ian Sabroe.

2017-2021 “Using super-resolution microscopy to understand the intracellular fate of Staphylococcus aureus” Florey/MRC SHIELD PhD Studentship (Yin Xin Ho) co-supervisor: Dr Ashley Cadby.

2017-2021 “Find-me and eat me: understanding how signals from dying cells control and subvert macrophage behavior” MRC DiMeN PhD studentship (Olivier Tardy) lead supervisor: Dr Iwan Evans.

2014-ongoing “Effect of Hypoglycemia on Inflammatory Responses and the Response to Low Dose Endotoxemia in Humans. MRC Clinical Training Fellowship (Ahmed Iqbal) co-supervisor with: Prof Ian Sabroe, Prof Sheila Francis & Prof Simon Heller.

2014-ongoing: The role of Pellino-1 in host responses to Haemophilus influenzae (in collaboration with Prof Ian Sabroe and Prof Alison Condliffe).

PhD opportunities: No funded posts available at this time. Applications from motivated and high quality applicants who can secure their own funding are encouraged to join our enthusiastic and productive team.

I am grateful to the Medical Research Council and British Lung Foundation for supporting recent research.

Publications:

For key publications see below.  For a full list of publications click here.

Journal articles