Dr Lynne Prince MSc PhD
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Beech Hill Road
Tel: +44 (0)114 215 9546
Fax: +44 (0)114 271 1863
I graduated from Newcastle University in 1997 with a degree in Medical Microbiology and relocated to Sheffield to study for an MSc in pathological sciences (University of Sheffield, 1999). This was followed by my PhD entitled `The Regulation of Neutrophil Apoptosis by Bacterial Products´ (University of Sheffield, 2000-04) under the supervision of Professor Moira Whyte. In 2004 I was awarded a University of Sheffield Russell Research Fellowship to study the molecular mechanisms of neutrophil activation and apoptosis.
Inflammation and inflammatory diseases such as chronic obstructive pulmonary disease, or rheumatoid arthritis are extremely difficult to treat effectively. During inflammation, inflammatory cells, in particular neutrophils and monocytes, are thought to be key mediators of both tissue damage and perpetuation of further inflammatory signalling. My research focuses on the role of neutrophils during infection and inflammation, and how their inflammatory potential and function is regulated by apoptosis. I also study how the immune response is subverted by pathogens such as Staphylococcus aureus and Haemophilus influenzae, via the Florey Institute for host-pathogen interactions.
- Deputy Chair of School Graduate Research Committee.
- Post-Graduate Year Tutor for the Medical School and Staff-Student Liaison Committee member.
- I teach on the MBChB Phase 2a course.
- Member of the Society for Leukocyte Biology.
2018-2021 “Do ErbB inhibitors have therapeutic potential in the resolution of inflammatory disease?” Faculty of MDH Studentship (Kimberley Herman) co-supervisor: Prof Steve Renshaw.
2018-2021 “Investigating phagocyte defects in diabetes” IICD/SHIELD studentship (Rebecca Dowey) lead supervisor Prof Ian Sabroe.
2017-2021 “Using super-resolution microscopy to understand the intracellular fate of Staphylococcus aureus” Florey/MRC SHIELD PhD Studentship (Yin Xin Ho) co-supervisor: Dr Ashley Cadby.
2017-2021 “Find-me and eat me: understanding how signals from dying cells control and subvert macrophage behavior” MRC DiMeN PhD studentship (Olivier Tardy) lead supervisor: Dr Iwan Evans.
2014-ongoing “Effect of Hypoglycemia on Inflammatory Responses and the Response to Low Dose Endotoxemia in Humans. MRC Clinical Training Fellowship (Ahmed Iqbal) co-supervisor with: Prof Ian Sabroe, Prof Sheila Francis & Prof Simon Heller.
2014-ongoing: The role of Pellino-1 in host responses to Haemophilus influenzae (in collaboration with Prof Ian Sabroe and Prof Alison Condliffe).
PhD opportunities: No funded posts available at this time. Applications from motivated and high quality applicants who can secure their own funding are encouraged to join our enthusiastic and productive team.
I am grateful to the Medical Research Council and British Lung Foundation for supporting recent research.
For key publications see below. For a full list of publications click here.
- Iqbal A, Prince LR, Novodvorsky P, Bernjak A, Thomas MR, Birch L, Lambert D, Kay LJ, Wright FJ, Macdonald IA , Jacques RM et al (2018) Effect of Hypoglycemia on Inflammatory Responses and the Response to Low Dose Endotoxemia in Humans.. Journal of Clinical Endocrinology and Metabolism. View this article in WRRO
- Connolly J, Boldock E, Prince LR, Renshaw SA, Whyte MK & Foster SJ (2017) Identification of Staphylococcus aureus Factors Required for Pathogenicity and Growth in Human Blood. Infection and immunity, 85(11). View this article in WRRO
- Prince LR, Dannewitz Prosseda S, Higgins K, Carlring J, Prestwich EC, Ogryzko NV, Rahman A, Basran A, Falciani F, Taylor P , Renshaw SA et al (2017) NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival. Blood, 130, 1014-1025. View this article in WRRO
- Prince LR, Maxwell NC, Gill SK, Dockrell DH, Sabroe I, McGreal EP, Kotecha S & Whyte MK (2014) Macrophage Phenotype Is Associated with Disease Severity in Preterm Infants with Chronic Lung Disease. PLoS ONE, 9(8), e103059. View this article in WRRO
- Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, Sawtell AK, Hamza B, Willson J, Walmsley SR , Anderson SR et al (2014) A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.. Sci Transl Med, 6(225), 225ra29. View this article in WRRO
- Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MKB, Walmsley SR, Higgins KR, Vogel SN, Wilson HL , Prince LR et al (2013) Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.. J Leukoc Biol, 93(1), 7-19. View this article in WRRO
- Bennett JA, Prince LR, Parker LC, Stokes CA, de Bruin HG, van den Berge M, Heijink IH, Whyte MK & Sabroe I (2012) Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol, 86(12), 6595-6604.
- Prince LR, Graham KJ, Connolly J, Anwar S, Ridley R, Sabroe I, Foster SJ & Whyte MKB (2012) Staphylococcus aureus induces eosinophil cell death mediated by α-hemolysin.. PLoS One, 7(2), e31506. View this article in WRRO
- Dick EP, Prince LR, Prestwich EC, Renshaw SA, Whyte MKB & Sabroe I (2009) Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils.. Immunology, 127(2), 249-255.
- Dick EP, Prince LR & Sabroe I (2008) Ex vivo-expanded bone marrow CD34+ derived neutrophils have limited bactericidal ability.. Stem Cells, 26(10), 2552-2563.
- Prince LR, Bianchi SM, Vaughan KM, Bewley MA, Marriott HM, Walmsley SR, Taylor GW, Buttle DJ, Sabroe I, Dockrell DH & Whyte MKB (2008) Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin.. J Immunol, 180(5), 3502-3511. View this article in WRRO
- Bianchi SM, Prince LR, McPhillips K, Allen L, Marriott HM, Taylor GW, Hellewell PG, Sabroe I, Dockrell DH, Henson PW & Whyte MKB (2008) Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.. Am J Respir Crit Care Med, 177(1), 35-43. View this article in WRRO
- Prince LR, Allen L, Jones EC, Hellewell PG, Dower SK, Whyte MKB & Sabroe I (2004) The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival.. Am J Pathol, 165(5), 1819-1826.
- Kotecha S, Mildner RJ, Prince LR, Vyas JR, Currie AE, Lawson RA & Whyte MKB (2003) The role of neutrophil apoptosis in the resolution of acute lung injury in newborn infants. THORAX, 58(11), 961-967.
- Sabroe I, Prince LR, Jones EC, Horsburgh MJ, Foster SJ, Vogel SN, Dower SK & Whyte MKB (2003) Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span.. J Immunol, 170(10), 5268-5275.
- Usher LR, Lawson RA, Geary I, Taylor CJ, Bingle CD, Taylor GW & Whyte MK (2002) Induction of Neutrophil Apoptosis by the Pseudomonas aeruginosa Exotoxin Pyocyanin: A Potential Mechanism of Persistent Infection. Journal of Immunology, 168(4), 1861-1868. View this article in WRRO