Dr Lynne Prince MSc PhD

Russell FellowLynne Prince

Department of Infection, Immunity & Cardiovascular Disease
L Floor
University of Sheffield
Medical School
Beech Hill Road
S10 2RX

Tel: +44 (0)114 215 9546
Fax: +44 (0)114 271 1863
Email: l.r.prince@sheffield.ac.uk


I graduated from Newcastle University in 1997 with a degree in Medical Microbiology and relocated to Sheffield to study for an MSc in Pathological Sciences (University of Sheffield, 1999). This was followed by my PhD entitled `The Regulation of Neutrophil Apoptosis by Bacterial Products´ (University of Sheffield, 2000-04) under the supervision of Professor Moira Whyte. In 2004 I was awarded a University of Sheffield Russell Research Fellowship to study the molecular mechanisms of neutrophil activation and apoptosis.

Research Interests:

Inflammation and inflammatory diseases such as chronic obstructive pulmonary disease or rheumatoid arthritis are extremely difficult to treat effectively. During inflammation, inflammatory cells, in particular neutrophils and monocytes, are thought to be key mediators of both tissue damage and perpetuation of further inflammatory signalling. My research focuses on the role of neutrophils during infection and inflammation and how their inflammatory potential and function is regulated by apoptosis. I also study how the neutrophilic immune response is subverted by pathogens such as Staphylococcus aureus via the Florey Institute for host-pathogen interactions.

Professional Activities:

Deputy Chair of School Graduate Research Committee.
Post-Graduate Year Tutor for the Medical School and Staff-Student Liaison Committee member. Member of the Society for Leukocyte Biology.
I teach on the MBChB Phase 2a course.

Current Projects:

2016-2018 British Lung Foundation project grant to study "The role of Pellino1 in the maladaptive inflammatory response to NTHi infection” (Lead PI: Dr Lynne Prince, co-applicants: Prof Ian Sabroe, Prof Alison Condliffe).

2017-2021 “Using super-resolution microscopy to understand the intracellular fate of Staphylococcus aureus” Florey/MRC SHIELD PhD Studentship (Yin Xin Ho, Co-Supervisor: Dr Ashley Cadby).

2017-2021 “Find-me and eat me: understanding how signals from dying cells control and subvert macrophage behavior” MRC DiMeN PhD studentship (Olivier Tardy, Lead Supervisor: Dr Iwan Evans).


For key publications see below.  For a full list of publications click here.

Journal articles