Dr Alex Rothman MA, BM BCh, MRes, PhD, MRCP

Wellcome Trust Clinical Research Career Development Fellow & NIHR Clinical Lecturer in CardiologyDr Alex Rothman

Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Medical School
Beech Hill Road
Sheffield
S10 2RX
UK

Tel: +44 (0)114 215 9550
Fax: +44 (0)114 271 1863
Email: a.rothman@sheffield.ac.uk

Biography:

I joined the University of Sheffield in 2008 as an Academic Clinical Fellow working as part of a team investigating the therapeutic tractability of inflammation in patients suffering heart attacks (the MRC ILA Heart study). Through my MRC Clinical Research Training Fellowship I developed an interest in the pathology and treatment of cardiovascular diseases and have been closely involved in studies investigating new therapies and devices for the treatment of pulmonary arterial hypertension, atherosclerosis and heart failure. I am currently a Wellcome Trust Career Development Fellow and NIHR Clinical Lecturer in cardiology and an Honorary Cardiology Registrar at Sheffield Teaching Hospitals NHS Trust.

Research Interests:

My research interests are the pathology and treatment of cardiovascular and pulmonary vascular diseases. The MRC ILA Heart study was the first randomised study to demonstrate the therapeutic tractability of inflammatory signalling in coronary artery disease. Findings were published in the European Heart Journal and the New England Journal of Medicine, and validated by CANTOS, a phase III study of the interleukin-1 beta targeted therapy Canakinumab that demonstrated a reduction in recurrent cardiac events. My current work focuses on the pathology of pulmonary arterial hypertension and the development of novel therapeutic strategies. Recent pre-clinical studies have led to early phase clinical studies of pulmonary artery denervation and implantable pulmonary artery pressure monitors.

Teaching Interests:

I enjoy lecturing clinical cardiology to both undergraduates and post-graduates and I teach clinical skills to medical students and doctors.

Current Projects:

  • Wellcome Trust Clinical Research Career Development Fellowship: Determining Novel SMURF1 Signalling Pathways and Precision Medicine Strategies in Patients with Pulmonary Arterial Hypertension, £460,409.
  • MRC Confidence in Concepts, The Feasibility of Novel Clinical Trial Infrastructure, Design and Technology for Early Phase Studies in Patients with Pulmonary Arterial Hypertension (FIT-PH), £65,610 (PI)
  • British Heart Foundation, Development of a Prototype Pericardial Left Ventricular Assist Device, £249,967 (Co-I)
  • Medtronic Inc. Non-invasive phenotyping of arrhythmias in pulmonary arterial hypertension, £200,000
  • Association of Physicians of Great Britain and Ireland Young Investigator Award, £19,973
  • Academy of Medical Sciences, Starter Grants for Clinical Lecturers: Inhibition of SMURF1 for the Treatment of Pulmonary Arterial Hypertension, £30,000
  • EPSRC/HEFCE and Endotronix: Intra-arterial Pulmonary Artery Pressure Monitoring in Pulmonary Hypertension: Re-defining Clinical Measurement of Treatment Effect and Disease Progression, £84,711
  • TROPHY: Therapeutic Intravascular Ultrasound for the treatment of pulmonary arterial hypertension (https://clinicaltrials.gov/ct2/show/NCT02516722)
  • SIRONA: A Prospective, Multi-Center, Open-Label, Single-Arm Clinical Trial Evaluating the Safety and Efficacy of the Cordella Heart Failure System in NYHA Class III Heart Failure Patients. (https://clinicaltrials.gov/ct2/show/NCT03375710)

Publications:

For key publications see below. For a full list of publications click here.

Journal articles