Dr Jovana Serbanovic-Canic

BHF Intermediate Basic Science Research Fellow

Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Medical School
Beech Hill Road
S10 2RX
United Kingdom

Office: OU143
Tel: +44 (0) 114 215 9502
Email: j.serbanovic-canic@sheffield.ac.uk

Dr Jovana Serbanovic-Canic


In 2013 I received my PhD from the University of Cambridge where, as a Marie Curie Fellow in the lab of Professor Willem Ouwehand, I used the zebrafish model for studying regulators of haematopoiesis. Following my PhD, I took up the position of John Stokes Postdoctoral Fellow in the lab of Professor Paul Evans at the University of Sheffield. Here I developed a platform for functional screening of flow-responsive apoptotic regulators in zebrafish. I subsequently used this model to identify mechanoreceptors regulating endothelial apoptosis in response to flow, which was the basis for my British Heart Foundation Intermediate Basic Science Research Fellowship, awarded in February 2018.

Research Interests:

I am interested in mechanoreceptors on endothelial cells which convert mechanical signals associated with blood flow into physiological changes. Disturbed blood flow conditions lead to endothelial cell injury which contributes to the development of cardiovascular disease, one of the leading causes of death globally. My work is aimed at identifying mechanoreceptors which regulate endothelial cell death in response to mechanical forces and to study this I use a range of different models and approaches, including zebrafish, murine models and human cells. Understanding the function and downstream pathways of these mechanoreceptors may provide useful targets for the prevention and treatment of cardiovascular disease.

Professional Activities:

  • Member of British Atherosclerosis Society (since 2013)

Current Projects:

  • Role of the mechanoreceptor Pkd1 in endothelial dysfunction and atherosclerosis (British Heart Foundation funding, 2018-2023).


For Key Publications see below. For a full list of publications click here.

Journal articles

  • Mahmoud M, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis S, Van der Heiden K, Ridger V & Evans P (2017) Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Scientific Reports, 7. View this article in WRRO RIS download Bibtex download
  • Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C, Bowden N, Ashton JP, Walczak H, Firmin D, Krams R, Mason JC, Haskard DO, Sherwin S, Ridger V, Chico TJ & Evans PC (2016) Zebrafish Model for Functional Screening of Flow-Responsive Genes.. Arterioscler Thromb Vasc Biol, 37, 130-143. View this article in WRRO RIS download Bibtex download
  • Bowden N, Bryan MT, Duckles H, Feng S, Hsiao S, Kim HR, Mahmoud M, Moers B, Serbanovic-Canic J, Xanthis I, Ridger VC & Evans PC (2016) Experimental Approaches to Study Endothelial Responses to Shear Stress. Antioxidants & Redox Signaling, 25(7), 389-400. RIS download Bibtex download
  • Bryan MT, Duckles H, Feng S, Hsiao ST, Kim HR, Serbanovic-Canic J & Evans PC (2014) Mechanoresponsive networks controlling vascular inflammation.. Arterioscler Thromb Vasc Biol, 34(10), 2199-2205. RIS download Bibtex download
  • Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple DL, Ouwehand WH & Freson K (2011) Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake.. Blood, 118(18), 4967-4976. RIS download Bibtex download
  • Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y, Lopez LM, Mägi R, Meacham S, Okada Y, Pirastu N, Sorice R, Teumer A, Voss K, Zhang W, Ramirez-Solis R, Bis JC, Ellinghaus D, Gögele M, Hottenga J-J, Langenberg C, Kovacs P, O'Reilly PF, Shin S-Y, Esko T, Hartiala J, Kanoni S, Murgia F, Parsa A, Stephens J, van der Harst P, Ellen van der Schoot C, Allayee H, Attwood A, Balkau B, Bastardot F, Basu S, Baumeister SE, Biino G, Bomba L, Bonnefond A, Cambien F, Chambers JC, Cucca F, D'Adamo P, Davies G, de Boer RA, de Geus EJC, Döring A, Elliott P, Erdmann J, Evans DM, Falchi M, Feng W, Folsom AR, Frazer IH, Gibson QD, Glazer NL, Hammond C, Hartikainen A-L, Heckbert SR, Hengstenberg C, Hersch M, Illig T, Loos RJF, Jolley J, Tee Khaw K, Kühnel B, Kyrtsonis M-C, Lagou V, Lloyd-Jones H, Lumley T, Mangino M, Maschio A, Mateo Leach I, McKnight B, Memari Y, Mitchell BD, Montgomery GW, Nakamura Y, Nauck M, Navis G, Nöthlings U, Nolte IM, Porteous DJ, Pouta A, Pramstaller PP, Pullat J, Ring SM, Rotter JI, Ruggiero D, Ruokonen A, Sala C, Samani NJ, Sambrook J, Schlessinger D, Schreiber S, Schunkert H, Scott J, Smith NL, Snieder H, Starr JM, Stumvoll M, Takahashi A, Wilson Tang WH, Taylor K, Tenesa A, Lay Thein S, Tönjes A, Uda M, Ulivi S, van Veldhuisen DJ, Visscher PM, Völker U, Wichmann H-E, Wiggins KL, Willemsen G, Yang T-P, Hua Zhao J, Zitting P, Bradley JR, Dedoussis GV, Gasparini P, Hazen SL, Metspalu A, Pirastu M, Shuldiner AR, Joost van Pelt L, Zwaginga J-J, Boomsma DI, Deary IJ, Franke A, Froguel P, Ganesh SK, Jarvelin M-R, Martin NG, Meisinger C, Psaty BM, Spector TD, Wareham NJ, Akkerman J-WN, Ciullo M, Deloukas P, Greinacher A, Jupe S, Kamatani N, Khadake J, Kooner JS, Penninger J, Prokopenko I, Stemple D, Toniolo D, Wernisch L, Sanna S, Hicks AA, Rendon A, Ferreira MA, Ouwehand WH & Soranzo N (2011) New gene functions in megakaryopoiesis and platelet formation. Nature. RIS download Bibtex download