Dr Roger Thompson MB ChB BSc MRCP(UK) PhD
JG Graves Fellow
Department of Infection, Immunity and Cardiovascular Disease
University of Sheffield
Beech Hill Road
I moved to Sheffield in 2006 to take up an NIHR Academic Clinical Fellowship in Respiratory Medicine having completed my undergraduate training and a medical rotation in Edinburgh. I completed an MRC Training Fellowship and PhD in 2012 under the supervision of Professor Moira Whyte and Dr Sarah Walmsley. I completed my specialist clinical training as an NIHR Clinical Lecturer and in June 2016 was appointed as a JG Graves Postdoctoral Fellow.
Hypoxia has been the general theme of my research interests. In 2001 and 2003 I organised two successful high altitude research expeditions to Bolivia, focusing on the maladaptive response to hypoxia that can result in altitude illness (www.altitude.org). I hope to translate this interest in altitude hypoxia into understanding how the body responds to hypoxia in the context of respiratory disease at sea level. During my PhD, I broadened my interests into the field of cellular biology, specifically the role of HIF-2alpha in neutrophilic inflammation. I also continue to work on host pathogen interactions in hypoxia, a project for which I was awarded an Academy of Medical Sciences Starter Grant. Now I aim to align my research interests with my clinical interest in pulmonary hypertension using my background in pulmonary inflammation and hypoxia to provide new perspectives to this disease.
Pulmonary arterial hypertension (PAH) is a devastating condition characterised by progressive remodelling of pulmonary blood vessels leading to right heart failure and death. The pattern recognition receptor, Toll-like receptor 3 (TLR3) is critically involved in the recognition of viral pathogens and emerging evidence suggests it regulates vascular remodelling. I have generated novel unpublished data implicating double-stranded RNA (dsRNA), a TLR3 ligand, in the pathogenesis of PAH. I aim to dissect the mechanism by which dsRNA regulates PAH and to assess the therapeutic impact of activating dsRNA signalling pathways in PAH models.
- Hypoxic modulation of host responses to infection.
- Regulation of pulmonary vascular remodelling by endogenous double stranded RNA.
For key publications see below. For a full list of publications click here.
- Thompson AAR, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Coelho PDS, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MKB & Walmsley SR (2017) Hypoxia determines survival outcomes of bacterial infection through HIF-1α-dependent reprogramming of leukocyte metabolism. Science Immunology, 2(8). View this article in WRRO
- Thompson AAR & Lawrie A (2017) Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension. Trends in Molecular Medicine, 23(1), 31-45.
- Lodge KM, Thompson AAR, Chilvers ER & Condliffe AM (2016) Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection. Microbes and Infection. View this article in WRRO
- Hickey PM, Thompson AA, Charalampopoulos A, Elliot CA, Hamilton N, Kiely DG, Lawrie A, Sabroe I & Condliffe R (2016) Bosutinib therapy resulting in severe deterioration of pre-existing pulmonary arterial hypertension. Eur Respir J, 48(5), 1514-1514.
- Jones R, McDonald KE, Willson JA, Ghesquiere B, Sammut D, Daniel E, Harris AJ, Lewis A, Thompson AAR, Dickinson RS, Plant T, Murphy F, Sadiku P, Keevil BG, Carmeliet P, Whyte MKB, Newell-Price J & Walmsley SR (2016) Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1 expression. Blood, 127(21), 2641-2644. View this article in WRRO
- Finisguerra V, Di Conza G, Di Matteo M, Serneels J, Costa S, Thompson AAR, Wauters E, Walmsley S, Prenen H, Granot Z, Casazza A & Mazzone M (2015) MET is required for the recruitment of anti-tumoural neutrophils. Nature, 522(7556), 349-353. View this article in WRRO
- Hall DP, MacCormick IJC, Phythian-Adams AT, Rzechorzek NM, Hope-Jones D, Cosens S, Jackson S, Bates MGD, Collier DJ, Hume DA, Freeman T, Thompson AAR & Baillie JK (2014) Network Analysis Reveals Distinct Clinical Syndromes Underlying Acute Mountain Sickness. PLoS ONE, 9(1), e81229-e81229. View this article in WRRO
- Thompson AAR, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, Dockrell DH, Chilvers ER, Robbins PA, Percy MJ, Simon MC, Johnson RS, Renshaw SA, Whyte MKB & Walmsley SR (2014) Hypoxia-inducible factor 2 regulates key neutrophil functions in humans, mice, and zebrafish. Blood, 123(3), 366-376.
- Thompson AA, Binham J, Plant T, Whyte MK & Walmsley SR (2013) Hypoxia, the HIF pathway and neutrophilic inflammatory responses. Biological Chemistry, 394(4), 471-477.
- Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW, Ratcliffe PJ, Maxwell PH, Carmeliet P & Whyte MKB (2011) Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. Journal of Clinical Investigation, 121(3), 1053-1063. View this article in WRRO