Dr Gwendolen Reilly

DPhil, BSc

Department of Materials Science and Engineering

Professor of Musculoskeletal Bioengineering

Gwen Reilly
g.reilly@sheffield.ac.uk
+44 114 222 5986

Full contact details

Dr Gwendolen Reilly
Department of Materials Science and Engineering
Pam Liversidge Building
Mappin Street
Sheffield
S1 3JD
Profile

Gwendolen Reilly has been a member of academic staff since 2004.

She received her DPhil in Biology at the University of York, specialising in bone biomechanics. She has previously undertaken post-doctoral research at the University of Pennsylvania, Pennsylvania State College of Medicine and the Swiss Federal Institute of Technology in cell biomechanics, biomaterials and bone structure respectively. Subsequently, she undertook a position as Research Assistant Professor in Bioengineering at the University of Illinois, Chicago specializing in tissue engineering.

Gwen’s current research combines her expertise in biomechanics, biomaterials and orthopaedics.

Research interests

The research has applications in orthopaedic and dental medicine, where clinicians are looking for improved methods to repair skeletal tissues; bone, tendon and cartilage.

Bone tissue engineering
The aim of bone tissue engineering is to create bone matrix in the laboratory for clinical implantation and as an experimental tool. Our research in this area focuses on two main themes; the effects of mechanical stimulation on differentiation and matrix formation by bone cells and the interactions between precursor bone cells and their biomaterial substrate. Mechanical stimuli examined include dynamic compression, stretch and fluid flow induced shear stresses using a range of bioreactors (including a collaboration with ElectroForce systems group).

Musculoskeletal cell mechanobiology
We are interested in how skeletal cells respond to extrinsic and intrinsic stimuli by organizing the proteins and mineral they secrete in a way which enhances the strength of the matrix. This information can then be used to manipulate tissue-engineered structures in order to induce structurally sound matrix formation. We specifically focus on mechanosensation mechanisms found on the cell membrane; the cell’s proteoglycan (sugar-based) coat and a small organelle that protrudes from the cell membrane – the primary cilia.

Orthopaedic biomaterials
We investigate the interactions between musculoskeletal cells and orthopaedic and dental materials that are implanted into bone. Materials investigated include porous metals, polymer scaffolds and peptide coated surfaces (in collaboration with Orla Protein Technologies). This research encompasses the study of the mechanical properties of biomaterial scaffolds, cell-material interactions, cell mechanics and cell signalling.

Publications

Journal articles

Chapters

Conference proceedings papers

  • Dikici BA, Reilly G & Claeyssens F (2018) Assessment of the osteogenic and angiogenetic potential of in vitro generated extracellular matrix decorated multiscale porous polyHIPE scaffolds. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 256 RIS download Bibtex download
  • Dikici S, Dikici BA, Reilly G & Claeyssens F (2018) Investigating the barrier membrane properties of biphasic PCL scaffolds for guided tissue regeneration. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 256 RIS download Bibtex download
  • Tetteh G, Delaine-Smith R, Green N & Reilly G (2016) Collagen and Mineral Deposition by MLO-A5 Late-Stage Osteoblasts, is Guided by the Fibre Alignment of Electrospun Scaffolds. Proceedings of the 22nd Congress of the European Society of Biomechanics, 10 July 2016 - 13 July 2016. RIS download Bibtex download
  • Paterson TE, Dugan JM, Sherborne C, Green NH, Reilly GC & Claeyssens F (2015) Highly Porous Particles for Cell Recruitment and Delivery in Bone Tissue Engineering. TISSUE ENGINEERING PART A, Vol. 21 (pp S287-S288) RIS download Bibtex download
  • Tetteh G, Rehman IU & Reilly GC (2014) Using composite scaffolds to engineer bone templates for in-vitro testing. Bone Research Society Conference. Sheffield, 11 May 2014. RIS download Bibtex download
  • Tetteh G, Rehman IU & Reilly GC (2013) A polyurethane-hydroxyapatite composite scaffold as a template for an in-vitro bone model. ICMOBT 2013. Spain, 8 December 2013 - 12 December 2013. RIS download Bibtex download
  • Tetteh G, Rehman IU & Reilly GC (2013) Using Electrospun Composite Scaffolds as a Template for In-Vitro Bone Matrix Formation. Proc. of the 7th MSC Meeting. Birmingham, 12 September 2013 - 13 September 2013. RIS download Bibtex download
  • Tetteh G, Rehman IU & Reilly GC (2013) Polyurethane-Hydroxyapatite composite scaffolds for in vitro bone tissue engineering. European Cells and Materials, Vol. 26(7) (pp 38) RIS download Bibtex download
  • Emerson NJ, Carre MJ, Reilly GC & Offiah AC (2013) Simulation based upon medical data offers a fast and robust method for the prediction of fracture risk. 6TH ASIA-PACIFIC CONGRESS ON SPORTS TECHNOLOGY (APCST), Vol. 60 (pp 459-466) View this article in WRRO RIS download Bibtex download
  • Delaine-Smith RM & Reilly GC (2012) Primary cilia removal inhibits osteoblastic matrix-forming response to mechanical stimuli. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 6 RIS download Bibtex download
  • Puwanun S, Bye F, Delaine-Smith RM, Yates J, MacNeil S & Reilly GC (2012) Optimizing cell sources for cleft palate repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 6 (pp 4-4) RIS download Bibtex download
  • Malayeri A, Gabbott C, Reilly G, Ghassemieh E, Hatton PV & Claeyssens F (2012) Feasibility of 3D printing and stereolithography for fabrication of custom-shaped poly (lactic acid): hydroxyapatite composite biomaterial scaffolds. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 6 (pp 367-367) RIS download Bibtex download
  • Shaeri M, Chong CK, Reilly G & Delain-Smith R (2012) Mechanical stimulation of mesenchymal stem cells in a 3D glass scaffold using oscillating and unidirectional flow. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 6 (pp 344-344) RIS download Bibtex download
  • van Grunsven W, Goodall R & Reilly GC (2012) HIGHLY POROUS TITANIUM ALLOY: FABRICATION AND MECHANICAL PROPERTIES. Journal of Biomechanics, Vol. 45 (pp S339-S339) RIS download Bibtex download
  • Chirasatitsin S, Vishwanathan P, Reilly G, Battaglia G & Engler AJ (2012) Diblock copolymer foam surface chemistry influences mesenchymal stem cell fate. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 243 RIS download Bibtex download
  • Wang N, Robaye B, Agrawal A, Reilly G, Boeynaems JM & Gartland A (2011) Deletion of the P2Y13 receptor leads to reduced bone turnover and protection from ovariectomy-induced bone loss. BONE, Vol. 48 (pp S227-S227) RIS download Bibtex download
  • Morris HL, Haycock JW & Reilly GC (2011) Hyaluronan as a potential mechanotransduction mediator. European Cells and Materials, Vol. 22(SUPPL.2) (pp 6) RIS download Bibtex download
  • Flores-Merino MV, Reilly GC & Battaglia G (2011) Synthesis of interpenetrating polymer networks scaffolds of poly (vinyl pyrrolidone) and poly (acrylic acid). European Cells and Materials, Vol. 22(SUPPL.2) (pp 45) RIS download Bibtex download
  • Delaine-Smith RM, Reilly G & MacNeil S (2011) Response of dermal fibroblasts to dynamic tensile loading. European Cells and Materials, Vol. 22(SUPPL.2) (pp 41) RIS download Bibtex download
  • van Grunsven W, Goodall R & Reilly GC (2011) Porous metal implants for enhanced bone ingrowth and stability. European Cells and Materials, Vol. 22(SUPPL.3) (pp 1) RIS download Bibtex download
  • Bye F, Puwanun S, Reilly G & MacNeil S (2011) Using a tissue engineering approach for the treatment of cleft palate. European Cells and Materials, Vol. 22(SUPPL.3) (pp 6) RIS download Bibtex download
  • Viswanathan P, Chirasatitsin S, Reilly G, Engler A & Battaglia G (2011) 3D cell instructive scaffolds to direct stem cell fate. Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011, Vol. 3 (pp 256-259) RIS download Bibtex download
  • Flores-Merino MV, Reilly GC, Engler AJ & Battaglia G (2009) Nano-domain detection in Poly (vinyl pyrrolidinone) hydrogels. European Cells and Materials, Vol. 18(SUPPL. 2) (pp 33) RIS download Bibtex download
  • Sittichokechaiwut A, Jacobs CR & Reilly GC (2009) Mechanical responses of bone tissue formation in 3D engineered constructs via primary cilia. European Cells and Materials, Vol. 18(SUPPL. 2) (pp 16) RIS download Bibtex download
  • Sittichokechaiwut A & Reilly G (2009) Development of a Culture System to Modulate Tissue Engineered Bone Formation by Varying Loading Conditions.. Proceedings of the 7th International Conference on Manufacturing Research, Vol. 7 (pp 443-448) RIS download Bibtex download
  • Morris HL, Sittichokechaiwut A, Jacobs CR, Haycock JW & Reilly GC (2008) The Response of Matrix Synthesizing MLO-A5 Cells to Fluid Shear. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S147-S147) RIS download Bibtex download
  • Stevens-Smith JL, Scutt A & Reilly G (2008) Interactions between Obesity, Cardiovascular Disease and Bone Formation.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S489-S489) RIS download Bibtex download
  • Clarke D, Coll C, Ryan A, Crawford A & Reilly G (2008) FOAM VERSUS FIBRE SCAFFOLDS FOR MECHANICAL STIMULATION OF CELLS IN BONE TISSUE ENGINEERING. Journal of Biomechanics, Vol. 41 (pp S385-S385) RIS download Bibtex download
  • Sittichokechaiwut A, Scutt AM & Reilly GC (2008) CALCIUM DEPOSITION BY RAPIDLY MINERALIZING OSTEOBLASTS IS REGULATED BY DYNAMIC COMPRESSION. Journal of Biomechanics, Vol. 41 (pp S193-S193) RIS download Bibtex download
  • Rumney RMH, Sittichokechaiwut A, Reilly G & Gartland A (2008) ATP release from osteoblasts is increased in response to mechanical loading by different amounts when grown in standard monolayer and novel 3D scaffolds. CALCIFIED TISSUE INT, Vol. 83(1) (pp 16-16) RIS download Bibtex download
  • Sebastine IM, Sittichokechaiwut A, Clarke DA, Williams C, Reilly GC & Williams DJ (2008) Effects of frequency and loading duration on mechanically modulated collagen production by osteoblasts in bone tissue engineering. TISSUE ENGINEERING PART A, Vol. 14(5) (pp 844-844) RIS download Bibtex download
  • Rumney R, Wang N, Sittichokechaiwut A, Reilly G & Gartland A (2008) Different types of mechanical loading induce differentitial ATP release from osteoblasts grown on 3-dimensional scaffolds. PURINERG SIGNAL, Vol. 4 (pp S164-S165) RIS download Bibtex download
  • Sittichokechaiwut A, Tummala P, Reilly G & Jacobs C (2008) The role of the primary cilia in mediating mechanically induced increases in matrix production during bone tissue engineering. TISSUE ENGINEERING PART A, Vol. 14(5) (pp 788-788) RIS download Bibtex download
  • Clarke D, Puppi D, Detta N, Ferrer MCC, Crawford A, Reilly G & Chiellini F (2008) Electrospun polyurethane scaffolds for mechanical stimulation of cells in bone tissue engineering. TISSUE ENGINEERING PART A, Vol. 14(5) (pp 846-846) RIS download Bibtex download
  • Flores-Merino MV, Ryan AJ, Reilly G & Battaglia. G (2008) Nanofunctionalization of hydrogels using amphiphilic copolymers.. 8th World Biomaterials Congress 2008, Vol. 2 (pp 1062) RIS download Bibtex download
  • Morris HL, Haycock JW & Reilly GC (2008) The role of mechanotransduction in bone tissue engineering. European Cells and Materials, Vol. 16(SUPPL. 3) (pp 84) RIS download Bibtex download
  • Flores-Merino MV, Reilly G & Battaglia G (2008) Nanofuntionalized polymeric networks for tissue engineering applications. European Cells and Materials, Vol. 16(SUPPL. 3) (pp 54) RIS download Bibtex download
  • Rumney RMH, Sittichokechaiwut A, Reilly GC & Gartland A (2008) Cyclical compressive loading induces changes in cellular behaviour and ATP release from osteoblasts grown on 3-dimensional scaffolds. CALCIFIED TISSUE INT, Vol. 82 (pp S115-S116) RIS download Bibtex download
  • Sittichokechaiwut A, Scutt A & Reilly GC (2007) The effects of compressive loading on matrix production by osteoblastic cells cultured in polyurethane scaffolds. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22 (pp S359-S359) RIS download Bibtex download
  • Sittichockechaiwut A, Brown LE & Reilly GC (2007) Collagen and osteopontin upregulation by mechanical loading of bone cells in porous 3D scaffolds. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22 (pp S268-S268) RIS download Bibtex download
  • Sittichockechaiwut A, Brown LE & Reilly GC (2007) Osteopontin upregulation in a compression bioreactor using two different scaffolds. TISSUE ENGINEERING, Vol. 13(7) (pp 1740-1740) RIS download Bibtex download
  • Clarke DA, Coll C, Drury P, Crawford A & Reilly GC (2007) Polyurethane scaffolds for long term mechanical loading in musculoskeletal tissue engineering. TISSUE ENGINEERING, Vol. 13(7) (pp 1743-1743) RIS download Bibtex download
  • Sittichokechaiwut A, Clarke DA & Reilly GC (2006) Mechanical stimulation of osteoblastic cells in a 3 dimensional polyurethane foam scaffold.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 21 (pp S373-S373) RIS download Bibtex download
  • Sittichokechaiwut A, Ryan AJ & Reilly G (2006) A 3-dimensional, in vitro model to study the effects of compressive loading on osteoblastic cells. European Cells and Materials, Vol. 11(SUPPL.2) (pp 84) RIS download Bibtex download
  • Jacobs C, You J, Reilly G, Batra N, Li Y, Malone A, Themiyasathit S, Tang J, Stearns T & Anderson C (2006) Cellular mechanotransduction in Bone: Moving towards a molecular mechanism. European Cells and Materials, Vol. 11(SUPPL.2) (pp 8) RIS download Bibtex download
  • Williams S, Reilly G, Sittichokechaiwut A, Clarke DA, Nickel T & Mejia L (2006) Biodynamic loading in orthopaedic tissue engineering. MCB Molecular and Cellular Biomechanics, Vol. 3(4) (pp 137-138) RIS download Bibtex download
  • Notomi T, Ludwig A, Reilly G, Hofmann FB & Skerry TM (2005) HCN2 ion channels regulate bone development, mass and strength.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(9) (pp S62-S62) RIS download Bibtex download
  • Yao J, Radin S, Reilly G, Leboy PS & Ducheyne P (2005) Solution mediated effect of bioactive glass in poly (lactic-co-glycolic acid)-bioactive glass composites on osteogenesis of marrow stromal cells. BIOCERAMICS 17, Vol. 17 (pp 619-622) RIS download Bibtex download
  • Radin S, Reilly G, Bhargave G, Leboy PS & Ducheyne P (2004) Osteogenic effect of bioactive glass on bone marrow cells: Biochemical, chemical and morphological study. Transactions - 7th World Biomaterials Congress (pp 200) RIS download Bibtex download
  • Reilly GC, Radin S, Bhargave GA, Ducheyne P & Leboy PS (2003) Differential osteogenic effects of 45S bioactive glass on rat and human mesenchymal stem cells.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18 (pp S346-S346) RIS download Bibtex download
  • Jacobs CR, You J, Reilly G, Saunders MM, Kurokouchi K, Yellowley CE & Donahue HJ (2001) An overview of oscialltory fluid flow as a potent loading-induced physical signal in bone cells. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, Vol. 50 (pp 339-340) RIS download Bibtex download
  • Reilly GC, Haut TR, Yellowley CE, Donahue HJ & Jacobs CR (2001) Manipulation of the glycocalyx of an osteocytic and an osteoblastic cell line does not affect the intracellular calcium increase in response to fluid flow.. J BONE MINER RES, Vol. 16 (pp S481-S481) RIS download Bibtex download
  • REILLY G, KNAPP H, STEMMER A, NIEDERER P & TATE M (2001) Investigation of the morphology of the lacunocanalicular system of cortical bone using atomic force microscopy. Conference on the Mechanical Properties of Cells and Tissues, Vol. 29 (pp 1074-1081) RIS download Bibtex download
  • Reilly GC, Yellowley CE, Donahue HJ & Jacobs CR (2000) Investigation of the signalling pathways involved in the calcium response of bone cells to oscillating fluid flow.. J BONE MINER RES, Vol. 15 (pp S508-S508) RIS download Bibtex download
  • Reilly GC & Jacobs CR (2000) Investigation of the glycocalyx of cultured bone cells.. J BONE MINER RES, Vol. 15 (pp S376-S376) RIS download Bibtex download
  • Reilly GC, Knapp HF, Stemmer AC, Niederer P & Tate MLK (1999) Using atomic force microscopy to image the lacunocanalicular system of cortical bone.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 14 (pp S553-S553) RIS download Bibtex download
  • Reilly GC (1996) Stress-induced damage in bone: Microcracking and other toughening mechanisms. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 11(10) (pp P28-P28) RIS download Bibtex download
  • Patterson T, Sherborne C, Reilly G & Claeyssens F () Manufacturing of PolyHIPE-based Porous Microparticles for Bone Tissue Engineering. USES Conference Proceedings RIS download Bibtex download
  • Rigelsford JM, Way L, Gray C, Reilly G & Scutt AM () Using a novel stretching device to study the effects of mechanical strain on tenocytes in-vitro. 3rd international conference on Mechanics of Biomaterials and Tissues. Clearwater Beach, Florida, USA., 2009. RIS download Bibtex download

Datasets

Other

Research group
  • Gifty Tetteh (In vitro bone models for biomaterials testing)
  • Wing Kiu Yeung (Surface coatings for orthopaedic implants)
  • Tom Patterson (PolyHIPE particles for bone tissue engineering).
  • Robert Owen (In vitro bone models for osteoporosis research).
  • Zena Wally (Additive manufacturing of porous metals for dental implants).
  • Dirar Qassim (Serum free culture of progenitor cells for craniofacial repair).
  • Stefania Marcotti (Mechanobiology of the glycocalyx of bone cells).
  • Hossein Bahmaee (Microfluidics for co-culture of bone cells).
  • Liam Boyle (Mechanobiology of the primary cilia of bone cells).
  • Hannah Murray (A* collaboration with Nanyang Technological University, Singapore on angiogenesis of tissue-engineered scaffolds).
  • Leonardo Antonini (sandwich PhD student from Federal University of Rio Grande do Sul, Brazil).
Professional activities
  • President of the European Society of Biomechanics
  • Special visiting researcher (PVE): UFRGS, Brazil
  • Fellow of the Higher Education Academy
  • Alice L Jee Young Investigator Award at the 37th International Sun Valley Workshop on Skeletal Biology
  • Editorial boards of: European Cells and Materials, PLoS ONE, Heliyon and Frontiers in Bioengineering
  • Panel member for Marie Skłodowska-Curie Fellowships H2020 programme, Life sciences
  • Member of the American Society of Bone and Mineral Research, Orthopaedic Research Society, Tissue and Cell Engineering Society and Tissue Engineering and Regenerative Medicine International Society
Women in Engineering

We interviewed Gwen for the Faculty of Engineering's Wall of Women when she was a Senior Lecturer in Bioengineering. Here's Gwen's interview:

The Wall of Women profiles were taken over a 4/5 year time period and are a snapshot of what our engineers were doing at that time.