Dr Alberto Marzo
Department of Mechanical Engineering
MSc Bioengineering Director
+44 114 222 0155
Full contact details
Department of Mechanical Engineering
Sir Frederick Mappin Building
Dr Marzo is a Senior Lecturer at the Department of Mechanical Engineering, University of Sheffield.
Dr Marzo has a five-year degree in Mechanical Engineering from the University of Cagliari, Italy, and a PhD from the University of Sheffield.
In the early stages of his PhD he was awarded the David Crighton Fellowship, and spent one year of his doctoral studies at the Department of Applied Mathematics and Theoretical Physics, the University of Cambridge. Here he investigated the theory behind flow-induced oscillations in elastic vessels.
In 2011-12 he worked as a Principal Research Scientist for the NHS to support technology development, dissemination, and adoption, for people with long-term disabilities.
Dr Marzo's research area stands at the interface between the physical and life sciences. It is firmly rooted in engineering and mathematics in the context of computational fluid mechanics, including state-of-the-art fluid-structure interaction, and cardiovascular biomechanics, but has a strong emphasis on clinical interpretation and translation of engineering technologies into clinical tools.
- Research interests
- Image-based 3D cardiovascular modelling
- 1D whole-circulation modelling of blood flow through elastic vessels
- Optimisation of medical devices used in treatment of respiratory disease
- Influence of haemodynamics on cardiovascular disease
- Influence of fluid flows on bacterial biofilms
- Use of HPC-based approaches and statistical emulators for verification, validation and uncertainty quantification
- A multiscale computational framework to evaluate flow alterations during mechanical thrombectomy for treatment of ischaemic stroke. Frontiers in Cardiovascular Medicine, 10.
- Reducing the complexity of musculoskeletal models using gaussian process emulators. Applied Sciences, 12(24).
- Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. PLoS ONE, 17(7). View this article in WRRO
- Determining clinically-viable biomarkers for ischaemic stroke through a mechanistic and machine learning approach. Annals of Biomedical Engineering. View this article in WRRO
- Delivering computationally-intensive digital patient applications to the clinic: An exemplar solution to predict femoral bone strength from CT data. Computer Methods and Programs in Biomedicine, 208. View this article in WRRO
- A clinically aligned experimental approach for quantitative characterization of patient-specific cardiovascular models. AIP Advances, 10(4). View this article in WRRO
- Role of distal cerebral vasculature in vessel constriction after aneurysm treatment with flow diverter stents. Journal of NeuroInterventional Surgery. View this article in WRRO
- Improved biomechanical metrics of cerebral vasospasm identified via sensitivity analysis of a 1D cerebral circulation model. Journal of Biomechanics, 90, 24-32. View this article in WRRO
- An engineering approach towards a more discrete and efficient urinary drainage system. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 233(1), 58-67.
- Reversible Brain Edema Associated to Flow Diverter Stent Procedures: A Retrospective Single Center Study to Evaluate Frequency, Clinical Evolution and Possible Mechanism.. World Neurosurgery. View this article in WRRO
- Non-invasive Stenotic Renal Artery Haemodynamics by in silico Medicine. Frontiers in Physiology, 9. View this article in WRRO
- The Role of Hemodynamics in Intracranial Bifurcation Arteries after Aneurysm Treatment with Flow-Diverter Stents. American Journal of Neuroradiology, 39(2), 323-330. View this article in WRRO
- Bayesian sensitivity analysis of a 1D vascular model with Gaussian process emulators. International Journal for Numerical Methods in Biomedical Engineering, 33(12). View this article in WRRO
- Abstract WP90: The Role of Haemodynamics in a Bifurcation Vessel Narrowing or Occlusion After Aneurysm Treatment with Flow Diverter Stents. Stroke, 48(suppl_1).
- Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles. Neurobiology of Disease, 82, 593-606. View this article in WRRO
- Modeling of the Acute Effects of Primary Hypertension and Hypotension on the Hemodynamics of Intracranial Aneurysms. Annals of Biomedical Engineering, 43(1), 207-221.
- Modifiable lifestyle factors in dementia: a systematic review of longitudinal observational cohort studies.. J Alzheimers Dis, 42(1), 119-135.
- Development of two electronic bladder diaries: a patient and healthcare professionals pilot study.. Neurourol Urodyn, 33(7), 1101-1109.
- Accuracy vs. computational time: Translating aortic simulations to the clinic. Journal of Biomechanics, 45(3), 516-523.
- Predicting hemodynamics in native and residual coarctation: preliminary results of a Rigid-Wall Computational-Fluid-Dynamics model (RW-CFD) validated against clinically invasive pressure measures at rest and during pharmacological stress. Journal of Cardiovascular Magnetic Resonance, 13(S1).
- Three-dimensional morphological analysis of intracranial aneurysms: A fully automated method for aneurysm sac isolation and quantification. MED PHYS, 38(5), 2439-2449.
- Patient-Specific Modeling of Cerebral Blood Flow: Geometrical Variations in a 1D Model. Cardiovascular Engineering and Technology, 2(4), 334-348.
- @neurIST Complex Information Processing toolchain for the integrated management of cerebral aneurysm. Journal of the Royal Society Interface(1), 308-319.
- Computer Modelling of Haemodynamics and Morphology in Patient-specific Intracranial Aneurysms. Computer Aided Medical Engineering, 1, 24-26.
- Computational hemodynamics in cerebral aneurysms: the effects of modeled versus measured boundary conditions.. Ann Biomed Eng, 39(2), 884-896.
- Effects of smoking and hypertension on wall shear stress and oscillatory shear index at the site of intracranial aneurysm formation.. Clin Neurol Neurosurg, 112(4), 306-313.
- Effects of heparin on the hemodynamic characteristics of intracranial aneurysms.. J Neuroradiol, 37(5), 300-301.
- The effects of aortic coarctation on cerebral hemodynamics and its importance in the etiopathogenesis of intracranial aneurysms. Journal of Vascular and Interventional Radiology, 1(3), 17-30.
- The effects of aortic coarctation on cerebral hemodynamics and its importance in the etiopathogenesis of intracranial aneurysms.. J Vasc Interv Neurol, 3(1), 17-30.
- MR derived volumetric flow rate waveforms at locations within the common carotid, internal carotid, and basilar arteries.. J Cereb Blood Flow Metab, 29(12), 1975-1982.
- Influence of inlet boundary conditions on the local haemodynamics of intracranial aneurysms.. Comput Methods Biomech Biomed Engin, 12(4), 431-444.
- The role of computational fluid dynamics in the management of unruptured intracranial aneurysms: a clinicians' view.. Comput Intell Neurosci, 760364. View this article in WRRO
- Reproducibility of haemodynamical simulations in a subject-specific stented aneurysm model--a report on the Virtual Intracranial Stenting Challenge 2007.. J Biomech, 41(10), 2069-2081.
Conference proceedings papers
- pFIRE: parallel Framework for Image REgistration. Compbiomed Conference 2021
- Notice of Removal: Ultrasound study of hemodynamic changes by flow diverting stents in idealised and patient-specific anatomies. 2017 IEEE International Ultrasonics Symposium (IUS), 6 September 2017 - 9 September 2017.
- Multichannel foetal heartbeat detection by combining source cancellation with expectation-weighted estimation of fiducial points. Computing in Cardiology, Vol. 40 (pp 329-332)
- DEVELOPMENT AND ASSESSMENT OF TWO ELECTRONIC BLADDER DIARIES; A PILOT STUDY. NEUROUROLOGY AND URODYNAMICS, Vol. 31(6) (pp 770-771)
- Determination of Wall Strain in Model Cerebral Aneurysms by Image Registration. INTERNATIONAL CONFERENCE ON ADVANCEMENTS OF MEDICINE AND HEALTH CARE THROUGH TECHNOLOGY, Vol. 26 (pp 283-286)
- Three-dimensional collapse and steady flow in thick-walled flexible tubes. JOURNAL OF FLUIDS AND STRUCTURES, Vol. 20(6) (pp 817-835)
- Data for 'A clinically aligned experimental and numerical approach for quantitative validation of typical patient-specific cardiovascular CFD models'.
- 2013-17 VPH-DARE@IT (EU FP7 - ICT) - Large-scale Intergated Project (IP) on patient-specific predictive models for early diagnosis of dementias and their evolution (co-investigator, PI Prof Alejandro Frangi)
- 2014-15 NHS/EPSRC Urinary catheters: a more efficient and dignified solution for patients suffering from urinary incontinence (Principal Investigator)
2016 - 2019 CompBioMed (EU H2020, phase 1) A Centre of Excellence in Computational Biomedicine (PI)
2019 - 2023 CompBioMed (EU H2020, phase 2) A Centre of Excellence in Computational Biomedicine (PI)
- Teaching activities
- MEC320 Computational Fluid Dynamics
- MEC458/BIE6434 Cardiovascular Biomechanics
- IPE61007 Applied Modelling Skills and Virtual Reality
- Current available PhDs
- An efficient computational approach to guide intervention in treatment of stroke