Events in The Medical School
All of the upcoming events in The Medical School are listed below.
Infection, Immunity and Cardiovascular Disease seminars
Friday 10th December at 12:30pm (GMT)
Speaker - Dr David Adlam, University of Leicester
Title - 'Spontaneous Coronary Artery Dissection: diagnosis, management and pathophysiology'
Wednesday 12th January 2022 at 2pm (GMT)
Speaker - Dr Tijana Mitić, University of Edinburgh.
Title - TBC
Abstract - TBC
Wednesday 23rd February 2022 at 2pm (GMT)
Speaker - Dr Pedro Moura Alves, University of Oxford.
Title - 'AhR sensing bacterial quorum during infection'
Abstract - The interaction between a bacterial pathogen and its host can be viewed as an “arms race” in which each participant continuously responds to the evolving strategies of the other partner. A mechanism allowing bacteria to rapidly adapt to such changing circumstances is provided by density-dependent cell-to-cell communication known as Quorum Sensing (QS). QS involves a hierarchy of signaling molecules, which in pathogenic bacteria is associated with biofilm formation and virulence regulation. Notably, some QS molecules are detected by the host, and these can provoke specific immune responses. However, the receptors and their signaling pathways that the host uses to eavesdrop on bacteria remain poorly understood. We hypothesized that if a host sensor can detect and differentiate between bacterial QS molecules and their expression patterns, it will allow hosts to customize their immune responses according to the stage and state of infection. We have previously discovered that the host aryl hydrocarbon receptor (AhR) directly recognizes bacterial pigmented virulence factors, such as Pseudomonas aeruginosa (P.aeruginosa) phenazines. Currently, our results demonstrate that infected hosts show differential modulation of host AhR signaling over the course of P. aeruginosa infection in zebrafish, mice, and human cells. Further, modulation of AhR signaling depends on the relative abundances of several classes of P. aeruginosa QS molecules. In vitro and in vivo studies show that the AhR not only detects P. aeruginosa QS molecules in a qualitative way but also quantifies their relative abundances. Quantitative assessment enables the host to sense bacterial community densities that may have distinct gene expression programs and infection dynamics, and thereby to regulate the scale and intensity of host defense mechanisms, which can range from induction of inflammatory mediators to immune cell recruitment and bacterial clearance. We propose that by spying on bacterial quorum, the AhR acts as a major sensor of infection dynamics, capable of orchestrating host defense according to the status quo of infection.
Neuroscience seminars
There are currently no upcoming seminars.
Oncology and Metabolism seminars
Friday 3rd December at 1pm (GMT)
Speaker - Dr Katherine Brooke-Wavell, Loughborough University.
Title - 'Bone adaptation to exercise- from postmenopausal hips to fast bowlers’ spines'.
Biography - Katherine researches the influence of exercise on bone health, having conducted research in populations ranging from older people to elite athletes. She will give an overview of this research and colleagues will describe some recent studies. Dr Chris Hartley (currently lecturer at Birmingham City University) will talk about his recent PhD study examining influence of high impact (hopping) exercise on bone and joint outcomes in postmenopausal women. Dr Simin Li (senior lecturer, Loughborough University) will summarise recent findings using high resolution quantitative computed tomography to visualise and quantify microarchitectural adaptation to this exercise. Dr Pete Alway (postdoctoral researcher, Loughborough University) will describe the adaptation of the lumbar spine to high magnitude loading in elite cricket fast bowlers.
Friday 10th December at 1pm
Internal Seminar Series
Virtual Sheffield Paediatric Endocrine Teaching - ViSPET
Our departmental Paediatric Endocrine Teaching will usually take place on the 2nd Monday (15:00) and 4th Wednesday (16:00) of the month.
Please click on the topic to access the live and recorded presentations.
- Past recorded webinars
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Date
Time
Topic
Speaker
11/05/2020
1500
Nils Krone - Sheffield
27/05/2020
1600
Tim Cheetham - Newcastle
08/06/2020
1500
Alan Rogol - University of Virginia
24/06/2020
1600
Genetics of pituitary disorders
Mehul Dattani - London
13/07/2020
1500
Senthil Senniappan - Liverpool
22/07/2020
1600
Guftar Shaikh - Glasgow
10/08/2020
1500
Louise Metherell - London
26/08/2020
1600
Nick Bishop - Sheffield
14/09/2020
1500
Paul Arundel - Sheffield
23/09/2020 1600 Diagnosis and management of rare diabetes Tim Barrett - Birmingham 12/10/2020 1500 Endocrine management of Late Effects Paul Dimitri - Sheffield ESPE CONNECT ONLINE 06/11 - 14/11/2020 25/11/2020 1600 Diagnosis and management of hypogonadism Faisal Ahmed - Glasgow
For questions and suggestions, please contact Nils Krone (n.krone@sheffield.ac.uk)