Events in The Medical School

Infection, Immunity and Cardiovascular Disease seminars

Wednesday 21st April 2021

Time - 2pm - 3pm (BST)

Speaker - Dr Sveta Chakrabarti, Indian Institute of Science.

Title - 'Drosophila blood cells link immunity to wound response'.

Abstract

Innate immunity provides the first line of defense against invading organisms. Organisms sense pathogens using specific signatures called microbe-associated molecular patterns (MAMPs) found in microbes such as lipopolysaccharide, peptidoglycan, and lipoproteins. Upon recognizing these signatures, the host activates signaling cascades that cause immune effectors and regulators' expression. Animals have acquired the capacity to recognize signals called damage-associated molecular patterns (DAMPs). DAMPs are associated with tissue damage and wounding, and are involved in activating specific pathways involved in repair or in inflammation. Numerous DAMPs have been identified in mammals, which include cellular components such as ATP, uric acid, nucleic acids, and the components of actin cytoskeleton. However, the pathway and effector mechanisms that are activated by DAMPs and the cellular response to these cues are poorly understood.

When damage occurs in adult Drosophila, not only is there a local response of the injured tissue, but a coordinated action across different tissues is elicited to help the organism overcome the deleterious effect of an injury. In our recently published work, we show that the production of hydrogen peroxide from a wound activates flies blood cells (also known as hemocytes). In some ways, hydrogen peroxide acts as a DAMP signal to help home hemocytes damage and activate them. Hemocytes contribute to increasing levels of hydrogen peroxide near the wound by producing it using an oxidase called DUOX. We provide evidence that production of the cytokine Upd3 involves the accumulation of intracellular ROS in hemocytes, which is facilitated by the diffusion of hydrogen peroxide through a newly identified channel protein, Prip. Thus, levels of ROS inside hemocytes appear as a critical mechanism that regulates the inflammatory response of hemocytes. The innate immune pathway Toll is also induced on injury and protects flies. This Toll pathway activation following a wound protects flies from subsequent infection with a bacterium like Enterococcus faecali.

Wednesday 19th May 2021

Time - 2pm - 3pm (BST)

Speaker - Professor Charalambos Antoniades, University of Oxford.

Title - 'Perivascular fat: Atherapeutic target or a window to coronary inflammation?'

Abstract - To follow.

These seminars will be hosted in Blackboard, please contact iicd@sheffield.ac.uk if you would like to attend. 

These seminars are restricted to University staff and students and NHS colleagues.

Neuroscience seminars

There are currently no upcoming seminars.

Oncology and Metabolism seminars

O&M Seminar Series

These seminars will be hosted in Blackboard, please contact om-communications@sheffield.ac.uk if you would like to attend. These seminars are restricted to University staff and students and NHS colleagues.

Virtual Sheffield Paediatric Endocrine Teaching - ViSPET

Our departmental Paediatric Endocrine Teaching will usually take place on the 2^nd Monday (15:00) and 4^th Wednesday (16:00) of the month. 

Please click on the topic to access the live and recorded presentations. 

Past recorded webinars

Date	Time	Topic	Speaker
11/05/2020	1500	CAH - management aspects in the UK and beyond	Nils Krone - Sheffield
27/05/2020	1600	Thyroid - Stuff I have learned	Tim Cheetham - Newcastle
08/06/2020	1500	Turner syndrome	Alan Rogol - University of Virginia
24/06/2020	1600	Genetics of pituitary disorders	Mehul Dattani - London
13/07/2020	1500	Neonatal hypoglycaemia and Congenital hyperinsulinism	Senthil Senniappan - Liverpool
22/07/2020	1600	Management of patients with Prader Willi syndrome	Guftar Shaikh - Glasgow
10/08/2020	1500	The expanding spectrum of inherited adrenal insufficiency	Louise Metherell - London
26/08/2020	1600	Hypophosphatemic rickets	Nick Bishop - Sheffield
14/09/2020	1500	New treatments for bone disease	Paul Arundel - Sheffield
23/09/2020	1600	Diagnosis and management of rare diabetes	Tim Barrett - Birmingham
12/10/2020	1500	Endocrine management of Late Effects	Paul Dimitri - Sheffield
		ESPE CONNECT ONLINE 06/11 - 14/11/2020
25/11/2020	1600	Diagnosis and management of hypogonadism	Faisal Ahmed - Glasgow

For questions and suggestions, please contact Nils Krone (n.krone@sheffield.ac.uk)