Events in The Medical School
All of the upcoming events in The Medical School are listed below.
Infection, Immunity and Cardiovascular Disease seminars
Wednesday 21st April 2021
Time - 2pm - 3pm (BST)
Speaker - Dr Sveta Chakrabarti, Indian Institute of Science.
Title - 'Drosophila blood cells link immunity to wound response'.
Innate immunity provides the first line of defense against invading organisms. Organisms sense pathogens using specific signatures called microbe-associated molecular patterns (MAMPs) found in microbes such as lipopolysaccharide, peptidoglycan, and lipoproteins. Upon recognizing these signatures, the host activates signaling cascades that cause immune effectors and regulators' expression. Animals have acquired the capacity to recognize signals called damage-associated molecular patterns (DAMPs). DAMPs are associated with tissue damage and wounding, and are involved in activating specific pathways involved in repair or in inflammation. Numerous DAMPs have been identified in mammals, which include cellular components such as ATP, uric acid, nucleic acids, and the components of actin cytoskeleton. However, the pathway and effector mechanisms that are activated by DAMPs and the cellular response to these cues are poorly understood.
When damage occurs in adult Drosophila, not only is there a local response of the injured tissue, but a coordinated action across different tissues is elicited to help the organism overcome the deleterious effect of an injury. In our recently published work, we show that the production of hydrogen peroxide from a wound activates flies blood cells (also known as hemocytes). In some ways, hydrogen peroxide acts as a DAMP signal to help home hemocytes damage and activate them. Hemocytes contribute to increasing levels of hydrogen peroxide near the wound by producing it using an oxidase called DUOX. We provide evidence that production of the cytokine Upd3 involves the accumulation of intracellular ROS in hemocytes, which is facilitated by the diffusion of hydrogen peroxide through a newly identified channel protein, Prip. Thus, levels of ROS inside hemocytes appear as a critical mechanism that regulates the inflammatory response of hemocytes. The innate immune pathway Toll is also induced on injury and protects flies. This Toll pathway activation following a wound protects flies from subsequent infection with a bacterium like Enterococcus faecali.
Wednesday 19th May 2021
Time - 2pm - 3pm (BST)
Speaker - Professor Charalambos Antoniades, University of Oxford.
Title - 'Perivascular fat: Atherapeutic target or a window to coronary inflammation?'
Abstract - To follow.
These seminars will be hosted in Blackboard, please contact email@example.com if you would like to attend.
These seminars are restricted to University staff and students and NHS colleagues.
There are currently no upcoming seminars.
Oncology and Metabolism seminars
O&M Seminar Series
Date & Time:
|Friday 26th March 2021 at 1pm||"Causes and consequences of cell cycle heterogeneity"||Dr Alexis Barr, Imperial College London||Cancer|
|Friday 23rd April 2021 at 1pm||"Next-generation prostheses for joint replacement"||Professor Paul Beaulé, University of Ottowa, Canada||Bone & Joint (Mellanby)|
|Friday 30th April 2021 at 1pm||Keratins as guardians of colon health: Modeling of colitis and colorectal cancer||Professor Diana Toivola, Åbo Akademi University, Finland.||Cancer|
|Friday 7th May 2021 at 1pm||Internal Seminar Series|
|Friday 14th May 2021 at 1pm||"Functional genomics approaches for understanding the genetics of complex diseases"||Dr Gisela Orozco, University of Manchester.||Bone & Joint (Mellanby)|
|Friday 21st May 2021 at 1pm||Internal Seminar Series|
These seminars will be hosted in Blackboard, please contact firstname.lastname@example.org if you would like to attend. These seminars are restricted to University staff and students and NHS colleagues.
Virtual Sheffield Paediatric Endocrine Teaching - ViSPET
Our departmental Paediatric Endocrine Teaching will usually take place on the 2nd Monday (15:00) and 4th Wednesday (16:00) of the month.
Please click on the topic to access the live and recorded presentations.
- Past recorded webinars
Nils Krone - Sheffield
Tim Cheetham - Newcastle
Alan Rogol - University of Virginia
Genetics of pituitary disorders
Mehul Dattani - London
Senthil Senniappan - Liverpool
Guftar Shaikh - Glasgow
Louise Metherell - London
Nick Bishop - Sheffield
Paul Arundel - Sheffield
23/09/2020 1600 Diagnosis and management of rare diabetes Tim Barrett - Birmingham 12/10/2020 1500 Endocrine management of Late Effects Paul Dimitri - Sheffield ESPE CONNECT ONLINE 06/11 - 14/11/2020 25/11/2020 1600 Diagnosis and management of hypogonadism Faisal Ahmed - Glasgow
For questions and suggestions, please contact Nils Krone (email@example.com)
Events at the University
Browse upcoming public lectures, exhibitions, family events, concerts, shows and festivals across the University.