Events in The Medical School

Infection, Immunity and Cardiovascular Disease seminars

Wednesday 7th October 2020

Time: 2pm - 3pm (BST)

Title: Single-Cell Biology of Barrier Tissues and COVID-19.

Speaker: Dr. Jose Ordovas-Montanes, Boston Children's Hospital, Harvard Medical School, Harvard Stem Cell Institute, and Broad Institute.

Abstract: Our lab is focused on understanding the principles of how inflammation drives sensing, adaptation and memory formation by essential or resident cell types in barrier tissues. In this talk, I will discuss some of our recent studies utilizing single-cell genomics to comprehensively map the cell types, subsets, and states that compose human barrier tissues. I will specifically discuss our findings related to health and disease in the nasal and intestinal mucosa, recent work to understand the potential cellular targets of SARS-CoV-2 in these tissues, and our ongoing efforts to understand distinct outcomes in Covid-19 patients.

Speaker Bio: Dr. José Ordovas-Montañes, PhD is a principal investigator at Boston Children’s Hospital, assistant professor at Harvard Medical School, associate member at the Broad Institute, and principal faculty at Harvard Stem Cell Institute. He received his BA in Biology from Tufts University, and PhD from Harvard University, where he studied how the nervous system and the immune system function together as the principal sensory interfaces between the internal and external environments. As a Damon Runyon Postdoctoral Fellow at MIT, the Broad Institute, and the Ragon Institute, he began charting maps of human gut and airway, and discovered how human stem cells can be shaped by, and remember, inflammation. Jose started his group in 2019 at Boston Children's Hospital, where his group seeks to understand the principles of how inflammation drives memory formation in human barrier tissues. He is supported by a fantastic team of students and colleagues.

This seminar will be hosted in Blackboard, please contact iicd@sheffield.ac.uk if you would like to attend.

Wednesday 11th November 2020

Time: 2pm - 3pm (GMT)

Title: Nck adaptor proteins in atherogenic endothelial activation.

Speaker: Professor Wayne Orr, LSU Health Shreveport, Louisiana.

Abstract: Alterations in hemodynamic shear stress at atherosclerosis-prone sites promotes endothelial activation, characterized by nuclear factor-κB (NF-κB)-driven expression of cell adhesion molecules that mediate leukocyte homing. In addition to flow patterns, proinflammatory cytokines (e.g. IL-1β) and oxidized lipoproteins also promote NF-κB-dependent endothelial activation to drive the early stages of plaque development. While the recent CANTOS trial using an IL-1β antagonist highlights the potential for treating atherogenic inflammation beyond lipid lowering therapies alone, our understanding of how endothelial activation contributes to this effect remains limited. My laboratory has identified the Nck family of signaling adaptors, including both Nck1 and Nck2, as critical regulators of the endothelial response to flow. In this presentation, I will discuss our recent data on the differential role of Nck1 and Nck2 in regulating flow-induced changes in endothelial phenotype and novel data linking Nck1 to IL-1 receptor signaling in the endothelium.

This seminar will be hosted in Blackboard, please contact iicd@sheffield.ac.uk if you would like to attend.

Neuroscience seminars

There are currently no upcoming seminars.

Oncology and Metabolism seminars

Virtual Sheffield Paediatric Endocrine Teaching - ViSPET

Our departmental Paediatric Endocrine Teaching will usually take place on the 2^nd Monday (15:00) and 4^th Wednesday (16:00) of the month. 

Please click on the topic to access the live and recorded presentations. 

Past recorded webinars

Date	Time	Topic	Speaker
11/05/2020	1500	CAH - management aspects in the UK and beyond	Nils Krone - Sheffield
27/05/2020	1600	Thyroid - Stuff I have learned	Tim Cheetham - Newcastle
08/06/2020	1500	Turner syndrome	Alan Rogol - University of Virginia
24/06/2020	1600	Genetics of pituitary disorders	Mehul Dattani - London
13/07/2020	1500	Neonatal hypoglycaemia and Congenital hyperinsulinism	Senthil Senniappan - Liverpool
22/07/2020	1600	Management of patients with Prader Willi syndrome	Guftar Shaikh - Glasgow
10/08/2020	1500	The expanding spectrum of inherited adrenal insufficiency	Louise Metherell - London
26/08/2020	1600	Hypophosphatemic rickets	Nick Bishop - Sheffield
14/09/2020	1500	New treatments for bone disease	Paul Arundel - Sheffield

Current dates and topics are listed below:

For questions and suggestions, please contact Nils Krone (n.krone@sheffield.ac.uk) or Gillian Griffiths (g.l.griffiths@sheffield.ac.uk). 

Friday 19 June 2020

Hosted by Oncology

Time: 1:00 - 2:00pm (via Webinar)

Title: "Patient-derived models reveal novel molecular insights into Ewing sarcoma"

Speaker: Professor Sue Burchill, University of Leeds

If you would like to join the webinar, please email Gillian Griffiths (g.l.griffiths@sheffield.ac.uk) by Wednesday 17 June 2020.

Internal seminar series

The department also holds internal seminars - for more information, see the full programme.