Dr Carolyn Staton

PhD, MBiochem, SFHEA

Academic Unit of Medical Education

Senior Lecturer

c.a.staton@sheffield.ac.uk
+44 114 215 9063

The Medical School

Full contact details

Dr Carolyn Staton
Academic Unit of Medical Education
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

I joined the University in 1997 as a PhD student. During the course of my PhD, I discovered a number of novel anti-angiogenic agents which were patented by the University of Sheffield and led to me being given the AACR – Novartis Scholar In Training Award (2000) and the BACR Translational Research Award (2005) - both in open competition.

In 2004 I was appointed to a lectureship and was awarded the Certificate in Learning and Teaching in 2009. In 2013 I designed and established the MSc(Res) in Translational Oncology and in 2016 I became a Senior Fellow of the Higher Education Academy and Senior Lecturer. I was the departmental director of learning and teaching for the Department of Oncology & Metabolism from 2018-2021.

I am currently the Director of Intercalated Studies, the Deputy Director of the Personal Academic Tutoring scheme, the medical school Disability Liaison officer for PGT, and the History of Medicine Lead. I am also a member of the University Discipline Committee.

Research interests

My current research interests are student perceptions and decision-making processes around intercalation.

Collaborative research with colleagues in Sheffield also includes investigations into incidentaloma in modern medicine, the challenges and potential solutions.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Cole-Healy Z, Vergani P, Hunter K, Brown NJ, Reed MWR & Staton CA (2015) The relationship between semaphorin 3C and microvessel density in the progression of breast and oral neoplasia. Experimental and Molecular Pathology, 99(1), 19-24.
Young RJ, Woll PJ, Staton CA, Reed MWR & Brown NJ (2014) Vascular-targeted agents for the treatment of angiosarcoma.. Cancer Chemother Pharmacol, 73(2), 259-270.
Staton CA, Koay I, Wu JM, Hoh L, Reed MWR & Brown NJ (2013) Neuropilin-1 and neuropilin-2 expression in the adenoma-carcinoma sequence of colorectal cancer.. Histopathology, 62(6), 908-915.
Wu JM & Staton CA (2012) Anti-angiogenic drug discovery: lessons from the past and thoughts for the future.. Expert Opin Drug Discov, 7(8), 723-743.
Wild JRL, Staton CA, Chapple K & Corfe BM (2012) Neuropilins: expression and roles in the epithelium.. Int J Exp Pathol, 93(2), 81-103.
Hsu Y-P, Staton CA, Cross N & Buttle DJ (2012) Anti-angiogenic properties of ADAMTS-4 in vitro.. Int J Exp Pathol, 93(1), 70-77.
Mackinder MA, Evans CA, Chowdry J, Staton CA & Corfe BM (2012) Alteration in composition of keratin intermediate filaments in a model of breast cancer progression and the potential to reverse hallmarks of metastasis.. Cancer Biomark, 12(2), 49-64.
Valluru M, Staton CA, Reed MWR & Brown NJ (2011) Transforming Growth Factor-β and Endoglin Signaling Orchestrate Wound Healing.. Front Physiol, 2, 89. View this article in WRRO
Staton CA, Shaw LA, Valluru M, Hoh L, Koay I, Cross SS, Reed MW & Brown NJ (2011) Expression of class 3 semaphorins and their receptors in human breast neoplasia.. Histopathology, 59(2), 274-282.
Valluru M, Brown NJ, Cross SS, Reed MWR & Staton CA (2011) Blood vessel characterization in human dermal wound repair and scarring.. Br J Dermatol, 165(1), 221-224.
Yu DCW, Bury JP, Tiernan J, Waby JS, Staton CA & Corfe BM (2011) Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenoma.. Mol Cancer, 10, 27. View this article in WRRO
Bluff JE, Amarzguioui M, Slattery J, Reed MWR, Brown NJ & Staton CA (2011) Anti-tissue factor short hairpin RNA inhibits breast cancer growth in vivo.. Breast Cancer Res Treat, 128(3), 691-701.
Yu DCW, Waby JS, Chirakkal H, Staton CA & Corfe BM (2010) Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation.. Mol Cancer, 9, 276. View this article in WRRO
Staton CA, Valluru M, Hoh L, Reed MWR & Brown NJ (2010) Angiopoietin-1, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring.. Br J Dermatol, 163(5), 920-927.
Kumar I, Staton CA, Cross SS, Reed MWR & Brown NJ (2009) Angiogenesis, vascular endothelial growth factor and its receptors in human surgical wounds.. Br J Surg, 96(12), 1484-1491.
Bluff JE, Menakuru SR, Cross SS, Higham SE, Balasubramanian SP, Brown NJ, Reed MW & Staton CA (2009) Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease.. Br J Cancer, 101(4), 666-672. View this article in WRRO
Staton CA, Reed MWR & Brown NJ (2009) A critical analysis of current in vitro and in vivo angiogenesis assays.. Int J Exp Pathol, 90(3), 195-221.

All publications

Books

Staton C, Lewis CE & Bicknell R (2007) Angiogenesis Assays: A Critical Appraisal of Current Techniques. Wiley-Blackwell.

Journal articles

Kapoore RV, Coyle R, Staton CA, Brown NJ & Vaidyanathan S (2017) Influence of washing and quenching in profiling the metabolome of adherent mammalian cells: a case study with the metastatic breast cancer cell line MDA-MB-231. Analyst, 142(11), 2038-2049. View this article in WRRO
Kapoore RV, Coyle R, Staton CA, Brown NJ & Vaidyanathan S (2015) Cell line dependence of metabolite leakage in metabolome analyses of adherent normal and cancer cell lines. Metabolomics, 11(6), 1743-1755. View this article in WRRO
Cole-Healy Z, Vergani P, Hunter K, Brown NJ, Reed MWR & Staton CA (2015) The relationship between semaphorin 3C and microvessel density in the progression of breast and oral neoplasia. Experimental and Molecular Pathology, 99(1), 19-24.
Young RJ, Woll PJ, Staton CA, Reed MWR & Brown NJ (2014) Vascular-targeted agents for the treatment of angiosarcoma.. Cancer Chemother Pharmacol, 73(2), 259-270.
Wild J, Gunarwardene A, Staton C, Chapple K & Corfe B (2013) Expression of neuropilin-1 in the normal colonic epithelium is enteroendocrine-like. International Journal of Surgery, 11(8), 600-600.
Narramore R, Wild J, Corfe B, Staton C, Yu D & Chapple K (2013) Alteration in enteroendocrine cell population in early colonic neoplasia. International Journal of Surgery, 11(8), 624-624.
Staton CA, Koay I, Wu JM, Hoh L, Reed MWR & Brown NJ (2013) Neuropilin-1 and neuropilin-2 expression in the adenoma-carcinoma sequence of colorectal cancer.. Histopathology, 62(6), 908-915.
Wu JM & Staton CA (2012) Anti-angiogenic drug discovery: lessons from the past and thoughts for the future.. Expert Opin Drug Discov, 7(8), 723-743.
Wild JRL, Staton CA, Chapple K & Corfe BM (2012) Neuropilins: expression and roles in the epithelium.. Int J Exp Pathol, 93(2), 81-103.
Hsu Y-P, Staton CA, Cross N & Buttle DJ (2012) Anti-angiogenic properties of ADAMTS-4 in vitro.. Int J Exp Pathol, 93(1), 70-77.
Mackinder MA, Evans CA, Chowdry J, Staton CA & Corfe BM (2012) Alteration in composition of keratin intermediate filaments in a model of breast cancer progression and the potential to reverse hallmarks of metastasis.. Cancer Biomark, 12(2), 49-64.
Staton CA (2011) Class 3 semaphorins and their receptors in physiological and pathological angiogenesis.. Biochem Soc Trans, 39(6), 1565-1570.
Valluru M, Staton CA, Reed MWR & Brown NJ (2011) Transforming Growth Factor-β and Endoglin Signaling Orchestrate Wound Healing.. Front Physiol, 2, 89. View this article in WRRO
Staton CA, Hoh L, Baldwin A, Shaw L, Globe J, Cross SS, Reed MW & Brown NJ (2011) Angiopoietins 1 and 2 and Tie-2 receptor expression in human ductal breast disease.. Histopathology, 59(2), 256-263.
Staton CA, Shaw LA, Valluru M, Hoh L, Koay I, Cross SS, Reed MW & Brown NJ (2011) Expression of class 3 semaphorins and their receptors in human breast neoplasia.. Histopathology, 59(2), 274-282.
Young RJ, Brown NJ, Staton CA, Reed MW & Woll PJ (2011) Functional studies in two angiosarcoma cell lines.. J Clin Oncol, 29(15_suppl), e20511.
Gunawardene AR, Corfe BM & Staton CA (2011) Classification and functions of enteroendocrine cells of the lower gastrointestinal tract.. Int J Exp Pathol, 92(4), 219-231.
Valluru M, Brown NJ, Cross SS, Reed MWR & Staton CA (2011) Blood vessel characterization in human dermal wound repair and scarring.. Br J Dermatol, 165(1), 221-224.
Yu DCW, Bury JP, Tiernan J, Waby JS, Staton CA & Corfe BM (2011) Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenoma.. Mol Cancer, 10, 27. View this article in WRRO
Bluff JE, Amarzguioui M, Slattery J, Reed MWR, Brown NJ & Staton CA (2011) Anti-tissue factor short hairpin RNA inhibits breast cancer growth in vivo.. Breast Cancer Res Treat, 128(3), 691-701.
Krajewska E, Lewis C, Staton C, MacGowan A & MacNeil S (2011) New insights into induction of early-stage neovascularization in an improved tissue-engineered model of psoriasis.. J Tissue Eng Regen Med, 5(5), 363-374.
Yu DCW, Waby JS, Chirakkal H, Staton CA & Corfe BM (2010) Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation.. Mol Cancer, 9, 276. View this article in WRRO
Staton CA, Valluru M, Hoh L, Reed MWR & Brown NJ (2010) Angiopoietin-1, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring.. Br J Dermatol, 163(5), 920-927.
Krajewska E, Lewis CE, Chen Y-Y, Welford A, Tazzyman S & Staton CA (2010) A novel fragment derived from the beta chain of human fibrinogen, beta43-63, is a potent inhibitor of activated endothelial cells in vitro and in vivo.. Br J Cancer, 102(3), 594-601. View this article in WRRO
Kumar I, Staton CA, Cross SS, Reed MWR & Brown NJ (2009) Angiogenesis, vascular endothelial growth factor and its receptors in human surgical wounds.. Br J Surg, 96(12), 1484-1491.
Staton CA, Brown NJ & Reed MWR (2009) Current status and future prospects for anti-angiogenic therapies in cancer. EXPERT OPIN DRUG DIS, 4(9), 961-979.
Bluff JE, Menakuru SR, Cross SS, Higham SE, Balasubramanian SP, Brown NJ, Reed MW & Staton CA (2009) Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease.. Br J Cancer, 101(4), 666-672. View this article in WRRO
Staton CA, Reed MWR & Brown NJ (2009) A critical analysis of current in vitro and in vivo angiogenesis assays.. Int J Exp Pathol, 90(3), 195-221.
Menakuru SR, Brown NJ, Staton CA & Reed MWR (2008) Angiogenesis in pre-malignant conditions.. Br J Cancer, 99(12), 1961-1966. View this article in WRRO
Kumar I, Balasubraminian S, Staton C, Brown N & Reed M (2008) Neuropilins 1 and 2 play a role in human wound healing. European Journal of Surgical Oncology (EJSO), 34(10), 1194-1194.
Bluff JE, Brown NJ, Reed MWR & Staton CA (2008) Tissue factor, angiogenesis and tumour progression.. Breast Cancer Res, 10(2), 204. View this article in WRRO
Staton CA, Chetwood ASA, Cameron IC, Cross SS, Brown NJ & Reed MWR (2007) The angiogenic switch occurs at the adenoma stage of the adenoma carcinoma sequence in colorectal cancer.. Gut, 56(10), 1426-1432.
Staton CA, Lewis C & Bicknell R (2007) Preface. Angiogenesis Assays: A Critical Appraisal of Current Techniques.
Staton CA, Kumar I, Reed MWR & Brown NJ (2007) Neuropilins in physiological and pathological angiogenesis.. J Pathol, 212(3), 237-248.
Staton CA, Stribbling SM, García-Echeverría C, Bury JP, Tazzyman S, Lewis CE & Brown NJ (2007) Identification of key residues involved in mediating the in vivo anti-tumor/anti-endothelial activity of Alphastatin.. J Thromb Haemost, 5(4), 846-854.
Staton CA & Lewis CE (2005) Angiogenesis inhibitors found within the haemostasis pathway.. J Cell Mol Med, 9(2), 286-302.
Staton CA, Stribbling SM, Tazzyman S, Hughes R, Brown NJ & Lewis CE (2004) Current methods for assaying angiogenesis in vitro and in vivo.. Int J Exp Pathol, 85(5), 233-248.
Staton CA, Brown NJ, Rodgers G, Corke KP, Tazzyman S, Underwood JCE & Lewis CE (2004) OC9 ALPHASTATIN, A 24-AMINO ACID FRAGMENT OF FIBRINOGEN IS A NOVEL ANTI-ANGIOGENIC AND ANTI-VASCULAR AGENT. Microcirculation, 11(6), 531-532.
Staton CA, Brown NJ, Rodgers GR, Corke KP, Tazzyman S, Underwood JCE & Lewis CE (2004) Alphastatin, a 24-amino acid fragment of human fibrinogen, is a potent new inhibitor of activated endothelial cells in vitro and in vivo.. Blood, 103(2), 601-606.
Staton CA, Brown NJ & Lewis CE (2003) The role of fibrinogen and related fragments in tumour angiogenesis and metastasis.. Expert Opin Biol Ther, 3(7), 1105-1120.
Brown NJ, Staton CA, Rodgers GR, Corke KP, Underwood JCE & Lewis CE (2002) Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model.. Br J Cancer, 86(11), 1813-1816. View this article in WRRO
Bootle-Wilbraham CA, Tazzyman S, Thompson WD, Stirk CM & Lewis CE (2001) Fibrin fragment E stimulates the proliferation, migration and differentiation of human microvascular endothelial cells in vitro.. Angiogenesis, 4(4), 269-275.
Bootle-Wilbraham CA, Tazzyman S, Marshall JM & Lewis CE (2000) Fibrinogen E-fragment inhibits the migration and tubule formation of human dermal microvascular endothelial cells in vitro.. Cancer Res, 60(17), 4719-4724.
Jeziore-Sassoon Y, Hamblin PA, Bootle-Wilbraham CA, Poole PS & Armitage JP (1998) Metabolism is required for chemotaxis to sugars in Rhodobacter sphaeroides.. Microbiology, 144 ( Pt 1), 229-239.

Chapters

Staton CA & Smith EJ (2006) Tubule Formation Assays In Staton C, Lewis CE & Bicknell R (Ed.), Angiogenesis Assays: A Critical Appraisal of Current Techniques (pp. 65-88). Wiley-Blackwell
Staton CA & Lewis CE (2006) Alphastatin: a pluripotent inhibitor of activated endothelial cells In Siemann DW (Ed.), Vascular-targeted therapies in oncology (pp. 205-220). Wiley-Blackwell
Staton CA & Lewis CE (2005) Haemostatic Regulators as drug targets in tumour angiogenesis In Weber GF (Ed.), Cancer therapy (pp. 187-220). Taylor & Francis
Staton CA, Brown NJ & Lewis CE (2004) Effects of fibrinogen and associated peptide fragments on the activation of human endothelial cells by VEGF in vitro In Harmey JH (Ed.), VEGF and Cancer (pp. 117-132). Springer

Conference proceedings papers

Wild JRL, Staton CA, Chapple KS & Corfe BM (2013) Comparison and Optimisation of a strategy to isolate a single cell population of epithelial cells from the crypt compartment of the murine colon. BRITISH JOURNAL OF SURGERY, Vol. 100 (pp 99-99)
Wild JRL, Gunawardene AR, Staton CA, Chapple KS & Corfe BM (2013) Neuropilin-1 expression in the normal colon is enteroendocrine-like. BRITISH JOURNAL OF SURGERY, Vol. 100 (pp 123-123)
Bury JP, Riley S, Evans CA, Williams EA, Staton CA, Murabito E, Smallbone K & Corfe BM (2012) Why do Patients get Metachronous Colorectal Adenomas?. JOURNAL OF PATHOLOGY, Vol. 228 (pp S3-S3)
Wild JRL, Khan AQ, Li NX, Staton C, Chapple K & Corfe BM (2012) Neuropilin-1: A predictor of early carcinogenesis in the colonic epithelium. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 24-24)
Khan AQ, Wild J, Nai X, Brown S, Staton C, Brown S & Corfe B (2012) Faecal butyrate levels have different effect on cancer and adenoma tissues: Suggestion of early beneficial role of butyrate during carcinogenesis. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 29-29)
Young R, Woll PJ, Staton CA, Reed MW & Brown NJ (2011) Targeting VEGF in Human Angiosarcoma Cell Lines in Vitro. EUROPEAN JOURNAL OF CANCER, Vol. 47 (pp S665-S665)
Young RJ, Tin A, Brown NJ, Staton C, Lee SM, Jital M & Woll P (2011) SERUM BIOMARKERS IN LUNG CANCER PATIENTS FROM TWO CLINICAL TRIALS OF CHEMOTHERAPY WITH OR WITHOUT THALIDOMIDE. J THORAC ONCOL, Vol. 6(6) (pp S1058-S1059)
Young RJ, Brown NJ, Staton CA, Reed MW & Woll PJ (2011) Functional studies in two angiosarcoma cell lines. JOURNAL OF CLINICAL ONCOLOGY, Vol. 29(15)
Lunj S, Staton CA, Holen I, Ballmer-Hofer K, Reed MW & Brown NJ (2011) Abstract 5131: Escape from breast cancer therapy, are neuropilins the key. Tumor Biology
Hsu YP, Staton CA & Buttle DJ (2010) ADAMTS-4 may regulate VEGF-stimulated angiogenesis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 91(6) (pp A32-A33)
Hsu YP, Staton CA & Buttle DJ (2010) Molecular interactions of ADAMTS-4 in the VEGFR2 signalling complex. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 91(2) (pp A30-A30)
Hsu YP, Staton CA & Buttle DJ (2009) The molecular interactions involved in VEGF-induced signalling pathways. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 90(2) (pp A114-A114)
Bluff JE, Cross SS, Brown NJ, Reed MW & Staton CA (2008) Assessment of angiogenesis in the hyperplasia preinvasive, invasive breast carcinoma sequence. BREAST CANCER RESEARCH, Vol. 10 (pp S24-S24)
Staton CA, Yang Z, Reed MWR & Brown NJ (2008) Bevacizumab resistance in breast cancer: are neuropilins the key?. BREAST CANCER RESEARCH, Vol. 10 (pp S38-S38) View this article in WRRO

Teaching interests: I am passionate about student support and welfare and am the Disability Liaison Officer for the Medical School PGT students and the deputy academic director of the Personal Academic Tutor scheme (MBChB) and an associate director of student affairs. I am a personal academic tutor and/or mentor for undergraduate medical students, PGT and PGR students in the Medical school and was nominated for Best Academic Mentor in the Annual Academic Awards 2018.

Teaching activities

I am the Director of Intercalation studies and am the course lead of the BSc Medical Sciences Research and the BSc Medical Sciences (Surgery). I am also the History of Medicine SSC lead, the deputy ILA lead (phase 1 and 2), and involved in physiology teaching for first-year MBChB students as well as assessment setting and quality assurance.

I lead the Tumour Microenvironment and Literature Review modules on the MSc(Res) in Translational Oncology course and teach on the MSc in Molecular Medicine course.

Professional activities and memberships

Senior Fellow of the Higher Education Academy
Director of Intercalated Studies
Disability Liaison Officer for Medical School PGT
Academic Lead – BSc Medical Sciences Research
Academic Lead – BSc Medical Sciences (Surgery)
Academic Lead – History of Medicine SSC
Deputy Academic Director of the Personal Academic Tutor scheme for MBChB
Honorary Treasurer – British Microcirculation Society (2016-2021)
External Examiner at the University of Nottingham & Hull