Dr Carolyn Staton

PhD, MBiochem, SFHEA

Academic Unit of Medical Education

Senior Lecturer

c.a.staton@sheffield.ac.uk
+44 114 215 9063

Full contact details

Dr Carolyn Staton
Academic Unit of Medical Education
Office: EU35
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I first joined the University of Sheffield in 1997 as a PhD student. During the course of my PhD I discovered a number of novel anti-angiogenic agents which were patented by the University of Sheffield and led to me being given the AACR – Novartis Scholar In Training Award (2000) and the BACR Translational Research Award (2005) - both in open competition.

In 2004 I was appointed to a lectureship within the Microcirculation Research Group in the Academic Unit of Surgical Oncology.

I was awarded the Certificate in Learning and Teaching in 2009, in 2013 I designed and established the MSc(Res) in Translational Oncology and in 2016 I became a Senior Fellow of the Higher Education Academy. I am currently the Director of Intercalated Studies, Departmental Director of Learning and Teaching for the Department of Oncology & Metabolism, the Medical School Disability Liaison Officer and have been appointed by the Senate to the University Discipline Committee (2016-date).

Research interests

My research is mainly focused on the regulation of angiogenesis, the development of new blood vessels from the pre-existing vasculature, in wound healing and tumour development and progression to metastasis.

Collaborative research with colleagues in Sheffield also includes investigating the effects of HDACi on the expression of angiogenesis related proteins in cancer and the potential anti-cancer effects of metformin.

Publications

Show: Featured publications All publications

Journal articles

All publications

Books

  • Staton C, Lewis CE & Bicknell R (2007) Angiogenesis Assays: A Critical Appraisal of Current Techniques. Wiley-Blackwell. RIS download Bibtex download

Journal articles

Chapters

  • Staton CA & Smith EJ (2006) Tubule Formation Assays In Staton C, Lewis CE & Bicknell R (Ed.), Angiogenesis Assays: A Critical Appraisal of Current Techniques (pp. 65-88). Wiley-Blackwell RIS download Bibtex download
  • Staton CA & Lewis CE (2006) Alphastatin: a pluripotent inhibitor of activated endothelial cells In Siemann DW (Ed.), Vascular-targeted therapies in oncology (pp. 205-220). Wiley-Blackwell RIS download Bibtex download
  • Staton CA & Lewis CE (2005) Haemostatic Regulators as drug targets in tumour angiogenesis In Weber GF (Ed.), Cancer therapy (pp. 187-220). Taylor & Francis RIS download Bibtex download
  • Staton CA, Brown NJ & Lewis CE (2004) Effects of fibrinogen and associated peptide fragments on the activation of human endothelial cells by VEGF in vitro In Harmey JH (Ed.), VEGF and Cancer (pp. 117-132). Springer RIS download Bibtex download

Conference proceedings papers

  • Wild JRL, Staton CA, Chapple KS & Corfe BM (2013) Comparison and Optimisation of a strategy to isolate a single cell population of epithelial cells from the crypt compartment of the murine colon. BRITISH JOURNAL OF SURGERY, Vol. 100 (pp 99-99) RIS download Bibtex download
  • Wild JRL, Gunawardene AR, Staton CA, Chapple KS & Corfe BM (2013) Neuropilin-1 expression in the normal colon is enteroendocrine-like. BRITISH JOURNAL OF SURGERY, Vol. 100 (pp 123-123) RIS download Bibtex download
  • Bury JP, Riley S, Evans CA, Williams EA, Staton CA, Murabito E, Smallbone K & Corfe BM (2012) Why do Patients get Metachronous Colorectal Adenomas?. JOURNAL OF PATHOLOGY, Vol. 228 (pp S3-S3) RIS download Bibtex download
  • Wild JRL, Khan AQ, Li NX, Staton C, Chapple K & Corfe BM (2012) Neuropilin-1: A predictor of early carcinogenesis in the colonic epithelium. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 24-24) RIS download Bibtex download
  • Khan AQ, Wild J, Nai X, Brown S, Staton C, Brown S & Corfe B (2012) Faecal butyrate levels have different effect on cancer and adenoma tissues: Suggestion of early beneficial role of butyrate during carcinogenesis. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 29-29) RIS download Bibtex download
  • Young R, Woll PJ, Staton CA, Reed MW & Brown NJ (2011) Targeting VEGF in Human Angiosarcoma Cell Lines in Vitro. EUROPEAN JOURNAL OF CANCER, Vol. 47 (pp S665-S665) RIS download Bibtex download
  • Young RJ, Tin A, Brown NJ, Staton C, Lee SM, Jital M & Woll P (2011) SERUM BIOMARKERS IN LUNG CANCER PATIENTS FROM TWO CLINICAL TRIALS OF CHEMOTHERAPY WITH OR WITHOUT THALIDOMIDE. J THORAC ONCOL, Vol. 6(6) (pp S1058-S1059) RIS download Bibtex download
  • Young RJ, Brown NJ, Staton CA, Reed MW & Woll PJ (2011) Functional studies in two angiosarcoma cell lines. JOURNAL OF CLINICAL ONCOLOGY, Vol. 29(15) RIS download Bibtex download
  • Lunj S, Staton CA, Holen I, Ballmer-Hofer K, Reed MW & Brown NJ (2011) Abstract 5131: Escape from breast cancer therapy, are neuropilins the key. Tumor Biology RIS download Bibtex download
  • Hsu YP, Staton CA & Buttle DJ (2010) ADAMTS-4 may regulate VEGF-stimulated angiogenesis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 91(6) (pp A32-A33) RIS download Bibtex download
  • Hsu YP, Staton CA & Buttle DJ (2010) Molecular interactions of ADAMTS-4 in the VEGFR2 signalling complex. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 91(2) (pp A30-A30) RIS download Bibtex download
  • Hsu YP, Staton CA & Buttle DJ (2009) The molecular interactions involved in VEGF-induced signalling pathways. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 90(2) (pp A114-A114) RIS download Bibtex download
  • Bluff JE, Cross SS, Brown NJ, Reed MW & Staton CA (2008) Assessment of angiogenesis in the hyperplasia preinvasive, invasive breast carcinoma sequence. BREAST CANCER RESEARCH, Vol. 10 (pp S24-S24) RIS download Bibtex download
  • Staton CA, Yang Z, Reed MWR & Brown NJ (2008) Bevacizumab resistance in breast cancer: are neuropilins the key?. BREAST CANCER RESEARCH, Vol. 10 (pp S38-S38) View this article in WRRO RIS download Bibtex download
Research group

PhD students

  • Nashwa Shesha
Teaching interests

I am the course lead for the MSc(Res) Translational Oncology (OCPT01), a one year Masters course featuring five months of taught modules giving students a thorough grounding in all aspects of translational oncology before moving on to the six months research project. I am also Admissions Tutor and Module lead for OCP604 Tumour Microenvironment, OCP606 Literature Review and OCP607 Research Project.

I am module lead for MED673 Molecular Pathology of Cancer module, deputy module lead for MED6040 Molecular Basis of Tumourigenesis and Metastasis module, and teach on undergraduate modules MBB164 Molecular Biology and MBB334 Biochemical Basis of Human Disease.

I run the intercalation programme at the University of Sheffield Medical School, and have recently re-designed our intercalated BSc option, the BSc Medical Sciences Research and BSc Medical Sciences (Surgery).

I am passionate about student support and welfare, and am the Disability Liaison Officer for the Medical School PGT students and the department of Oncology& Metabolism. I am personal academic tutor and/or mentor for undergraduate medical students, PGT and PGR students in the Medical school and was nominated for Best Academic Mentor in the Annual Academic Awards 2018.

Professional activities
  • Senior Fellow of the Higher Education Academy
  • Departmental Director of Learning and Teaching
  • Programme Level Approach Lead for Department of Oncology & Metabolism
  • Director of Intercalated Studies
  • Disability Liaison Officer for Medical School PGT
  • Academic Lead – BSc Medical Sciences Research
  • Academic Lead – BSc Medical Sciences (Surgery)
  • Academic Lead – MSc(Res) Translational Oncology
  • Honorary Treasurer – British Microcirculation Society
  • External Examiner at the University of Chester