Dr Carolyn Staton
PhD, MBiochem, SFHEA
Academic Unit of Medical Education
Senior Lecturer
c.a.staton@sheffield.ac.uk
+44 114 215 9063
+44 114 215 9063
Office: EU35, The Medical School
Full contact details
Dr Carolyn Staton
Academic Unit of Medical Education
Office: EU35
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Academic Unit of Medical Education
Office: EU35
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
I first joined the University of Sheffield in 1997 as a PhD student. During the course of my PhD I discovered a number of novel anti-angiogenic agents which were patented by the University of Sheffield and led to me being given the AACR – Novartis Scholar In Training Award (2000) and the BACR Translational Research Award (2005) - both in open competition.
In 2004 I was appointed to a lectureship within the Microcirculation Research Group in the Academic Unit of Surgical Oncology.
I was awarded the Certificate in Learning and Teaching in 2009, in 2013 I designed and established the MSc(Res) in Translational Oncology and in 2016 I became a Senior Fellow of the Higher Education Academy. I am currently the Director of Intercalated Studies, Departmental Director of Learning and Teaching for the Department of Oncology & Metabolism, the Medical School Disability Liaison Officer and have been appointed by the Senate to the University Discipline Committee (2016-date).
- Research interests
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My research is mainly focused on the regulation of angiogenesis, the development of new blood vessels from the pre-existing vasculature, in wound healing and tumour development and progression to metastasis.
Collaborative research with colleagues in Sheffield also includes investigating the effects of HDACi on the expression of angiogenesis related proteins in cancer and the potential anti-cancer effects of metformin.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- The relationship between semaphorin 3C and microvessel density in the progression of breast and oral neoplasia. Experimental and Molecular Pathology, 99(1), 19-24.
- Vascular-targeted agents for the treatment of angiosarcoma.. Cancer Chemother Pharmacol, 73(2), 259-270.
- Neuropilin-1 and neuropilin-2 expression in the adenoma-carcinoma sequence of colorectal cancer.. Histopathology, 62(6), 908-915.
- Anti-angiogenic drug discovery: lessons from the past and thoughts for the future.. Expert Opin Drug Discov, 7(8), 723-743.
- Neuropilins: expression and roles in the epithelium.. Int J Exp Pathol, 93(2), 81-103.
- Anti-angiogenic properties of ADAMTS-4 in vitro.. Int J Exp Pathol, 93(1), 70-77.
- Alteration in composition of keratin intermediate filaments in a model of breast cancer progression and the potential to reverse hallmarks of metastasis.. Cancer Biomark, 12(2), 49-64.
- Transforming Growth Factor-β and Endoglin Signaling Orchestrate Wound Healing.. Front Physiol, 2, 89. View this article in WRRO
- Expression of class 3 semaphorins and their receptors in human breast neoplasia.. Histopathology, 59(2), 274-282.
- Blood vessel characterization in human dermal wound repair and scarring.. Br J Dermatol, 165(1), 221-224.
- Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenoma.. Mol Cancer, 10, 27. View this article in WRRO
- Anti-tissue factor short hairpin RNA inhibits breast cancer growth in vivo.. Breast Cancer Res Treat, 128(3), 691-701.
- Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation.. Mol Cancer, 9, 276. View this article in WRRO
- Angiopoietin-1, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring.. Br J Dermatol, 163(5), 920-927.
- Angiogenesis, vascular endothelial growth factor and its receptors in human surgical wounds.. Br J Surg, 96(12), 1484-1491.
- Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease.. Br J Cancer, 101(4), 666-672. View this article in WRRO
- A critical analysis of current in vitro and in vivo angiogenesis assays.. Int J Exp Pathol, 90(3), 195-221.
All publications
Books
- Angiogenesis Assays: A Critical Appraisal of Current Techniques. Wiley-Blackwell.
Journal articles
- Influence of washing and quenching in profiling the metabolome of adherent mammalian cells: a case study with the metastatic breast cancer cell line MDA-MB-231. Analyst, 142(11), 2038-2049. View this article in WRRO
- Cell line dependence of metabolite leakage in metabolome analyses of adherent normal and cancer cell lines. Metabolomics, 11(6), 1743-1755. View this article in WRRO
- The relationship between semaphorin 3C and microvessel density in the progression of breast and oral neoplasia. Experimental and Molecular Pathology, 99(1), 19-24.
- Vascular-targeted agents for the treatment of angiosarcoma.. Cancer Chemother Pharmacol, 73(2), 259-270.
- Expression of neuropilin-1 in the normal colonic epithelium is enteroendocrine-like. International Journal of Surgery, 11(8), 600-600.
- Alteration in enteroendocrine cell population in early colonic neoplasia. International Journal of Surgery, 11(8), 624-624.
- Neuropilin-1 and neuropilin-2 expression in the adenoma-carcinoma sequence of colorectal cancer.. Histopathology, 62(6), 908-915.
- Anti-angiogenic drug discovery: lessons from the past and thoughts for the future.. Expert Opin Drug Discov, 7(8), 723-743.
- Neuropilins: expression and roles in the epithelium.. Int J Exp Pathol, 93(2), 81-103.
- Anti-angiogenic properties of ADAMTS-4 in vitro.. Int J Exp Pathol, 93(1), 70-77.
- Alteration in composition of keratin intermediate filaments in a model of breast cancer progression and the potential to reverse hallmarks of metastasis.. Cancer Biomark, 12(2), 49-64.
- Class 3 semaphorins and their receptors in physiological and pathological angiogenesis.. Biochem Soc Trans, 39(6), 1565-1570.
- Transforming Growth Factor-β and Endoglin Signaling Orchestrate Wound Healing.. Front Physiol, 2, 89. View this article in WRRO
- Angiopoietins 1 and 2 and Tie-2 receptor expression in human ductal breast disease.. Histopathology, 59(2), 256-263.
- Expression of class 3 semaphorins and their receptors in human breast neoplasia.. Histopathology, 59(2), 274-282.
- Functional studies in two angiosarcoma cell lines.. J Clin Oncol, 29(15_suppl), e20511.
- Classification and functions of enteroendocrine cells of the lower gastrointestinal tract.. Int J Exp Pathol, 92(4), 219-231.
- Blood vessel characterization in human dermal wound repair and scarring.. Br J Dermatol, 165(1), 221-224.
- Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenoma.. Mol Cancer, 10, 27. View this article in WRRO
- Anti-tissue factor short hairpin RNA inhibits breast cancer growth in vivo.. Breast Cancer Res Treat, 128(3), 691-701.
- New insights into induction of early-stage neovascularization in an improved tissue-engineered model of psoriasis.. J Tissue Eng Regen Med, 5(5), 363-374.
- Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation.. Mol Cancer, 9, 276. View this article in WRRO
- Angiopoietin-1, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring.. Br J Dermatol, 163(5), 920-927.
- A novel fragment derived from the beta chain of human fibrinogen, beta43-63, is a potent inhibitor of activated endothelial cells in vitro and in vivo.. Br J Cancer, 102(3), 594-601. View this article in WRRO
- Angiogenesis, vascular endothelial growth factor and its receptors in human surgical wounds.. Br J Surg, 96(12), 1484-1491.
- Current status and future prospects for anti-angiogenic therapies in cancer. EXPERT OPIN DRUG DIS, 4(9), 961-979.
- Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease.. Br J Cancer, 101(4), 666-672. View this article in WRRO
- A critical analysis of current in vitro and in vivo angiogenesis assays.. Int J Exp Pathol, 90(3), 195-221.
- Angiogenesis in pre-malignant conditions.. Br J Cancer, 99(12), 1961-1966. View this article in WRRO
- Neuropilins 1 and 2 play a role in human wound healing. European Journal of Surgical Oncology (EJSO), 34(10), 1194-1194.
- Tissue factor, angiogenesis and tumour progression.. Breast Cancer Res, 10(2), 204. View this article in WRRO
- The angiogenic switch occurs at the adenoma stage of the adenoma carcinoma sequence in colorectal cancer.. Gut, 56(10), 1426-1432.
- Preface. Angiogenesis Assays: A Critical Appraisal of Current Techniques.
- Neuropilins in physiological and pathological angiogenesis.. J Pathol, 212(3), 237-248.
- Identification of key residues involved in mediating the in vivo anti-tumor/anti-endothelial activity of Alphastatin.. J Thromb Haemost, 5(4), 846-854.
- Angiogenesis inhibitors found within the haemostasis pathway.. J Cell Mol Med, 9(2), 286-302.
- Current methods for assaying angiogenesis in vitro and in vivo.. Int J Exp Pathol, 85(5), 233-248.
- OC9 ALPHASTATIN, A 24-AMINO ACID FRAGMENT OF FIBRINOGEN IS A NOVEL ANTI-ANGIOGENIC AND ANTI-VASCULAR AGENT. Microcirculation, 11(6), 531-532.
- Alphastatin, a 24-amino acid fragment of human fibrinogen, is a potent new inhibitor of activated endothelial cells in vitro and in vivo.. Blood, 103(2), 601-606.
- The role of fibrinogen and related fragments in tumour angiogenesis and metastasis.. Expert Opin Biol Ther, 3(7), 1105-1120.
- Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model.. Br J Cancer, 86(11), 1813-1816. View this article in WRRO
- Fibrin fragment E stimulates the proliferation, migration and differentiation of human microvascular endothelial cells in vitro.. Angiogenesis, 4(4), 269-275.
- Fibrinogen E-fragment inhibits the migration and tubule formation of human dermal microvascular endothelial cells in vitro.. Cancer Res, 60(17), 4719-4724.
- Metabolism is required for chemotaxis to sugars in Rhodobacter sphaeroides.. Microbiology, 144 ( Pt 1), 229-239.
Chapters
- Tubule Formation Assays In Staton C, Lewis CE & Bicknell R (Ed.), Angiogenesis Assays: A Critical Appraisal of Current Techniques (pp. 65-88). Wiley-Blackwell
- Alphastatin: a pluripotent inhibitor of activated endothelial cells In Siemann DW (Ed.), Vascular-targeted therapies in oncology (pp. 205-220). Wiley-Blackwell
- Haemostatic Regulators as drug targets in tumour angiogenesis In Weber GF (Ed.), Cancer therapy (pp. 187-220). Taylor & Francis
- Effects of fibrinogen and associated peptide fragments on the activation of human endothelial cells by VEGF in vitro In Harmey JH (Ed.), VEGF and Cancer (pp. 117-132). Springer
Conference proceedings papers
- Comparison and Optimisation of a strategy to isolate a single cell population of epithelial cells from the crypt compartment of the murine colon. BRITISH JOURNAL OF SURGERY, Vol. 100 (pp 99-99)
- Neuropilin-1 expression in the normal colon is enteroendocrine-like. BRITISH JOURNAL OF SURGERY, Vol. 100 (pp 123-123)
- Why do Patients get Metachronous Colorectal Adenomas?. JOURNAL OF PATHOLOGY, Vol. 228 (pp S3-S3)
- Neuropilin-1: A predictor of early carcinogenesis in the colonic epithelium. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 24-24)
- Faecal butyrate levels have different effect on cancer and adenoma tissues: Suggestion of early beneficial role of butyrate during carcinogenesis. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 29-29)
- Targeting VEGF in Human Angiosarcoma Cell Lines in Vitro. EUROPEAN JOURNAL OF CANCER, Vol. 47 (pp S665-S665)
- SERUM BIOMARKERS IN LUNG CANCER PATIENTS FROM TWO CLINICAL TRIALS OF CHEMOTHERAPY WITH OR WITHOUT THALIDOMIDE. J THORAC ONCOL, Vol. 6(6) (pp S1058-S1059)
- Functional studies in two angiosarcoma cell lines. JOURNAL OF CLINICAL ONCOLOGY, Vol. 29(15)
- Abstract 5131: Escape from breast cancer therapy, are neuropilins the key. Tumor Biology
- ADAMTS-4 may regulate VEGF-stimulated angiogenesis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 91(6) (pp A32-A33)
- Molecular interactions of ADAMTS-4 in the VEGFR2 signalling complex. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 91(2) (pp A30-A30)
- The molecular interactions involved in VEGF-induced signalling pathways. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 90(2) (pp A114-A114)
- Assessment of angiogenesis in the hyperplasia preinvasive, invasive breast carcinoma sequence. BREAST CANCER RESEARCH, Vol. 10 (pp S24-S24)
- Bevacizumab resistance in breast cancer: are neuropilins the key?. BREAST CANCER RESEARCH, Vol. 10 (pp S38-S38) View this article in WRRO
- The relationship between semaphorin 3C and microvessel density in the progression of breast and oral neoplasia. Experimental and Molecular Pathology, 99(1), 19-24.
- Research group
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PhD students
- Nashwa Shesha
- Teaching interests
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I am the course lead for the MSc(Res) Translational Oncology (OCPT01), a one year Masters course featuring five months of taught modules giving students a thorough grounding in all aspects of translational oncology before moving on to the six months research project. I am also Admissions Tutor and Module lead for OCP604 Tumour Microenvironment, OCP606 Literature Review and OCP607 Research Project.
I am module lead for MED673 Molecular Pathology of Cancer module, deputy module lead for MED6040 Molecular Basis of Tumourigenesis and Metastasis module, and teach on undergraduate modules MBB164 Molecular Biology and MBB334 Biochemical Basis of Human Disease.
I run the intercalation programme at the University of Sheffield Medical School, and have recently re-designed our intercalated BSc option, the BSc Medical Sciences Research and BSc Medical Sciences (Surgery).
I am passionate about student support and welfare, and am the Disability Liaison Officer for the Medical School PGT students and the department of Oncology& Metabolism. I am personal academic tutor and/or mentor for undergraduate medical students, PGT and PGR students in the Medical school and was nominated for Best Academic Mentor in the Annual Academic Awards 2018.
- Professional activities
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- Senior Fellow of the Higher Education Academy
- Departmental Director of Learning and Teaching
- Programme Level Approach Lead for Department of Oncology & Metabolism
- Director of Intercalated Studies
- Disability Liaison Officer for Medical School PGT
- Academic Lead – BSc Medical Sciences Research
- Academic Lead – BSc Medical Sciences (Surgery)
- Academic Lead – MSc(Res) Translational Oncology
- Honorary Treasurer – British Microcirculation Society
- External Examiner at the University of Chester