Dr Lisa Parker

BSc, MRes, PhD

Department of Infection, Immunity and Cardiovascular Disease

Lecturer in Inflammation Biology

l.c.parker@sheffield.ac.uk
+44 114 215 9544

Full contact details

Dr Lisa Parker
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries, please contact – iicd-om-operational@sheffield.ac.uk

I graduated from the University of Manchester in 1996 with a BSc (First Class Honours) in Neuroscience. I then completed an MRes in Neuroscience (University of Manchester, 1997) followed by my PhD entitled `Interleukin-1 and its receptors in the brain´ under the supervision of Professor Dame Nancy Rothwell (University of Manchester, 1997-2000).

I joined the University of Sheffield in 2001 to take up my first post-doctoral position, where I was keen to maintain and develop my interest into inflammatory mechanisms in disease, with a focus on the respiratory system. In 2010 I was appointed to a lectureship within the Inflammation Biology Research Group in the Department of Infection, Immunity & Cardiovascular Disease.

During my time at the University of Sheffield my interest in learning and teaching has also continued to develop. In 2014 I was awarded the Postgraduate Certificate in Learning and Teaching (PG CiLT), and also became a Fellow of The Higher Education Academy (FHEA). I am currently the Deputy Departmental Director of Learning and Teaching for the Department of Infection, Immunity & Cardiovascular Disease.

Qualifications

Academic:

  • 2000    PhD. Division of Neuroscience. The University of Manchester. Professor Dame Nancy Rothwell & Dr Giamal Luheshi.
  • 1997    MRes. Division of Neuroscience. The University of Manchester.
  • 1996    BSc (Hons) First class. Neuroscience. The University of Manchester.

Professional:

  • 2014    Postgraduate Certificate in Learning and Teaching (PGCert Learning and Teaching). The University of Sheffield.
  • 2014    Fellow of the Higher Education Academy (FHEA).
Research interests

My current research aims to identify how respiratory viruses infect and trigger proinflammatory responses in airway epithelial cells and to determine how the responses that are generated may be modified. Pathogens are detected by Toll-Like receptors (TLRs), a family of receptors that regulate cell activation, however the mechanisms through which pathogens initiate airway exacerbations remain inadequately defined. A more complete understanding of the host innate immune responses and the complex signalling pathways that are triggered by viral pathogens is crucial, as viruses are a major trigger of acute exacerbations in asthma and chronic obstructive pulmonary disease (COPD).

My current goals are investigating key players in these pathways to ultimately enable the development of novel therapeutic targets and approaches to manage airway inflammation.


Current Projects

  • 2021-2022 Sheffield Children’s NHS Foundation Trust “A potential new treatment for respiratory syncytial viral (RSV) infection, and bacterial co-infections, in children”. Dr Lisa Parker, Dr Kelechi Ugonna.
  • 2018-2021 Rosetrees Trust PhD research grant “Reversing viral-induced cell stress to treat asthma”. Dr Lisa Parker, Prof Alison Condliffe.
  • 2018-2021 PhD studentship FMDH Summer 2018 PGT to PGR Scholarship “Investigating the role of membrane microdomains in Respiratory Syncytial Viral infection and their potential as novel therapeutic targets”. Dr Lisa Parker, Prof I Sabroe.
Publications

Show: Featured publications All publications

Journal articles

All publications

Journal articles

Chapters

Conference proceedings papers

  • Marsh EK, Prestwich EC, Marriott HM, Williams L, Hart AR, Muir CF, Parker LC, Jonker MR, Heijink IH, Timens W , Fife M et al (2018) S98 Pellino-1 regulates the responses of the airway to viral infection. The influence of influenza: from cells to humans RIS download Bibtex download
  • Mills J, Sabroe I, Midwood K & Parker L (2018) Human rhinovirus infection of airway epithelial cells induces tenascin-C release mas. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 99(6) (pp A59-A59) RIS download Bibtex download
  • Bradley KL, Stokes CA, Parker LC & Condliffe AM (2017) P55 Exploring rhinovirus-induced er stress in bronchial airway epithelial cells. Cellular insights into lung injury repair RIS download Bibtex download
  • Marsh EK, Prestwich EC, Marriott HM, Paiva C, Bennett JA, Jonker MR, Timens W, Heijink IH, Parker LC, Dockrell DH & Sabroe I (2016) The Role Of Pellino-1 In Modulating Signalling Pathways Controlling The Inflammatory Response To Viral Stimuli In Airway Epithelial Cells. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193 RIS download Bibtex download
  • Ismail S, Roberts RL, Stokes CA, Juss JK, Sabroe I & Parker LC (2013) Phosphoinositide 3-kinase (PI3K) inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy. IMMUNOLOGY, Vol. 140 (pp 84-85) RIS download Bibtex download
  • Prestwich E, Paiva C, Parker L & Sabroe I (2013) The role of Pellino1 in modulating signalling pathways controlling the inflammatory response to viruses in airway epithelial cells. IMMUNOLOGY, Vol. 140 (pp 82-82) RIS download Bibtex download
  • Stokes CA, Glanville N, Kaur R, Hume RD, Robinson D, Perrie Y, Edwards MR, O'Donnell V, Harwood J, Parker LC & Sabroe I (2013) Phosphatidylserine-containing liposomes: modulators of rhinovirus induced inflammatory responses. IMMUNOLOGY, Vol. 140 (pp 108-108) RIS download Bibtex download
  • Parmar S, Thompson AAR, Higgins KR, Sabroe I, Parker LC, Lawrie A, Arnold J, Walker S, Elliot CA, Condliffe R , Kiely DG et al (2012) Elucidating The Mechanism By Which Monocytes Can Inhibit Hypoxic PA-SMC Proliferation. D33. ASTHMA PATHOGENESIS RIS download Bibtex download
  • Bennett JA, Prince LR, Stokes CA, Parker LC, Whyte MK & Sabroe I (2011) INVESTIGATING THE ROLE OF PELLIN01, AN E3 UBIQUITIN LIGASE, IN MODULATING SIGNALLING PATHWAYS CONTROLLING THE INFLAMMATORY RESPONSE. THORAX, Vol. 66 (pp A60-A61) RIS download Bibtex download
  • Chaudhuri N, Jary H, Lea S, Khan N, Parker LC, Singh D & Sabroe I (2011) CHRONIC DIESEL EXHAUST PARTICLE (DEP) EXPOSURE DIFFERENTIALLY ALTERS MONOCYTE DIFFERENTIATION AND FUNCTION IN HEALTHY CONTROLS COMPARED TO COPD. THORAX, Vol. 66 (pp A114-A114) RIS download Bibtex download
  • Jabeen M, Stokes CA, Prince LR, Sabroe I & Parker L (2011) The role of neutrophils as anti-inflammatory mediators of airway inflammation. CLINICAL AND EXPERIMENTAL ALLERGY, Vol. 41(12) (pp 1830-1830) RIS download Bibtex download
  • Jary H, Piddock K, Donaldson K, Prince LR, Parker LC, Sabroe I & Chaudhuri N (2010) DIESEL EXHAUST PARTICLES ALTER MONOCYTE DIFFERENTIATION IN VITRO BUT HAVE LITTLE IMPACT ON NEUTROPHIL FUNCTION. THORAX, Vol. 65 (pp A66-A67) RIS download Bibtex download
  • Stokes CA, Dick EP, Bennett JA, Ismail S, Edwards MR, Sabroe L & Parker LC (2010) THE ROLE OF MYD88 IN RHINOVIRUS 1B INFECTION. THORAX, Vol. 65 (pp A37-A38) RIS download Bibtex download
  • Chaudhuri N, Parker LC, Sabroe I & Donaldson K (2009) DIESEL EXHAUST PARTICLES POTENTIATE INFLAMMATION AND RENDER IT RESISTANT TO IL-1 ANTAGONISM IN VITRO. THORAX, Vol. 64 (pp A54-A55) RIS download Bibtex download
  • Parker LC, Jones EC, Ward JR & Sabroe I (2007) Inhibition of TLR-induced inflammatory responses by SAPS. JOURNAL OF LEUKOCYTE BIOLOGY (pp 51-51) RIS download Bibtex download
  • West PW, Parker LC, Ward JR & Sabroe I (2007) Regulation of TLR induced human inflammatory responses by macrophage migration inhibitory factor. JOURNAL OF LEUKOCYTE BIOLOGY (pp 60-60) RIS download Bibtex download
  • Chaudhuri N, Donaldson K, Parker LC & Sabroe I (2007) The role of Cell networks in the response to Diesel Exhaust Particles (DEP).. JOURNAL OF LEUKOCYTE BIOLOGY (pp 25-25) RIS download Bibtex download
  • Parker LC, Jones EC, Morris GE, Dower SK, Whyte MK & Sabroe I (2006) The induction of antiviral responses in human airway smooth muscle and epithelial cells. THORAX, Vol. 61 (pp II9-II9) RIS download Bibtex download
  • Parker LC, Jones EC, Whyte MKB, Dower SK & Sabroe I (2005) Toll-like receptor (TLR) 4 activation induces tolerance in the human neutrophil. FASEB JOURNAL, Vol. 19(4) (pp A912-A912) RIS download Bibtex download
  • Parker LC, Jones EC, Whyte MK, Dower SK & Sabroe I (2004) Endotoxin tolerance in the human neutrophil. JOURNAL OF LEUKOCYTE BIOLOGY (pp 43-44) RIS download Bibtex download
  • Allan SM, Parker LC, Grundy RI & Collins B (2000) Site-specific actions of interleukin-1 in neurodegeneration. PHARMACOLOGY OF CEREBRAL ISCHEMIA 2000 (pp 425-431) RIS download Bibtex download
Research group

PhD Students

  • Joanne Mckenzie
  • Kirsty Bradley
Teaching interests

I come from a background of scientific research where collaboration, critical thinking and discussion are key to the construction of new knowledge, and I believe these principles can also be applied to my teaching practice within the classroom environment. I am committed to the continual improvement of my own teaching practice, and teaching within my Department and Faculty, and ultimately providing students with the very best learning experiences.

I am Deputy Departmental Director of Learning & Teaching for the Department and I teach at all levels within the Faculty of MDH and for the School of Biosciences (see Teaching activities). I also provide pastoral support to students and am an active member of the Think Ahead mentoring scheme.  

Teaching activities

Undergraduate:

  • CDL21001 Research Skills in Biomedical Science (Course lead)
  • CDL302 Pharmacology of Respiratory Disease (Module lead)
  • ORT107 Anatomy & physiology
  • MBChB Phase 2A Research attachment SSC
  • MBChB Personal & Academic Tutoring

Postgraduate:

  • MED6090 Project Literature Review (Module lead)
  • MED60n3 Project Presentation (Module lead)
  • MED6006 Modulating Immunity
  • MED6060 Virulence Mechanisms of Viruses and Fungi
  • CDL402: Vascular Disease: Models and Clinical Practice (Module lead)
  • MSc and PhD Personal & Academic Tutoring
Professional activities