Dr Lisa Parker

BSc, MRes, PhD

Department of Infection, Immunity and Cardiovascular Disease

Lecturer in Inflammation Biology

l.c.parker@sheffield.ac.uk
+44 114 215 9544

+44 114 271 1863 (fax)

The Medical School

Full contact details

Dr Lisa Parker
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

I joined the University of Manchester in 1993 and obtained a BSc (First Class Honours) degree (1996) and MRes (1997) within the Department of Neuroscience.

I then completed an MRC funded PhD(2000), investigating `Interleukin-1 and its receptors in the brain´, under the supervision of Professor Dame Nancy Rothwell.

I moved to the University of Sheffield in 2001 where, maintaining my interest in inflammatory mechanisms in disease, I obtained a post-doctoral position (funded by the ARC) working with Professor Ian Sabroe in the Department of Infection and Immunity.

My research interests now focussed on Toll-like receptors (TLRs), which show many common features with IL-1 receptors, and their role in inflammation in the lung. I remained in Sheffield taking up a second post-doctoral position (MRC-funded) to continue my research into airway inflammation.

I am currently a Lecturer in Inflammation Biology within the Department of Infection, Immunity & Cardiovascular Disease. (2010-present).

Research interests

My research interests focus on how respiratory pathogens trigger or exacerbate airway inflammation and disease.

Bacterial and viral pathogens are a major trigger of acute exacerbations in asthma and chronic obstructive pulmonary disease (COPD). Pathogens are detected by Toll-Like receptors (TLRs), a family of receptors that regulate cell activation, however the mechanisms through which pathogens initiate airway exacerbations remain inadequately defined.

My current research aims to identify how respiratory viruses infect and trigger proinflammatory responses in airway epithelial cells and to determine how the response that is generated may be modified.

A more complete understanding of the host innate immune responses and complex signalling pathways that are triggered in the course of chronic inflammation, and during single or multiple infections, will lead to the elucidation of novel therapeutic targets and approaches to manage airway inflammation.

Current Projects

2018-2021 Rosetrees Trust PhD research grant “Reversing viral-induced cell stress to treat asthma”. Dr Lisa Parker, Prof Alison Condliffe.
2018-2021 PhD studentship FMDH Summer 2018 PGT to PGR Scholarship “Investigating the role of membrane microdomains in Respiratory Syncytial Viral infection and their potential as novel therapeutic targets”. Lead applicant Dr Lisa Parker, co-applicant Prof I Sabroe.
2018-2019 BLF pump-priming research grant. “Treating RSV infection by targeting membrane microdomains” Lead applicant LC Parker, co-applicants Dr Clare Stokes, Dr Fiona Culley (Imperial College London), I Sabroe.
2014-2018 Asthma UK PhD studentship "Investigating the role of tenascin-C in rhinovirus-induced acute exacerbations of asthma". Lead applicant, co-applicants Dr Kim Midwood (Oxford University), Dr Michael Edwards (Imperial College London), Prof Ian Sabroe.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Mills JT, Schwenzer A, Marsh EK, Edwards MR, Sabroe I, Midwood KS & Parker LC (2019) Airway epithelial cells generate pro-inflammatory Tenascin-C and small extracellular vesicles in response to TLR3 stimuli and rhinovirus infection. Frontiers in Immunology, 10. View this article in WRRO
Manley GCA, Stokes CA, Marsh EK, Sabroe I & Parker LC (2019) DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus Through IL-1β Signalling. Journal of Virology. View this article in WRRO
Stokes CA, Kaur R, Edwards MR, Mondhe M, Robinson D, Prestwich EC, Hume RD, Marshall CA, Perrie Y, O'Donnell VB , Harwood JL et al (2016) Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 9(5), 1303-1303. View this article in WRRO
Ismail S, Stokes CA, Prestwich EC, Roberts RL, Juss JK, Sabroe I & Parker LC (2014) Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy.. PLoS One, 9(12). View this article in WRRO
Parker LC, Stokes CA & Sabroe I (2014) Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.. Clin Exp Allergy, 44(1), 20-28.
Piper SC, Ferguson J, Kay L, Parker LC, Sabroe I, Sleeman MA, Briend E & Finch DK (2013) The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells.. PLoS One, 8(5), e63365. View this article in WRRO
Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MKB, Walmsley SR, Higgins KR, Vogel SN, Wilson HL , Prince LR et al (2013) Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.. J Leukoc Biol, 93(1), 7-19. View this article in WRRO
Bennett JA, Prince LR, Parker LC, Stokes CA, de Bruin HG, van den Berge M, Heijink IH, Whyte MK & Sabroe I (2012) Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol, 86(12), 6595-6604.
Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I , Dockrell DH et al (2011) Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.. J Clin Invest, 121(3), 1053-1063. View this article in WRRO
Stokes CA, Ismail S, Dick EP, Bennett JA, Johnston SL, Edwards MR, Sabroe I & Parker LC (2011) Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.. J Virol, 85(15), 7912-7921. View this article in WRRO
Chaudhuri N, Paiva C, Donaldson K, Duffin R, Parker LC & Sabroe I (2010) Diesel exhaust particles override natural injury-limiting pathways in the lung.. Am J Physiol Lung Cell Mol Physiol, 299(2), L263-L271.
Parker LC, Prestwich EC, Ward JR, Smythe E, Berry A, Triantafilou M, Triantafilou K & Sabroe I (2008) A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.. J Immunol, 181(8), 5606-5617.
Sabroe I, Parker LC, Calverley PMA, Dower SK & Whyte MKB (2008) Pathological networking: a new approach to understanding COPD.. Postgrad Med J, 84(991), 259-264.
Sabroe I, Parker LC, Dower SK & Whyte MKB (2008) The role of TLR activation in inflammation.. J Pathol, 214(2), 126-135.
Sabroe I, Parker LC, Calverley PMA, Dower SK & Whyte MKB (2007) Pathological networking: a new approach to understanding COPD.. Thorax, 62(8), 733-738.
Parker LC, Whyte MKB, Dower SK & Sabroe I (2005) The expression and roles of Toll-like receptors in the biology of the human neutrophil.. J Leukoc Biol, 77(6), 886-892.
Touzani O, Boutin H, LeFeuvre R, Parker L, Miller A, Luheshi G & Rothwell N (2002) Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor.. J Neurosci, 22(1), 38-43.

All publications

Journal articles

Mills JT, Schwenzer A, Marsh EK, Edwards MR, Sabroe I, Midwood KS & Parker LC (2019) Airway epithelial cells generate pro-inflammatory Tenascin-C and small extracellular vesicles in response to TLR3 stimuli and rhinovirus infection. Frontiers in Immunology, 10. View this article in WRRO
Manley GCA, Parker LC & Zhang Y (2019) Emerging Regulatory Roles of Dual-Specificity Phosphatases in Inflammatory Airway Disease. International Journal of Molecular Sciences, 20(3). View this article in WRRO
Manley GCA, Stokes CA, Marsh EK, Sabroe I & Parker LC (2019) DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus Through IL-1β Signalling. Journal of Virology. View this article in WRRO
Stokes C, Kaur R, Edwards MR, Mohdhe M, Robinson D, Prestwich EC, Hume RD, Marshall CA, Perrie Y, O'Donnell VB , Harwood JL et al (2017) Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 10. View this article in WRRO
Stokes CA, Kaur R, Edwards MR, Mondhe M, Robinson D, Prestwich EC, Hume RD, Marshall CA, Perrie Y, O'Donnell VB , Harwood JL et al (2016) Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 9(5), 1303-1303. View this article in WRRO
Ismail S, Stokes CA, Prestwich EC, Roberts RL, Juss JK, Sabroe I & Parker LC (2014) Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy.. PLoS One, 9(12). View this article in WRRO
Parker LC, Stokes CA & Sabroe I (2014) Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.. Clin Exp Allergy, 44(1), 20-28.
Piper SC, Ferguson J, Kay L, Parker LC, Sabroe I, Sleeman MA, Briend E & Finch DK (2013) The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells.. PLoS One, 8(5), e63365. View this article in WRRO
Sabroe RA, Stokes CA, Parker LC, Higgins K, Prince LR & Sabroe I (2013) Muckle-Wells syndrome without mutation in exon 3 of the NLRP3 gene, identified by evidence of excessive monocyte production of functional interleukin 1β and rapid response to anakinra. Clinical and Experimental Dermatology.
Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MKB, Walmsley SR, Higgins KR, Vogel SN, Wilson HL , Prince LR et al (2013) Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.. J Leukoc Biol, 93(1), 7-19. View this article in WRRO
Chaudhuri N, Jary H, Lea S, Khan N, Piddock KC, Dockrell DH, Donaldson K, Duffin R, Singh D, Parker LC & Sabroe I (2012) Diesel exhaust particle exposure in vitro alters monocyte differentiation and function.. PLoS One, 7(12), e51107. View this article in WRRO
Bennett JA, Prince LR, Parker LC, Stokes CA, de Bruin HG, van den Berge M, Heijink IH, Whyte MK & Sabroe I (2012) Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol, 86(12), 6595-6604.
Prince LR, Whyte MK, Sabroe I & Parker LC (2011) The role of TLRs in neutrophil activation. CURR OPIN PHARMACOL, 11(4), 397-403. View this article in WRRO
Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I , Dockrell DH et al (2011) Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.. J Clin Invest, 121(3), 1053-1063. View this article in WRRO
Walmsley SR, Chilvers ER, Thompson A, Vaughan K, Marriott H, Parker L, Shaw G, Parmar S, Schneider M, Sabroe I , Dockrell D et al (2011) Prolyl Hydroxylase Phd3 Is Essential For Hypoxic Regulation Of Neutrophilic Inflammation. C13. PATHOGENESIS OF ACUTE LUNG INJURY.
Stokes CA, Ismail S, Dick EP, Bennett JA, Johnston SL, Edwards MR, Sabroe I & Parker LC (2011) Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.. J Virol, 85(15), 7912-7921. View this article in WRRO
Ward JR, West PW, Ariaans MP, Parker LC, Francis SE, Crossman DC, Sabroe I & Wilson HL (2010) Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.. J Biol Chem, 285(30), 23147-23158.
Chaudhuri N, Paiva C, Donaldson K, Duffin R, Parker LC & Sabroe I (2010) Diesel exhaust particles override natural injury-limiting pathways in the lung.. Am J Physiol Lung Cell Mol Physiol, 299(2), L263-L271.
Chaudhuri N, Piddock K, Donaldson K, Parker L & Sabroe I (2010) Diesel Exhaust Particles Alter Monocyte Differentiation In Vitro. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 181.
Chaudhuri N, Donaldson K, Parker LC & Sabroe I (2009) The Role of Cell Networks in Response to Diesel Exhaust Particles. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 179.
Parker LC, Prince LR, Buttle DJ & Sabroe I (2009) The generation of highly purified primary human neutrophils and assessment of apoptosis in response to Toll-like receptor ligands.. Methods Mol Biol, 517, 191-204.
Parker LC, Prestwich EC, Ward JR, Smythe E, Berry A, Triantafilou M, Triantafilou K & Sabroe I (2008) A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.. J Immunol, 181(8), 5606-5617.
West PW, Parker LC, Ward JR & Sabroe I (2008) Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1.. Immunology, 125(1), 101-110.
Sabroe I, Parker LC, Calverley PMA, Dower SK & Whyte MKB (2008) Pathological networking: a new approach to understanding COPD.. Postgrad Med J, 84(991), 259-264.
Sabroe I, Parker LC, Dower SK & Whyte MKB (2008) The role of TLR activation in inflammation.. J Pathol, 214(2), 126-135.
Sabroe I, Parker LC, Dower SK & Whyte MKB (2007) Practical and conceptual models of chronic obstructive pulmonary disease.. Proc Am Thorac Soc, 4(8), 606-610.
Sabroe I, Parker LC, Calverley PMA, Dower SK & Whyte MKB (2007) Pathological networking: a new approach to understanding COPD.. Thorax, 62(8), 733-738.
Sabroe I, Parker LC, Dockrell DH, Davies DE, Dower SK & Whyte MKB (2007) Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.. Am J Respir Crit Care Med, 175(4), 306-311. View this article in WRRO
Parker LC, Prince LR & Sabroe I (2007) Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity.. Clin Exp Immunol, 147(2), 199-207.
Morris GE, Parker LC, Ward JR, Jones EC, Whyte MKB, Brightling CE, Bradding P, Dower SK & Sabroe I (2006) Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.. FASEB J, 20(12), 2153-2155.
Parker LC, Jones EC, Prince LR, Dower SK, Whyte MKB & Sabroe I (2005) Endotoxin tolerance induces selective alterations in neutrophil function.. J Leukoc Biol, 78(6), 1301-1305.
Parker LC, Whyte MKB, Dower SK & Sabroe I (2005) The expression and roles of Toll-like receptors in the biology of the human neutrophil.. J Leukoc Biol, 77(6), 886-892.
Parker LC, Whyte MKB, Vogel SN, Dower SK & Sabroe I (2004) Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells.. J Immunol, 172(8), 4977-4986.
Pinteaux E, Parker LC, Rothwell NJ & Luheshi GN (2002) Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells.. J Neurochem, 83(4), 754-763.
Sabroe IAN, Jones EC, Usher LR, Alapati S, Parker LC, Whyte MKB & Dower SK (2002) The Role of TLRs in Leukocyte Function. Clinical Science, 103(s47), 55P-55P.
Sabroe I, Parker LC, Wilson AG, Whyte MKB & Dower SK (2002) Toll-like receptors: their role in allergy and non-allergic inflammatory disease.. Clin Exp Allergy, 32(7), 984-989.
Parker LC, Luheshi GN, Rothwell NJ & Pinteaux E (2002) IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice.. Br J Pharmacol, 136(2), 312-320.
Touzani O, Boutin H, LeFeuvre R, Parker L, Miller A, Luheshi G & Rothwell N (2002) Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor.. J Neurosci, 22(1), 38-43.
Parker LC, Rushforth DA, Rothwell NJ & Luheshi GN (2000) IL-1beta induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat.. Brain Res Mol Brain Res, 79(1-2), 156-158.
Allan SM, Parker LC, Collins B, Davies R, Luheshi GN & Rothwell NJ (2000) Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat.. Proc Natl Acad Sci U S A, 97(10), 5580-5585.
Parker LC, Luheshi GN, Rothwell NJ & Pinteaux E (2000) Expression of the IL-1 type I receptor and accessory protein in mouse primary glial cell cultures. EUR J NEUROSCI, 12, 359-359.
Parker LC, Balderson DJ, Owen F, Rothwell NJ & Luheshi GN (1998) Interleukin-1 type-1 receptor expression in the rat hypothalamus. BRIT J PHARMACOL, 123, U106-U106.
Cody FW, Henley NC, Parker L & Turner G (1998) Phasic and tonic reflexes evoked in human antagonistic wrist muscles by tendon vibration.. Electroencephalogr Clin Neurophysiol, 109(1), 24-35.
Cody FWJ, Henley NC, Parker LC & Turner GR (1997) Autogenetic and reciprocal tonic reflex actions of muscle vibration-evoked afferent input studied in human wrist muscles.. J PHYSIOL-LONDON, 504P, P119-P119.
Bradley KL, Stokes CA, Marciniak SJ, Parker LC & Condliffe AM () Role of unfolded proteins in lung disease. Thorax.
Marsh EK, Prestwich EC, Williams L, Hart AR, Muir CF, Parker LC, Jonker MR, Heijink IH, Timens W, Fife M , Hussell T et al () Pellino-1 Regulates the Responses of the Airway to Viral Infection. Frontiers in Cellular and Infection Microbiology, 10.

Chapters

Prince L, Parker L & Sabroe I (2020) Pathogen Recognition Receptors and the Lung, Reference Module in Biomedical Sciences Elsevier

Conference proceedings papers

Marsh EK, Prestwich EC, Marriott HM, Williams L, Hart AR, Muir CF, Parker LC, Jonker MR, Heijink IH, Timens W , Fife M et al (2018) S98 Pellino-1 regulates the responses of the airway to viral infection. The influence of influenza: from cells to humans
Mills J, Sabroe I, Midwood K & Parker L (2018) Human rhinovirus infection of airway epithelial cells induces tenascin-C release mas. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 99(6) (pp A59-A59)
Bradley KL, Stokes CA, Parker LC & Condliffe AM (2017) P55 Exploring rhinovirus-induced er stress in bronchial airway epithelial cells. Cellular insights into lung injury repair
Marsh EK, Prestwich EC, Marriott HM, Paiva C, Bennett JA, Jonker MR, Timens W, Heijink IH, Parker LC, Dockrell DH & Sabroe I (2016) The Role Of Pellino-1 In Modulating Signalling Pathways Controlling The Inflammatory Response To Viral Stimuli In Airway Epithelial Cells. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
Ismail S, Roberts RL, Stokes CA, Juss JK, Sabroe I & Parker LC (2013) Phosphoinositide 3-kinase (PI3K) inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy. IMMUNOLOGY, Vol. 140 (pp 84-85)
Prestwich E, Paiva C, Parker L & Sabroe I (2013) The role of Pellino1 in modulating signalling pathways controlling the inflammatory response to viruses in airway epithelial cells. IMMUNOLOGY, Vol. 140 (pp 82-82)
Stokes CA, Glanville N, Kaur R, Hume RD, Robinson D, Perrie Y, Edwards MR, O'Donnell V, Harwood J, Parker LC & Sabroe I (2013) Phosphatidylserine-containing liposomes: modulators of rhinovirus induced inflammatory responses. IMMUNOLOGY, Vol. 140 (pp 108-108)
Parmar S, Thompson AAR, Higgins KR, Sabroe I, Parker LC, Lawrie A, Arnold J, Walker S, Elliot CA, Condliffe R , Kiely DG et al (2012) Elucidating The Mechanism By Which Monocytes Can Inhibit Hypoxic PA-SMC Proliferation. D33. ASTHMA PATHOGENESIS
Bennett JA, Prince LR, Stokes CA, Parker LC, Whyte MK & Sabroe I (2011) INVESTIGATING THE ROLE OF PELLIN01, AN E3 UBIQUITIN LIGASE, IN MODULATING SIGNALLING PATHWAYS CONTROLLING THE INFLAMMATORY RESPONSE. THORAX, Vol. 66 (pp A60-A61)
Chaudhuri N, Jary H, Lea S, Khan N, Parker LC, Singh D & Sabroe I (2011) CHRONIC DIESEL EXHAUST PARTICLE (DEP) EXPOSURE DIFFERENTIALLY ALTERS MONOCYTE DIFFERENTIATION AND FUNCTION IN HEALTHY CONTROLS COMPARED TO COPD. THORAX, Vol. 66 (pp A114-A114)
Jabeen M, Stokes CA, Prince LR, Sabroe I & Parker L (2011) The role of neutrophils as anti-inflammatory mediators of airway inflammation. CLINICAL AND EXPERIMENTAL ALLERGY, Vol. 41(12) (pp 1830-1830)
Jary H, Piddock K, Donaldson K, Prince LR, Parker LC, Sabroe I & Chaudhuri N (2010) DIESEL EXHAUST PARTICLES ALTER MONOCYTE DIFFERENTIATION IN VITRO BUT HAVE LITTLE IMPACT ON NEUTROPHIL FUNCTION. THORAX, Vol. 65 (pp A66-A67)
Stokes CA, Dick EP, Bennett JA, Ismail S, Edwards MR, Sabroe L & Parker LC (2010) THE ROLE OF MYD88 IN RHINOVIRUS 1B INFECTION. THORAX, Vol. 65 (pp A37-A38)
Chaudhuri N, Parker LC, Sabroe I & Donaldson K (2009) DIESEL EXHAUST PARTICLES POTENTIATE INFLAMMATION AND RENDER IT RESISTANT TO IL-1 ANTAGONISM IN VITRO. THORAX, Vol. 64 (pp A54-A55)
Parker LC, Jones EC, Ward JR & Sabroe I (2007) Inhibition of TLR-induced inflammatory responses by SAPS. JOURNAL OF LEUKOCYTE BIOLOGY (pp 51-51)
West PW, Parker LC, Ward JR & Sabroe I (2007) Regulation of TLR induced human inflammatory responses by macrophage migration inhibitory factor. JOURNAL OF LEUKOCYTE BIOLOGY (pp 60-60)
Chaudhuri N, Donaldson K, Parker LC & Sabroe I (2007) The role of Cell networks in the response to Diesel Exhaust Particles (DEP).. JOURNAL OF LEUKOCYTE BIOLOGY (pp 25-25)
Parker LC, Jones EC, Morris GE, Dower SK, Whyte MK & Sabroe I (2006) The induction of antiviral responses in human airway smooth muscle and epithelial cells. THORAX, Vol. 61 (pp II9-II9)
Parker LC, Jones EC, Whyte MKB, Dower SK & Sabroe I (2005) Toll-like receptor (TLR) 4 activation induces tolerance in the human neutrophil. FASEB JOURNAL, Vol. 19(4) (pp A912-A912)
Parker LC, Jones EC, Whyte MK, Dower SK & Sabroe I (2004) Endotoxin tolerance in the human neutrophil. JOURNAL OF LEUKOCYTE BIOLOGY (pp 43-44)
Allan SM, Parker LC, Grundy RI & Collins B (2000) Site-specific actions of interleukin-1 in neurodegeneration. PHARMACOLOGY OF CEREBRAL ISCHEMIA 2000 (pp 425-431)

Research group

PhD Students

Joanne Mckenzie
Kirsty Bradley

Teaching interests

I am Deputy Departmental Director of Learning & Teaching for the Department of Infection, Immunity & Cardiovascular Disease.

My current teaching activities include module coordinator and lecturer for the MSc in Molecular Medicine. I coordinate the “Research Literature Review” and “Project Presentation” modules, and I teach on the Microbes and Infection Pathway, as well as regularly supervising laboratory projects. I am also module coordinator and lecturer for the MRes in Cardiovascular Science: From Molecule to Man, specifically the "Vascular Disease - Models and Clinical Practice” module. I also developed, coordinate and lecture on "Pharmacology of Respiratory Disease” a level 3 undergraduate module for Biomedical Sciences.

Professional activities

Member of the Society for Leukocyte Biology
Science and Engineering Ambassador (STEMNET programme)
Early Career Group representative, Department of Infection, Immunity & Cardiovascular Disease (IICD)
Research Meeting Working Group representative, Department of Infection, Immunity & Cardiovascular Disease (IICD)
Member of Centre for Membrane Interactions and Dynamics (CMIAD)
Member of the British Society for Immunology