Dr Lisa Parker

BSc, MRes, PhD

Department of Infection, Immunity and Cardiovascular Disease

Lecturer in Inflammation Biology

l.c.parker@sheffield.ac.uk
+44 114 215 9544

Full contact details

Dr Lisa Parker
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries, please contact – iicd-operational@sheffield.ac.uk

I joined the University of Manchester in 1993 and obtained a BSc (First Class Honours) degree (1996) and MRes (1997) within the Department of Neuroscience.

I then completed an MRC funded PhD(2000), investigating `Interleukin-1 and its receptors in the brain´, under the supervision of Professor Dame Nancy Rothwell.

I moved to the University of Sheffield in 2001 where, maintaining my interest in inflammatory mechanisms in disease, I obtained a post-doctoral position (funded by the ARC) working with Professor Ian Sabroe in the Department of Infection and Immunity.

My research interests now focussed on Toll-like receptors (TLRs), which show many common features with IL-1 receptors, and their role in inflammation in the lung. I remained in Sheffield taking up a second post-doctoral position (MRC-funded) to continue my research into airway inflammation.

I am currently a Lecturer in Inflammation Biology within the Department of Infection, Immunity & Cardiovascular Disease. (2010-present).

Research interests

My research interests focus on how respiratory pathogens trigger or exacerbate airway inflammation and disease.

Bacterial and viral pathogens are a major trigger of acute exacerbations in asthma and chronic obstructive pulmonary disease (COPD). Pathogens are detected by Toll-Like receptors (TLRs), a family of receptors that regulate cell activation, however the mechanisms through which pathogens initiate airway exacerbations remain inadequately defined.

My current research aims to identify how respiratory viruses infect and trigger proinflammatory responses in airway epithelial cells and to determine how the response that is generated may be modified.

A more complete understanding of the host innate immune responses and complex signalling pathways that are triggered in the course of chronic inflammation, and during single or multiple infections, will lead to the elucidation of novel therapeutic targets and approaches to manage airway inflammation.


Current Projects

  • 2018-2021 Rosetrees Trust PhD research grant “Reversing viral-induced cell stress to treat asthma”. Dr Lisa Parker, Prof Alison Condliffe.
  • 2018-2021 PhD studentship FMDH Summer 2018 PGT to PGR Scholarship “Investigating the role of membrane microdomains in Respiratory Syncytial Viral infection and their potential as novel therapeutic targets”. Lead applicant Dr Lisa Parker, co-applicant Prof I Sabroe.
  • 2018-2019 BLF pump-priming research grant. “Treating RSV infection by targeting membrane microdomains” Lead applicant LC Parker, co-applicants Dr Clare Stokes, Dr Fiona Culley (Imperial College London), I Sabroe.
  • 2014-2018 Asthma UK PhD studentship "Investigating the role of tenascin-C in rhinovirus-induced acute exacerbations of asthma". Lead applicant, co-applicants Dr Kim Midwood (Oxford University), Dr Michael Edwards (Imperial College London), Prof Ian Sabroe.
Publications

Show: Featured publications All publications

Journal articles

All publications

Journal articles

Chapters

Conference proceedings papers

  • Marsh EK, Prestwich EC, Marriott HM, Williams L, Hart AR, Muir CF, Parker LC, Jonker MR, Heijink IH, Timens W , Fife M et al (2018) S98 Pellino-1 regulates the responses of the airway to viral infection. The influence of influenza: from cells to humans RIS download Bibtex download
  • Mills J, Sabroe I, Midwood K & Parker L (2018) Human rhinovirus infection of airway epithelial cells induces tenascin-C release mas. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 99(6) (pp A59-A59) RIS download Bibtex download
  • Bradley KL, Stokes CA, Parker LC & Condliffe AM (2017) P55 Exploring rhinovirus-induced er stress in bronchial airway epithelial cells. Cellular insights into lung injury repair RIS download Bibtex download
  • Marsh EK, Prestwich EC, Marriott HM, Paiva C, Bennett JA, Jonker MR, Timens W, Heijink IH, Parker LC, Dockrell DH & Sabroe I (2016) The Role Of Pellino-1 In Modulating Signalling Pathways Controlling The Inflammatory Response To Viral Stimuli In Airway Epithelial Cells. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193 RIS download Bibtex download
  • Ismail S, Roberts RL, Stokes CA, Juss JK, Sabroe I & Parker LC (2013) Phosphoinositide 3-kinase (PI3K) inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy. IMMUNOLOGY, Vol. 140 (pp 84-85) RIS download Bibtex download
  • Prestwich E, Paiva C, Parker L & Sabroe I (2013) The role of Pellino1 in modulating signalling pathways controlling the inflammatory response to viruses in airway epithelial cells. IMMUNOLOGY, Vol. 140 (pp 82-82) RIS download Bibtex download
  • Stokes CA, Glanville N, Kaur R, Hume RD, Robinson D, Perrie Y, Edwards MR, O'Donnell V, Harwood J, Parker LC & Sabroe I (2013) Phosphatidylserine-containing liposomes: modulators of rhinovirus induced inflammatory responses. IMMUNOLOGY, Vol. 140 (pp 108-108) RIS download Bibtex download
  • Parmar S, Thompson AAR, Higgins KR, Sabroe I, Parker LC, Lawrie A, Arnold J, Walker S, Elliot CA, Condliffe R , Kiely DG et al (2012) Elucidating The Mechanism By Which Monocytes Can Inhibit Hypoxic PA-SMC Proliferation. D33. ASTHMA PATHOGENESIS RIS download Bibtex download
  • Bennett JA, Prince LR, Stokes CA, Parker LC, Whyte MK & Sabroe I (2011) INVESTIGATING THE ROLE OF PELLIN01, AN E3 UBIQUITIN LIGASE, IN MODULATING SIGNALLING PATHWAYS CONTROLLING THE INFLAMMATORY RESPONSE. THORAX, Vol. 66 (pp A60-A61) RIS download Bibtex download
  • Chaudhuri N, Jary H, Lea S, Khan N, Parker LC, Singh D & Sabroe I (2011) CHRONIC DIESEL EXHAUST PARTICLE (DEP) EXPOSURE DIFFERENTIALLY ALTERS MONOCYTE DIFFERENTIATION AND FUNCTION IN HEALTHY CONTROLS COMPARED TO COPD. THORAX, Vol. 66 (pp A114-A114) RIS download Bibtex download
  • Jabeen M, Stokes CA, Prince LR, Sabroe I & Parker L (2011) The role of neutrophils as anti-inflammatory mediators of airway inflammation. CLINICAL AND EXPERIMENTAL ALLERGY, Vol. 41(12) (pp 1830-1830) RIS download Bibtex download
  • Jary H, Piddock K, Donaldson K, Prince LR, Parker LC, Sabroe I & Chaudhuri N (2010) DIESEL EXHAUST PARTICLES ALTER MONOCYTE DIFFERENTIATION IN VITRO BUT HAVE LITTLE IMPACT ON NEUTROPHIL FUNCTION. THORAX, Vol. 65 (pp A66-A67) RIS download Bibtex download
  • Stokes CA, Dick EP, Bennett JA, Ismail S, Edwards MR, Sabroe L & Parker LC (2010) THE ROLE OF MYD88 IN RHINOVIRUS 1B INFECTION. THORAX, Vol. 65 (pp A37-A38) RIS download Bibtex download
  • Chaudhuri N, Parker LC, Sabroe I & Donaldson K (2009) DIESEL EXHAUST PARTICLES POTENTIATE INFLAMMATION AND RENDER IT RESISTANT TO IL-1 ANTAGONISM IN VITRO. THORAX, Vol. 64 (pp A54-A55) RIS download Bibtex download
  • Parker LC, Jones EC, Ward JR & Sabroe I (2007) Inhibition of TLR-induced inflammatory responses by SAPS. JOURNAL OF LEUKOCYTE BIOLOGY (pp 51-51) RIS download Bibtex download
  • West PW, Parker LC, Ward JR & Sabroe I (2007) Regulation of TLR induced human inflammatory responses by macrophage migration inhibitory factor. JOURNAL OF LEUKOCYTE BIOLOGY (pp 60-60) RIS download Bibtex download
  • Chaudhuri N, Donaldson K, Parker LC & Sabroe I (2007) The role of Cell networks in the response to Diesel Exhaust Particles (DEP).. JOURNAL OF LEUKOCYTE BIOLOGY (pp 25-25) RIS download Bibtex download
  • Parker LC, Jones EC, Morris GE, Dower SK, Whyte MK & Sabroe I (2006) The induction of antiviral responses in human airway smooth muscle and epithelial cells. THORAX, Vol. 61 (pp II9-II9) RIS download Bibtex download
  • Parker LC, Jones EC, Whyte MKB, Dower SK & Sabroe I (2005) Toll-like receptor (TLR) 4 activation induces tolerance in the human neutrophil. FASEB JOURNAL, Vol. 19(4) (pp A912-A912) RIS download Bibtex download
  • Parker LC, Jones EC, Whyte MK, Dower SK & Sabroe I (2004) Endotoxin tolerance in the human neutrophil. JOURNAL OF LEUKOCYTE BIOLOGY (pp 43-44) RIS download Bibtex download
  • Allan SM, Parker LC, Grundy RI & Collins B (2000) Site-specific actions of interleukin-1 in neurodegeneration. PHARMACOLOGY OF CEREBRAL ISCHEMIA 2000 (pp 425-431) RIS download Bibtex download
Research group

PhD Students

  • Joanne Mckenzie
  • Kirsty Bradley
Teaching interests

I am Deputy Departmental Director of Learning & Teaching for the Department of Infection, Immunity & Cardiovascular Disease.

My current teaching activities include module coordinator and lecturer for the MSc in Molecular Medicine. I coordinate the “Research Literature Review” and “Project Presentation” modules, and I teach on the Microbes and Infection Pathway, as well as regularly supervising laboratory projects. I am also module coordinator and lecturer for the MRes in Cardiovascular Science: From Molecule to Man, specifically the "Vascular Disease - Models and Clinical Practice” module. I also developed, coordinate and lecture on "Pharmacology of Respiratory Disease” a level 3 undergraduate module for Biomedical Sciences.

Professional activities