Dr Lisa Parker
BSc, MRes, PhD
Department of Infection, Immunity and Cardiovascular Disease
Lecturer in Inflammation Biology
l.c.parker@sheffield.ac.uk
+44 114 215 9544
+44 114 215 9544
+44 114 271 1863
(fax)
The Medical School
Full contact details
Dr Lisa Parker
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
For enquiries, please contact – iicd-operational@sheffield.ac.uk
I joined the University of Manchester in 1993 and obtained a BSc (First Class Honours) degree (1996) and MRes (1997) within the Department of Neuroscience.
I then completed an MRC funded PhD(2000), investigating `Interleukin-1 and its receptors in the brain´, under the supervision of Professor Dame Nancy Rothwell.
I moved to the University of Sheffield in 2001 where, maintaining my interest in inflammatory mechanisms in disease, I obtained a post-doctoral position (funded by the ARC) working with Professor Ian Sabroe in the Department of Infection and Immunity.
My research interests now focussed on Toll-like receptors (TLRs), which show many common features with IL-1 receptors, and their role in inflammation in the lung. I remained in Sheffield taking up a second post-doctoral position (MRC-funded) to continue my research into airway inflammation.
I am currently a Lecturer in Inflammation Biology within the Department of Infection, Immunity & Cardiovascular Disease. (2010-present).
- Research interests
-
My research interests focus on how respiratory pathogens trigger or exacerbate airway inflammation and disease.
Bacterial and viral pathogens are a major trigger of acute exacerbations in asthma and chronic obstructive pulmonary disease (COPD). Pathogens are detected by Toll-Like receptors (TLRs), a family of receptors that regulate cell activation, however the mechanisms through which pathogens initiate airway exacerbations remain inadequately defined.
My current research aims to identify how respiratory viruses infect and trigger proinflammatory responses in airway epithelial cells and to determine how the response that is generated may be modified.
A more complete understanding of the host innate immune responses and complex signalling pathways that are triggered in the course of chronic inflammation, and during single or multiple infections, will lead to the elucidation of novel therapeutic targets and approaches to manage airway inflammation.
Current Projects
- 2018-2021 Rosetrees Trust PhD research grant “Reversing viral-induced cell stress to treat asthma”. Dr Lisa Parker, Prof Alison Condliffe.
- 2018-2021 PhD studentship FMDH Summer 2018 PGT to PGR Scholarship “Investigating the role of membrane microdomains in Respiratory Syncytial Viral infection and their potential as novel therapeutic targets”. Lead applicant Dr Lisa Parker, co-applicant Prof I Sabroe.
- 2018-2019 BLF pump-priming research grant. “Treating RSV infection by targeting membrane microdomains” Lead applicant LC Parker, co-applicants Dr Clare Stokes, Dr Fiona Culley (Imperial College London), I Sabroe.
- 2014-2018 Asthma UK PhD studentship "Investigating the role of tenascin-C in rhinovirus-induced acute exacerbations of asthma". Lead applicant, co-applicants Dr Kim Midwood (Oxford University), Dr Michael Edwards (Imperial College London), Prof Ian Sabroe.
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
- Airway epithelial cells generate pro-inflammatory Tenascin-C and small extracellular vesicles in response to TLR3 stimuli and rhinovirus infection. Frontiers in Immunology, 10. View this article in WRRO
- DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus Through IL-1β Signalling. Journal of Virology. View this article in WRRO
- Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 9(5), 1303-1303. View this article in WRRO
- Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy.. PLoS One, 9(12). View this article in WRRO
- Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.. Clin Exp Allergy, 44(1), 20-28.
- The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells.. PLoS One, 8(5), e63365. View this article in WRRO
- Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.. J Leukoc Biol, 93(1), 7-19. View this article in WRRO
- Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol, 86(12), 6595-6604.
- Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.. J Clin Invest, 121(3), 1053-1063. View this article in WRRO
- Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.. J Virol, 85(15), 7912-7921. View this article in WRRO
- Diesel exhaust particles override natural injury-limiting pathways in the lung.. Am J Physiol Lung Cell Mol Physiol, 299(2), L263-L271.
- A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.. J Immunol, 181(8), 5606-5617.
- Pathological networking: a new approach to understanding COPD.. Postgrad Med J, 84(991), 259-264.
- The role of TLR activation in inflammation.. J Pathol, 214(2), 126-135.
- Pathological networking: a new approach to understanding COPD.. Thorax, 62(8), 733-738.
- The expression and roles of Toll-like receptors in the biology of the human neutrophil.. J Leukoc Biol, 77(6), 886-892.
- Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor.. J Neurosci, 22(1), 38-43.
All publications
Journal articles
- Airway epithelial cells generate pro-inflammatory Tenascin-C and small extracellular vesicles in response to TLR3 stimuli and rhinovirus infection. Frontiers in Immunology, 10. View this article in WRRO
- Emerging Regulatory Roles of Dual-Specificity Phosphatases in Inflammatory Airway Disease. International Journal of Molecular Sciences, 20(3). View this article in WRRO
- DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus Through IL-1β Signalling. Journal of Virology. View this article in WRRO
- Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 10. View this article in WRRO
- Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology, 9(5), 1303-1303. View this article in WRRO
- Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy.. PLoS One, 9(12). View this article in WRRO
- Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells.. Clin Exp Allergy, 44(1), 20-28.
- The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells.. PLoS One, 8(5), e63365. View this article in WRRO
- Muckle-Wells syndrome without mutation in exon 3 of the NLRP3 gene, identified by evidence of excessive monocyte production of functional interleukin 1β and rapid response to anakinra. Clinical and Experimental Dermatology.
- Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.. J Leukoc Biol, 93(1), 7-19. View this article in WRRO
- Diesel exhaust particle exposure in vitro alters monocyte differentiation and function.. PLoS One, 7(12), e51107. View this article in WRRO
- Pellino-1 selectively regulates epithelial cell responses to rhinovirus.. J Virol, 86(12), 6595-6604.
- The role of TLRs in neutrophil activation. CURR OPIN PHARMACOL, 11(4), 397-403. View this article in WRRO
- Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.. J Clin Invest, 121(3), 1053-1063. View this article in WRRO
- Prolyl Hydroxylase Phd3 Is Essential For Hypoxic Regulation Of Neutrophilic Inflammation. C13. PATHOGENESIS OF ACUTE LUNG INJURY.
- Role of interleukin-1 and MyD88-dependent signaling in rhinovirus infection.. J Virol, 85(15), 7912-7921. View this article in WRRO
- Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.. J Biol Chem, 285(30), 23147-23158.
- Diesel exhaust particles override natural injury-limiting pathways in the lung.. Am J Physiol Lung Cell Mol Physiol, 299(2), L263-L271.
- Diesel Exhaust Particles Alter Monocyte Differentiation In Vitro. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 181.
- The Role of Cell Networks in Response to Diesel Exhaust Particles. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 179.
- The generation of highly purified primary human neutrophils and assessment of apoptosis in response to Toll-like receptor ligands.. Methods Mol Biol, 517, 191-204.
- A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.. J Immunol, 181(8), 5606-5617.
- Differential and cell-type specific regulation of responses to Toll-like receptor agonists by ISO-1.. Immunology, 125(1), 101-110.
- Pathological networking: a new approach to understanding COPD.. Postgrad Med J, 84(991), 259-264.
- The role of TLR activation in inflammation.. J Pathol, 214(2), 126-135.
- Practical and conceptual models of chronic obstructive pulmonary disease.. Proc Am Thorac Soc, 4(8), 606-610.
- Pathological networking: a new approach to understanding COPD.. Thorax, 62(8), 733-738.
- Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.. Am J Respir Crit Care Med, 175(4), 306-311. View this article in WRRO
- Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity.. Clin Exp Immunol, 147(2), 199-207.
- Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.. FASEB J, 20(12), 2153-2155.
- Endotoxin tolerance induces selective alterations in neutrophil function.. J Leukoc Biol, 78(6), 1301-1305.
- The expression and roles of Toll-like receptors in the biology of the human neutrophil.. J Leukoc Biol, 77(6), 886-892.
- Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells.. J Immunol, 172(8), 4977-4986.
- Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells.. J Neurochem, 83(4), 754-763.
- The Role of TLRs in Leukocyte Function. Clinical Science, 103(s47), 55P-55P.
- Toll-like receptors: their role in allergy and non-allergic inflammatory disease.. Clin Exp Allergy, 32(7), 984-989.
- IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice.. Br J Pharmacol, 136(2), 312-320.
- Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor.. J Neurosci, 22(1), 38-43.
- IL-1beta induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat.. Brain Res Mol Brain Res, 79(1-2), 156-158.
- Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat.. Proc Natl Acad Sci U S A, 97(10), 5580-5585.
- Expression of the IL-1 type I receptor and accessory protein in mouse primary glial cell cultures. EUR J NEUROSCI, 12, 359-359.
- Interleukin-1 type-1 receptor expression in the rat hypothalamus. BRIT J PHARMACOL, 123, U106-U106.
- Phasic and tonic reflexes evoked in human antagonistic wrist muscles by tendon vibration.. Electroencephalogr Clin Neurophysiol, 109(1), 24-35.
- Autogenetic and reciprocal tonic reflex actions of muscle vibration-evoked afferent input studied in human wrist muscles.. J PHYSIOL-LONDON, 504P, P119-P119.
- Role of unfolded proteins in lung disease. Thorax.
- Pellino-1 Regulates the Responses of the Airway to Viral Infection. Frontiers in Cellular and Infection Microbiology, 10.
Chapters
- Pathogen Recognition Receptors and the Lung, Reference Module in Biomedical Sciences Elsevier
Conference proceedings papers
- S98 Pellino-1 regulates the responses of the airway to viral infection. The influence of influenza: from cells to humans
- Human rhinovirus infection of airway epithelial cells induces tenascin-C release mas. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 99(6) (pp A59-A59)
- P55 Exploring rhinovirus-induced er stress in bronchial airway epithelial cells. Cellular insights into lung injury repair
- The Role Of Pellino-1 In Modulating Signalling Pathways Controlling The Inflammatory Response To Viral Stimuli In Airway Epithelial Cells. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 193
- Phosphoinositide 3-kinase (PI3K) inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy. IMMUNOLOGY, Vol. 140 (pp 84-85)
- The role of Pellino1 in modulating signalling pathways controlling the inflammatory response to viruses in airway epithelial cells. IMMUNOLOGY, Vol. 140 (pp 82-82)
- Phosphatidylserine-containing liposomes: modulators of rhinovirus induced inflammatory responses. IMMUNOLOGY, Vol. 140 (pp 108-108)
- Elucidating The Mechanism By Which Monocytes Can Inhibit Hypoxic PA-SMC Proliferation. D33. ASTHMA PATHOGENESIS
- INVESTIGATING THE ROLE OF PELLIN01, AN E3 UBIQUITIN LIGASE, IN MODULATING SIGNALLING PATHWAYS CONTROLLING THE INFLAMMATORY RESPONSE. THORAX, Vol. 66 (pp A60-A61)
- CHRONIC DIESEL EXHAUST PARTICLE (DEP) EXPOSURE DIFFERENTIALLY ALTERS MONOCYTE DIFFERENTIATION AND FUNCTION IN HEALTHY CONTROLS COMPARED TO COPD. THORAX, Vol. 66 (pp A114-A114)
- The role of neutrophils as anti-inflammatory mediators of airway inflammation. CLINICAL AND EXPERIMENTAL ALLERGY, Vol. 41(12) (pp 1830-1830)
- DIESEL EXHAUST PARTICLES ALTER MONOCYTE DIFFERENTIATION IN VITRO BUT HAVE LITTLE IMPACT ON NEUTROPHIL FUNCTION. THORAX, Vol. 65 (pp A66-A67)
- THE ROLE OF MYD88 IN RHINOVIRUS 1B INFECTION. THORAX, Vol. 65 (pp A37-A38)
- DIESEL EXHAUST PARTICLES POTENTIATE INFLAMMATION AND RENDER IT RESISTANT TO IL-1 ANTAGONISM IN VITRO. THORAX, Vol. 64 (pp A54-A55)
- Inhibition of TLR-induced inflammatory responses by SAPS. JOURNAL OF LEUKOCYTE BIOLOGY (pp 51-51)
- Regulation of TLR induced human inflammatory responses by macrophage migration inhibitory factor. JOURNAL OF LEUKOCYTE BIOLOGY (pp 60-60)
- The role of Cell networks in the response to Diesel Exhaust Particles (DEP).. JOURNAL OF LEUKOCYTE BIOLOGY (pp 25-25)
- The induction of antiviral responses in human airway smooth muscle and epithelial cells. THORAX, Vol. 61 (pp II9-II9)
- Toll-like receptor (TLR) 4 activation induces tolerance in the human neutrophil. FASEB JOURNAL, Vol. 19(4) (pp A912-A912)
- Endotoxin tolerance in the human neutrophil. JOURNAL OF LEUKOCYTE BIOLOGY (pp 43-44)
- Site-specific actions of interleukin-1 in neurodegeneration. PHARMACOLOGY OF CEREBRAL ISCHEMIA 2000 (pp 425-431)
- Airway epithelial cells generate pro-inflammatory Tenascin-C and small extracellular vesicles in response to TLR3 stimuli and rhinovirus infection. Frontiers in Immunology, 10. View this article in WRRO
- Research group
-
PhD Students
- Joanne Mckenzie
- Kirsty Bradley
- Teaching interests
-
I am Deputy Departmental Director of Learning & Teaching for the Department of Infection, Immunity & Cardiovascular Disease.
My current teaching activities include module coordinator and lecturer for the MSc in Molecular Medicine. I coordinate the “Research Literature Review” and “Project Presentation” modules, and I teach on the Microbes and Infection Pathway, as well as regularly supervising laboratory projects. I am also module coordinator and lecturer for the MRes in Cardiovascular Science: From Molecule to Man, specifically the "Vascular Disease - Models and Clinical Practice” module. I also developed, coordinate and lecture on "Pharmacology of Respiratory Disease” a level 3 undergraduate module for Biomedical Sciences.
- Professional activities
-
- Member of the Society for Leukocyte Biology
- Science and Engineering Ambassador (STEMNET programme)
- Early Career Group representative, Department of Infection, Immunity & Cardiovascular Disease (IICD)
- Research Meeting Working Group representative, Department of Infection, Immunity & Cardiovascular Disease (IICD)
- Member of Centre for Membrane Interactions and Dynamics (CMIAD)
- Member of the British Society for Immunology