Dr Lynne Prince

Department of Infection, Immunity and Cardiovascular Disease

Senior Lecturer

l.r.prince@sheffield.ac.uk
+44 114 215 9546

Full contact details

Dr Lynne Prince
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I graduated from Newcastle University in 1997 with a degree in Medical Microbiology and relocated to Sheffield to study for an MSc in Pathological Sciences (University of Sheffield/Sheffield Hallam University, 1999).  This was followed by my PhD entitled `The Regulation of Neutrophil Apoptosis by Bacterial Products´ (University of Sheffield, 2000-04) under the supervision of Professor Moira Whyte.  In 2004 I was awarded a University of Sheffield Russell Research Fellowship to study the molecular mechanisms of neutrophil activation and apoptosis. 

I was appointed to Senior Lecturer in Innate Immunity in 2022.

Research interests

Inflammation and inflammatory diseases such as chronic obstructive pulmonary disease or rheumatoid arthritis are extremely difficult to treat effectively.  During inflammation, inflammatory cells, in particular neutrophils and monocytes, are thought to be key mediators of both tissue damage and perpetuation of further inflammatory signalling.  My research focuses on the role of neutrophils during infection and inflammation and how their inflammatory potential and function is regulated by cell death programme, in particular, apoptosis and NETosis. We are currently studying whether an orally active protein kinase C beta inhibitor (ruboxistaurin) and a clinical EGFR/ErbB inhibitor (neratinib) have therapeutic potential in lung and cardiovascular diseases.

My group also studies how the neutrophilic immune response is subverted by pathogens such as Staphylococcus aureus via the Florey Institute for host-pathogen interactions.

My research has been supported by the British Lung Foundation, the Medical Research Council, the Rosetrees Trust, Asthma UK, Dunhill Medical Trust and The University of Sheffield (including the HELSI Institute).

Publications

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Journal articles

All publications

Journal articles

Chapters

Conference proceedings papers

  • Iqbal A, Thomas M, Novodvorsky P, Bernjak A, Birch L, Lambert D, Kay L, Wright F, Prince L, Francis S , Storey R et al (2017) Hypoglycaemia increases platelet reactivity and promotes formation of proatherogenic platelet-leucocyte aggregates. DIABETOLOGIA, Vol. 60 (pp S532-S532) RIS download Bibtex download
  • Iqbal A, Thomas M, Novodvorsky P, Bernjak A, Birch L, Lambert D, Kay L, Wright F, Prince L, Francis S , Storey R et al (2017) Effect of Hypoglycemia on Platelet Reactivity and Platelet-Leukocyte Kinetics. DIABETES, Vol. 66 (pp A41-A41) RIS download Bibtex download
  • Iqbal A, Novodvorksy P, Bernjak A, Chow E, Birch L, Lambert D, Kay L, Wright FJ, Prince L, Francis S , Sabroe I et al (2016) Hypoglycemia Increases Circulating Proatherogenic Intermediate Monocytes in Healthy Volunteers. DIABETES, Vol. 65 (pp A104-A104) RIS download Bibtex download
  • Thomas MR, Alsharif KF, Prince LR, Ridger VC, Judge HM, Dockrell DH, Sabroe I & Storey RF (2015) TICAGRELOR POTENTIATES NEUTROPHIL PHAGOCYTOSIS VIA INHIBITION OF ADENOSINE REUPTAKE BY ERYTHROCYTES. Journal of the American College of Cardiology, Vol. 65(10) (pp A259-A259) RIS download Bibtex download
  • Bennett JA, Prince LR, Stokes CA, Parker LC, Whyte MK & Sabroe I (2011) INVESTIGATING THE ROLE OF PELLIN01, AN E3 UBIQUITIN LIGASE, IN MODULATING SIGNALLING PATHWAYS CONTROLLING THE INFLAMMATORY RESPONSE. THORAX, Vol. 66 (pp A60-A61) RIS download Bibtex download
  • Jabeen M, Stokes CA, Prince LR, Sabroe I & Parker L (2011) The role of neutrophils as anti-inflammatory mediators of airway inflammation. CLINICAL AND EXPERIMENTAL ALLERGY, Vol. 41(12) (pp 1830-1830) RIS download Bibtex download
  • Jary H, Piddock K, Donaldson K, Prince LR, Parker LC, Sabroe I & Chaudhuri N (2010) DIESEL EXHAUST PARTICLES ALTER MONOCYTE DIFFERENTIATION IN VITRO BUT HAVE LITTLE IMPACT ON NEUTROPHIL FUNCTION. THORAX, Vol. 65 (pp A66-A67) RIS download Bibtex download
  • Anwar S, Prince LR, Sabroe I, Foster SJ & Whyte MK (2007) Subversion of neutrophil apoptosis by Staphylococcus aureus. THORAX, Vol. 62 (pp A114-A115) RIS download Bibtex download
  • Dick EP, Prince LR, Jones EC, Renshaw SA, Whyte MK & Sabroe I (2007) Lentivirus: A tool for the study of neutrophil biology. JOURNAL OF LEUKOCYTE BIOLOGY (pp 36-36) RIS download Bibtex download
  • Bianchi SM, Prince LR, Allen L, Dockrell DH, Taylor GW & Whyte MK (2005) A Pseudomonas aeruginosa exotoxin, pyocyanin, impairs phagocytosis and clearance of apoptotic cells. JOURNAL OF LEUKOCYTE BIOLOGY (pp 51-51) RIS download Bibtex download
  • Bianchi SM, Prince LR, Sabroe I, Dockrell DH, Taylor GW, Buttle DJ & Whyte MKB (2004) The Pseudomonas aeruginosa exotoxin pyocyanin induces cathepsin D-mediated neutrophil apoptosis. JOURNAL OF LEUKOCYTE BIOLOGY (pp 43-43) RIS download Bibtex download
  • Sabroe I, Prince LR, Jones EC, Dower SK & Whyte MKB (2003) The role of toll-like receptors in the regulation of neutrophilic lung inflammation. EUROPEAN RESPIRATORY JOURNAL, Vol. 22 (pp 48S-49S) RIS download Bibtex download
Teaching activities
  • MSc module lead (Molecular Medicine): Model Systems in Research.
  • Deputy module lead (BMS): Pharmacology of Respiratory Disease
  • MBChB teaching: I facilitate the ILA programme for phase 1 and give a Respiratory pharmacology lecture for phase 2a. 
  • Faculty postgraduate induction course (PIC)
Professional activities
  • Deputy Faculty PGR Director (Progression).

  • Member of the Faculty Graduate Research Committee (FGRC).

  • Deputy Department Theme Lead.

  • Member of the Society for Leukocyte Biology.

Previous roles: Chair of Medical School Graduate Research Committee (SGRC), Medical School Lead for Postgraduate Researcher Development, Medical School PGR Year Tutor, Co-Deputy Dept PGR Lead, Dept admissions tutor.