Professor Nigel Hoggard

MD, MRCP, FRCR

Department of Infection, Immunity and Cardiovascular Disease

Professor of Neuroradiology

n.hoggard@sheffield.ac.uk
+44 114 215 9607

Full contact details

Professor Nigel Hoggard
Department of Infection, Immunity and Cardiovascular Disease
Floor C
Royal Hallamshire Hospital
Glossop Road
Sheffield
S10 2JF
Profile

I joined the University of Sheffield in 2006 with interests in adult diagnostic neuroradiology and novel MR imaging agents. Prior to that I had been an NHS Consultant Neuroradiologist at the Manchester Neurosciences Centre, Hope Hospital Salford from 2003. I have been Professor of Neuroradiology since 2018.

I have published over 90 peer reviewed articles.

Research interests

My research interests remain primarily centred on the diagnostic applications of MR imaging in radiology with a particular emphasis on neuroscience and the cerebellum in particular. I work closely with Prof Marios Hadjivassiliou, we are part of the SIGReD group founded by Marios, a multi-disciplinary research group focussed on gluten related diseases. We have published numerous articles on gluten ataxia and brain imaging in gluten sensitivity.

The cerebellum is a small part of the brain that never the less contains over half of the neurons. It represents a highly compact system for combining and analysing information subconsciously for the rest of the brain, it can be thought of as the brain’s own supercomputer. It is designed to compare feedback information such as where is my hand in space to pre-existing models held in the cerebellum and then feed-forward into motor commands to ensure movements coordinated in real time such as would be required for catching a ball.The cerebellum not only helps the brain to control balance and coordination of movement but is now having its role in control of emotion, language and cognition gradually revealed. When it is damaged patients may be affected by falls and feel clumsy. They may lose the ability to walk, speak normally, use utensils or dress themselves and quite frequently may have to use a wheel chair as it becomes more severe.

The cerebellum is affected by a wide range of diseases including genetic conditions, degenerative conditions, alcohol and auto-immunity related diseases. There are new treatments being developed for diseases affecting the cerebellum but trials are hampered by the lack of suitable ways to measure their effectiveness. In dementia and MS many trial outcomes are based on MR imaging techniques as a well as clinical changes in the patients. But because the cerebellum’s activity is subconscious and represents feedback control beneath the surface it is difficult to measure clinically. Our group’s research is focussed on assessment of the cerebellum with advanced MR imaging based techniques. In particular, there is a need for measurements in the autoimmune cerebellar diseases and aggressive degenerative cerebellar disease such as MSA-C.

Gluten sensitivity, as well as causing ataxia, can be associated with accelerated white matter small vessel disease and imaging to assess this and the evaluation the blood brain barrier is an area of great interest to us in SIGReD. We recently published a paper demonstrating cognitive and structural brain changes in patients with coeliac ideas from the UK BioBank study in Gastroenterology. We have been recently funded by the Peter Sowerby Foundation to investigate the potential consequences of gluten possessing antibodies gliadins in the blood, which affects about 10% of the UK population, on brain structure and neuro-cognitive performance.

I have been heavily involved in the UK and European response to the evidence of the accumulation of gadolinium in the brain in patients after routine administration of gadolinium based contrast agents for MR scans.I co-chaired the PRAC which recommended to the Human Medicines agency to restrict the use of linear structure gadolinium based contrast agents in the European Union.

Publications

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Journal articles

All publications

Journal articles

Conference proceedings papers

  • Toh CL, Keslake A, Harding J, Baster K, Hoggard N, Bigley J, McDermott CJ, Shaw PJ, Wilkinson ID & Jenkins TM (2019) 222 Investigating directionality of neurodegeneration in vivo in ALS using multimodal MRI. Journal of Neurology Neurosurgery & Psychiatry, Vol. 90(12) (pp e55) RIS download Bibtex download
  • Toh C, Keslake A, Harding J, Baster K, Hoggard N, Bigley J, McDermott CJ, Shaw PJ, Wilkinson ID & Jenkins TM (2019) Investigating Directionality of Neurodegeneration in vivo in ALS using Multimodal MRI. NEUROLOGY, Vol. 92(15) RIS download Bibtex download
  • J H, L K-I, S B, L B, S P, A S, N H, M R & D P (2018) THUR 198 Safe monitoring of natalizumab therapy in multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 89(10) (pp A29.1-A29) RIS download Bibtex download
  • Jenkins TM, Alix J, Hoggard N, Rao G, O'brien E, Baster K, Bigley J, Wilkinson I, McDermott C & Shaw P (2018) Imaging denervation in amyotrophic lateral sclerosis for future clinical trials: 12-month follow-up from a longitudinal cohort study. EUROPEAN JOURNAL OF NEUROLOGY, Vol. 25 (pp 302-302) RIS download Bibtex download
  • Jenkins T, Alix J, Rao G, Hoggard N, O'Brien E, Baster K, Bradburn M, Bigley J, McDermott C, Wilkinson I & Shaw P (2017) Imaging denervation in motor neuron disease for future clinical trials: a longitudinal cohort study. Journal of the Neurological Sciences, Vol. 381 (pp 102-102) View this article in WRRO RIS download Bibtex download
  • Hewamadduma CA, Omalley R, Robinson M, Beauchamp N, Rogers T, Martindale J, Mcdermott C, Shaw P, Hoggard N & Hadjivassiliou M (2017) Mutations in SPG7 as an important cause of spastic-ataxia in a large british cohort: Hybrid phenotype helps direct screening. Journal of the Neurological Sciences, Vol. 381 (pp 304-305) View this article in WRRO RIS download Bibtex download
  • Penny HA, Aziz I, Ferrar M, Atkinson J, Hoggard N, Hadjivassiliou M, West JN & Sanders DS (2016) PWE-055 Coeliac Disease is More Common in Subjects with Postural Orthostatic Tachycardia Syndrome Compared to Healthy Controls. Gut, Vol. 65(Suppl 1) (pp A165.2-A166) RIS download Bibtex download
  • Wong L, Sharp P, Howarth C, Hoggard N, Berwick J & Francis S (2016) 179 Neurovascular Function in Atherosclerosis. Heart, Vol. 102(Suppl 6) (pp A123.2-A124), 6 June 2016 - 8 June 2016. RIS download Bibtex download
  • Raftopoulos R, Hickman S, Toosy A, Sharrack B, Malliki S, Paling D, Altman D, Yiannakas M, Malladi P, Sheridan R , Sarrigiannis P et al (2016) Prognostic Factors Associated with Axonal Loss after Optic Neuritis. NEUROLOGY, Vol. 86 RIS download Bibtex download
  • Raftopoulos R, Hickman S, Toosy A, Sharrack B, Mallik S, Paling D, Altmann D, Yiannakas M, Malladi P, Sheridan R , Sarrigiannis P et al (2016) Prognostic Factors Associated with Axonal Loss after Optic Neuritis. NEUROLOGY, Vol. 86 RIS download Bibtex download
  • Penny HA, Ferrar M, Atkinson J, Hoggard N, Hadjivassiliou M, West JN & Sanders DS (2015) PTU-184 Is there a relationship between gluten ingestion and postural tachycardia syndrome?. Gut, Vol. 64(Suppl 1) (pp A144.1-A144) RIS download Bibtex download
  • Bahl A, Larsen JJ, Craven I, Metherall P, McKevitt FM, Romanowski CAJ, Hoggard N & Jellinek DA (2012) TRANSFORMATION OF LOW-GRADE GLIOMA ASSESSED BY VOLUMETRIC 3T MRI. NEURO-ONCOLOGY, Vol. 14 (pp 4-4) RIS download Bibtex download
  • Hadjivassiliou M, Currie S, Sanders D & Hoggard N (2012) Alcoholic Cerebellar Degeneration: Not All Due to Alcohol. ANNALS OF NEUROLOGY, Vol. 72 (pp S96-S96) RIS download Bibtex download
  • Romanowski CA, Hoggard N, Jellinek DA, Clenton S, McKevitt F, Wharton S, Craven I, Buller A, Waddle C, Bigley J , Wilkinson ID et al (2011) SEMI-AUTOMATED VOLUMETRIC ANALYSIS OF LOW-GRADE GLIOMAS. NEURO-ONCOLOGY, Vol. 13 (pp 140-140) RIS download Bibtex download
  • Ireland RH, Wild JM, Woodhouse N, Hoggard N, Brown G, Swinscoe JA, Din O & Hatton MQ (2008) Can hyperpolarized He-3 MRI detect radiation induced lung damage?. LUNG CANCER, Vol. 60 (pp S28-S28) RIS download Bibtex download
  • Jellinek D, Hoggard N, Wilkinson I, Levy D, Giesel F, Romanowski C, Miller B & Griffiths P (2007) Dexamethasone and enhancing gliomas: Alterations in perfusion and blood-tumor barrier kinetics shown by magnetic resonace imaging. NEURO-ONCOLOGY, Vol. 9(4) (pp 578-578) RIS download Bibtex download
  • Ireland R, Woodhouse N, Hoggard N, Beek E, Swinscoe J, Brown G, Hatton M & Wild J (2007) Improved image registration of hyperpolarized helium-3 MRI and CT for NSCLC planning. RADIOTHERAPY AND ONCOLOGY, Vol. 84 (pp S173-S173) RIS download Bibtex download
  • Ireland RH, Wood SM, Hanney MB, Tindale WB, Dyker KE, Robinson MH, Woodhouse N, Hoggard N, Conway J, Swinscoe JA & Barber DC (2007) Non-rigid Registration Enables Radiotherapy Treatment Planning with Staging PET. Clinical Oncology, Vol. 19(3) (pp S5-S5) RIS download Bibtex download
Teaching interests

I am the lead for the Sheffield academic clinical radiology training scheme and Deputy Lead for the Sheffield academic training programme. The Sheffield radiology training scheme continues to show strong success developing academic radiologists all the way from thesis to tenured full time academic posts. I teach on the Neurology MSc course, the Sheffield Fundamentals of Neuroradiology course and the National ENT radiology Masterclass.

Professional activities
  • Editor-in-Chief British Journal of Radiology 2013-2016. 
  • Expert Advisory Panel member, Commission for Human Medicines/MHRA 2009-present.  
  • Expert Advisory Panel member, European Medicines Agency 2016.
  • Cancer Peer reviewer 2012-2013.
  • Member of the Royal College of Radiologists FRCR part I examination committee 2011-2014.
  • NIHR doctoral research fellowship selection panel member 2011 and 2013-present.
  • NIHR IAT panel for competitive bids for ACF and ACL posts 2015-present.
  • Sheffield Teaching Hospitals NHS Foundation Trust, Research Lead for the Directorate of Radiology 2008-present.
  • Member of the Sheffield Regional Ethics committee 2006-2012.