Professor Nigel Hoggard

MD, MRCP, FRCR

Department of Infection, Immunity and Cardiovascular Disease

Professor of Neuroradiology

n.hoggard@sheffield.ac.uk
+44 114 215 9607

+44 114 271 1714 (fax)

Floor C, Royal Hallamshire Hospital

Full contact details

Professor Nigel Hoggard
Department of Infection, Immunity and Cardiovascular Disease
Floor C
Royal Hallamshire Hospital
Glossop Road
Sheffield
S10 2JF

Profile

For enquiries, please contact – iicd-om-operational@sheffield.ac.uk

I joined the University of Sheffield in 2006 with interests in adult diagnostic neuroradiology and novel MR imaging agents. Prior to that I had been an NHS Consultant Neuroradiologist at the Manchester Neurosciences Centre, Hope Hospital Salford from 2003. I have been Professor of Neuroradiology since 2018.

I have published over 90 peer reviewed articles.

Research interests

My research interests remain primarily centred on the diagnostic applications of MR imaging in radiology with a particular emphasis on neuroscience and the cerebellum in particular. I work closely with Prof Marios Hadjivassiliou, we are part of the SIGReD group founded by Marios, a multi-disciplinary research group focussed on gluten related diseases. We have published numerous articles on gluten ataxia and brain imaging in gluten sensitivity.

The cerebellum is a small part of the brain that never the less contains over half of the neurons. It represents a highly compact system for combining and analysing information subconsciously for the rest of the brain, it can be thought of as the brain’s own supercomputer. It is designed to compare feedback information such as where is my hand in space to pre-existing models held in the cerebellum and then feed-forward into motor commands to ensure movements coordinated in real time such as would be required for catching a ball.The cerebellum not only helps the brain to control balance and coordination of movement but is now having its role in control of emotion, language and cognition gradually revealed. When it is damaged patients may be affected by falls and feel clumsy. They may lose the ability to walk, speak normally, use utensils or dress themselves and quite frequently may have to use a wheel chair as it becomes more severe.

The cerebellum is affected by a wide range of diseases including genetic conditions, degenerative conditions, alcohol and auto-immunity related diseases. There are new treatments being developed for diseases affecting the cerebellum but trials are hampered by the lack of suitable ways to measure their effectiveness. In dementia and MS many trial outcomes are based on MR imaging techniques as a well as clinical changes in the patients. But because the cerebellum’s activity is subconscious and represents feedback control beneath the surface it is difficult to measure clinically. Our group’s research is focussed on assessment of the cerebellum with advanced MR imaging based techniques. In particular, there is a need for measurements in the autoimmune cerebellar diseases and aggressive degenerative cerebellar disease such as MSA-C.

Gluten sensitivity, as well as causing ataxia, can be associated with accelerated white matter small vessel disease and imaging to assess this and the evaluation the blood brain barrier is an area of great interest to us in SIGReD. We recently published a paper demonstrating cognitive and structural brain changes in patients with coeliac ideas from the UK BioBank study in Gastroenterology. We have been recently funded by the Peter Sowerby Foundation to investigate the potential consequences of gluten possessing antibodies gliadins in the blood, which affects about 10% of the UK population, on brain structure and neuro-cognitive performance.

I have been heavily involved in the UK and European response to the evidence of the accumulation of gadolinium in the brain in patients after routine administration of gadolinium based contrast agents for MR scans.I co-chaired the PRAC which recommended to the Human Medicines agency to restrict the use of linear structure gadolinium based contrast agents in the European Union.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Croall ID, Sanders DS, Hadjivassiliou M & Hoggard N (2020) Cognitive deficit and white matter changes in persons with celiac disease: a population-based study. Gastroenterology. View this article in WRRO
Hadjivassiliou M, Martindale J, Shanmugarajah P, Grünewald RA, Sarrigiannis PG, Beauchamp N, Garrard K, Warburton R, Sanders DS, Friend D , Duty S et al (2016) Causes of progressive cerebellar ataxia: prospective evaluation of 1500 patients.. Journal of Neurology, Neurosurgery, and Psychiatry, 88, 301-309.
Hoggard N & Roditi GH (2016) T1 hyperintensity on brain imaging subsequent to gadolinium-based contrast agent administration: what do we know about intracranial gadolinium deposition?. British Journal of Radiology, 90(1069).
Raftopoulos R, Hickman SJ, Toosy A, Sharrack B, Mallik S, Paling D, Altmann DR, Yiannakas MC, Malladi P, Sheridan R , Sarrigiannis PG et al (2016) Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial. The Lancet Neurology, 15(3), 259-269.
Currie S, Hadjivassiliou M, Wilkinson ID, Griffiths PD & Hoggard N (2013) Magnetic resonance spectroscopy of the normal cerebellum: what degree of variability can be expected?. Cerebellum, 12(2), 205-211.
Leeds JS, Hopper AD, Sidhu R, Simmonette A, Azadbakht N, Hoggard N, Morley S & Sanders DS (2010) Some patients with irritable bowel syndrome may have exocrine pancreatic insufficiency.. Clin Gastroenterol Hepatol, 8(5), 433-438.
Hoggard N, Darwent G, Capener D, Wilkinson ID & Griffiths PD (2009) The high incidence and bioethics of findings on magnetic resonance brain imaging of normal volunteers for neuroscience research.. J Med Ethics, 35(3), 194-199.

All publications

Journal articles

Kon FC, Akil M, Kilding R, Kuet K-P, Shanmugarajah P, Hoggard N & Hadjivassiliou M (2022) P235 Cerebellar ataxia in primary Sjogren’s syndrome: is gluten sensitivity the answer?. Rheumatology, 61(Supplement_1).
Sassani M, Alix J, Mcdermott C, Baster K, Hoggard N, Wild J, Mortiboys H, Shaw P, Wilkinson I & Jenkins T (2021) Brain energy metabolism in ALS: A phosphorus-31 magnetic resonance spectroscopy study. Journal of the Neurological Sciences, 429, 119412-119412. View this article in WRRO
Mubarak Mohamed AS, Iqbal A, Prasad S, Hoggard N & Blackburn D (2021) Cushing’s disease presenting with psychosis. Practical Neurology, 21(4), 351-353.
Newrick L, Hoggard N & Hadjivassiliou M (2021) Recognition and management of rapid-onset gluten ataxias: case series.. Cerebellum Ataxias, 8(1), 16.
Kular S, Griffin K, Batty R, Hoggard N & Connolly D (2021) The role of MRI and CT of the brain in first episodes of psychosis and behavioural abnormality. Clinical Radiology.
Mahatma MM, Jayasuriya RL, Hughes D, Hoggard N, Buckley SC, Gordon A, Hamer AJ, Tomouk MW, Kerry RM, Eastell R & Wilkinson JM (2021) Denosumab after total hip arthroplasty – Authors' reply. The Lancet Rheumatology, 3(6), e406-e407.
Hadjivassiliou M, Croall ID, Grünewald RA, Trott N, Sanders DS & Hoggard N (2021) Neurological Evaluation of Patients with Newly Diagnosed Coeliac Disease Presenting to Gastroenterologists: A 7-Year Follow-Up Study.. Nutrients, 13(6).
Hadjivassiliou M, Zis P, Sanders DS, Hoggard N & Sarrigiannis PG (2021) Stiff person syndrome and gluten sensitivity. Nutrients, 13(4).
Croall ID, Hoggard N & Hadjivassiliou M (2021) Gluten and autism spectrum disorder. Nutrients, 13(2), 1-19.
Islam M, Hoggard N & Hadjivassiliou M (2021) Cerebrotendinous Xanthomatosis: diversity of presentation and refining treatment with chenodeoxycholic acid. Cerebellum and Ataxias, 8(1).
Mahatma MM, Jayasuriya RL, Hughes D, Hoggard N, Buckley SC, Gordon A, Hamer AJ, Tomouk MW, Kerry RM, Eastell R & Wilkinson JM (2021) Effect of denosumab on osteolytic lesion activity after total hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial. The Lancet Rheumatology.
Payne T, Sassani M, Buckley E, Moll S, Anton A, Appleby M, Maru S, Taylor R, McNeill A, Hoggard N , Mazza C et al (2020) Ursodeoxycholic acid as a novel disease-modifying treatment for Parkinson’s disease: protocol for a two-centre, randomised, double-blind, placebo-controlled trial, The 'UP' study. BMJ Open, 10(8), e038911-e038911.
Croall ID, Tooth C, Venneri A, Poyser C, Sanders DS, Hoggard N & Hadjivassiliou M (2020) Cognitive impairment in coeliac disease with respect to disease duration and gluten-free diet adherence : a pilot study. Nutrients, 12(7). View this article in WRRO
Croall ID, Sanders DS, Hadjivassiliou M & Hoggard N (2020) Cognitive deficit and white matter changes in persons with celiac disease: a population-based study. Gastroenterology. View this article in WRRO
Považan M, Mikkelsen M, Berrington A, Bhattacharyya PK, Brix MK, Buur PF, Cecil KM, Chan KL, Chen DYT, Craven AR , Cuypers K et al (2020) Comparison of Multivendor Single-Voxel MR Spectroscopy Data Acquired in Healthy Brain at 26 Sites. Radiology, 295(1), 171-180.
Arthurs OJ, Goh V, Hoggard N, Booth T, Messiou C, The J, Plumb A, Bidaut L, Turmezei T, Jethwa K , Robinson P et al (2020) Professional development and research are being neglected: a commentary on the 2019 RCR radiologists' supporting professional activities (SPA) survey. Clinical Radiology, 75(5), 348-350.
Jenkins TM, Alix JJP, Fingret J, Esmail T, Hoggard N, Baster K, McDermott CJ, Wilkinson ID & Shaw PJ (2020) Correction to: Longitudinal multi-modal muscle-based biomarker assessment in motor neuron disease. Journal of Neurology, 267(1), 257-258.
Kadodwala VH, Hadjivassiliou M, Currie S, Skipper N & Hoggard N (2019) Is 1H-MR spectroscopy useful as a diagnostic aid in MSA-C?. Cerebellum & Ataxias, 6(1).
Sarrigiannis PG, Zis P, Unwin ZC, Blackburn DJ, Hoggard N, Zhao Y, Billings SA, Khan AA, Yianni J & Hadjivassiliou M (2019) Tremor after long term lithium treatment; is it cortical myoclonus?. Cerebellum & Ataxias, 6(5). View this article in WRRO
Croall I, Trott N, Rej A, Aziz I, O'Brien D, George H, Hossain M, Marks L, Richardson J, Rigby R , Hadjivassiliou M et al (2019) A population survey of dietary attitudes towards gluten. Nutrients, 11(6). View this article in WRRO
Croall I, Aziz I, Trott N, Paola T, Hoggard N, Sanders D, Rej A & Hadjivassiliou M (2019) Gluten does not induce gastrointestinal symptoms in healthy volunteers; A double blind randomised placebo trial. Gastroenterology. View this article in WRRO
Mikkelsen M, Rimbault DL, Barker PB, Bhattacharyya PK, Brix MK, Buur PF, Cecil KM, Chan KL, Chen DY-T, Craven AR , Cuypers K et al (2019) Big GABA II: Water-referenced edited MR spectroscopy at 25 research sites. NeuroImage, 191, 537-548. View this article in WRRO
Hadjivassiliou M, Croall ID, Zis P, Sarrigiannis PG, Sanders DS, Aeschlimann P, Grünewald RA, Armitage PA, Connolly D, Aeschlimann D & Hoggard N (2019) Neurologic Deficits in Patients With Newly Diagnosed Celiac Disease are Frequent and Linked With Autoimmunity to TG6. Clinical Gastroenterology and Hepatology. View this article in WRRO
Rao MR, Norquay G, Stewart N, Hoggard N, Griffiths P & Wild J (2019) Assessment of brain perfusion using hyperpolarized 129Xe MRI in a subject with established stroke.. Journal of Magnetic Resonance Imaging. View this article in WRRO
Goh V, Smye SW, Allen L, Ashcroft J, Cooper M, Gilbert FJ, Goh V, Graham R, Keevil S, Matthews J , Mould A et al (2019) The National Institute for Health Research: making an impact in imaging research. Clinical Radiology, 74(3), 242-246.
Hewamadduma CA, Hoggard N, O'Malley R, Robinson MK, Beauchamp NJ, Segamogaite R, Martindale J, Rodgers T, Rao G, Sarrigiannis P , Shanmugarajah P et al (2018) Novel genotype-phenotype and MRI correlations in a large cohort of patients with SPG7 mutations. Neurology Genetics, 4(6), e279-e279. View this article in WRRO
Smith R, Hadjivassiliou M, Hoggard N, Kuet K-P, Kilding R & Akil M (2018) An unusual case of inflammatory meningitis in a young man with systemic lupus erythematosus.. Lupus. View this article in WRRO
Mcsweeney M, Reuber M, Hoggard N & Levita L (2018) Cortical thickness and gyrification patterns in patients with psychogenic non-epileptic seizures. Neuroscience Letters, 678(Epilepsia 54 2013), 124-130. View this article in WRRO
Dimitriadis PA, Saad M, Igra MS, Mandavia R, Bowes C, Hoggard N & Ray J (2018) White matter lesions in magnetic resonance imaging of the brain in 56 patients with visual vertigo. The Journal of Laryngology & Otology, 132(06), 550-553.
Blackburn DJ, Forbes M, Unwin Z, Hoggard N, Hadjivassiliou M & Sarrigiannis PG (2018) Exaggerated startle in post-infectious opsoclonus myoclonus syndrome. Clinical Neurophysiology, 129(7), 1372-1373. View this article in WRRO
Jenkins T, Alix J, David C, Pearson E, Ganesh Rao D, Hoggard N, O'Brien E, Baster K, Bradburn M, Bigley J , McDermott C et al (2018) Imaging muscle as a potential biomarker of denervation in motor neuron disease. Journal of Neurology, Neurosurgery, and Psychiatry, 89, 248-255. View this article in WRRO
Shanmugarajah PD, Hoggard N, Aeschlimann DP, Aeschlimann PC, Dennis GJ, Howell SJ, Reuber M, Grünewald RA & Hadjivassiliou M (2018) Phenytoin-related ataxia in patients with epilepsy: clinical and radiological characteristics. Seizure, 56, 26-30.
Larsen J, Hoggard N & McKevitt FM (2018) Imaging in low-grade glioma: a guide for neurologists.. Pract Neurol, 18(1), 27-34.
Zis P, Rao DG, Hoggard N, Sarrigiannis PG & Hadjivassiliou M (2017) Anti-MAG associated cerebellar ataxia and response to rituximab.. J Neurol.
Ng YS, Powell H, Hoggard N, Turnbull DM, Taylor RW & Hadjivassiliou M (2017) Novel POLG variants associated with late-onset de novo status epilepticus and progressive ataxia. Neurology Genetics, 3(5), e181-e181. View this article in WRRO
Mikkelsen M, Barker PB, Bhattacharyya PK, Brix MK, Buur PF, Cecil KM, Chan KL, Chen DY-T, Craven AR, Cuypers K , Dacko M et al (2017) Big GABA: Edited MR spectroscopy at 24 research sites. NeuroImage, 159, 32-45. View this article in WRRO
Mehmood S, Hoggard N & Hadjivassiliou M (2017) Gordon Holmes syndrome: finally genotype meets phenotype.. Pract Neurol.
Hadjivassiliou M, Grünewald RA, Sanders DS, Shanmugarajah P & Hoggard N (2017) Effect of gluten-free diet on cerebellar MR spectroscopy in gluten ataxia.. Neurology, 89(7), 705-709.
Igra MS, Paling D, Wattjes MP, Connolly DJ & Hoggard N (2017) Multiple sclerosis update: use of MRI for early diagnosis, disease monitoring and assessment of treatment related complications. British Journal of Radiology, 90(1074).
Zis P, Rao DG, Wagner BE, Nicholson-Goult L, Hoggard N & Hadjivassiliou M (2017) Cerebellar ataxia and sensory ganglionopathy associated with light-chain myeloma.. Cerebellum Ataxias, 4, 1-1. View this article in WRRO
Zis P, Sarrigiannis PG, Rao DG, Hoggard N, Sanders DS & Hadjivassiliou M (2017) Cerebellar ataxia with sensory ganglionopathy; does autoimmunity have a role to play?. Cerebellum & Ataxias, 4(1). View this article in WRRO
Hadjivassiliou M, Martindale J, Shanmugarajah P, Grünewald RA, Sarrigiannis PG, Beauchamp N, Garrard K, Warburton R, Sanders DS, Friend D , Duty S et al (2016) Causes of progressive cerebellar ataxia: prospective evaluation of 1500 patients.. Journal of Neurology, Neurosurgery, and Psychiatry, 88, 301-309.
Larsen J, Wharton SB, Romanowski C, McKevitt FM, Bridgewater C, Zaki H & Hoggard N (2016) Low grade glioma: An Update for Radiologists.. British Journal of Radiology. View this article in WRRO
Hoggard N & Roditi GH (2016) T1 hyperintensity on brain imaging subsequent to gadolinium-based contrast agent administration: what do we know about intracranial gadolinium deposition?. British Journal of Radiology, 90(1069).
Shanmugarajah PD, Hoggard N, Currie S, Aeschlimann DP, Aeschlimann PC, Gleeson DC, Karajeh M, Woodroofe N, Grünewald RA & Hadjivassiliou M (2016) Alcohol-related cerebellar degeneration: not all down to toxicity?. Cerebellum Ataxias, 3, 17-17. View this article in WRRO
Penny HA, Aziz I, Ferrar M, Atkinson J, Hoggard N, Hadjivassiliou M, West JN & Sanders DS (2016) Is there a relationship between gluten sensitivity and postural tachycardia syndrome?. European Journal of Gastroenterology & Hepatology, 28(12), 1383-1387.
He F, Sarrigiannis PG, Billings SA, Wei H, Rowe J, Romanowski C, Hoggard N, Hadjivassilliou M, Rao DG, Grünewald R , Khan A et al (2016) Nonlinear interactions in the thalamocortical loop in essential tremor: A model-based frequency domain analysis. Neuroscience, 324, 377-389. View this article in WRRO
Hadjivassiliou M, Rao DG, Grìnewald RA, Aeschlimann DP, Sarrigiannis PG, Hoggard N, Aeschlimann P, Mooney PD & Sanders DS (2016) Neurological Dysfunction in Coeliac Disease and Non-Coeliac Gluten Sensitivity. The American Journal of Gastroenterology, 111(4), 561-567. View this article in WRRO
Raftopoulos R, Hickman SJ, Toosy A, Sharrack B, Mallik S, Paling D, Altmann DR, Yiannakas MC, Malladi P, Sheridan R , Sarrigiannis PG et al (2016) Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial. The Lancet Neurology, 15(3), 259-269.
Stivaros SM, Radon MR, Mileva R, Connolly DJA, Cowell PE, Hoggard N, Wright NB, Tang V, Gledson A, Batty R , Keane JA et al (2016) Quantification of structural changes in the corpus callosumin children with profound hypoxic–ischaemic brain injury. Pediatric Radiology, 46(1), 73-81. View this article in WRRO
Baldarçara L, Currie S, Hadjivassiliou M, Hoggard N, Jack A, Jackowski AP, Mascalchi M, Parazzini C, Reetz K, Righini A , Schulz JB et al (2015) Consensus Paper: Radiological Biomarkers of Cerebellar Diseases. The Cerebellum, 14(2), 175-196. View this article in WRRO
Sandler RD, Hoggard N & Hadjivassiliou M (2015) Miller-Fisher Syndrome: Is the ataxia central or peripheral?. Cerebellum & Ataxias, 2(1). View this article in WRRO
Sarrigiannis PG, Zhao Y, He F, Wei H, Billings SA, Lawrence S, Rowe J, Romanowski C, Hoggard N, Rao DG , Grünewald R et al (2015) Direct Functional Connectivity between the Thalamus (Vim) and the Contralateral Motor Cortex: Just a Single Case Observation or a Common Pathway in the Human Brain?. Brain Stimulation, 8(6), 1230-1233.
Sarrigiannis P, Hoggard N, Aeschlimann D, Sanders D, Grunewald R, Unwin Z & Hadjivassiliou M (2014) Myoclonus ataxia and refractory coeliac disease. Cerebellum & Ataxias, 1. View this article in WRRO
Clark MJ, Prentice JR, Hoggard N, Paley MN, Hadjivassiliou M & Wilkinson JM (2014) Brain structure and function in patients after metal-on-metal hip resurfacing.. AJNR Am J Neuroradiol, 35(9), 1753-1758.
Stenberg R, Hadjivassiliou M, Aeschlimann P, Hoggard N & Aeschlimann D (2014) Anti-transglutaminase 6 antibodies in children and young adults with cerebral palsy.. Autoimmune Dis, 2014, 237107. View this article in WRRO
Bradley D & Hoggard N (2014) Happy new year from BJR!. British Journal of Radiology, 87(1033).
Kheder A, Hoggard N & Hickman SJ (2014) Neurological red flag: the numb chin.. Pract Neurol, 14(4), 258-260.
Janaway BM, Simpson JE, Hoggard N, Highley JR, Forster G, Drew D, Gebril OH, Matthews FE, Brayne C, Wharton SB , Ince PG et al (2014) Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds.. Neuropathol Appl Neurobiol, 40(3), 258-269. View this article in WRRO
Shanmugarajah P, Hoggard N, Howell S, Dennis G, Reuber M, Grunewald R & Hadjivassiliou M (2013) PHENYTOIN AND CEREBELLAR ATAXIA: NOT ALL DOWN TO TOXICITY?. J Neurol Neurosurg Psychiatry, 84(11), e2.
Hadjivassiliou M, Fotheringham J, Sanders D, Grunewald R, Hoggard N & Sarrigiannis P (2013) HYPEREXCITABLE BRAIN AND REFRACTORY COELIAC DISEASE: A NEW SYNDROME.. J Neurol Neurosurg Psychiatry, 84(11), e2.
Currie S, Hoggard N, Clark MJR, Sanders DS, Wilkinson ID, Griffiths PD & Hadjivassiliou M (2013) Alcohol Induces Sensitization to Gluten in Genetically Susceptible Individuals: A Case Control Study. PLoS ONE, 8(10). View this article in WRRO
Jenkins TM, Burness C, Connolly DJ, Rao DG, Hoggard N, Mawson S, McDermott CJ, Wilkinson ID & Shaw PJ (2013) A prospective pilot study measuring muscle volumetric change in amyotrophic lateral sclerosis.. Amyotroph Lateral Scler Frontotemporal Degener, 14(5-6), 414-423. View this article in WRRO
Blackburn DJ, Alix JJP, Sarrigiannis P, Hoggard N & Bandmann O (2013) Delayed toxic-hypoxic encephalopathy.. Pract Neurol, 13(2), 114-119.
Blackburn D, Randall MS, Hoggard N, Highley R & Harkness K (2013) Trigeminal neuralgia: no laughing matter.. Pract Neurol, 13(4), 263-267.
Goode SD, Hoggard N, Macdonald S, Evans DH, Cleveland TJ & Gaines PA (2013) Assessment of reverse flow as a means of cerebral protection during carotid artery stent placement with diffusion-weighted and transcranial Doppler imaging.. J Vasc Interv Radiol, 24(4), 528-533.
Hadjivassiliou M, Currie S & Hoggard N (2013) MR spectroscopy in paraneoplastic cerebellar degeneration.. J Neuroradiol, 40(4), 310-312.
Prentice JR, Clark MJ, Hoggard N, Morton AC, Tooth C, Paley MN, Stockley I, Hadjivassiliou M & Wilkinson JM (2013) Metal-on-metal hip prostheses and systemic health: a cross-sectional association study 8 years after implantation.. PLoS One, 8(6), e66186. View this article in WRRO
Khandanpour N, Griffiths P, Hoggard N & Warren D (2013) Prospective comparison of late 3T MRI with conventional angiography in evaluating the patency of cerebral arteriovenous malformations treated with stereotactic radiosurgery. Neuroradiology, 1-5.
Currie S, Hoggard N, Craven IJ, Hadjivassiliou M & Wilkinson ID (2013) Understanding MRI: basic MR physics for physicians.. Postgrad Med J, 89(1050), 209-223.
Currie S, Hadjivassiliou M, Craven IJ, Wilkinson ID, Griffiths PD & Hoggard N (2013) Magnetic resonance spectroscopy of the brain.. Postgrad Med J, 89(1048), 94-106.
Currie S, Hadjivassiliou M, Wilkinson ID, Griffiths PD & Hoggard N (2013) Magnetic resonance spectroscopy of the normal cerebellum: what degree of variability can be expected?. Cerebellum, 12(2), 205-211.
Khandanpour N, Hoggard N & Connolly DJA (2013) The role of MRI and CT of the brain in first episodes of psychosis.. Clin Radiol, 68(3), 245-250.
Currie S, Hadjivassiliou M, Craven IJ, Wilkinson ID, Griffiths PD & Hoggard N (2013) Magnetic resonance imaging biomarkers in patients with progressive ataxia: current status and future direction.. Cerebellum, 12(2), 245-266.
Khandanpour N, Connolly DJA, Raghavan A, Griffiths PD & Hoggard N (2012) Craniospinal abnormalities and neurologic complications of osteogenesis imperfecta: imaging overview.. Radiographics, 32(7), 2101-2112.
Alix JJP, Ponnusamy A, Bhattacharyya D, Hoggard N & Grünewald RA (2012) Complex partial seizures: going out with a hiccup.. Seizure, 21(10), 820-822.
Currie S, Hadjivassiliou M, Clark MJR, Sanders DS, Wilkinson ID, Griffiths PD & Hoggard N (2012) Should we be 'nervous' about coeliac disease? Brain abnormalities in patients with coeliac disease referred for neurological opinion.. J Neurol Neurosurg Psychiatry, 83(12), 1216-1221.
Yianni J, Rowe J, Khandanpour N, Nagy G, Hoggard N, Radatz M & Kemeny A (2012) Stereotactic radiosurgery for pineal tumours.. Br J Neurosurg, 26(3), 361-366.
Craven IJ, Griffiths PD, Bhattacharyya D, Grunewald RA, Hodgson T, Connolly DJA, Coley SC, Batty R, Romanowski CAJ & Hoggard N (2012) 3.0 T MRI of 2000 consecutive patients with localisation-related epilepsy.. Br J Radiol, 85(1017), 1236-1242.
Hadjivassiliou M, Wallis LI, Hoggard N, Grünewald RA, Griffiths PD & Wilkinson ID (2012) MR spectroscopy and atrophy in Gluten, Friedreich's and SCA6 ataxias.. Acta Neurol Scand, 126(2), 138-143.
Kotsarini C, Wilkinson ID, Jellinek D, Griffiths PD, Khandanpour N & Hoggard N (2011) USE OF MR SPECTROSCOPY AND DIFFUSION TO DIFFERENTIATE GBM FROM SOLITARY CEREBRAL METASTASES. NEURO-ONCOLOGY, 13, 141-141.
Kotsarini C, Wilkinson ID, Jellinek D, Griffiths PD, Bambrough P & Hoggard N (2011) CHO/CR RATIO APPEARS TO BE AN INDEPENDENT IMAGING BIOMARKER OF SURVIVAL FOR PATIENTS NOT SUITABLE FOR OPEN RESECTION OF GLIOBLASTOMA. NEURO-ONCOLOGY, 13, 141-142.
Blackburn D, Chavada G, Dunleavy D, Hoggard N, Sharrack B, Ponnusamy S & Price S (2011) GUILLAIN-BARRE SYNDROME (GBS) PRESENTING WITH POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME. J NEUROL NEUROSUR PS, 82(9).
Wilkinson VH, Carroll T & Hoggard N (2011) Contrasting natural histories of thoracic spine pneumatocysts: resolution versus rapid enlargement.. Br J Radiol, 84(1000), e79-e82.
Craven I, Griffiths PD & Hoggard N (2011) Magnetic resonance imaging of epilepsy at 3 Tesla. Clinical Radiology.
Kotsarini C, Griffiths PD, Wilkinson ID & Hoggard N (2010) A systematic review of the literature on the effects of dexamethasone on the brain from in vivo human-based studies: implications for physiological brain imaging of patients with intracranial tumors.. Neurosurgery, 67(6), 1799-1815.
Craven I, Kotsarini C & Hoggard N (2010) Recent advances in imaging epilepsy.. Postgrad Med J, 86(1019), 552-559.
Warren DJ, Musson R, Connolly DJA, Griffiths PD & Hoggard N (2010) Imaging in acute ischaemic stroke: essential for modern stroke care.. Postgrad Med J, 86(1017), 409-418.
Boye T, Yousefpour A, Smith A & Hoggard N (2010) P15 A pictorial review of the role of CT angiography (CTA) in head and neck cancer imaging. British Journal of Oral and Maxillofacial Surgery, 48, S28-S28.
Leeds JS, Hopper AD, Sidhu R, Simmonette A, Azadbakht N, Hoggard N, Morley S & Sanders DS (2010) Some patients with irritable bowel syndrome may have exocrine pancreatic insufficiency.. Clin Gastroenterol Hepatol, 8(5), 433-438.
Wignall EL, Griffiths PD, Papadakis NG, Wilkinson ID, Wallis LI, Bandmann O, Cowell PEE & Hoggard N (2010) Corpus Callosum Morphology and Microstructure Assessed Using Structural MR Imaging and Diffusion Tensor Imaging: Initial Findings in Adults with Neurofibromatosis Type 1. AM J NEURORADIOL, 31(5), 856-861.
Bigley J, Griffiths PD, Prydderch A, Romanowski CAJ, Miles L, Lidiard H & Hoggard N (2010) Neurolinguistic programming used to reduce the need for anaesthesia in claustrophobic patients undergoing MRI.. Br J Radiol, 83(986), 113-117.
Gwilliam MN, Hoggard N, Capener D, Singh P, Marzo A, Verma PK & Wilkinson ID (2009) MR derived volumetric flow rate waveforms at locations within the common carotid, internal carotid, and basilar arteries.. J Cereb Blood Flow Metab, 29(12), 1975-1982.
Griffiths PD & Hoggard N (2009) Distribution and conspicuity of intracranial abnormalities on MR imaging in adults with tuberous sclerosis complex: A comparison of sequences including ultrafast T2-weighted images.. Epilepsia, 50(12), 2605-2610.
Woodhouse N, Wild JM, van Beek EJR, Hoggard N, Barker N & Taylor CJ (2009) Assessment of hyperpolarized 3He lung MRI for regional evaluation of interventional therapy: a pilot study in pediatric cystic fibrosis.. J Magn Reson Imaging, 30(5), 981-988.
Hoggard N (2009) Re: Development and initial testing of normal reference MR images for the brain at ages 65-70 and 75-80 years. EUR RADIOL, 19(4), 1025-1025.
Hoggard N, Darwent G, Capener D, Wilkinson ID & Griffiths PD (2009) The high incidence and bioethics of findings on magnetic resonance brain imaging of normal volunteers for neuroscience research.. J Med Ethics, 35(3), 194-199.
Ireland RH, Woodhouse N, Hoggard N, Swinscoe JA, Foran BH, Hatton MQ & Wild JM (2008) An image acquisition and registration strategy for the fusion of hyperpolarized helium-3 MRI and x-ray CT images of the lung.. Phys Med Biol, 53(21), 6055-6063.
Hoggard N, Wilkinson ID, Griffiths PD, Vaughan P, Kemeny AA & Rowe JG (2008) The clinical course after stereotactic radiosurgical amygdalohippocampectomy with neuroradiological correlates.. Neurosurgery, 62(2), 336-344.
Wilkinson ID, Hoggard N, Jellinek DA, Levy D, Kotsarini C, Batty R, Griffiths PD & Romanowski CAJ (2008) MR perfusion: Techniques used for intracranial tumour assessment. Neuroradiology Journal, 21(SUPPL. 1), 20-26.
Romanowski CAJ, Hoggard N, Jellinek DA, Levy D, Wharton SB, Kotsarini C, Batty R & Wilkinson ID (2008) Low grade gliomas. Can we predict tumour behaviour from imaging features?. Neuroradiology Journal, 21(SUPPL. 1), 47-66.
Warren DJ, Hoggard N, Walton L, Radatz MWR, Kemeny AA, Forster DMC, Wilkinson ID & Griffiths PD (2007) Cerebral arteriovenous malformations: comparison of novel magnetic resonance angiographic techniques and conventional catheter angiography.. Neurosurgery, 61(1 Suppl), 187-196.
Ireland RH, Dyker KE, Barber DC, Wood SM, Hanney MB, Tindale WB, Woodhouse N, Hoggard N, Conway J & Robinson MH (2007) Nonrigid image registration for head and neck cancer radiotherapy treatment planning with PET/CT.. Int J Radiat Oncol Biol Phys, 68(3), 952-957.
Griffiths PD, Pandya H, Wilkinson ID & Hoggard N (2006) Sequential dynamic gadolinium magnetic resonance perfusion-weighted imaging: effects on transit time and cerebral blood volume measurements.. Acta Radiol, 47(10), 1079-1084.
Hoggard N, Feasby TE, Kennedy J, Quan H & Ghali WA (2004) Importance of the imaging modality in decision making about carotid endarterectomy. Neurology, 63(7), 1340-1341.
Hoggard N (2004) Conventional digital subtraction x-ray angiography versus magnetic resonance angiography in the evaluation of carotid disease: patient satisfaction and preferences.. Clin Radiol, 59(4), 356-357.
Wilkinson ID, Griffiths PD, Hoggard N, Cleveland TJ, Gaines PA, Macdonald S, McKevitt F & Venables GS (2003) Short-term changes in cerebral microhemodynamics after carotid stenting.. AJNR Am J Neuroradiol, 24(8), 1501-1507.
Madlom MM, Hoggard N, Griffiths PD & Chan J (2003) Facial naevus flammeus with choroidal haemangioma and without intracranial involvement. DEV MED CHILD NEUROL, 45(2), 139-139.
Hoggard N, Wilkinson ID, Paley MNI & Griffiths PD (2002) Imaging of haemorrhagic stroke.. Clin Radiol, 57(11), 957-968.
Hoggard N, Paley MN, Whitby EH & Griffiths P (2001) Comparison of the aging of neonatal and adult blood samples in an in vitro subdural hemorrhage model. RADIOLOGY, 221, 487-487.
Griffiths PD, Wilkinson ID, Wels T & Hoggard N (2001) Brain MR perfusion imaging in humans - Advantages of high-molarity gadolinium chelates. ACTA RADIOL, 42(6), 555-559.
Griffiths PD, Wilkinson ID, Wels T & Hoggard N (2001) Brain MR perfusion imaging in humans.. Acta Radiol, 42(6), 555-559.
Griffiths PD, Wilkinson ID, Mitchell P, Patel MC, Paley MN, Romanowski CA, Powell T, Hodgson TJ, Hoggard N & Jellinek D (2001) Multimodality MR imaging depiction of hemodynamic changes and cerebral ischemia in subarachnoid hemorrhage.. AJNR Am J Neuroradiol, 22(9), 1690-1697.
Sanders DS, Carter MJ, Lobo AJ & Hoggard N (2001) Research outcomes in British gastroenterology: an audit of the subsequent full publication of abstracts presented at the British Society of Gastroenterology. GUT, 49(1), 154-155.
Graham JM, Paley MNJ, Grünewald RA, Hoggard N & Griffiths PD (2001) Erratum: Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence (Brain (December 2000) 123:12 (2423-2431)). Brain, 124(6), 1258.
Warren DJ, Hoggard N, Walton L, Radatz MWR, Kemeny AA, Forster DMC, Wilkinson ID & Griffiths PD (2001) Cerebral Arteriovenous Malformations: Comparison of Novel Magnetic Resonance Angiographic Techniques and Conventional Catheter Angiography. Neurosurgery, 48(5), 973-983.
Warren DJ, Hoggard N, Walton L, Radatz MW, Kemeny AA, Forster DM, Wilkinson ID & Griffiths PD (2001) Cerebral arteriovenous malformations: comparison of novel magnetic resonance angiographic techniques and conventional catheter angiography.. Neurosurgery, 48(5), 973-982.
Hoggard N, Wilkinson ID & Griffiths PD (2001) The imaging of ischaemic stroke.. Clin Radiol, 56(3), 171-183.
Mitchell P, Wilkinson ID, Hoggard N, Paley MN, Jellinek DA, Powell T, Romanowski C, Hodgson T & Griffiths PD (2001) Detection of subarachnoid haemorrhage with magnetic resonance imaging.. J Neurol Neurosurg Psychiatry, 70(2), 205-211.
Dugar N, Hoggard N, Wilkinson ID & Griffiths PD (2001) MR imaging in acute stroke. Imaging Decisions MRI, 5(1), 2-10.
Griffiths PD, Hoggard N, Dannels WR & Wilkinson ID (2001) In vivo measurement of cerebral blood flow: a review of methods and applications.. Vasc Med, 6(1), 51-60.
Graham JM, Paley MN, Grünewald RA, Hoggard N & Griffiths PD (2000) Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence.. Brain, 123 Pt 12, 2423-2431.
Griffiths PD, Hoggard N, Warren DJ, Wilkinson ID, Anderson B & Romanowski CA (2000) Brain arteriovenous malformations: assessment with dynamic MR digital subtraction angiography.. AJNR Am J Neuroradiol, 21(10), 1892-1899.
Bretschneider T & Strotzer M (2000) Leptomeningeal Enhancement and Extravasation of Contrast Medium into the CSF Space?. Stroke, 31(9), 2266-2278.
Lu C-J, Sun Y & Huang K-M (2000) Leptomeningeal Enhancement After Carotid Stenting. Stroke, 31(9), 2266-2278.
Wilkinson ID, Griffiths PD, Hoggard N, Cleveland TJ, Gaines PA & Venables GS (2000) Leptomeningeal enhancement and extravasation of contrast medium into the CSF space? Response. STROKE, 31(9), 2276-2277.
Sanders DS, Carter MJ, Hurlstone P, Hoggard N & Lobo AJ (2000) Full publication of abstracts presented at the British Society of Gastroenterology.. GASTROENTEROLOGY, 118(4), A217-A217.
Sanders DS, Carter MJ, Hurlstone JP, Hoggard N & Lobo AJ (2000) Full publication of abstracts presented at the British Society of Gastroenterology. GUT, 46, A18-A18.
Wilkinson ID, Griffiths PD, Hoggard N, Cleveland TJ, Gaines PA & Venables GS (2000) Unilateral leptomeningeal enhancement after carotid stent insertion detected by magnetic resonance imaging.. Stroke, 31(4), 848-851.
Flores Martin A, Shanmugarajah P, Hoggard N & Hadjivassiliou M () Treatment Response of Deferiprone in Infratentorial Superficial Siderosis: a Systematic Review. The Cerebellum.
Hadjivassiliou M, Sarrigiannis PG, Shanmugarajah PD, Sanders DS, Grünewald RA, Zis P & Hoggard N () Clinical Characteristics and Management of 50 Patients with Anti-GAD Ataxia: Gluten-Free Diet Has a Major Impact. The Cerebellum.
Pattrick M, Sarrigiannis PG, Kruger S, Davies B, Hoggard N, Irani SR, Unwin Z, Zis P, Blackburn DJ & Hadjivassiliou M () Brain hyper-excitability in DPPX ataxia. Journal of Neurology.
Croall ID, Hoggard N, Aziz I, Hadjivassiliou M & Sanders DS () Brain fog and non-coeliac gluten sensitivity: Proof of concept brain MRI pilot study. PLOS ONE, 15(8), e0238283-e0238283.
Hadjivassiliou M, Grünewald R, Sanders D, Zis P, Croall I, Shanmugarajah P, Sarrigiannis P, Trott N, Wild G & Hoggard N () The Significance of Low Titre Antigliadin Antibodies in the Diagnosis of Gluten Ataxia. Nutrients, 10(10), 1444-1444.
Khandanpour N, Connolly D, Raghavan A, Griffiths P & Hoggard N () Kraniospinale Anomalien und neurologische Komplikationen bei Osteogenesis imperfecta: Bildgebung im Überblick. Neuroradiologie Scan, 03(04), 285-298.
Friedman SN, Bambrough PJ, Kotsarini C, Khandanpour N & Hoggard N () Semi-automated and automated glioma grading using dynamic susceptibility-weighted contrast-enhanced perfusion MRI relative cerebral blood volume measurements.. Br J Radiol.
Hadjivassiliou M, Graus F, Honnorat J, Jarius S, Titulaer M, Manto M, Hoggard N, Sarrigiannis P & Mitoma H () Diagnostic criteria for primary autoimmune cerebellar ataxia—guidelines from an international task force on immune-mediated cerebellar ataxias. The Cerebellum. View this article in WRRO
Hadjivassiliou M, Grunewald R, Shanmugarajah P, Sarrigiannis P, Zis P, Skarlatou V & Hoggard N () Treatment of primary autoimmune cerebellar ataxia with mycophenolate. The Cerebellum. View this article in WRRO
Jenkins TM, Alix JJP, Fingret J, Esmail T, Hoggard N, Baster K, McDermott CJ, Wilkinson ID & Shaw PJ () Longitudinal multi-modal muscle-based biomarker assessment in motor neuron disease. Journal of Neurology. View this article in WRRO
Sassani M, Alix J, McDermott C, Baster K, Hoggard N, Wild J, Mortiboys H, Shaw P, Wilkinson I & Jenkins T () Magnetic resonance spectroscopy reveals mitochondrial dysfunction in amyotrophic lateral sclerosis. Brain.
Anton A, Mead RJ, Shaw PJ, Edden RAE, Bigley J, Jenkins TM, Wild JM, Hoggard N & Wilkinson ID () Assessment of the Precision in Measuring Glutathione at 3 T With a MEGA‐PRESS Sequence in Primary Motor Cortex and Occipital Cortex. Journal of Magnetic Resonance Imaging.

Conference proceedings papers

Toh CL, Keslake A, Harding J, Baster K, Hoggard N, Bigley J, McDermott CJ, Shaw PJ, Wilkinson ID & Jenkins TM (2019) 222 Investigating directionality of neurodegeneration in vivo in ALS using multimodal MRI. Journal of Neurology Neurosurgery & Psychiatry, Vol. 90(12) (pp e55)
Toh C, Keslake A, Harding J, Baster K, Hoggard N, Bigley J, McDermott CJ, Shaw PJ, Wilkinson ID & Jenkins TM (2019) Investigating Directionality of Neurodegeneration in vivo in ALS using Multimodal MRI. NEUROLOGY, Vol. 92(15)
J H, L K-I, S B, L B, S P, A S, N H, M R & D P (2018) THUR 198 Safe monitoring of natalizumab therapy in multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 89(10) (pp A29.1-A29)
Jenkins TM, Alix J, Hoggard N, Rao G, O'brien E, Baster K, Bigley J, Wilkinson I, McDermott C & Shaw P (2018) Imaging denervation in amyotrophic lateral sclerosis for future clinical trials: 12-month follow-up from a longitudinal cohort study. EUROPEAN JOURNAL OF NEUROLOGY, Vol. 25 (pp 302-302)
Jenkins T, Alix J, Rao G, Hoggard N, O'Brien E, Baster K, Bradburn M, Bigley J, McDermott C, Wilkinson I & Shaw P (2017) Imaging denervation in motor neuron disease for future clinical trials: a longitudinal cohort study. Journal of the Neurological Sciences, Vol. 381 (pp 102-102) View this article in WRRO
Hewamadduma CA, Omalley R, Robinson M, Beauchamp N, Rogers T, Martindale J, Mcdermott C, Shaw P, Hoggard N & Hadjivassiliou M (2017) Mutations in SPG7 as an important cause of spastic-ataxia in a large british cohort: Hybrid phenotype helps direct screening. Journal of the Neurological Sciences, Vol. 381 (pp 304-305) View this article in WRRO
Penny HA, Aziz I, Ferrar M, Atkinson J, Hoggard N, Hadjivassiliou M, West JN & Sanders DS (2016) PWE-055 Coeliac Disease is More Common in Subjects with Postural Orthostatic Tachycardia Syndrome Compared to Healthy Controls. Gut, Vol. 65(Suppl 1) (pp A165.2-A166)
Wong L, Sharp P, Howarth C, Hoggard N, Berwick J & Francis S (2016) 179 Neurovascular Function in Atherosclerosis. Heart, Vol. 102(Suppl 6) (pp A123.2-A124), 6 June 2016 - 8 June 2016.
Raftopoulos R, Hickman S, Toosy A, Sharrack B, Malliki S, Paling D, Altman D, Yiannakas M, Malladi P, Sheridan R , Sarrigiannis P et al (2016) Prognostic Factors Associated with Axonal Loss after Optic Neuritis. NEUROLOGY, Vol. 86
Raftopoulos R, Hickman S, Toosy A, Sharrack B, Mallik S, Paling D, Altmann D, Yiannakas M, Malladi P, Sheridan R , Sarrigiannis P et al (2016) Prognostic Factors Associated with Axonal Loss after Optic Neuritis. NEUROLOGY, Vol. 86
Penny HA, Ferrar M, Atkinson J, Hoggard N, Hadjivassiliou M, West JN & Sanders DS (2015) PTU-184 Is there a relationship between gluten ingestion and postural tachycardia syndrome?. Gut, Vol. 64(Suppl 1) (pp A144.1-A144)
Bahl A, Larsen JJ, Craven I, Metherall P, McKevitt FM, Romanowski CAJ, Hoggard N & Jellinek DA (2012) TRANSFORMATION OF LOW-GRADE GLIOMA ASSESSED BY VOLUMETRIC 3T MRI. NEURO-ONCOLOGY, Vol. 14 (pp 4-4)
Hadjivassiliou M, Currie S, Sanders D & Hoggard N (2012) Alcoholic Cerebellar Degeneration: Not All Due to Alcohol. ANNALS OF NEUROLOGY, Vol. 72 (pp S96-S96)
Romanowski CA, Hoggard N, Jellinek DA, Clenton S, McKevitt F, Wharton S, Craven I, Buller A, Waddle C, Bigley J , Wilkinson ID et al (2011) SEMI-AUTOMATED VOLUMETRIC ANALYSIS OF LOW-GRADE GLIOMAS. NEURO-ONCOLOGY, Vol. 13 (pp 140-140)
Ireland RH, Wild JM, Woodhouse N, Hoggard N, Brown G, Swinscoe JA, Din O & Hatton MQ (2008) Can hyperpolarized He-3 MRI detect radiation induced lung damage?. LUNG CANCER, Vol. 60 (pp S28-S28)
Jellinek D, Hoggard N, Wilkinson I, Levy D, Giesel F, Romanowski C, Miller B & Griffiths P (2007) Dexamethasone and enhancing gliomas: Alterations in perfusion and blood-tumor barrier kinetics shown by magnetic resonace imaging. NEURO-ONCOLOGY, Vol. 9(4) (pp 578-578)
Ireland R, Woodhouse N, Hoggard N, Beek E, Swinscoe J, Brown G, Hatton M & Wild J (2007) Improved image registration of hyperpolarized helium-3 MRI and CT for NSCLC planning. RADIOTHERAPY AND ONCOLOGY, Vol. 84 (pp S173-S173)
Ireland RH, Wood SM, Hanney MB, Tindale WB, Dyker KE, Robinson MH, Woodhouse N, Hoggard N, Conway J, Swinscoe JA & Barber DC (2007) Non-rigid Registration Enables Radiotherapy Treatment Planning with Staging PET. Clinical Oncology, Vol. 19(3) (pp S5-S5)

Teaching interests: I am the lead for the Sheffield academic clinical radiology training scheme and Deputy Lead for the Sheffield academic training programme. The Sheffield radiology training scheme continues to show strong success developing academic radiologists all the way from thesis to tenured full time academic posts. I teach on the Neurology MSc course, the Sheffield Fundamentals of Neuroradiology course and the National ENT radiology Masterclass.

Professional activities

Editor-in-Chief British Journal of Radiology 2013-2016.
Expert Advisory Panel member, Commission for Human Medicines/MHRA 2009-present.
Expert Advisory Panel member, European Medicines Agency 2016.
Cancer Peer reviewer 2012-2013.
Member of the Royal College of Radiologists FRCR part I examination committee 2011-2014.
NIHR doctoral research fellowship selection panel member 2011 and 2013-present.
NIHR IAT panel for competitive bids for ACF and ACL posts 2015-present.
Sheffield Teaching Hospitals NHS Foundation Trust, Research Lead for the Directorate of Radiology 2008-present.
Member of the Sheffield Regional Ethics committee 2006-2012.

The Medical School

Professor Nigel Hoggard

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Conference proceedings papers