Dr Osman Shabir

BSc (Hons), MSc, PhD

Department of Infection, Immunity and Cardiovascular Disease

Postdoctoral Research Associate

Alzheimer’s Research UK (ARUK) Yorkshire Network ECR Representative.

Dr Osman Shabir
Dr Osman Shabir
+44 114 222 6554

Full contact details

Dr Osman Shabir
Department of Infection, Immunity and Cardiovascular Disease
Alfred Denny Building
Western Bank
S10 2TN

For enquiries, please contact – iicd-om-operational@sheffield.ac.uk

I graduated with a BSc (Hons) in Biomedical Science in 2015 from the University of Sheffield, specialising in neuroscience in my final year. I then went on to complete an MSc in Translational Neuroscience in SITraN in 2016. In 2020, I was awarded my PhD in Neurovascular Neuroscience, supervised by Dr Jason Berwick & Prof Sheila Francis.

In 2020, Prof Sheila Francis was awarded a BHF project grant titled “Atherosclerosis, the brain and vascular dementia – the role of inflammation in neurovascular function”; based on pilot data from my PhD thesis, on which I am currently the postdoc on.

Research interests

I study neurovascular function in neurodegenerative and cerebrovascular diseases such as Alzheimer’s disease/vascular dementia & cardiovascular disease (atherosclerosis). I use preclinical models of human disease to study neurophysiology, neuropathology & neuroinflammation in these models to gain a better understanding of disease mechanisms and processes.

neurovascular function, heart disease
Neurovascular function; 'healthy' & 'heart disease.

To study neurovascular function, I use neuroimaging techniques including 2D-optical imaging spectroscopy, 2-photon microscopy, GCaMP fluorescence and microelectrode electrophysiology. In addition, I use standard cellular and molecular neuroscience techniques to validate in vivo observations.


Show: Featured publications All publications

Journal articles

All publications

Journal articles

Conference proceedings papers

  • Howarth C, Lee L, Shabir O & Berwick J (2022) Investigating the involvement of nitric oxide in neurovascular coupling. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol. 42(1_SUPPL) (pp 60-60) RIS download Bibtex download
Research group

Prof Sheila Francis is the PI on the BHF grant on which I am the postdoc on. I am a member of the Sheffield Neurovascular Lab where I work directly with Dr Jason Berwick and Dr Clare Howarth (co-PIs on the BHF grant). I also work directly with Dave Drew who is a research technician on the BHF grant. I further collaborate with Prof Stephen Wharton in SITraN.