Professor Sarah Rowland-Jones
B.M. B.Ch., M.A. (Cantab), D.M. (Oxon), FRCP, F.Med.Sci.
Department of Infection, Immunity and Cardiovascular Disease
Florey Professor of Infection and Immunity
+44 114 215 9608
Full contact details
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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I trained in medicine in Cambridge and Oxford Universities, then did post-graduate training in medicine in London and Sheffield before completing specialist training in Infectious Diseases in Oxford.
I became interested in HIV infection as a junior doctor in London, looking after some of the first AIDS patients to be diagnosed in the UK. I started my research career with a doctorate in the Weatherall Institute of Molecular Oxford supervised by Professor Andrew McMichael, studying the role of HIV-specific cytotoxic T lymphocytes (CTL) in the outcomes of HIV-1 infection and exposure.
My research has been supported by a series of MRC Clinical research fellowships (Training, Clinician Scientist, Senior), culminating in the award of an MRC Clinical Research Professorship from 2008 to 2014.
I became increasingly interested in working in the tropics and was fortunate to have the opportunity to collaborate in studies of cellular immune responses to viral infections with researchers in places such as The Gambia, Kenya, Thailand, Viet Nam and China. This led to me becoming Director of the Oxford Centre for Tropical Medicine between 2001 and 2004, and then moving to West Africa to become Research Director of the MRC Laboratories, The Gambia, the UK’s oldest and largest tropical research unit between 2004 and 2008. Whilst in The Gambia my research interests focused on HIV-2 pathogenesis and the development of infant immunity in response to pathogens and vaccines in early life.
I joined the IICD department in 2018 as Florey Professor of Infection and Immunity, and now divide my time between Sheffield and Oxford. I remain an active clinician, holding an Honorary Consultant contract in adult Infectious Diseases. I was President of the Royal Society of Tropical Medicine and Hygiene between 2018 and 2019 after six years as a Trustee of the Society, and am also a Fellow of Christ Church, Oxford.
- Research interests
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My research interests focus on host-pathogen interactions in viral infections, with a particular interest in HIV infection and how CMV co-infection contributes to pathogenesis in both HIV-infected people and uninfected infants born to HIV-infected women.
I collaborate closely with Professor Rashida Ferrand (LSHTM) in Harare, Zimbabwe, in studies of HIV pathogenesis and immunology in older children and adolescents with perinatally-acquired HIV infection (PHIV).
In Sheffield I co-lead a research group with Dr Thushan de Silva, where I am working on projects to evaluate vaccine-induced immunity in older children with PHIV, and to characterise acquisition of viral immunity in patients who have undergone Haemapoietic Stem Cell Transplantation (HSCT).
Current projects
- How does the immune system reconstitute cellular responses (T-cells and NK cells) to persistent virus infection following HSCT.
- What levels of antibody responses to routine childhood vaccines given as part of the Expanded Programme of Immunisation persist in children who present late with PHIV? Are booster immunisations required in this age-group?
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Structure of HIV-2 Nef Reveals Features Distinct from HIV-1 Involved in Immune Regulation. iScience, 23(1).
- Unexpectedly High Prevalence of Cytomegalovirus DNAemia in Older Children and Adolescents With Perinatally Acquired Human Immunodeficiency Virus Infection. Clinical Infectious Diseases, 69(4), 580-587.
- Low-Bias RNA Sequencing of the HIV-2 Genome from Blood Plasma. Journal of Virology, 93(1). View this article in WRRO
- HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation. AIDS, 6, 704-709. View this article in WRRO
- Early Virological and Immunological Events in Asymptomatic Epstein-Barr Virus Infection in African Children. PLOS Pathogens, 11(3). View this article in WRRO
- Correlates of T-cell–mediated viral control and phenotype of CD8+ T cells in HIV-2, a naturally contained human retroviral infection. Blood, 121(21), 4330-4339.
- HIV‐1–Specific Cytotoxic T Lymphocytes and Breast Milk HIV‐1 Transmission. The Journal of Infectious Diseases, 199(6), 889-898.
- Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection. Journal of Clinical Investigation, 117(10), 3067-3074.
- Cutting Edge: Allele-Specific and Peptide-Dependent Interactions between KIR3DL1 and HLA-A and HLA-B. The Journal of Immunology, 178(1), 33-37.
- Increased frequencies of CD4+CD25high regulatory T cells in acute dengue infection. Journal of Experimental Medicine, 204(5), 979-985.
- HIV-specific Cytotoxic T Cells from Long-Term Survivors Select a Unique T Cell Receptor. Journal of Experimental Medicine, 200(12), 1547-1557.
- CD8+ lymphocytes respond to different HIV epitopes in seronegative and infected subjects. Journal of Clinical Investigation, 107(10), 1303-1310.
- Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nature Medicine, 3(2), 212-217.
- HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Nature Medicine, 1(1), 59-64.
- Negative Correlation between Circulating CD4+FOXP3+CD127− Regulatory T Cells and Subsequent Antibody Responses to Infant Measles Vaccine but Not Diphtheria–Tetanus–Pertussis Vaccine Implies a Regulatory Role. Frontiers in Immunology, 8.
- Sex-Differential Non-Vaccine-Specific Immunological Effects of Diphtheria-Tetanus-Pertussis and Measles Vaccination. Clinical Infectious Diseases, ciw492-ciw492.
- Minimal Sex-Differential Modulation of Reactivity to Pathogens and Toll-Like Receptor Ligands following Infant Bacillus Calmette–Guérin Russia Vaccination. Frontiers in Immunology, 8.
All publications
Books
Journal articles
- Role of antenatal plasma cytomegalovirus DNA levels on pregnancy outcome and HIV-1 vertical transmission among mothers in the University of Zimbabwe birth cohort study (UZBCS). Virology Journal, 18(1).
- Sensing our Z-RNA. Nature Reviews Immunology, 21(2), 71.
- The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design. Biochemical and Biophysical Research Communications.
- Variation of HLA class I (-A and -C) genes in individuals infected with hepatitis B or hepatitis C virus in Cameroon. Heliyon, 6(10), e05232-e05232.
- Chronic lung disease in patients with perinatally acquired HIV in England: a retrospective case-note review. Pediatric Infectious Disease Journal. View this article in WRRO
- Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus. Cell. View this article in WRRO
- A commentary on the interagency symposium: ‘Building a Healthier Future: A Human Capital Perspective on Health and Education’, presented at the European Congress of Tropical Medicine and International Health, Liverpool, UK, October 2019. International Health, 12(4), 235-237.
- Chronic comorbidities in children and adolescents with perinatally acquired HIV infection in sub-Saharan Africa in the era of antiretroviral therapy. The Lancet Child & Adolescent Health.
- A novel full‐length two‐domain
KIR2DL5A
allele isolated in Zimbabwean samples:
KIR2DL5A*0010104. HLA, 96(1), 135-136.
- Chronic lung disease in children and adolescents with HIV: a case–control study. Tropical Medicine & International Health, 25(5), 590-599.
- Structure of HIV-2 Nef Reveals Features Distinct from HIV-1 Involved in Immune Regulation. iScience, 23(1).
- Killer Cell Immunoglobulin-Like Receptor Genotypes and Haplotypes Contribute to Susceptibility to Hepatitis B Virus and Hepatitis C Virus Infection in Cameroon. OMICS: A Journal of Integrative Biology, 24(2), 110-115.
- HIV-2 as a model to identify a functional HIV cure. AIDS Research and Therapy, 16(1). View this article in WRRO
- History of tuberculosis is associated with lower exhaled nitric oxide levels in HIV-infected children. AIDS, 33(11), 1711-1718. View this article in WRRO
- Unexpectedly High Prevalence of Cytomegalovirus DNAemia in Older Children and Adolescents With Perinatally Acquired Human Immunodeficiency Virus Infection. Clinical Infectious Diseases, 69(4), 580-587.
- A17 The effect of intra-host evolution of HIV-2 capsid on disease progression. Virus Evolution, 5(Supplement_1).
- Aberrant natural killer (NK) cell activation and dysfunction among ART-treated HIV-infected adults in an African cohort. Clinical Immunology, 201, 55-60.
- New insights are game-changers in HIV-2 disease management – Authors' reply. The Lancet HIV, 6(4), e214-e215.
- Dimorphism in the T-cell receptor constant region affects T-cell function, phenotype and HIV outcome. AIDS, 33(9), 1421-1429.
- Pilot testing of an online training module about screening for acute HIV infection in adult patients seeking urgent healthcare. International Health, 11(2), 93-100.
- KIR and HLA-C Genetic Polymorphisms Influence Plasma IP-10 Concentration in Antiretroviral Therapy-Naive HIV-Infected Adult Zimbabweans. OMICS: A Journal of Integrative Biology, 23(2), 111-118.
- Delayed disease progression in HIV‐2: the importance of TRIM5α and the retroviral capsid. Clinical & Experimental Immunology, 196(3), 305-317.
- Long-term follow-up of HIV-2-related AIDS and mortality in Guinea-Bissau: a prospective open cohort study. The Lancet HIV, 6(1), e25-e31.
- Low-Bias RNA Sequencing of the HIV-2 Genome from Blood Plasma. Journal of Virology, 93(1). View this article in WRRO
- Analysis of HIV-1 envelope evolution suggests antibody-mediated selection of common epitopes among Chinese former plasma donors from a narrow-source outbreak. Scientific Reports, 8(1).
- P069UTR SNPS rs111686073 and rs73410010 independently modify expression of tapasin in blacks. Human Immunology, 79, 113-113.
- CD4 count recovery following initiation of HIV antiretroviral therapy in older childhood and adolescence. AIDS, 1-1.
- HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation. AIDS, 6, 704-709. View this article in WRRO
- Impact of a single HLA-A*24:02-associated escape mutation on the detrimental effect of HLA-B*35:01 in HIV-1 control. EBioMedicine, 36, 103-112.
- Azithromycin versus placebo for the treatment of HIV-associated chronic lung disease in children and adolescents (BREATHE trial): study protocol for a randomised controlled trial. Trials, 18(1).
- Genome-wide profiling of humoral immunity and pathogen genes under selection identifies immune evasion tactics of Chlamydia trachomatis during ocular infection. Scientific Reports, 7(1).
- Snapin promotes
HIV
‐1 transmission from dendritic cells by dampening
TLR
8 signaling. The EMBO Journal, 36(20), 2998-3011.
- Cytomegalovirus viraemia is associated with poor growth and T-cell activation with an increased burden in HIV-exposed uninfected infants. AIDS, 31(13), 1809-1818.
- A35 Viral evolution and innate immune responses during acute HIV-1 infection and their association with disease pathogenesis. Virus Evolution, 3(suppl_1).
- KIR Gene Content Diversity in a Zimbabwean Population: Does KIR2DL2 Have a Role in Protection Against Human Immunodeficiency Virus Infection?. OMICS: A Journal of Integrative Biology, 20(12), 727-735.
- Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2–Infected Controllers. The Journal of Immunology, 197(7), 2787-2795.
- Chronic lung disease in HIV-infected children established on antiretroviral therapy. AIDS, 30(18), 2795-2803.
- Viral Evolution and Cytotoxic T Cell Restricted Selection in Acute Infant HIV-1 Infection. Scientific Reports, 6. View this article in WRRO
- HLA-C*16:01:01:02, a recently isolated HLA class I allele from Southern Africa. HLA, 87(6), 470-471.
- Isolation of full-lengthHLA-C*18:02allele in an individual from Sub-Saharan Africa. HLA, 87(6), 471-472.
- Higher Type 1 Interferon Levels in Plasma of Asymptomatic HIV-2 than in HIV-1 Individuals. Advances in Infectious Diseases, 06(01), 15-23.
- HLA-C*06:04:02a novel HLA-C allele isolated from donors of Southern African descent. HLA, 87(5), 402-403.
- Changing oral vaccine to inactivated polio vaccine might increase mortality. The Lancet, 387(10023), 1054-1055.
- Chikungunya: out of the tropical forests and heading our way …. Transactions of The Royal Society of Tropical Medicine and Hygiene, 110(2), 85-86.
- Predicting the extinction of HIV-2 in rural Guinea-Bissau. AIDS, 29(18), 2479-2486. View this article in WRRO
- Outcomes of prevention of mother to child transmission of the human immunodeficiency virus-1 in rural Kenya—a cohort study. BMC Public Health, 15(1).
- Correction. European Journal of Immunology, 45(9), 2701-2701.
- A novel HLA allele,HLA-DRB1*15:116, discovered in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens, 86(2), 149-150.
- 8th IAS Conference on HIV Pathogenesis, Treatment & Prevention 19-22 July 2015, Vancouver, Canada. Journal of the International AIDS Society, 18, 20479-20479.
- Differential Expressions of Selected Activating and Inhibitory Receptors on K562-Stimulated Natural Killer (NK) Cells in HIV-1 and HIV-2 Infections. World Journal of AIDS, 05(01), 21-29.
- KIR3DS1*0130111: A novel KIR allele identified using molecular typing methods. Tissue Antigens, 85(4), 296-297.
- Early Virological and Immunological Events in Asymptomatic Epstein-Barr Virus Infection in African Children. PLOS Pathogens, 11(3). View this article in WRRO
- KIR3DL1*0250102: a novel three-domain KIR subtype identified in West Africa. Tissue Antigens, 85(2), 151-152.
- Identification of a novel three-domain KIR allele:KIR3DL1*087using high-resolution molecular techniques. Tissue Antigens, 85(2), 153-154.
- KIR3DS1*0130109: A novel activating three-domain KIR identified using sequence-based typing. Tissue Antigens, 86(3), 222-223.
- Detection of a novel KIR3DL1*0150210 allele by sequencing. Tissue Antigens, 86(4), 311.
- Detection of a novelKIR3DL1*0150210allele by sequencing. Tissue Antigens, 86(4), 311-311.
- KIR3DS1*0130109: a novel activating three-domain KIR identified using sequence-based typing. Tissue Antigens, 86(3), 222-223.
- The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated. European Journal of Immunology, 45(8), 2232-2242.
- Full-length sequence ofKIR3DL1*0310102detected in DNA samples from West Africa. Tissue Antigens, 86(4), 312-313.
- KIR3DL1*0040102- a novel three-domain KIR subtype isolated from donors of African descent. Tissue Antigens, 86(3), 220-221.
- KIR3DL1*0250103: a novel three-domain KIR allele isolated in West African samples. Tissue Antigens, 86(2), 150-151.
- The identification of a killer cell immunoglobulin-like receptor 3DL1*0150209 in an Asian population using molecular techniques. Tissue Antigens, 86(2), 152-153.
- The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated. European Journal of Immunology.
- The identification of a killer cell immunoglobulin-like receptor3DL1*0150209in an Asian population using molecular techniques. Tissue Antigens, 86(2), 152-153.
- A novelKIR3DL1*0150103subtype identified in West Africa. Tissue Antigens, 86(1), 70-71.
- HLA Correlates of Long-Term Survival in Vertically Infected HIV-1-Positive Adolescents in Harare, Zimbabwe. AIDS Research and Human Retroviruses, 31(5), 504-507.
- KIR3DS1*0130111: a novel KIR allele identified using molecular typing methods. Tissue Antigens, 85(4), 296-297.
- How does the humoral response to HIV-2 infection differ from HIV-1 and can this explain the distinct natural history of infection with these two human retroviruses?. Immunology Letters, 163(1), 69-75.
- Isolation of full-length genomic sequences of theKIR3DL1*0040103allele from African donors using sequence-based techniques. Tissue Antigens, 84(6), 594-595.
- Complete genomic sequence ofKIR3DL1*0150102. Tissue Antigens, 84(6), 595-596.
- Description of a novelKIR3DL1*0150211allele isolated using molecular techniques. Tissue Antigens, 84(6), 596-597.
- A new variant of killer-cell immunoglobulin-like receptorKIR3DL1*03101isolated using sequence-based techniques. Tissue Antigens, 84(5), 521-522.
- Genomic full length sequence of a novel killer-cell immunoglobulin-like receptor,KIR3DL1*0010103identified by sequencing. Tissue Antigens, 84(5), 520-521.
- Full length KIR3DS1*0130110 allele isolated by SBT. Tissue Antigens, 84(4), 423-424.
- KIR3DS1*0130108 isolated using full length sequence-based typing. Tissue Antigens, 84(2), 251-252.
- Report of a novel activating killer-cell immunoglobulin-like receptor allele3DS1*078identified using sequence-based typing. Tissue Antigens, 84(2), 252-254.
- A novel KIR3DS1*0130107 allele isolated by sequencing from an Asian donor. International Journal of Immunogenetics, 41(3), 267-268.
- A novel full-length KIR3DS1*0130106 allele identified by sequencing. Tissue Antigens, 83(5), 371-372.
- Identification of KIR3DL1*0150208 using long-range sequence-based techniques. Tissue Antigens, 83(5), 372-373.
- The protective effect of HIV-2 infection. AIDS, 28(7), 1065-1067.
- Sex differences in immune responses to vaccines. International Journal of Infectious Diseases, 21, 65-65.
- HIV-exposed uninfected children: a growing population with a vulnerable immune system?. Clinical & Experimental Immunology, 176(1), 11-22.
- Identification of the KIR3DL1*0050105 allele by sequence-based techniques. Tissue Antigens, 83(4), 301-302.
- Detection of a novel killer-cell immunoglobulin-like receptor allele - KIR3DL1*0150207 - in Asian individuals. Tissue Antigens, 83(4), 304-305.
- TheKIR3DS1*0130105allele identified using high-resolution sequence-based typing. Tissue Antigens, 83(4), 302-303.
- Killer-cell immunoglobulin-like receptor gene3DL1*077isolated using long-range sequence-based techniques. Tissue Antigens, 83(3), 206-207.
- A novel KIR3DL1*0070104 allele found in individuals from Asia. Tissue Antigens, 83(3), 204-206.
- HIV-1 progression links with viral genetic variability and subtype, and patient's HLA type: Analysis of a Nairobi-Kenyan cohort. Medical Microbiology and Immunology, 203(1), 57-63.
- Two novel KIR3DL1 alleles, 3DL1*0150205 and 3DL1*0150206, identified by full-length DNA sequencing. Tissue Antigens, 83(2), 128-129.
- Report of a novel KIR3DS1*0130104 allele discovered using advanced molecular techniques. Tissue Antigens, 83(2), 121-122.
- Full-length genomic sequence of a new KIR3DL1*0150203 allele. Tissue Antigens, 83(2), 122-123.
- Identification of KIR3DL1*0200101 by long-range sequence-based techniques. Tissue Antigens, 83(2), 127-128.
- Long-range sequencing revealed a new KIR3DL1*0150204 allele in 20 individuals of Asian descent. Tissue Antigens, 83(2), 123-124.
- Description of a novel KIR3DL1*0050104 allele identified using sequence-based techniques. Tissue Antigens, 83(2), 124-125.
- Full lengthKIR3DS1*0130110allele isolated by SBT. Tissue Antigens, 84(4), 423-424.
- Full-lengthKIR3DL1*022detected in an African donor. Tissue Antigens, 84(4), 427-429.
- KIR3DS1*0130108isolated using full length sequence-based typing. Tissue Antigens, 84(2), 251-252.
- Report of a novel activating killer-cell immunoglobulin-like receptor allele 3DS1078 identified using sequence-based typing. Tissue Antigens.
- A novel full-lengthKIR3DS1*0130106allele identified by sequencing. Tissue Antigens, 83(5), 371-372.
- Identification ofKIR3DL1*0150208using long-range sequence-based techniques. Tissue Antigens, 83(5), 372-373.
- Detection of a novel killer-cell immunoglobulin-like receptor allele - KIR3DL1*0150207 - in asian individuals. Tissue Antigens.
- A novelKIR3DL1*0200102allele isolated from a West African donor by sequence-based typing. Tissue Antigens, 83(4), 305-306.
- A novelKIR3DL1*0070104allele found in individuals from Asia. Tissue Antigens, 83(3), 204-206.
- Identification of theKIR3DL1*0050105allele by sequence-based techniques. Tissue Antigens, 83(4), 301-302.
- Killer-cell immunoglobulin-like receptor gene 3DL1*077 isolated using long-range sequence-based techniques. Tissue Antigens.
- Long-range sequencing revealed a newKIR3DL1*0150204allele in 20 individuals of Asian descent. Tissue Antigens, 83(2), 123-124.
- Two novel KIR3DL1 alleles,3DL1*0150205and3DL1*0150206, identified by full-length DNA sequencing. Tissue Antigens, 83(2), 128-129.
- HIV-1 progression links with viral genetic variability and subtype, and patient’s HLA type: analysis of a Nairobi-Kenyan cohort. Medical Microbiology and Immunology, 203(1), 57-63.
- Report of a novelKIR3DS1*0130104allele discovered using advanced molecular techniques. Tissue Antigens, 83(2), 121-122.
- Identification ofKIR3DL1*0200101by long-range sequence-based techniques. Tissue Antigens, 83(2), 127-128.
- Description of a novelKIR3DL1*0050104allele identified using sequence-based techniques. Tissue Antigens, 83(2), 124-125.
- Full-length genomic sequence of a newKIR3DL1*0150203allele. Tissue Antigens, 83(2), 122-123.
- Full-length sequence ofKIR3DL1*01501allele found in Sub-Saharan Africa by long-range sequencing. Tissue Antigens, 83(2), 126-127.
- A novel full length KIR3DL1*0070103 identified by molecular typing. Tissue Antigens, 82(6), 445-446.
- Identification of KIR3DL1*0050103 by the sequence-based techniques. Tissue Antigens, 82(6), 444-445.
- HLA correlates in a cohort of slow progressors from China. AIDS, 27(17), 2822-2824.
- The role of CD8+ T-cell responses in the pathogenesis of HIV-2, a naturally contained human retroviral infection. Journal of Infection, 67(4), 344-344.
- Comparing HIV-1 and HIV-2 infection: Lessons for viral immunopathogenesis. Reviews in Medical Virology, 23(4), 221-240.
- Population-specific evolution of HIV Gag epitopes in genetically diverged patients. Infection, Genetics and Evolution, 16, 78-86.
- Correlates of T-cell–mediated viral control and phenotype of CD8+ T cells in HIV-2, a naturally contained human retroviral infection. Blood, 121(21), 4330-4339.
- ST111 Immune selection and vpu variability in a unique narrow source HIV-Positive village cohort. JAIDS Journal of Acquired Immune Deficiency Syndromes, 62, S69-S69.
- Antigen-sensitive CD8 T-cell clones with tough HIV-1 suppression. The Lancet, 381, S44-S44.
- A novel full lengthKIR3DL1*0070103identified by molecular typing. Tissue Antigens, 82(6), 445-446.
- Identification ofKIR3DL1*0050103by the sequence-based techniques. Tissue Antigens, 82(6), 444-445.
- Population dynamics of HIV-2 in rural West Africa. AIDS, 27(1), 125-134.
- Structural features underlying T-cell receptor sensitivity to concealed MHC class I micropolymorphisms. Proceedings of the National Academy of Sciences, 109(50), E3483-E3492.
- Effect of HIV-2 Infection on HIV-1 Disease Progression. New England Journal of Medicine, 367(20), 1961-1963.
- Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. Journal of Clinical Investigation, 122(11), 4301-4301.
- Epitope Mapping of Broadly Neutralizing HIV-2 Human Monoclonal Antibodies. Journal of Virology, 86(22), 12115-12128.
- Breast milk cellular HIV-specific interferon γ responses are associated with protection from peripartum HIV transmission. AIDS, 26(16), 2007-2016.
- Acute Cytomegalovirus Infection Is Associated with Increased Frequencies of Activated and Apoptosis-Vulnerable T Cells in HIV-1-Infected Infants. Journal of Virology, 86(20), 11373-11379.
- Immune Reconstitution Inflammatory Syndrome and the Influence of T Regulatory Cells: A Cohort Study in the Gambia. PLoS ONE, 7(6). View this article in WRRO
- High Frequency of HIV Mutations Associated with HLA-C Suggests Enhanced HLA-C–Restricted CTL Selective Pressure Associated with an AIDS-Protective Polymorphism. The Journal of Immunology, 188(9), 4663-4670.
- Efficient Nef-Mediated Downmodulation of TCR-CD3 and CD28 Is Associated with High CD4+ T Cell Counts in Viremic HIV-2 Infection. Journal of Virology, 86(9), 4906-4920.
- Immune approaches for the prevention of breast milk transmission of HIV-1. Advances in Experimental Medicine and Biology, 743, 185-195.
- T-cell immunity to Kaposi sarcoma–associated herpesvirus: recognition of primary effusion lymphoma by LANA-specific CD4+ T cells. Blood, 119(9), 2083-2092.
- Potent Autologous and Heterologous Neutralizing Antibody Responses Occur in HIV-2 Infection across a Broad Range of Infection Outcomes. Journal of Virology, 86(2), 930-946.
- Novel agents for the treatment of HIV-2 infection. Antiviral Therapy, 17(3), 435-438.
- A 2 Amino Acid Shift in Position Leads to a Substantial Difference in the Pattern of Processing of 2 HIV-1 Epitopes. JAIDS Journal of Acquired Immune Deficiency Syndromes, 59(4), 335-339.
- Clinical predictors cannot replace biological predictors in HIV-2 infection in a community setting in West Africa. International Journal of Infectious Diseases, 16(5), e337-e343.
- Immunological impact of an additional early measles vaccine in Gambian children: Responses to a boost at 3 years. Vaccine, 30(15), 2543-2550.
- Immunological impact of an additional early measles vaccine in Gambian children: Responses to a boost at 3 years. Vaccine, 30(15), 2543-2550.
- Identification of H5N1-Specific T-Cell Responses in a High-risk Cohort in Vietnam Indicates the Existence of Potential Asymptomatic Infections. The Journal of Infectious Diseases, 205(1), 20-27.
- Emergence of HBV resistance to lamivudine (3TC) in HIV/HBV co-infected patients in The Gambia, West Africa. BMC Research Notes, 4. View this article in WRRO
- HTLV-1 and HIV-2 Infection Are Associated with Increased Mortality in a Rural West African Community. PLoS ONE, 6(12). View this article in WRRO
- HLA allele distributions and associations in a cohort of LTNPs from China. Retrovirology, 8(S1).
- Mortality and immunovirological outcomes on antiretroviral therapy in HIV-1 and HIV-2-infected individuals in the Gambia. AIDS, 25(17), 2167-2175.
- HLA-C as a mediator of natural killer and T-cell activation: spectator or key player?. Immunology, 133(1), 1-7.
- Antiretroviral Therapy for HIV-2 Infection: Recommendations for Management in Low-Resource Settings. AIDS Research and Treatment, 2011. View this article in WRRO
- Multilayered Defense in HLA-B51–Associated HIV Viral Control. The Journal of Immunology, 187(2), 684-691.
- Immunogenicity of the tuberculosis vaccine MVA85A is reduced by coadministration with EPI vaccines in a randomized controlled trial in gambian infants. Science Translational Medicine, 3(88).
- An underestimated lentivirus model: what can HIV-2 research contribute to the development of an effective HIV-1 vaccine?. Expert Review of Anti-infective Therapy, 9(2), 195-206.
- Botswana's painful journey. Nature Medicine, 16(12), 1367-1367.
- HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form. Retrovirology, 7(1). View this article in WRRO
- Influence of HLA Class I and HLA-KIR Compound Genotypes on HIV-2 Infection and Markers of Disease Progression in a Manjako Community in West Africa. Journal of Virology, 84(16), 8202-8208.
- Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection. European Journal of Immunology, 40(7), 1963-1972.
- HTLV-1 in rural Guinea-Bissau: prevalence, incidence and a continued association with HIV between 1990 and 2007. Retrovirology, 7(1), 50-50.
- Polyfunctional CD4+ and CD8+ T Cell Responses to Tuberculosis Antigens in HIV-1–Infected Patients before and after Anti-Retroviral Treatment. The Journal of Immunology, 184(11), 6537-6544.
- HIV-2 capsids distinguish high and low virus load patients in a West African community cohort. Vaccine, 28, B60-B67.
- Dual infection with HIV-1 and HIV-2: double trouble or destructive interference?. HIV Therapy, 4(3), 305-323.
- Characterization of an HLA-C-restricted CTL response in chronic HIV infection. European Journal of Immunology, 40(4), 1036-1041.
- Two Distinct Epidemics: The Rise of HIV-1 and Decline of HIV-2 Infection Between 1990 and 2007 in Rural Guinea-Bissau. JAIDS Journal of Acquired Immune Deficiency Syndromes, 53(5), 640-647.
- Hepatitis B viral load and risk for liver cirrhosis and hepatocellular carcinoma in The Gambia, West Africa. Journal of Viral Hepatitis, 17(2), 115-122.
- Placental Malaria is associated with reduced early life weight development of affected children independent of low birth weight. Malaria Journal, 9(1).
- Direct Relationship between Virus Load and Systemic Immune Activation in HIV‐2 Infection. The Journal of Infectious Diseases, 201(1), 114-122.
- HIV viral set point and host immune control in individuals with HIV-specific CD8+ T-cell responses prior to HIV acquisition. AIDS, 24(10), 1449-1454.
- The effect of placental malaria infection on cord blood and maternal immunoregulatory responses at birth. European Journal of Immunology, 40(4), 1062-1072.
- Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians. Virology Journal, 7.
- Timing of CD8+ T Cell Responses in Relation to Commencement of Capillary Leakage in Children with Dengue. The Journal of Immunology, 184(12), 7281-7287.
- Immune-based Approaches to the Prevention of Mother-to-child Transmission of HIV-1: Active and Passive Immunization. Clinics in Perinatology, 37(4), 787-805.
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- Limited Impact of Human Cytomegalovirus Infection in African Infants on Vaccine-Specific Responses Following Diphtheria-Tetanus-Pertussis and Measles Vaccination. Frontiers in Immunology, 11.
- Will SARS-CoV-2 Infection Elicit Long-Lasting Protective or Sterilising Immunity? Implications for Vaccine Strategies (2020). Frontiers in Immunology, 11.
- Epidemiology of Cytomegalovirus among pregnant women in Africa. The Journal of Infection in Developing Countries, 13(10), 865-876.
- Reply to Cevik et al. Clinical Infectious Diseases.
- Effect of antiretroviral therapy on longitudinal lung function trends in older children and adolescents with HIV-infection. PLOS ONE, 14(3), e0213556-e0213556.
- HLA-C*18:01 and KIR2DL2+C1 genetic variants are associated with low viral load in cART naïve HIV-infected adult Zimbabweans. The Journal of Infection in Developing Countries, 12(12), 1105-1111.
- Killer-cell immunoglobulin-like receptors associate with HIV-1 infection in a narrow-source Han Chinese cohort. PLOS ONE, 13(4), e0195452-e0195452.
- Targeting TRIM5α in HIV Cure Strategies for the CRISPR-Cas9 Era. Frontiers in Immunology, 8.
- KIR content genotypes associate with carriage of hepatitis B surface antigen, e antigen and HBV viral load in Gambians. PLOS ONE, 12(11), e0188307-e0188307.
- Editorial: Immune Mechanisms Underlying the Increased Morbidity and Mortality of HIV-Exposed Uninfected (HEU) Children. Frontiers in Immunology, 8.
- Negative Correlation between Circulating CD4+FOXP3+CD127− Regulatory T Cells and Subsequent Antibody Responses to Infant Measles Vaccine but Not Diphtheria–Tetanus–Pertussis Vaccine Implies a Regulatory Role. Frontiers in Immunology, 8.
- Recent advances in understanding HIV evolution. F1000Research, 6, 597-597.
- Sex-Differential Non-Vaccine-Specific Immunological Effects of Diphtheria-Tetanus-Pertussis and Measles Vaccination. Clinical Infectious Diseases, ciw492-ciw492.
- A Comprehensive Analysis of the Impact of HIV on HCV Immune Responses and Its Association with Liver Disease Progression in a Unique Plasma Donor Cohort. PLOS ONE, 11(7), e0158037-e0158037.
- Cytomegalovirus Infection May Contribute to the Reduced Immune Function, Growth, Development, and Health of HIV-Exposed, Uninfected African Children. Frontiers in Immunology, 7.
- Altered Memory T-Cell Responses to Bacillus Calmette-Guerin and Tetanus Toxoid Vaccination and Altered Cytokine Responses to Polyclonal Stimulation in HIV-Exposed Uninfected Kenyan Infants. PLOS ONE, 10(11), e0143043-e0143043.
- Clinical Outcome of HIV Viraemic Controllers and Noncontrollers with Normal CD4 Counts Is Exclusively Determined by Antigen-Specific CD8+ T-Cell-Mediated HIV Suppression. PLOS ONE, 10(3), e0118871-e0118871.
- HIV-1 Subtype A Gag Variability and Epitope Evolution. PLoS ONE, 9(6), e93415-e93415.
- How can we design better vaccines to prevent HIV infection in women?. Frontiers in Microbiology, 5.
- A Phase I Randomized Clinical Trial of Candidate Human Immunodeficiency Virus type 1 Vaccine MVA.HIVA Administered to Gambian Infants. PLoS ONE, 8(10), e78289-e78289.
- Examination of Influenza Specific T Cell Responses after Influenza Virus Challenge in Individuals Vaccinated with MVA-NP+M1 Vaccine. PLoS ONE, 8(5), e62778-e62778.
- Are Plasma Biomarkers of Immune Activation Predictive of HIV Progression: A Longitudinal Comparison and Analyses in HIV-1 and HIV-2 Infections?. PLoS ONE, 7(9), e44411-e44411.
- HMOX1 Gene Promoter Alleles and High HO-1 Levels Are Associated with Severe Malaria in Gambian Children. PLoS Pathogens, 8(3), e1002579-e1002579.
- The impact of HIV-1 infection and exposure on natural killer (NK) cell phenotype in Kenyan infants during the first year of life. Frontiers in Immunology, 3.
- Functional Differences Exist between TNFα Promoters Encoding the Common −237G SNP and the Rarer HLA-B*5701-Linked A Variant. PLoS ONE, 7(7), e40100-e40100.
- Revisiting the Effect of Acute P. falciparum Malaria on Epstein-Barr Virus: Host Balance in the Setting of Reduced Malaria Endemicity. PLoS ONE, 7(2), e31142-e31142.
- A Novel Immunodominant CD8+ T Cell Response Restricted by a Common HLA-C Allele Targets a Conserved Region of Gag HIV-1 Clade CRF01_AE Infected Thais. PLoS ONE, 6(8), e23603-e23603.
- The Antiviral Efficacy of HIV-Specific CD8+ T-Cells to a Conserved Epitope Is Heavily Dependent on the Infecting HIV-1 Isolate. PLoS Pathogens, 7(5), e1001341-e1001341.
- Phenotypic Characterization of HIV-Specific CD8+ T Cells during Early and Chronic Infant HIV-1 Infection. PLoS ONE, 6(5), e20375-e20375.
- Epstein-Barr Virus but Not Cytomegalovirus Is Associated with Reduced Vaccine Antibody Responses in Gambian Infants. PLoS ONE, 5(11), e14013-e14013.
- The Tuberculin Skin Test (TST) Is Affected by Recent BCG Vaccination but Not by Exposure to Non-Tuberculosis Mycobacteria (NTM) during Early Life. PLoS ONE, 5(8), e12287-e12287.
- Maintenance of Large Subpopulations of Differentiated CD8 T-Cells Two Years after Cytomegalovirus Infection in Gambian Infants. PLoS ONE, 3(8), e2905-e2905.
- Characterization of Melan-A reactive memory CD8+ T cells in a healthy donor. International Immunology, 20(8), 1087-1096.
- Correction: Resisting Immune Exhaustion in HIV-1 Infection. PLoS Medicine, 5(6), e134-e134.
- Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. Journal of Clinical Investigation.
- Risk Factors for and Clinical Outcome of Congenital Cytomegalovirus Infection in a Peri-Urban West-African Birth Cohort. PLoS ONE, 2(6), e492-e492.
- High Pro-Inflammatory Cytokine Secretion and Loss of High Avidity Cross-Reactive Cytotoxic T-Cells during the Course of Secondary Dengue Virus Infection. PLoS ONE, 2(12), e1192-e1192.
- Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection. PLoS Biology, 2(2), e20-e20.
- Minimal Sex-Differential Modulation of Reactivity to Pathogens and Toll-Like Receptor Ligands following Infant Bacillus Calmette–Guérin Russia Vaccination. Frontiers in Immunology, 8.
- Low Postseroconversion CD4+T-cell Level Is Associated with Faster Disease Progression and Higher Viral Evolutionary Rate in HIV-2 Infection. mBio, 10(1).
Chapters
- Cellular Immune Response to HIV-2 Infection, Encyclopedia of AIDS (pp. 259-268). Springer New York
- Cardiovascular Complications, Encyclopedia of AIDS (pp. 219-224). Springer New York
- The Cellular Immune Response to HIV-2 Infection, Encyclopedia of AIDS (pp. 1-10). Springer New York
- Contributors, Models of Protection Against HIV/SIV (pp. xi-xii). Elsevier
- Chapter 11 Immune Mechanisms of Viral Control in HIV-2 Infection, Models of Protection Against HIV/SIV (pp. 293-315).
- Immune Mechanisms of Viral Control in HIV-2 Infection, Models of Protection Against HIV/SIV (pp. 293-315). Elsevier
- Lung Immunology and HIV, AIDS and Respiratory Medicine (pp. 15-40). Springer US
Conference proceedings papers
- Extensive HLA-driven viral diversity following a narrow-source HIV-1 outbreak in rural China. Blood, Vol. 118(1) (pp 98-106)
- Comparison of Cytotoxic activity and Interferon-g secretion by Natural Killer Cells in HIV-1 and HIV-2 infected individuals. Retrovirology, Vol. 7(S1)
- 139 HIV-2 Capsids Distinguishing High and Low Virus Load Patients in a West African Community Cohort. JAIDS Journal of Acquired Immune Deficiency Syndromes, Vol. 51 (pp 1-1)
- Transition From Long-Term Nonprogression to HIV-1 Disease Associated With Escape From Cellular Immune Control. JAIDS Journal of Acquired Immune Deficiency Syndromes, Vol. 48(2) (pp 119-126)
- Maternal HLA Homozygosity and Mother‐Child HLA Concordance Increase the Risk of Vertical Transmission of HIV‐1. The Journal of Infectious Diseases, Vol. 197(8) (pp 1156-1161)
- Detection of broad functional gag-specific CD4+ T cell responses in HIV-1-infected subjects following therapeutic immunization with rMVA expressing an HIV-1 gag immunogen. Retrovirology, Vol. 3(S1)
- HIV-2 gene product-specific T cell responses and viraemia control. Retrovirology, Vol. 3(S1)
- Modified vaccinia Ankara expressing HIVA antigen stimulates HIV-1-specific CD8 T cells in ELISpot assays of HIV-1 exposed infants. Vaccine, Vol. 23(38) (pp 4711-4719)
- Influence of HLA Supertypes on Susceptibility and Resistance to Human Immunodeficiency Virus Type 1 Infection. The Journal of Infectious Diseases, Vol. 181(5) (pp 1581-1589)
- Memory CD8+T cells in HIV infection. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, Vol. 355(1395) (pp 363-367)
- Broadly cross-reactive HIV-specific cytotoxic T-lymphocytes in highly-exposed persistently seronegative donors. Immunology Letters, Vol. 66(1-3) (pp 9-14)
- Structure of HIV-2 Nef Reveals Features Distinct from HIV-1 Involved in Immune Regulation. iScience, 23(1).
- Teaching interests
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I enjoy teaching and currently lecture on the M.Sc courses in Molecular Medicine (IICD) and Antimicrobial Resistance (Florey Institute). I am a Mentor on the Academy of Medical Sciences scheme for early career researchers on intermediate fellowships.
- Professional activities
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- Co-coordinator (with Professor Simon Foster), Florey Institute for Host-Pathogen interactions
- Theme Lead, Infection theme, IICD
- Academic Editor, Public Library of Science (Biology), 2003 to present, Member of PLOS Biology Advisory Board from 2015 onwards
- Member, Newton Advanced Fellowships panel, Royal Society, 2015 – present
- Member, Swedish Research Council, Global Health Panel, 2016 – present
- Member, Future Leaders African Independent Research (FLAIR) fellowship panel (Royal Society), 2018 – present
- Member of the Faculty of 1000 since its inception in 2002 to present
- Academy of Medical Sciences, member of Global Health group, from 2007
- Academy of Medical Sciences, Fellowship committee (panel 4), from 2017 – present
- External Examiner, Department of Pathology, University of Zimbabwe College of Health Sciences, 2017 - present