Professor Tim Chico

MBChB, MRCP, MD

School of Medicine and Population Health

Professor of Cardiovascular Medicine

Honorary Consultant Cardiologist

Director South Yorkshire EPSRC DIgital Health Hub

Professor Tim Chico

t.j.chico@sheffield.ac.uk
+44 114 222 2396

+44 114 271 1863 (Fax)

The Medical School

Full contact details

Professor Tim Chico
School of Medicine and Population Health
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

Tim is Professor of Cardiovascular Medicine at the University of Sheffield and a consultant Cardiologist at Sheffield Teaching Hospitals NHS Foundation Trust. His national roles include Associate Director of the British Heart Foundation Data Science Centre, where he leads the Smartphone and Wearable data theme. Tim's career has spanned academia and industry across genetics, vascular biology, drug discovery and health data science. He jointly leads South Yorkshire's specialist service for pregnant women with heart disease and sits on the council of the UK Maternal Cardiology Society.

Research interests

My research focuses on how data from smartphones and wearables can be used to improve health and healthcare. These devices are used by over 90% of adults, and provide data on a range of important aspects of health. This includes physical activity, sleep, heart rate, and environment. However, such data is not yet used in medicine due to a range of obstacles that need to be overcome.

Current projects

Next-generation sequencing of peripheral blood in patients with acute coronary syndromes
Using the zebrafish to study macrophage/endothelial interactions

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Kugler EC, van Lessen M, Daetwyler S, Chhabria K, Savage AM, Silva V, Plant K, MacDonald RB, Huisken J, Wilkinson RN , Schulte‐Merker S et al (2019) Cerebrovascular endothelial cells form transient Notch‐dependent cystic structures in zebrafish. EMBO reports. View this article in WRRO
Chhabria K, Plant K, Bandmann O, Wilkinson R, Martin C, Kugler E, Armitage P, Santoscoy P, Cunliffe V, Huisken J , Mcgown A et al (2018) The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish. Journal of Cerebral Blood Flow and Metabolism. View this article in WRRO
Alabed S, Sabouni A, Providencia R, Atallah E, Qintar M & Chico TJ (2017) Adenosine versus intravenous calcium channel antagonists for supraventricular tachycardia. Cochrane Database Syst Rev, 10. View this article in WRRO
Brown HK, Schiavone K, Tazzyman S, Heymann D & Chico TJ (2017) Zebrafish xenograft models of cancer and metastasis for drug discovery.. Expert Opinion on Drug Discovery, 12(4), 379-389. View this article in WRRO
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C , Bowden N et al (2016) Zebrafish Model for Functional Screening of Flow-Responsive Genes.. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(1), 130-143. View this article in WRRO
Mahmoud M, Kim HR, Xing R, Hsiao S, Mammmoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R , Ariaans M et al (2016) TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circulation Research, 119, 450-462. View this article in WRRO
Vidal-Rosas EE, Billings SA, Chico T & Coca D (2016) Reproducibility of parameters of postocclusive reactive hyperemia measured by diffuse optical tomography.. J Biomed Opt, 21(6), 66012-66012. View this article in WRRO
Pandor A, Pollard D, Chico T, Henderson R & Stevenson M (2016) Rivaroxaban for Preventing Atherothrombotic Events in People with Acute Coronary Syndrome and Elevated Cardiac Biomarkers: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 34(5), 463-477. View this article in WRRO
Martin RIR, Babaei MS, Choy M-K, Owens WA, Chico TJA, Keenan D, Yonan N, Koref MS & Keavney BD (2015) Genetic variants associated with risk of atrial fibrillation regulate expression of PITX2, CAV1, MYOZ1, C9orf3 and FANCC. Journal of Molecular and Cellular Cardiology, 85, 207-214.
Ellam T, Hameed A, ul Haque R, Muthana M, Wilkie M, Francis SE & Chico TJA (2014) Vitamin D deficiency and exogenous vitamin D excess similarly increase diffuse atherosclerotic calcification in apolipoprotein E knockout mice.. PLoS One, 9(2), e88767. View this article in WRRO
Ogryzko NV, Hoggett EE, Solaymani-Kohal S, Tazzyman S, Chico TJA, Renshaw SA & Wilson HL (2014) Zebrafish tissue injury causes upregulation of interleukin-1 and caspase-dependent amplification of the inflammatory response.. Dis Model Mech, 7(2), 259-264. View this article in WRRO
Ellam T, Fotheringham J, Wilkie ME, Francis SE & Chico TJA (2014) Bone mineral metabolism parameters and urinary albumin excretion in a representative US population sample.. PLoS One, 9(2), e88388. View this article in WRRO
Novodvorsky P & Chico TJA (2014) The role of the transcription factor KLF2 in vascular development and disease.. Prog Mol Biol Transl Sci, 124, 155-188. View this article in WRRO
Watson O, Novodvorsky P, Gray C, Rothman AMK, Lawrie A, Crossman DC, Haase A, McMahon K, Gering M, Van Eeden FJM & Chico TJA (2013) Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling.. Cardiovasc Res, 100(2), 252-261. View this article in WRRO
Gray C, Bratt D, Lees J, daCosta M, Plant K, Watson OJ, Solaymani-Kohal S, Tazzyman S, Serbanovic-Canic J, Crossman DC , Keavney BD et al (2013) Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development.. Arterioscler Thromb Vasc Biol, 33(6), 1257-1263.
Gorsi B, Liu F, Ma X, Chico TJA, Shrinivasan A, Kramer KL, Bridges E, Monteiro R, Harris AL, Patient R & Stringer SE (2013) The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity. Angiogenesis, 1-15.
Ellam TJ & Chico TJA (2012) Phosphate: the new cholesterol? The role of the phosphate axis in non-uremic vascular disease.. Atherosclerosis, 220(2), 310-318.
Ellam T, Wilkie M, Chamberlain J, Crossman D, Eastell R, Francis S & Chico TJA (2011) Dietary phosphate modulates atherogenesis and insulin resistance in apolipoprotein E knockout mice--brief report.. Arterioscler Thromb Vasc Biol, 31(9), 1988-1990.
Novodvorsky P, Watson O, Gray C, Wilkinson RN, Reeve S, Smythe C, Beniston R, Plant K, Maguire R, M. K. Rothman A , Elworthy S et al () klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLoS ONE, 10(10). View this article in WRRO

All publications

Journal articles

Zaman S, Wasfy JH, Kapil V, Ziaeian B, Parsonage WA, Sriswasdi S, Chico TJA, Capodanno D, Colleran R, Sutton NR , Song L et al (2025) The Lancet Commission on rethinking coronary artery disease: moving from ischaemia to atheroma. The Lancet, 405(10486), 1264-1312.
Marra C, Chico T, Alexandrow A, Dixon WG, Briffa N, Rainaldi E, Little MA, Size K, Tsanas A, Franklin JB , Kapur R et al (2024) Addressing the challenges of integrating digital health technologies to measure patient-centred outcomes in clinical registries. The Lancet Digital Health.
Raffetti E, Bolton T, Nolan J, Zuccolo L, Denholm R, Smith G, Akbari A, Harron K, Curry G, Allara E , Lawlor DA et al (2024) COVID-19 diagnosis, vaccination during pregnancy, and adverse pregnancy outcomes of 865,654 women in England and Wales: a population-based cohort study. The Lancet Regional Health - Europe, 45, 101037-101037.
Abdullayev K, Gorvett O, Sochiera A, Laidlaw L, Chico T, Manktelow M, Buckley O, Condell J, Van Arkel R, Diaz V & Matcham F (2024) Stakeholder perspectives on contributors to delayed and inaccurate diagnosis of cardiovascular disease and their implications for digital health technologies: a UK-based qualitative study. BMJ Open, 14(5), e080445-e080445.
Hughes ME & Chico TJA (2023) How could sensor-based measurement of physical activity be used in cardiovascular healthcare?. Sensors, 23(19). View this article in WRRO
Williams GJ, Al-Baraikan A, Rademakers FE, Ciravegna F, van de Vosse FN, Lawrie A, Rothman A, Ashley EA, Wilkins MR, Lawford PV , Omholt SW et al (2023) Wearable technology and the cardiovascular system: the future of patient assessment. The Lancet Digital Health, 5(7), e467-e476.
Abdullayev K, Chico TJA, Manktelow M, Buckley O, Condell J, Van Arkel RJ, Diaz V & Matcham F (2023) Stakeholder-led understanding of the implementation of digital technologies within heart disease diagnosis: a qualitative study protocol. BMJ Open, 13(6), e072952-e072952.
Shiwani MA, Chico TJA, Ciravegna F & Mihaylova L (2023) Continuous monitoring of health and mobility indicators in patients with cardiovascular disease: a review of recent technologies. Sensors, 23(12).
Snodgrass RO, Govindpani K, Plant K, Kugler EC, Doh C, Dawson T, McCormack LE, Arthur HM & Chico TJA (2023) Therapeutic targeting of vascular malformation in a zebrafish model of hereditary haemorrhagic telangiectasia. Disease Models & Mechanisms, 16(4).
Canham L, Sendac S, Diagbouga MR, Wolodimeroff E, Pirri D, Tardajos Ayllon B, Feng S, Souilhol C, Chico TJA, Evans PC & Serbanovic-Canic J (2023) EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy. Arteriosclerosis, Thrombosis, and Vascular Biology, 43(4), 547-561.
Huang J-D, Wang J, Ramsey E, Leavey G, Chico TJA & Condell J (2022) Applying Artificial Intelligence to wearable sensor data to diagnose and predict cardiovascular disease: a review. Sensors, 22(20).
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ , Ariaans M et al (2022) JAG1-NOTCH4 mechanosensing drives atherosclerosis. Science Advances, 8(35).
Kugler EC, Rampun A, Chico TJA & Armitage PA (2022) Analytical approaches for the segmentation of the zebrafish brain vasculature. Current Protocols, 2. View this article in WRRO
Kugler EC, Frost J, Silva V, Plant K, Chhabria K, Chico TJA & Armitage PA (2022) Zebrafish vascular quantification: a tool for quantification of three-dimensional zebrafish cerebrovascular architecture by automated image analysis. Development, 149(3).
Bowley G, Chico TJ, Serbanovic-Canic J & Evans PC (2021) Quantifying endothelial cell proliferation in the zebrafish embryo. F1000Research, 10, 1032.
Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Hamilton N, Evans PC, Chico T & Armitage P (2021) The effect of absent blood flow on the zebrafish cerebral and trunk vasculature. Vascular Biology, 3(1), 1-16.
(2021) Correction: Effect of sports massage on performance and recovery: a systematic review and meta-analysis. BMJ Open Sport & Exercise Medicine, 7(2), e000614corr1-e000614corr1.
Waspe J, Chico TJA & Hansen TG (2021) Applying the adverse outcome pathway concept to questions in anaesthetic neurotoxicity. British Journal of Anaesthesia.
Chico TJA & Kugler EC (2021) Cerebrovascular development: mechanisms and experimental approaches.. Cell Mol Life Sci.
Derrick CJ, Sánchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & Noël ES (2021) Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development. Cardiovascular Research. View this article in WRRO
Snodgrass RO, Chico TJA & Arthur HM (2021) Hereditary haemorrhagic telangiectasia, an inherited vascular disorder in need of improved evidence-based pharmaceutical interventions. Genes, 12(2).
Al-Mohammad A, Partridge DG, Fent G, Watson O, Lewis NT, Storey RF, Makris M & Chico TJ (2020) The cardiac complications of COVID-19; many publications, multiple uncertainties. Vascular Biology.
Davis HL, Alabed S & Chico TJA (2020) Effect of sports massage on performance and recovery : a systematic review and meta-analysis. BMJ Open Sport & Exercise Medicine, 6(1). View this article in WRRO
Alabed S, Sabouni A, Providencia R, Atallah E, Qintar M & Chico TJA (2020) Adenosine versus intravenous calcium channel antagonists for supraventricular tachycardia. Emergencias, 32(1), 57-58.
Souilhol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H & Evans PC (2020) Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes. Nature Reviews Cardiology, 17(1), 52-63.
Chhabria K, Vouros A, Gray C, MacDonald R, Jiang Z, Wilkinson R, Plant K, Vasilaki E, Howarth C & Chico T (2019) Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish. DMM Disease Models and Mechanisms, 12(9). View this article in WRRO
Adekoya A, Ong C A & Chico T (2019) SAT-259 DIFFERENT MARKERS OF ENDOTHELIAL DYSFUNCTION ARE ALTERED IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE PATIENTS WITH EARLY AND LATE DISEASE. Kidney International Reports, 4(7), S115-S115.
Kugler EC, van Lessen M, Daetwyler S, Chhabria K, Savage AM, Silva V, Plant K, MacDonald RB, Huisken J, Wilkinson RN , Schulte‐Merker S et al (2019) Cerebrovascular endothelial cells form transient Notch‐dependent cystic structures in zebrafish. EMBO reports. View this article in WRRO
Elworthy S, Savage AM, Wilkinson RN, Malicki JJ & Chico TJA (2019) The role of endothelial cilia in post‐embryonic vascular development. Developmental Dynamics. View this article in WRRO
Griffiths PD, Mousa HA, Finney C, Mooney C, Mandefield L, Chico TJA & Jarvis D (2019) An integrated in utero MR method for assessing structural brain abnormalities and measuring intracranial volumes in fetuses with congenital heart disease: results of a prospective case-control feasibility study. Neuroradiology. View this article in WRRO
Savage AM, Kurusamy S, Chen Y, Jiang Z, Chhabria K, MacDonald RB, Kim HR, Wilson HL, van Eeden FJM, Armesilla AL , Chico TJA et al (2019) tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature Communications, 10. View this article in WRRO
Neal A, Nornes S, Payne S, Wallace MD, Fritzsche M, Louphrasitthiphol P, Wilkinson RN, Chouliaras KM, Liu K, Plant K , Sholapurkar R et al (2019) Venous identity requires BMP signalling through ALK3. Nature Communications, 10. View this article in WRRO
Kugler E, Plant K, Chico T & Armitage P (2019) Enhancement and Segmentation Workflow for the Developing Zebrafish Vasculature †. Journal of Imaging, 5(1). View this article in WRRO
Chhabria K, Plant K, Bandmann O, Wilkinson R, Martin C, Kugler E, Armitage P, Santoscoy P, Cunliffe V, Huisken J , Mcgown A et al (2018) The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish. Journal of Cerebral Blood Flow and Metabolism. View this article in WRRO
Alabed S, Providência R & Chico TJA (2018) Cochrane corner: adenosine versus intravenous calcium channel antagonists for supraventricular tachycardia. Heart, 104(24), 1993-1994. View this article in WRRO
Lee JA, Chico TJA & Renshaw SA (2017) The triune of intestinal microbiome, genetics and inflammatory status and its impact on the healing of lower gastrointestinal anastomoses. FEBS Journal. View this article in WRRO
Alabed S, Sabouni A, Providencia R, Atallah E, Qintar M & Chico TJ (2017) Adenosine versus intravenous calcium channel antagonists for supraventricular tachycardia. Cochrane Database Syst Rev, 10. View this article in WRRO
Brown HK, Schiavone K, Tazzyman S, Heymann D & Chico TJ (2017) Zebrafish xenograft models of cancer and metastasis for drug discovery.. Expert Opinion on Drug Discovery, 12(4), 379-389. View this article in WRRO
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C , Bowden N et al (2016) Zebrafish Model for Functional Screening of Flow-Responsive Genes.. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(1), 130-143. View this article in WRRO
Mahmoud M, Kim HR, Xing R, Hsiao S, Mammmoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R , Ariaans M et al (2016) TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circulation Research, 119, 450-462. View this article in WRRO
Vidal-Rosas EE, Billings SA, Chico T & Coca D (2016) Reproducibility of parameters of postocclusive reactive hyperemia measured by diffuse optical tomography.. J Biomed Opt, 21(6), 66012-66012. View this article in WRRO
Pandor A, Pollard D, Chico T, Henderson R & Stevenson M (2016) Rivaroxaban for Preventing Atherothrombotic Events in People with Acute Coronary Syndrome and Elevated Cardiac Biomarkers: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. PharmacoEconomics, 34(5), 463-477. View this article in WRRO
Jiang Z, Tomova M, Chico TJA & Wilkinson RN (2015) The forkhead transcription factor foxc1a plays a key role in cranial vasculogenesis and angiogenesis in zebrafish. Atherosclerosis, 244, E7-E7.
Njegic AM, Chico TJA, van Eeden FJ & Watson OJ (2015) The effect of macrophage depletion on hypoxia signalling induced angiogenesis in zebrafish. Atherosclerosis, 244, E8-E9.
Martin RIR, Babaei MS, Choy M-K, Owens WA, Chico TJA, Keenan D, Yonan N, Koref MS & Keavney BD (2015) Genetic variants associated with risk of atrial fibrillation regulate expression of PITX2, CAV1, MYOZ1, C9orf3 and FANCC. Journal of Molecular and Cellular Cardiology, 85, 207-214.
Ellam T, Hameed A, ul Haque R, Muthana M, Wilkie M, Francis SE & Chico TJA (2014) Vitamin D deficiency and exogenous vitamin D excess similarly increase diffuse atherosclerotic calcification in apolipoprotein E knockout mice.. PLoS One, 9(2), e88767. View this article in WRRO
Ogryzko NV, Hoggett EE, Solaymani-Kohal S, Tazzyman S, Chico TJA, Renshaw SA & Wilson HL (2014) Zebrafish tissue injury causes upregulation of interleukin-1 and caspase-dependent amplification of the inflammatory response.. Dis Model Mech, 7(2), 259-264. View this article in WRRO
Ellam T, Fotheringham J, Wilkie ME, Francis SE & Chico TJA (2014) Bone mineral metabolism parameters and urinary albumin excretion in a representative US population sample.. PLoS One, 9(2), e88388. View this article in WRRO
Rothman AMK, Chico TJA & Lawrie A (2014) MicroRNA in pulmonary vascular disease.. Prog Mol Biol Transl Sci, 124, 43-63.
Chico TJA (2014) Preface. Progress in Molecular Biology and Translational Science, 124.
Novodvorsky P & Chico TJA (2014) The role of the transcription factor KLF2 in vascular development and disease.. Prog Mol Biol Transl Sci, 124, 155-188. View this article in WRRO
Watson O, Novodvorsky P, Gray C, Rothman AMK, Lawrie A, Crossman DC, Haase A, McMahon K, Gering M, Van Eeden FJM & Chico TJA (2013) Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling.. Cardiovasc Res, 100(2), 252-261. View this article in WRRO
Bright R, Storey R & Chico T (2013) Zebrafish as a model to investigate the effect of P2Y12 knockdown on leukocyte migration. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, 450-450.
Gray C, Bratt D, Lees J, daCosta M, Plant K, Watson OJ, Solaymani-Kohal S, Tazzyman S, Serbanovic-Canic J, Crossman DC , Keavney BD et al (2013) Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development.. Arterioscler Thromb Vasc Biol, 33(6), 1257-1263.
Bourke L, Kirkbride P, Hooper R, Rosario AJ, Chico TJA & Rosario DJ (2013) Endocrine therapy in prostate cancer: Time for reappraisal of risks, benefits and cost-effectiveness?. British Journal of Cancer, 108(1), 9-13. View this article in WRRO
Gorsi B, Liu F, Ma X, Chico TJA, Shrinivasan A, Kramer KL, Bridges E, Monteiro R, Harris AL, Patient R & Stringer SE (2013) The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity. Angiogenesis, 1-15.
Hudson RC, Gray C, Kiss-Toth E, Chico TJA & Qwarnstrom EE (2012) Bioinformatics Analysis of the FREM1 Gene—Evolutionary Development of the IL-1R1 Co-Receptor, TILRR. Biology, 1(3), 484-494. View this article in WRRO
Quaife NM, Watson O & Chico TJA (2012) Zebrafish: an emerging model of vascular development and remodelling.. Curr Opin Pharmacol, 12(5), 608-614.
Bourke L, Chico TJA, Albertsen PC, Hamdy FC & Rosario DJ (2012) Cardiovascular risk in androgen suppression: underappreciated, under-researched and unresolved.. Heart, 98(5), 345-348.
Ellam TJ & Chico TJA (2012) Phosphate: the new cholesterol? The role of the phosphate axis in non-uremic vascular disease.. Atherosclerosis, 220(2), 310-318.
Ellam T, Wilkie M, Chamberlain J, Crossman D, Eastell R, Francis S & Chico TJA (2011) Dietary phosphate modulates atherogenesis and insulin resistance in apolipoprotein E knockout mice--brief report.. Arterioscler Thromb Vasc Biol, 31(9), 1988-1990.
Holden BJ, Bratt DG & Chico TJA (2011) Molecular control of vascular development in the zebrafish.. Birth Defects Res C Embryo Today, 93(2), 134-140.
Gray C, Loynes CA, Whyte MKB, Crossman DC, Renshaw SA & Chico TJA (2011) Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish.. Thromb Haemost, 105(5), 811-819. View this article in WRRO
Bugeon L, Taylor HB, Progatzky F, Lin MI, Ellis CD, Welsh N, Smith E, Vargesson N, Gray C, Renshaw SA , Chico TJA et al (2011) The NOTCH pathway contributes to cell fate decision in myelopoiesis. Haematologica, 96(12), 1753-1760.
Ellam TJ & Chico TJA (2011) Phosphate: The new cholesterol? The role of the phosphate axis in non-uremic vascular disease. Atherosclerosis.
Bourke L, Tew GA, Milo M, Crossman DC, Saxton JM & Chico TJA (2010) Study protocol: a randomised controlled trial investigating the effect of exercise training on peripheral blood gene expression in patients with stable angina.. BMC Public Health, 10, 620. View this article in WRRO
McLeish JA, Chico TJA, Taylor HB, Tucker C, Donaldson K & Brown SB (2010) Skin exposure to micro- and nano-particles can cause haemostasis in zebrafish larvae. Thrombosis and Haemostasis, 103(4), 797-807.
Chico TJA, Milo M & Crossman DC (2010) The genetics of cardiovascular disease: new insights from emerging approaches.. J Pathol, 220(2), 186-197.
Packham IM, Gray C, Heath PR, Hellewell PG, Ingham PW, Crossman DC, Milo M & Chico TJA (2009) Microarray profiling reveals CXCR4a is downregulated by blood flow in vivo and mediates collateral formation in zebrafish embryos.. Physiol Genomics, 38(3), 319-327.
Stewart D, Chico T & Ackroyd R (2009) Chylopericardial tamponade complicating oesophago-gastrectomy.. Interact Cardiovasc Thorac Surg, 8(1), 176-177.
Rocke J, Lees J, Packham I & Chico T (2009) The zebrafish as a novel tool for cardiovascular drug discovery. Recent Pat Cardiovasc Drug Discov, 4, 1-5.
Gray C CDC (2009) The effect of altered macrophage behaviour on zebrafish collateral vessel development.. Heart, 95, e2.
Kelly DJ, Mecinovic J, Schofield CJ, Crossman D, Ingham P, Gershlick AH & Chico T (2008) In-vivo observations on angiogenesis in embryonic zebrafish: dose-dependent effects of the prolyl-4-hydroxylase inhibitor, Di-methyl oxalyl-glycine, on arterial development. EUROPEAN HEART JOURNAL, 29, 239-239.
Chico TJA, Ingham PW & Crossman DC (2008) Modeling cardiovascular disease in the zebrafish.. Trends Cardiovasc Med, 18(4), 150-155.
Gray C, Packham IM, Wurmser F, Eastley NC, Hellewell PG, Ingham PW, Crossman DC & Chico TJA (2007) Ischemia is not required for arteriogenesis in zebrafish embryos.. Arterioscler Thromb Vasc Biol, 27(10), 2135-2141.
Chico T, Gray C, Packham I, Wurmser F, Hellewell P, Ingham P & Crossman D (2006) The zebrafish as a novel model of arteriogenesis. Vascular Pharmacology, 45(3), e60-e60.
Greve JM, Chico TJ, Goldman H, Bunting S, Peale FV, Daugherty A, van Bruggen N & Williams SP (2006) Magnetic resonance angiography reveals therapeutic enlargement of collateral vessels induced by VEGF in a murine model of peripheral arterial disease. J Magn Reson Imaging, 24, 1124-1132.
Buckley MG, Coombs H, Harrison R, Shaw SA & Dean JD (2003) Investigation of the Knowledge and Awareness between Smoking and Diabetic Complications in a Diabetic Population. Clinical Science, 104(s48), 4P-5P.
Chico T & Williamson R (2002) Science and medicine 2001. Clin Med, 2, 256-257.
Chico TJ, Chamberlain J, Gunn J, Arnold N, Bullens SL, Gadek TR, Francis SE, Bunting S, Horton M, Shepherd L , Lipari MT et al (2001) Effect of selective or combined inhibition of integrins alpha(IIb)beta(3) and alpha(v)beta(3) on thrombosis and neointima after oversized porcine coronary angioplasty.. Circulation, 103(8), 1135-1141.
Chico TJ & Crossman DC (1999) Key developments in unstable angina.. Practitioner, 243(1603), 706-714.
Chico TJA, Gunn J, Arnold ND, Bullens SL, Bunting S, Cumberland DC & Crossman DC (1999) Platelet glycoprotein IIb/IIIa inhibition by Lamifiban reduces the neointimal response to angioplasty in a porcine model. Heart, 81(SUPPL. 1).
Abdullayev K, Chico TJA, Canson J, Mantelow M, Buckley O, Condell J, Van Arkel RJ, Diaz-Zuccarini V & Matcham F () Exploring Stakeholder Perspectives on the Barriers and Facilitators of Implementing Digital Technologies for Heart Disease Diagnosis: Qualitative Study. JMIR Cardio, 9, e66464-e66464.
Bowley G, Irving S, Hoefer I, Wilkinson R, Pasterkamp G, Darwish HMS, White S, Francis SE, Chico T, Noel E , Serbanovic-Canic J et al () Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation. Scientific Reports, 14(1).
Morris PD, Anderton RA, Marshall-Goebel K, Britton JK, Lee SMC, Smith NP, van de Vosse FN, Ong KM, Newman TA, Taylor DJ , Chico T et al () Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight. Nature Reviews Cardiology.
Stamatakis E, Ahmadi M, Murphy MH, Chico TJ, Milton K, Del Pozo Cruz B, Katzmarzyk PT, Lee I-M & Gill J () Journey of a thousand miles: from ‘Manpo-Kei’ to the first steps-based physical activity recommendations. British Journal of Sports Medicine.
Chico TJ, Stamatakis E, Ciravegna F, Dunn J, Redwood S, Al-lamee R, Sofat R & Gill J () Device-based measurement of physical activity in cardiovascular healthcare: possibilities and challenges. British Journal of Sports Medicine.
Gill JMR, Chico TJ, Doherty A, Dunn J, Ekelund U, Katzmarzyk PT, Milton K, Murphy MH & Stamatakis E () Potential impact of wearables on physical activity guidelines and interventions: opportunities and challenges. British Journal of Sports Medicine.
Winter PD & Chico TJA () Using the Non-Adoption, Abandonment, Scale-Up, Spread, and Sustainability (NASSS) Framework to Identify Barriers and Facilitators for the Implementation of Digital Twins in Cardiovascular Medicine. Sensors, 23(14), 6333-6333.
Dixon WG, van der Veer SN, Ali SM, Laidlaw L, Dobson RJB, Sudlow C, Chico T, MacArthur JAL & Doherty A () Charting a Course for Smartphones and Wearables to Transform Population Health Research. Journal of Medical Internet Research, 25, e42449-e42449.
Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, Noël ES & Serbanovic‐Canic J () Zebrafish as a tractable model of human cardiovascular disease. British Journal of Pharmacology.
Jiang Z, Evans T, Savage AM, Loose M, Chico TJA, van Eeden FJM & Wilkinson RN () foxc1a and foxc1b differentially regulate angiogenesis from arteries and veins by modulating Vascular Endothelial Growth Factor signalling.
Kugler E, Chhabria K, Daetwyler S, Huisken J, Plant K, Savage AM, Wilkinson RN, Armitage PA & Chico TJA () Endothelial cells form transient Notch-dependent NO-containing cystic structures during zebrafish cerebrovascular development. View this article in WRRO
() Correction: Bone Mineral Metabolism Parameters and Urinary Albumin Excretion in a Representative US Population Sample. PLoS ONE, 9(5), e97392-e97392.
Novodvorsky P, Da Costa MMJ & Chico TJA () Zebrafish-based small molecule screens for novel cardiovascular drugs. Drug Discovery Today: Technologies. View this article in WRRO
Kugler EC, Rampun A, Chico TJA & Armitage PA () Segmentation of the Zebrafish Brain Vasculature from Light Sheet Fluorescence Microscopy Datasets.
Novodvorsky P, Watson O, Gray C, Wilkinson RN, Reeve S, Smythe C, Beniston R, Plant K, Maguire R, M. K. Rothman A , Elworthy S et al () klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLoS ONE, 10(10). View this article in WRRO
Kugler EC, Frost J, Silva V, Plant K, Chhabria K, Chico TJA & Armitage PA () 3D quantification of zebrafish cerebrovascular architecture by automated image analysis of light sheet fluorescence microscopy datasets.

Chapters

Kugler E, Chico T & Armitage PA (2020) Validating Segmentation of the Zebrafish Vasculature, Communications in Computer and Information Science (pp. 270-281). Springer International Publishing
Parviz Y, Orme R, Watson O & Chico T () Acute Coronary Syndromes and Anaesthesia, AAGBI Core Topics in Anaesthesia 2015 (pp. 15-27). John Wiley & Sons, Inc.

Conference proceedings papers

Abdullayev K, Chico T, Gorvett O, Sochiera A, Manktelow M, Buckley O, Condell J, Van Arkel RJ, Diaz-Zuccarini V & Matcham F (2023) BS85 A clinician-led understanding of the implementation of digital technologies within heart disease diagnosis: a qualitative investigation. Basic Science
Serbanovic-Canic J, Evans PC & Chico T (2023) BS1 Polycystin-1 suppresses apoptotic signalling in endothelial cells and protects from atherosclerosis. Basic Science
Shah D, Govindpani K, Plant K & Chico T (2022) BS42 Characterising spatiotemporal membrane and F-actin dynamics in Kugeln, a novel endothelial membrane behaviour in the zebrafish cerebral vasculature. Basic science
Snodgrass R, Chico T & Arthur H (2021) BS11 Inhibition of VEGF signalling mitigates the hereditary haemorrhagic telangiectasia-like phenotype in endoglin mutant zebrafish. Basic science
Bowley G, Evans P, Serbanovic-Canic J & Chico T (2021) BS15 Using zebrafish embryos to identify genes that regulate endothelial proliferation. Basic science
Snodgrass RO, Arthur HM & Chico TJA (2021) Inhibition of VEGF Signalling Mitigates the Hereditary Haemorrhagic Telangiectasia-Like Phenotype in Endoglin Mutant Zebrafish. JOURNAL OF VASCULAR RESEARCH, Vol. 58 (pp 2-2)
Kugler E, Chhabria K, Daetwyler S, Plant K, Savage A, Wilkinson R, Armitage P & Chico TJA (2019) Endothelial Cells Form Transient Cystic Structures During Zebrafish Cerebrovascular Development. CARDIOVASCULAR DRUGS AND THERAPY, Vol. 33(2) (pp 265-265)
Kugler E, Chico T & Armitage P (2018) Image analysis in light sheet fluorescence microscopy images of transgenic zebrafish vascular development. Medical Image Understanding and Analysis, Vol. 894 (pp 343-353), 9 July 2018 - 11 July 2018. View this article in WRRO
Maguire RJ & Chico TJ (2015) Dissecting the pathways controlling the regulation of DLL4 by blood flow. Atherosclerosis, Vol. 241(1) (pp e73-e73)
Serbanovic-Canic J, de Luca A, Warboys C, Chico T & Evans P (2013) IDENTIFICATION OF NOVEL SHEAR STRESS-RESPONSIVE REGULATORS OF ENDOTHELIAL CELL DYSFUNCTION USING THE ZEBRAFISH MODEL. HEART, Vol. 99 (pp A6-A6)
Chico T, Watson O & van Eeden F (2013) BLOOD FLOW SUPPRESSES NOTCH SIGNALLING VIA DLL4 AND IS REQUIRED FOR ANGIOGENESIS IN RESPONSE TO HYPOXIC SIGNALLING. HEART, Vol. 99
Bright RJ, Storey RF & Chico TJ (2012) ZEBRAFISH AS A MODEL TO INVESTIGATE THE ROLES OF THE P2Y12 RECEPTOR IN VIVO. ATHEROSCLEROSIS, Vol. 225(2) (pp E1-E1)
Solaymani-Kohal S, Milo M & Chico TJA (2012) KIAA1109 IS DIFFERENTIALLY EXPRESSED POST MYOCARDIAL INFARCTION AND IS REQUIRED FOR VASCULAR INTEGRITY IN ZEBRAFISH. HEART, Vol. 98 (pp A5-A5)
Hoggar EC, Placzek M & Chico TJ (2012) FLOW INDUCED VESSEL REMODELLING IN THE CHICKEN EMBRYO IS ASSOCIATED WITH A SPECIFIC GENE EXPRESSION PROFILE. HEART, Vol. 98 (pp A4-A4)
Loynes CA, Gray C, Chico T & Renshaw SA (2012) Macrophage-delivered signals drive inflammation resolution in an in vivo zebrafish model. IMMUNOLOGY, Vol. 137 (pp 255-255)
Evans T, Tazzyman S, Chico T, Thornhill M & Murdoch C (2012) Using zebrafish as an in vivo model to study Candida albicans-mediated systemic candidiasis. MYCOSES, Vol. 55 (pp 11-11)
Quaife NM & Chico TJA (2012) BLOOD FLOW IS REQUIRED FOR ENDOTHELIAL REPAIR IN A NOVEL IN VIVO MODEL USING ZEBRAFISH EMBRYOS. HEART, Vol. 98 (pp A68-A68)
Karunakaran A, Judge H, Morton A, Milano A, Arnold J, Chico TJ, Flaherty L, Baker D, Daly R & Storey RF (2011) Cytochrome P450 2C19 Loss-Of-Function Genetic Variants but not Paraoxonase-1 Activity Modulate P2Y12 Blockade in Response to Clopidogrel Therapy. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 58(20) (pp B45-B45)
Ellam T, Wilkie M, Crossman D, Francis S & Chico T (2011) THE EFFECTS OF DIETARY PHOSPHATE INTAKE ON ATHEROGENESIS AND INSULIN RESISTANCE IN APOLIPOPROTEIN E KNOCKOUT MICE. HEART, Vol. 97(20) (pp 1-1)
Hoggar EC, Placzek M & Chico TJ (2011) TRANSCRIPTIONAL PROFILING REVEALS A REQUIREMENT FOR PHOSPHODIESTERASE 10A DURING FLOW-INDUCED VESSEL REMODELLING IN THE CHICK EMBRYO. HEART, Vol. 97(20) (pp 15-15)
Bratt DG, Lees J, Crossman DC, Gering M & Chico TJA (2011) PARATHYROID HORMONE RECEPTOR 1 KNOCKDOWN INDUCES LOCALISED AORTIC OCCLUSION BY DOWN REGULATING NOTCH SIGNALLING IN ZEBRAFISH. HEART, Vol. 97(20) (pp 8-8)
Holden BJ, van Eeden FJ, Ong ACM & Chico TJ (2011) PKD2 MUTANT ZEBRAFISH DISPLAY EXCESSIVE DEVELOPMENTAL ANGIOGENESIS. HEART, Vol. 97(20) (pp 12-12)
Rothman AMK, Morton AC, Chico TJ, Crossman DC & Milo M (2011) PERIPHERAL WHOLE BLOOD MICRORNA SIGNATURE DIFFERENTIATES BETWEEN MYOCARDIAL INFARCTION AND UNSTABLE ANGINA. HEART, Vol. 97(20) (pp 7-7)
Watson OJ, van Eeden FJ, Gray C & Chico TJA (2011) ANGIOGENESIS IN RESPONSE TO UPREGULATED HYPOXIC SIGNALLING IS DEPENDENT ON HAEMODYNAMIC FLOW. HEART, Vol. 97 (pp A43-A43)
Gorsi B, Ma X, Chico TJA, Srinivasan A, Kramer KL, Lui F, Patient R & Stringer SE (2010) Sulf1 mediates zebrafish arterial venous identity. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 91(6) (pp A12-A12)
Chico TJA, Gray C, Renshaw S & Crossman DC (2010) Wiskott Aldrich syndrome protein knockdown enhances collateral vessel formation in zebrafish. EUROPEAN HEART JOURNAL, Vol. 31 (pp 622-622)
Hoggar E, Pugh S, Wilson S, Placzek M, Crossman D & Chico T (2009) A NOVEL CHICK EMBRYO MODEL REVEALS THAT ENDOTHELIN RECEPTOR B IS ESSENTIAL FOR COLLATERAL VESSEL DEVELOPMENT. HEART, Vol. 95(22)
Rocke J, Barclay R, Tura O & Chico TJA (2009) HUMAN CD34+BUT NOT CD34-VE CELLS SURVIVE IN THE ZEBRAFISH VASCULATURE. HEART, Vol. 95(22)
Gray C, Crossman DC & Chico TJA (2009) THE EFFECT OF ALTERED MACROPHAGE BEHAVIOUR ON ZEBRAFISH COLLATERAL VESSEL DEVELOPMENT. HEART, Vol. 95(22)
Tazzyman S, Chico T, Tozer GM & Lewis CE (2009) VISUALISING ANGIOGENESIS AND BLOOD FLOW IN HUMAN TUMOUR XENOGRAFTS GROWN IN ZEBRAFISH EMBRYOS. HEART, Vol. 95(22)
Lees JC, Crossman DC & Chico TJA (2009) PARATHYROID HORMONE RECEPTOR 1 GENE KNOCKDOWN INDUCES AORTIC OCCLUSION IN ZEBRAFISH EMBRYOS. HEART, Vol. 95(22)
Lees JC, Crossman DC & Chico TJA (2009) PARATHYROID HORMONE RECEPTOR 1 GENE KNOCKDOWN INDUCES AORTIC OCCLUSION IN ZEBRAFISH EMBRYOS. HEART, Vol. 95 (pp A67-A68)
Hoggar EC, Pugh SD, Wilson S, Placzek M, Crossman DC & Chico TJA (2009) A NOVEL CHICK EMBRYO MODEL REVEALS ENDOTHELIN RECEPTOR B IS ESSENTIAL FOR COLLATERAL VESSEL DEVELOPMENT. HEART, Vol. 95 (pp A65-A65)
Kelly DJ, Mecinovic J, Schofield CJ, Gunn J, Gershlick AH & Chico T (2008) In-vivo observations on angiogenesis: Dose-dependent effects of the prolyl-4-hydroxylase inhibitor, di-methyl oxalyl-glycine, on arterial development in embryonic zebrafish. HEART, Vol. 94 (pp A47-A48)
Packham IM, Gray C, Eastley N, Ingham PW, Crossman DC & Chico TJ (2007) Identifying novel regulators of arteriogenesis using the zebrafish. CIRCULATION, Vol. 116(16) (pp 41-42)
Packham IM, Gray C, Ingham PW, Hellewell PG, Crossman DC & Chico TJ (2007) Site of arterial occlusion determines nitric oxide requirement during arteriogenesis in a zebrafish model. HEART, Vol. 93(2)
Chico TJ, Milo M, Packham IM, Gray C, Heath PR, Hellewell PG, Ingham PW & Crossman DC (2007) Determining the transcriptional effect of shear stress in vivo. HEART, Vol. 93(2)
Ma X, Gray C, Packham IM, Ingham PW, Chico TJ & Stringer S (2007) Sulf1C is required for correct aortic construction in zebrafish. HEART, Vol. 93(2)
Chico T, Gray C, Packham I, Wurmser F, Hellewell P, Ingham P & Crossman D (2006) The zebrafish as a novel model of arteriogenesis. HEART, Vol. 92 (pp A1-A1)
Chico TJA, Gray C, Hellewell PG, Ingham PW & Crossman DC (2005) Nitric oxide is not required for vasculogenesis or angiogenesis in zebrafish embryos. HEART, Vol. 91 (pp A28-A28)
Chico TJA, Greve J, Steinmetz H, Bunting S, Van Bruggen N & Williams SP (2003) High-resolution magnetic resonance angiography demonstrates arteriogenesis in response to sustained release murine vascular endothelial growth factor in a mouse model of peripheral arterial disease. EUROPEAN HEART JOURNAL, Vol. 24 (pp 221-221)
Chico TJA, Gunn J, Arnold N, Bullens S, Lipari MT, Bunting S, Cumberland DC & Crossman DC (2000) Integrin αIIbβ3 and ανβ3 inhibition reduces neointima after porcine coronary angioplasty. Heart, Vol. 83(SUPPL. 1)
Chico TJA, Gunn J, Bullens SL, Arnold N, Bunting S, Cumberland DC & Crossman DC (1999) A selective integrin alpha V beta 3 antagonist reduces neointimal proliferation in a porcine coronary angioplasty model via a thrombus independent mechanism. CIRCULATION, Vol. 100(18) (pp 414-414)
Chico TJA, Gunn J, Arnold ND, Bullens S, Bunting S, Cumberland DC & Crossman DC (1999) Antagonists of integrins alpha IIb beta 3 and alpha v beta 3 reduce the neointimal response to arterial injury in a porcine coronary angioplasty model.. AM J CARDIOL, Vol. 84(6A) (pp 29P-30P)

Preprints

Abdullayev K, Gorvett O, Sochiera A, Laidlaw L, Chico TJA, Manktelow M, Buckley O, Condell J, Van Arkel RJ, Diaz-Zuccarini V & Matcham F (2023) Stakeholder perspectives on contributors to delayed and inaccurate diagnosis of cardiovascular disease: a UK-based qualitative study, Cold Spring Harbor Laboratory.
Abdullayev K, Chico TJA, Manktelow M, Buckley O, Condell J, Van Arkel RJ, Diaz-Zuccarini V & Matcham F (2023) A Stakeholder-Led Understanding of the Implementation of Digital Technologies Within Heart Disease Diagnosis: A Qualitative Study Protocol, Cold Spring Harbor Laboratory.
Snodgrass RO, Arthur HM & Chico TJA () Synergistic TOR and ERK inhibition mitigates the hereditary haemorrhagic telangiectasia-like phenotype and excess kugel formation in endoglin mutant zebrafish, Cold Spring Harbor Laboratory.
Kugler E, Snodgrass R, Bowley G, Plant K, Serbanovic-Canic J, Evans PC, Chico T & Armitage P () The effect of absent blood flow on the zebrafish cerebral and trunk vasculature, Cold Spring Harbor Laboratory.
Souilhol C, Li X, Canham L, Roddie H, Pirri D, Ayllon BT, Chambers EV, Dunning MJ, Ariaans M, Li J , Fang Y et al () JAG1-NOTCH4 Mechanosensing Drives Atherosclerosis, Cold Spring Harbor Laboratory.
Derrick CJ, Sánchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & Noël ES () Asymmetric Hapln1a drives regionalised cardiac ECM expansion and promotes heart morphogenesis during zebrafish development, Cold Spring Harbor Laboratory.
Chhabria K, Vouros A, Gray C, MacDonald RB, Jiang Z, Wilkinson RN, Plant K, Vasilaki E, Howarth C & Chico TJA () Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish.

Teaching interests: My teaching and other lecture duties cover clinical cardiology, developmental biology, cardiovascular physiology and pathology and the use of non-mammalian models of cardiovascular disease. I also have an interest in the effect of exercise on cardiovascular physiology and health.

Professional activities and memberships

I am on the British Heart Foundation Projects Grant Committee. I regularly review manuscripts and grants for a range of journals and funders.

I am a mentor on the University of Sheffield Elite Sports Performance Scheme.