Professor, Dame Pamela J Shaw

DBE, MBBS, MD, FRCP, FMedSci, FAAN, FANA, FAAAS

Department of Neuroscience

Professor of Neurology

Director, Sheffield Institute for Translational Neuroscience (SITraN)

Director, NIHR Biomedical Research Centre Translational Neuroscience for Chronic Neurological Disorders

Director, Sheffield Care and Research Centre for Motor Neuron Disorders

Consultant Neurologist, Sheffield Teaching Hospitals NHS Foundation Trust

pamela.shaw@sheffield.ac.uk
+44 114 222 2261
+44 114 226 1049 (Medical NHS Secretary: Erica Waines)
+44 114 222 2295 (Academic Administrator: Bev Carter)

Full contact details

Professor, Dame Pamela J Shaw
Department of Neuroscience
Royal Hallamshire Hospital
Glossop Road
Sheffield
S10 2JF
Profile

Professor Shaw graduated in Medicine with 1st Class Honours from the University of Newcastle in 1979. She undertook her MRCP and Specialist Training in Neurology training in Newcastle.

In 1988 she was awarded an MD with commendation for her work on the neurological complications of coronary bypass surgery. After an intermediate fellowship award from the Wellcome Trust, she was awarded a Wellcome Senior Fellowship in Clinical Science which she held from 1991 -2000.

In 1997 she was appointed Professor of Neurological Medicine at the University of Newcastle and in 2000 was appointed as Professor of Neurology at the University of Sheffield.

As an undergraduate in Newcastle she was awarded the Stephen Scott; Gibb; Mary Gordon; Mona McNaughton and Phillipson Prizes/Scholarships and achieved distinction in all undergraduate examinations.

Research interests

Professor Shaw is a Clinician Scientist in Neurology, an NIHR Senior Investigator and formerly a Wellcome Senior Clinical Fellow. Supported by long-term programme funding from the Wellcome Trust, she has since 1991 led a major multidisciplinary programme of research investigating genetic, molecular and neurochemical factors underlying neurodegenerative disorders of the human motor system.

Her team use robust cellular and in vivo models of neurodegeneration and correlate key findings with disease related changes in the human nervous system. Significant research achievements include:

  1. Identification of cell specific features of motor neurons which underlie susceptibility to neurodegeneration.
  2. Understanding the cellular pathways of motor neuron injury in the presence of mutant SOD1 using a combination of cell biology, proteomics and gene expression profiling.
  3. Identifying the different subtypes of motor neuron disease (MND) based on genetics and molecular pathology.
  4. Development of new small molecule and gene therapy candidate treatments for patients using staged screening programmes in cellular and other experimental model systems.
  5. Promoting the introduction of one neuroprotective drug for MND into clinical practice – riluzole.
  6. Establishing the role of non-invasive ventilation (NIV) in improving the quality of life and prolonging survival of MND patients.

Professor Shaw’s research is currently funded by the Medical Research Council, NIHR, the Motor Neurone Disease Association, the European Union and biotechnology & pharmaceutical industry partners. Since 1983 she has generated more than £56m in research income.


Current projects

Professor Shaw’s research is focused on 3 main goals:

  1. To understand the function of motor neurons in health and disease and to translate basic science findings into health benefits for patients with degenerative motor system disorders.
  2. To provide excellent clinical care for patients with motor system disorders, at all disease stages incorporating: multidisciplinary team working, evidence based standards of care for symptomatic management, and evaluation of new neuroprotective therapies.
  3. To foster excellent training for clinical and scientific junior staff with the aim of ensuring high standards of future care and linking new developments in medical science firmly to the needs of patients with neurological disorders.

Since 1983 she has supervised the research training of > 120 individuals from medicine and science including 45 PhD/MD students.

Publications

Books

  • Eisen AA & Shaw PJ (2007) Preface. Elsevier. RIS download Bibtex download
  • Shaw PJ, Eisen A, Aminoff MJ, Boller F & Swaab DF (2007) Motor Neuron Disorders and Related Diseases: Handbook of Clinical Neurology. Elsevier Health Sciences. RIS download Bibtex download
  • Shaw PJ & Strong MJ (2003) Blue Book of Practical Neurology: Motor Neuron Disorders. Philadelphia: Butterworth-Heinemann. RIS download Bibtex download

Journal articles

Chapters

  • Chandran JS, Scarrott JM, Shaw P & Azzouz M (2017) Gene Therapy in the Nervous System: Failures and Successes In El-Khamisy S (Ed.), Personalised Medicine Lessons from Neurodegeneration to Cancer Springer RIS download Bibtex download
  • Allen C, Shaw PJ & Ferraiuolo L (2017) Can Astrocytes Be a Target for Precision Medicine? In El-Khamisy (Ed.), Personalised Medicine View this article in WRRO RIS download Bibtex download
  • Chandran JS, Scarrott JM, Shaw PJ & Azzouz M (2017) Gene Therapy in the Nervous System: Failures and Successes, Advances in Experimental Medicine and Biology (pp. 241-257). Springer International Publishing View this article in WRRO RIS download Bibtex download
  • Hardiman O, Kelly JA, Bak TH, Elamin M, Mihaila DL, Shaw PJ, Mitsumoto H & Shefner JM (2016) Clinical Trials in Neurodegeneration, Neurodegenerative Disorders (pp. 289-303). Springer International Publishing RIS download Bibtex download
  • Alix JJP & Shaw PJ (2014) Chapter 18 Thyroid Disease and the Nervous System, Aminoff's Neurology and General Medicine (pp. 329-350). RIS download Bibtex download
  • Abrams GM, Albers GW, Alix JJP, Aminoff MJ, Bharucha AE, Batla A, Benson CM, Betjemann JP, Brosch JR, Camilleri M , Chen R et al (2014) Contributors, Aminoff's Neurology and General Medicine (pp. vii-xii). Elsevier RIS download Bibtex download
  • Shaw PJ (2012) 418 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases, Goldman's Cecil Medicine (pp. 2343-2347). RIS download Bibtex download
  • Abrams CS, Accurso FJ, Afdhal NH, Akin C, Aksamit AJ, Al-Awqati Q, Allos BM, Altshuler D, Aminoff MJ, Anderson JL , Anderson KE et al (2012) Contributors, Goldman's Cecil Medicine (pp. ix-xxx). Elsevier RIS download Bibtex download
  • Shaw PJ, Cooper-Knock J, Bury JJ, Ferraiuolo L, Goodall EF & Kirby J (2011) Gene Expression Profiling and its Application in Amyotrophic Lateral Sclerosis InTech Open Access RIS download Bibtex download
  • Shaw PJ & Wood-Allum C (2011) The Neurology of Thyroid Disease In Aminoff M (Ed.), Neurology of Systemic Disease RIS download Bibtex download
  • Shaw PJ, Gooodall EF, Bury JJ, Cooper-Knock J & Kirby J (2011) Genetics of Familial Amyotrophic Lateral Sclerosis InTech Open Access RIS download Bibtex download
  • Shaw PJ (2010) Amyotrophic Lateral Sclerosis and other Motor Neuron Diseases In Goldman L (Ed.), Cecil Textbook of Medicine Elsevier RIS download Bibtex download
  • Shaw PJ (2009) The Motor Neuron Disorders In Donaghy M (Ed.), Brain's Diseases of the Nervous System (pp. 637-686). OUP Oxford RIS download Bibtex download
  • Burness CE & Shaw PJ (2008) Thyroid Disease and the Nervous System, Neurology and General Medicine (pp. 357-381). Elsevier RIS download Bibtex download
  • Abrams GM, Albers GW, Allen BL, Aminoff MJ, Berg BO, Berger JR, Berger TG, Bharucha AE, Bolton CF, Brown DL , Burness CE et al (2008) Contributors, Neurology and General Medicine (pp. vii-xii). Elsevier RIS download Bibtex download
  • Shaw PJ & Hilton-Jones D (2008) The Lower Cranial Nerves and Dysphagia In Donaghy M (Ed.), Brain's Diseases of the Nervous System (pp. 517-540). OUP Oxford RIS download Bibtex download
  • Shaw PJ & Brockington A (2008) Vascular Endothelial Growth Factor and the Nervous System In Ribatti D (Ed.), Recent Advances in Angiogenesis in the Central Nervous Ssytem RIS download Bibtex download
  • Shaw PJ (2007) Molecular and Cellular Pathways of Neurodegeneration in Motor Neurone Disease In Chinnery PF (Ed.), Neuroscience for Neurologists (pp. 143-179). Imperial College Press RIS download Bibtex download
  • Shaw PJ, Hamdy FC, Heath P & Kirby J (2007) Gene Expression Arrays In Makowski GS (Ed.), Advances in Clinical Chemistry (pp. 247-292). Elsevier Inc. RIS download Bibtex download
  • Shaw PJ & Burness C (2007) Thyroid Disease and the Nervous System In Aminoff M (Ed.), Neurology of Systemic Disease RIS download Bibtex download
  • Shaw PJ & McDermott CJ (2007) Hereditary Spastic Paraparesis In Eisen A & Shaw PJ (Ed.), Handbook of Clinical Neurology Series 3rd Edition. Motor Neuron Disorders (pp. 327-352). Elsevier Health Sciences RIS download Bibtex download
  • Shaw PJ, Cox LE & Kirby J (2006) Pathogenesis of Motor Neuron Disease In Kiernan MC (Ed.), The Motor Neuron Disease Handbook (pp. 26-55). Australasian Medical Publishing Company Limited RIS download Bibtex download
  • Shaw PJ, Brockington A & Ince PG (2006) The Cinical and Pathological Spectrum of ALS In Strong M (Ed.), Dementia and Motor Neuron Diseases (pp. 31-58). Taylor and Francis RIS download Bibtex download
  • Shaw PJ & Brockington A (2006) Familial Motor Neuron Diseases other than ALS In Brown RH, Pasinelli P & Swash M (Ed.), Amyotrophic Lateral Sclerosis and Related Disorders London: Martin Dunitz, Taylor and Francis Group. RIS download Bibtex download
  • Shaw PJ & Barber SC (2006) Molecular Mechanisms of Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis In Eisen A & Shaw PJ (Ed.), Handbook of Clinical Neurology Series 3rd Edition. Motor Neuron Disorders (pp. 57-87). Elsevier Health Sciences RIS download Bibtex download
  • Shaw PJ & Heath P (2005) Excitotoxicity In Mitsumoto H, Przedborski S & Gordon P (Ed.), Amyotrophic Lateral Sclerosis (pp. 299-336). New York: Informa Healthcare. RIS download Bibtex download
  • Shaw PJ & Wood-Allum C (2005) Current and Potential Therapeutics in motor neuron diseases In M B, Lang AE & Ludolph AC (Ed.), Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics (pp. 772-793). Cambridge University Press RIS download Bibtex download
  • Shaw PJ (2004) Motor Neurone Disease In Jenkins R (Ed.), WHO Guide to Mental Health and Neurological Disorders in Primary Care RIS download Bibtex download
  • Shaw PJ, Kato S, Wood-Allum C, Leigh PN & Shaw C (2003) Motor Neuron Disorders In Dickson D (Ed.), Neurodegeneration: the Molecular Pathology of Dementia and Movement Disorders (pp. 349-377). Basel: ISN Neuropath Press. RIS download Bibtex download
  • Shaw PJ & Grierson AJ (2003) Cellular Biological Effects of SOD1 Mutations In Shaw PJ & Strong M (Ed.), Blue Book of Practical Neurology (pp. 237-258). Butterworth Heinemann, Philadelphia RIS download Bibtex download
  • Shaw PJ & Wood-Allum CA (2003) Mitochondrial Function in ALS/MND In Shaw PJ & Strong M (Ed.), Blue Book of Practical Neurology (pp. 285-314). Philadelphia: Butterworth Heinemann. RIS download Bibtex download
  • Shaw PJ & McDermott CJ (2003) Hereditary Spastic Paraparesis In shaw PJ & Strong M (Ed.), Blue Book of Practical Neurology (pp. 435-464). Philadelphia: Butterworth Heinemann. RIS download Bibtex download
  • Shaw PJ (2002) Motor Neurone Disease In Greenwood RJ, McMillan TM, Barnes MP & Ward CD (Ed.), Handbook of Neurological Rehabilitation (pp. 639-660). Psychology Press RIS download Bibtex download
  • Shaw PJ (2002) Glutamate Transporters In Creighton TE (Ed.), Encyclopedia of Molecular Medicine (pp. 1454-1459). John Wiley and Sons RIS download Bibtex download
  • Shaw PJ & Kuncl RW (2002) Current Concepts in the Pathogenesis of ALS In Saunders WB (Ed.), Major Problems in Neurology Series. Motor Neurone Disease (pp. 37-74). RIS download Bibtex download
  • Shaw PJ & McDermott CJ (2002) Hereditary Spastic Paraparesis In Schapira A (Ed.), International Review of Neurobiology: Mitochondrial Disorders of the Nervous System (pp. 191-204). RIS download Bibtex download
  • Shaw PJ (2002) Motor Neuron Disease In Asbury AK, McKham G, McDonald WI, Goadsby PJ & McArthur JC (Ed.), Diseases of the Nervous System: Clinical Neuroscience and Therapeutic Principles (pp. 1863-1879). Cambridge University Press RIS download Bibtex download
  • Shaw PJ (2001) Thyroid disease and the nervous system In Aminoff M (Ed.), Neurology and General Medicine, Third Edition (pp. 317-340). Churchill Livingstone RIS download Bibtex download
  • Shaw PJ (1999) Biochemical pathology In Brown R, Swash M & Pasinelli P (Ed.), Amyotrophic Lateral Sclerosis (pp. 113-141). Informa Healthcare RIS download Bibtex download
  • Shaw PJ (1998) Neurological abnormalities associated with thyroid disease In Goetz CG & Aminoff MJ (Ed.), Handbook of Clinical Neurology (pp. 81-110). Elsevier Science BV RIS download Bibtex download
  • Shaw PJ (1997) A Molecular Whodunit: the Pathways of Cell Death in Motor Neurone Disease., Wellcome Trust Review (pp. 19-22). RIS download Bibtex download
  • Shaw PJ (1997) Excitotoxicity, genetics and neurodegeneration in amyotrophic lateral sclerosis, Ernst Schering Research Foundation Workshop Series Volume 23. Excitatory Amino Acids: from Genes to Therapies (pp. 65-94). RIS download Bibtex download
  • Shaw PJ, Ince PG & Eggett C (1997) Role of excitotoxicity in neurological disease, Reviews in Contempoary Pharmacotherapy (pp. 195-212). RIS download Bibtex download
  • Shaw PJ (1992) The intellectual function of patients after coronary bypass surgery In Walter PJ (Ed.), Quality of Life after Open Heart Surgery (pp. 141-153). Kluwer Academic Press RIS download Bibtex download
  • Shaw PJ (1992) The neurological sequelae of cardiopulmonary bypass: the Newcastle experience In Smith P & Taylor K (Ed.), The Brain and Cardiac Surgery (pp. 24-33). Edward Arnold Publishers RIS download Bibtex download
  • Shaw PJ, Ince PG, Johnson M, Perry EK & Candy JM (1991) An autoradiographic study of glutamate receptor subtypes in the normal human motor system In Clifford Rose F (Ed.), New Evidence in ALS Research (pp. 237-248). London: Smith-Gordon & Company Ltd. RIS download Bibtex download
  • shaw PJ & Shaw, DA (1989) Pscychiatric morbidity following cardiac surgery: a review, Contemporary Themes in Psychiatry: a tribute to Sir Martin Roth London: Gaskell RIS download Bibtex download
  • Shaw PJ (1988) Cerebral complications of cardiac surgery In Sobel, BE, Julian, DG & Hugenholtz PG (Ed.), Perspectives in Cardiology (pp. 399-413). Current Medical Literature Ltd, London RIS download Bibtex download
  • Shaw PJ (1986) Neurological complications of cardiovascular surgery. Procedures involving the heart and thoracic aorta, Neurologic and Psychologic Complications of Surgery and Anesthesia (pp. 159-200). Litle, Brown & Co, Boston RIS download Bibtex download

Conference proceedings papers

  • Hewamadduma CA, Omalley R, Robinson M, Beauchamp N, Rogers T, Martindale J, Mcdermott C, Shaw P, Hoggard N & Hadjivassiliou M (2017) Mutations in SPG7 as an important cause of spastic-ataxia in a large british cohort: Hybrid phenotype helps direct screening. Journal of the Neurological Sciences, Vol. 381 (pp 304-305) View this article in WRRO RIS download Bibtex download
  • Jenkins T, Alix J, Rao G, Hoggard N, O'Brien E, Baster K, Bradburn M, Bigley J, McDermott C, Wilkinson I & Shaw P (2017) Imaging denervation in motor neuron disease for future clinical trials: a longitudinal cohort study. Journal of the Neurological Sciences, Vol. 381 (pp 102-102) View this article in WRRO RIS download Bibtex download
  • (2016) Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 June - 1 July 2016. The Journal of Pathology, Vol. 240 (pp S1-S48) View this article in WRRO RIS download Bibtex download
  • Iannitti T, Scarrot JM, Coldicott IRP, Kaspar BK, Ferraiuolo L, Shaw PJ & Azzouz M (2016) Gene Therapy for Familial ALS Using AAV9 Mediated Silencing of Mutant SOD1. HUMAN GENE THERAPY, Vol. 27(7) (pp A12-A12) View this article in WRRO RIS download Bibtex download
  • Lorente-Pons A, Wood JD, Shaw PJ, Ince PG, Cooper-Knock J, Ramachandran A, Kirby J & Highley JR (2016) Investigating the mechanisms underlying oligodendrocyte dysfunction in C9ORF72 ALS. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42(S1) (pp 28-28), 2 March 2016 - 4 March 2016. View this article in WRRO RIS download Bibtex download
  • Rafiq M, Proctor A, McDermott C & Shaw P (2015) SCREENING FOR RESPIRATORY FAILURE IN ALS USING CLINICAL QUESTIONING, RESPIRATORY FUNCTION TESTS AND TRANSCUTANEOUS CARBON DIOXIDE: WHICH IS THE BETTER TOOL?. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 86(11) (pp e4.54-e4) View this article in WRRO RIS download Bibtex download
  • Hewamadduma C, Grierson A, Higginbottom A & Shaw P (2015) Fibroblasts from patients with amyotrophic lateral sclerosis (ALS) associated with mutations in tardbp gene as model of TDP-43 proteinopathy. Journal of the Neurological Sciences, Vol. 357 (pp e49-e49) RIS download Bibtex download
  • Rafiq M, Lee E, Bradburn M, McDermott C & Shaw P (2015) Elevated creatine kinase is associated with a better prognosis in patients with amyotrophic lateral sclerosis. EUROPEAN JOURNAL OF NEUROLOGY, Vol. 22 (pp 741-741) View this article in WRRO RIS download Bibtex download
  • Rafiq M, Bradburn M, McDermott C & Shaw P (2015) Effects of cough augmentation on pulmonary morbidity, survival, and quality of life in patients with amyotrophic lateral sclerosis in respiratory failure: a randomised trial. EUROPEAN JOURNAL OF NEUROLOGY, Vol. 22 (pp 244-244) RIS download Bibtex download
  • Lorente-Pons A, Wood JD, Shaw PJ, Ince PG, Cooper-Knock J, Ramachandran A, Kirby J & Highley JR (2015) Investigating the mechanisms underlying oligodendrocyte dysfunction in C9ORF72 ALS. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 26-27) RIS download Bibtex download
  • Mathur R, Ince PG, Minett T, Garwood CJ, Shaw PJ, Matthews FE, Brayne C, Simpson JE, Wharton SB & Ageing MRCCF (2015) A reduced astrocyte response to beta-amyloid plaques in the ageing brain associates with dementia and cognitive impairment. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 41 (pp 30-31) View this article in WRRO RIS download Bibtex download
  • Beer A, Cooper-Knock J, Higginbottom A, Robin Highley J, Wharton SP, Milano A, Jones A, Al-Chalabi A, Kirby J & Shaw PJ (2014) AMYOTROPHIC LATERAL SCLEROSIS ASSOCIATED WITH AN INTERMEDIATE LENGTH GGGGCC REPEAT EXPANSION HAS DISTINCT NEUROPATHOLOGY COMPARED TO PATIENTS WITH LARGER EXPANSIONS. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.130-e4) RIS download Bibtex download
  • Rafiq MK, Bradburn M, Proctor A, Billings C, Bianchi S, McDermott C & Shaw P (2014) ROLE OF COUGH AUGMENTATION IN AMYOTROPHIC LATERAL SCLEROSIS. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.93-e4) RIS download Bibtex download
  • Simpson JE, Ince PG, Matthews F, Shaw PJ, Heath PR, Brayne C, Garwood C, Abdalla H, Higginbottom A & Wharton SB (2014) A neuronal DNA damage response is detected at low Braak stages and correlates with cognitive impairment in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 40 (pp 31-32) RIS download Bibtex download
  • Rafiq M, Lee E, Bradburn M, McDermott C & Shaw P (2013) Elevated creatine kinase suggests better prognosis in patients with amyotrophic lateral sclerosis.. J Neurol Neurosurg Psychiatry, Vol. 84(11) (pp e2). England RIS download Bibtex download
  • Binny C, Karyka E, Ning K, Bennett E, Ince P, Shaw P & Azzouz M (2013) Efficient scAAV9-mediated delivery of SMN to motor neurons in neonatal and juvenile mice. HUMAN GENE THERAPY, Vol. 24(5) (pp A38-A38) RIS download Bibtex download
  • Little D, Valori C, Wyles M, Shaw P, Azzouz M & Ning K (2013) Systemic delivery of scAAV9 expressing PTEN siRNA prolongs survival in a model of spinal muscular atrophy. HUMAN GENE THERAPY, Vol. 24(5) (pp A27-A27) RIS download Bibtex download
  • Highley JR, Cooper-Knock J, Frolov A, Charlesworth G, Kirby J, Wharton SB, Ince PG, Shaw PJ, Wood N & Bandman O (2013) A pathological basis for the association of parkinsonism and amyotrophic lateral sclerosis. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 39 (pp 51-51) RIS download Bibtex download
  • Cooper-Knock J, Highley JR, Hartley J, Milano A, Sawcer S, Compston A, Frolov A, Charlesworth G, Wood N, Bandmann O , McDermott CJ et al (2013) Neurodegeneration caused by intronic expansions of C9ORF72 is a clinically heterogeneous but pathologically distinct disease. LANCET, Vol. 381 (pp 32-32) RIS download Bibtex download
  • Woollacott I, Shatunov A, Jones A, Morrison KE, Leigh PN, Shaw PJ, Shaw CE & Al-Chalabi A (2013) Trimodal pattern of C9ORF72 GGGGCC normal allele repeat number in sporadic amyotrophic lateral sclerosis and lack of association with disease risk and age at onset. LANCET, Vol. 381 (pp 116-116) RIS download Bibtex download
  • Rafiq M, Proctor AR, McDermott CJ & Shaw P (2012) CLINICAL EVALUATION OF TRANSCUTANEOUS CARBON DIOXIDE MONITOR (TOSCA) IN PATIENTS WITH MOTOR NEURONE DISEASE. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83 RIS download Bibtex download
  • Al-Chalabi A, Shaw P, Kelly J, Morrison K, Murphy C, Thornhill M, Steen N & Leigh PN (2012) LITHIUM CARBONATE IS NOT BENEFICIAL FOR PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS: RESULTS OF THE LICALS TRIAL [EUDRACT NUMBER: 2008-006891-31]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83 RIS download Bibtex download
  • Gibbons CJ, Cousins R, Pomeroy IM, Ando H, Al-Chalabi A, Chataway J, Constaninescu C, Ealing J, Hawkins C, Morrison K , Palace J et al (2012) Work in progress: quality of life (QoL) and neurological disease - trajectories of outcome in neurological conditions (TONiC): a study protocol. EUROPEAN JOURNAL OF NEUROLOGY, Vol. 19 (pp 264-264) RIS download Bibtex download
  • Hewamadduma C, Grierson A, Moens C, Pan L, Ma T, Ingham P, Ramesh T & Shaw P (2012) A novel alternative splicing event rescues the mutant tardbp phenotype in a zebrafish model of TDP-43 related Amyotrophic Lateral Sclerosis (ALS). NEUROLOGY, Vol. 78 RIS download Bibtex download
  • Hewamadduma C, Grierson A, Moens C, Pan L, Ma T, Ingham P, Ramesh T & Shaw P (2012) A novel alternative splicing event rescues the mutant tardbp phenotype in a zebrafish model of TDP-43 related Amyotrophic Lateral Sclerosis (ALS). NEUROLOGY, Vol. 78 RIS download Bibtex download
  • Ramesh T, McGown A, Al Mashhadi S, Redhead N, Lyon A, Bettie CE & Shaw PJ (2012) THE HEAT IS "ON" IN THE NEURONS: NEURONAL STRESS IN A SOD1 ZEBRAFISH MODEL OF MND AFFECTS NEUROMUSCULAR JUNCTION INTEGRITY AND CAUSES MUSCLE DENERVATION. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83(3) RIS download Bibtex download
  • Hewamadduma C, Higgenbottom CAA, Moens C, Helde K, Raman R, Tennore R, Grierson A & Shaw PJ (2012) NOVEL IN VITRO AND IN VIVO MODELS OF ALS ASSOCIATED WITH TDP-43 PROTEINOPATHY. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83(3) RIS download Bibtex download
  • Aridegbe T, Kandler R, Walsh T, Shaw PJ & McDermott CJ (2012) THE NATURAL HISTORY OF MOTOR NEURONE DISEASE (MND): ASSESSING THE IMPACT OF SPECIALIST CARE. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83(3) RIS download Bibtex download
  • Brockington A, Ning K, Heath P, Wood E, Malik K, Fusi N, Wharton S, Ince PG & Shaw PJ (2012) MOTOR NEURONES SUBTYPES RESISTANT TO DEGENERATION IN AMYOTROPHIC LATERAL SCLEROSIS SHOW DISTINCT SYNAPTIC CHARACTERISTICS ACROSS SPECIES. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83(3) RIS download Bibtex download
  • Rajan S, Shaw P & Wood-Allum C (2012) DEFECTIVE REGENERATION OF OXIDATIVELY-INACTIVATED 2-CYS PEROXIREDOXINS IN SOD1-RELATED AMYOTROPHIC LATERAL SCLEROSIS. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83(3) RIS download Bibtex download
  • Ferraiuolo L, Higginbottom A, Heath PR, Barber S, Greenald D, Kirby J & Shaw PJ (2012) DYSREGULATION OF THE CROSS-TALK WITH ASTROCYTES AS A CONTRIBUTORY FACTOR TO MOTOR NEURON INJURY IN MOTOR NEURON DISEASE. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83(3) RIS download Bibtex download
  • McDermott C, Proctor A, Walsh T, Ackroyd R, Rao G, Bianchi S, Englert L, Rafiq MK & Shaw PJ (2012) EXPERIENCE OF THE USE OF DIAPHRAGM PACING IN PATIENTS WITH RESPIRATORY IMPAIRMENT DUE TO MOTOR NEURONE DISORDERS. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83(3) RIS download Bibtex download
  • Smith BN, Topp S, Barwell J, Al-Chalabi A, Kirby J, Shaw PJ, Paul H, Morrison KE, de Jong V, Baas F , Lewis CM et al (2012) Age-dependent penetrance and anticipation in ALS+/-FTLD kindreds due to C9ORF72 hexanucleotide intronic repeat expansion mutations (C9HIREM). DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, Vol. 33 (pp 282-282) RIS download Bibtex download
  • Smith BN, Topp S, Barwell J, Al-Chalabi A, Kirby J, Shaw PJ, Paul H, Morrison KE, de Jong V, Baas F , Lewis CM et al (2012) Age-dependent penetrance and anticipation in ALS+/-FTLD kindreds due to C9ORF72 hexanucleotide intronic repeat expansion mutations (C9HIREM). DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, Vol. 33 (pp 36-37) RIS download Bibtex download
  • Bunting E, Wood-Allum C, Barber S & Shaw P (2011) Congruent handedness and side of onset in ALS-evidence in favour of the exercise hypothesis?. JOURNAL OF NEUROLOGY, Vol. 258 (pp 57-57) RIS download Bibtex download
  • Eckmann J, Eckert SH, Leuner K, Bordet T, Pruss R, Grierson A, Shaw P, Clemens L, Nguyen HP, Mueller WE & Eckert GP (2011) Impact of Olesoxime on disease related mitochondrial membrane properties in mouse models of neurodegenerative diseases. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, Vol. 383 (pp 51-51) RIS download Bibtex download
  • Simpson JE, Ince PG, Heath PR, Raman R, Shaw PJ, Gelsthorpe C, Baxter L, Forster G, Matthews F, Savva G , Brayne C et al (2011) Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 33-33) RIS download Bibtex download
  • Highley R, Kirby J, Jansweijer JA, Heath PR, Shaw PJ & Ince PG (2011) TARDBP mutations, amyotrophic lateral sclerosis and alternative splicing. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 37 (pp 20-20) RIS download Bibtex download
  • Wain LV, Shrine NRG, Shaw C, Powell JF, Hardy J, Shaw P, Morrison KE, Brown RH, Orrell R, Mok B , Palmer LJ et al (2010) The Role of Common Copy Number Variation in Amyotrophic Lateral Sclerosis (ALS). GENETIC EPIDEMIOLOGY, Vol. 34(8) (pp 929-930) RIS download Bibtex download
  • Wood E, Heath P & Shaw P (2010) MICROARRAY ANALYSIS IDENTIFIES THE GENE SIGNATURE OF SPARED VS VULNERABLE MOTOR NEURONE GROUPS. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 81(11) (pp E33-E33) RIS download Bibtex download
  • Valori CF, Ning K, Wyles M, Mead RJ, Grierson AJ, Shaw PJ & Azzouz M (2010) Systemic delivery of scAAV9 expressing SMN prolongs survival in a mouse model of SMA. HUMAN GENE THERAPY, Vol. 21(10) (pp 1424-1425) RIS download Bibtex download
  • Simpson J, Ince P, Heath P, Raman R, Shaw P, Gelsthorpe C, Baxter L, Forster G, Matthews F, Savva G , Brayne C et al (2010) Microarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype. BRAIN PATHOLOGY, Vol. 20 (pp 46-46) RIS download Bibtex download
  • Philips A, Englert L, Ackroyd R, Shaw PJ & Mc Dermott C (2010) Laparoscopic insertion of a diaphragmatic pacing system in patients with non-spinal injury-related neurological respiratory failure: the first reported UK cases. ANAESTHESIA, Vol. 65(1) (pp 112-113) RIS download Bibtex download
  • Brockington A, Heath P, Holden H, Kasher P, Autiero M, Claes F, Lambrechts D, Carmeliet P & Shaw PJ (2009) TRANSCRIPTIONAL PROFILING OF SPINAL MOTOR NEURONES IN THE VEGF(delta/delta) MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 80(11) RIS download Bibtex download
  • Douglass CP, Kandler RH, Shaw PJ & McDermott CJ (2009) AN AUDIT OF NEUROPHYSIOLOGICAL CRITERIA USED IN THE DIAGNOSIS OF MOTOR NEURONE DISEASE. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 80(11) RIS download Bibtex download
  • Gibbons CJ, Mills RJ, Thornton EW, Talbot K, Mitchell JD, Ealing J, Shaw PJ, Tennant A, Pallant J & Young CA (2009) DEVELOPMENT AND VALIDATION OF THE NEUROLOGICAL FATIGUE INDEX FOR MOTOR NEURONE DISEASE. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 80(11) RIS download Bibtex download
  • Simpson JE, Ince PG, Theaker R, Haynes L, Forster G, Shaw PJ, Matthews F, Savva G, Brayne C, Wharton SB & MRC Cognitive Function & Ageing Ne (2009) Evidence of an astrocytic DNA damage response to oxidative stress in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 35 (pp 18-19) RIS download Bibtex download
  • Simpson J, Ince P, Theaker R, Haynes L, Forster G, Shaw P, Matthews F, Savva G, Brayne C & Wharton S (2008) DNA oxidative damage and repair mechanisms in astrocytes, and their relationship to Alzheimer-type pathology in the ageing brain. JOURNAL OF NEURAL TRANSMISSION, Vol. 115(12) (pp 1727-1727) RIS download Bibtex download
  • Simpson JE, El-Sayed OH, Wharton SB, Heath P, Holden H, Forster G, Fernando MS, Matthews F, Brayne C, Lewis CE , Barber R et al (2008) Microarray gene expression analysis of deep subcortical lesions in the ageing brain reveals changes in multiple functional pathways. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 30-31) RIS download Bibtex download
  • Simpson JE, Ince PG, Lace G, Forster G, Shaw PJ, Matthews F, Brayne C, Wharton SB & MRC Cognitive Function Ageing (2008) Characterisation of astrocytes in relation to Alzheimer-type pathology in the ageing brain using a population-based neuropathology cohort. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 34 (pp 31-31) RIS download Bibtex download
  • Simpson JE, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C , Shaw PJ et al (2007) Microglial activation in white matter of the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 255-255) RIS download Bibtex download
  • Highley JR, Smith O, Brockington A, Kirby J, Wharton SB, Spillantini M, Lowe JS, Layfield R, Shaw PJ & Ince PG (2007) Extra-motor manifestations of motor neurone disease and the role of TDP43 in ALS variants. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 264-265) RIS download Bibtex download
  • Simpson JE, El-Sayed OH, Wharton SB, Heath P, Holden H, Forster G, Fernando MS, Matthews F, Brayne C, Lewis CE , Barber R et al (2007) Microarray gene expression profiling of deep subcortical lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 33(2) (pp 254-255) RIS download Bibtex download
  • Blackburn D, Sargsyan S, Monk P, Shaw P, Heath P & Holden H (2007) The role of microglial cells in MND. NEURON GLIA BIOL, Vol. 2 (pp S56-S56) RIS download Bibtex download
  • Ince PG, Fernando MS, Matthews F, Brayne C, Wharton SB, O'Brien JT, Lewis C, Kalaria RN, Shaw PJ & Simpson J (2006) Molecular markers of tissue hypoxia and glial pathology associated with incidental white matter lesions in the ageing brain. BRAIN PATHOLOGY, Vol. 16 (pp S92-S92) RIS download Bibtex download
  • Gandhi RA, Selvarajah D, Wilkinson I, Emery C, Shaw PJ, Griffiths PD & Tesfaye S (2006) Preservation of thalamic neuronal function may be a prerequisite for pain perception in diabetic neuropathy. DIABETOLOGIA, Vol. 49 (pp 119-119) RIS download Bibtex download
  • Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C , Shaw PJ et al (2006) Glial cell pathology of periventricular and deep white matter lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 32(2) (pp 224-225) RIS download Bibtex download
  • Simpson JE, Fernando MS, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB , Shaw PJ et al (2006) Molecular markers of tissue hypoxia are associated with deep subcortical white matter lesions in the ageing brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 32(2) (pp 224-224) RIS download Bibtex download
  • Bourke SC, Tomlinson M, Williams TL, Bullock RE, Gibson GJ & Shaw PJ (2006) A randomised controlled trial of non-invasive ventilation (NIV) in motor neurone disease (MNC). JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 77(1) (pp 136-137) RIS download Bibtex download
  • McDermott CJ, Burness CE, Rao G, Kirby J, Shaw PJ & Spastin HSP Consortium Neurologist (2006) Further insights into HSP and spastin: Severe complicated phenotypes and evidence of lower motor neurone dysfunction. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 77(1) (pp 137-137) RIS download Bibtex download
  • Wood-Allum C, Barber S, Kirby J, Heath P, Holden H, Beaujeux T, Allen S, Alexson S, Ince P & Shaw P (2005) Impaired mitochondrial anti-oxidant defence in SOD1-related familial amyotrophic lateral sclerosis (FALS). JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol. 238 (pp S56-S56) RIS download Bibtex download
  • Wood-Allum C, Barber S, Kirby J, Heath P, Ince PG, Allen S & Shaw P (2005) Perturbation of mitochondrial anti-oxidant defence in a cell-culture model of SOD1-related familial amyotrophic lateral sclerosis. JOURNAL OF NEUROLOGY, Vol. 252 (pp 18-19) RIS download Bibtex download
  • Sathasivam S, Grierson AJ & Shaw PJ (2005) Alterations of the Bcl-2 family oncoprotein members in a cell culture model of familial SOD1-related motor neurone disease. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 76(1) (pp 157-157) RIS download Bibtex download
  • Bourke SC, Tomlinson M, Williams TL, Shaw PJ, Bullock RE & Gibson GJ (2004) Randomised controlled trial of now invasive ventilation in motor neurone disease. THORAX, Vol. 59(1) (pp 30-30) RIS download Bibtex download
  • Selvarajah D, Wilkinson ID, Emery CJ, Shaw PJ, Griffiths PD & Tesfaye S (2004) Spinal cord atrophy in diabetic neuropathy, a comparison with healthy volunteers and hereditary sensory motor neuropathy.. DIABETOLOGIA, Vol. 47 (pp A35-A36) RIS download Bibtex download
  • Tesfaye S, Selvarajah D, Emery CJ, Shaw PJ, Griffiths PD & Wilkinson JD (2004) Thalamic sensory neuronal dysfunction in distal symmetrical polyneuropathy. DIABETOLOGIA, Vol. 47 (pp A365-A365) RIS download Bibtex download
  • Wood-Allum CA, Allen S & Shaw PJ (2003) Proteomic analysis of mitochondrial protein expression in a cell culture model of SOD1-related familial amyotrophic lateral sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 74(10) (pp 1453-1453) RIS download Bibtex download
  • McDermott CJ, Grierson A, Wood J & Shaw PJ (2003) Hereditary spastic paraparesis associated with mutation in spastin (SPG4): A disorder of axonal transport?. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 74(10) (pp 1453-1453) RIS download Bibtex download
  • Holden M, Chapman L, Wymer B, Shaw P, McDermott C & Dalton A (2003) The results of screening all 17 exons of the spastin gene (SPG4) for autosomally dominantly transmitted Hereditary Spastic Paraplegia. JOURNAL OF MEDICAL GENETICS, Vol. 40 (pp S81-S81) RIS download Bibtex download
  • Selvarajah D, Wilkinson ID, Griffiths PD, Shaw PJ & Tesfaye S (2003) Early spinal cord involvement in diabetic peripheral neuropathy. DIABETOLOGIA, Vol. 46 (pp A312-A312) RIS download Bibtex download
  • Bourke SC, Shaw PJ, Bullock R & Gibson GJ (2002) Responsiveness of quality of life instruments and domains to non-invasive ventilation in motor neuron disease. J NEUROL NEUROSUR PS, Vol. 72(1) (pp 138-139) RIS download Bibtex download
  • McDermott CJ, Dayaratne RK, Tomkins J, Johnson MA, Casari G, Turnbull DM, Bushby K & Shaw PJ (2000) Hereditary spastic paraparesis with amyotrophy and OXPHOS muscle defect associated with a deletion in the paraplegin (SPG7) gene with apparent autosomal dominant transmission. NEUROLOGY, Vol. 54(7) (pp A425-A425) RIS download Bibtex download
  • Shaw PJ & Eggett CJ (2000) Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis. JOURNAL OF NEUROLOGY, Vol. 247 (pp 17-27) RIS download Bibtex download
  • Phul RK, Smith ME, Shaw PJ & Ince PG (1998) Expression of nitric oxide synthase in the spinal cord in amyotrophic lateral sclerosis. JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol. 160 (pp S87-S91) RIS download Bibtex download
  • Vianney de Jong JMB (1997) 48th ENMC International Workshop: Drug Trials and Clinical Research in ALS 12–14 January 1997, Naarden, The Netherlands. Neuromuscular Disorders, Vol. 7(6-7) (pp 404-406) RIS download Bibtex download
  • Shaw PJ (1997) Glutamate, excitotoxicity and amyotrophic lateral sclerosis. Journal of Neurology, Supplement, Vol. 244(2) RIS download Bibtex download
  • Shaw PJ, Tomkins J, Ince PG, Slade JY, Usher P, Curtis A & Bushby K (1997) Cu/Zn superoxide dismutase (SOD1) mutations in amyotrophic lateral sclerosis (ALS) CNS tissue: Exclusion of somatic mutations and correlations with molecular pathology. NEUROLOGY, Vol. 48(3) (pp 49005-49005) RIS download Bibtex download
  • Miller RG, Bouchard JP, Duquette P, Eisen A, Gelinas DF, Harati Y, Munsat TL, Powe L, Rothstein J, Salzman P , Sufit RL et al (1996) Clinical trials of riluzole in patients with ALS. NEUROLOGY, Vol. 47(4) (pp S86-S90) RIS download Bibtex download
  • Forrest V, Ince P, Leitch M, Marshall EF & Shaw PJ (1996) Serotonergic neurotransmission in the spinal cord and motor cortex of patients with motor neuron disease and controls: Quantitative autoradiography for 5-HT1a and 5-HT2 receptors. JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol. 139 (pp 83-90) RIS download Bibtex download

Reports

  • Shaw PJ (2003) Academic Neurology in the United Kingdom: Threats, Opportunities and Recommendations. RIS download Bibtex download

Datasets

Other

Research group

Current Scientific research team

  • Adrian Higginbottom
  • Paul Heath
  • Johnathan Cooper-Knock
  • James Alix
  • Rachel Waller
  • Stephanie Shepheard
  • Esther Hobson
  • Heledd Brown-Wright
  • Joseph Scarrott
  • Matthew Shaw
  • Yuri Cervio
  • Noemi Gatto
  • Chloe Allan
  • Llewellyn Griffiths

SITraN PI Scientific Collaborators

  • Laura Ferraiuolo
  • Robin Highley
  • Richard Mead
  • Janine Kirby
  • Scott Allen
  • Guillaume Hautbergue
  • Stuart Wilson
  • Winston Hide

Current Clinical Research Team

  • Hannah Hollinger
  • Theresa Walsh
  • Helen Wollff
  • Mbombe Kazoka
  • Lee Tuddenham
  • Haris Stavroulakis
  • James Alix
  • Stacy Young
  • Johnathan Cooper-Knock
  • Esther Hobson

SITraN PI Clinical Research Collaborators

  • Chris McDermott
  • Tom Jenkins
Grants

Principal Funding Sources

  • The Wellcome Trust
  • The Motor Neurone Disease Association
  • The Medical Research Council
  • NIHR
  • European Union
Professional activities

Professor Shaw is a member of multiple national and international committees, sits on the editorial board of several journals including Brain and Amyotrophic Lateral Sclerosis and is a reviewer for numerous other journals.

Membership of Editorial Boards

  • Muscle and Nerve
  • Editorial Panel for Research Frontiers in Science, British Medical Journal.
  • Editorial board of Amyotrophic Lateral Sclerosis & Frontotemporal Dementia
  • Editorial Board of Brain

She has been a research advisory panel member for the Wellcome Trust, MNDA, MRC,the Muscular Dystrophy Association the Academy of Medical Sciences, the Acade,my of Scienec Finland and reviews for multiple grant awarding bodies.

Membership of National and International Committees

  • Member of the Executive Committee of the Association of Physicians of Great Britain and Ireland from 1996 to 1999.
  • Member of the Motor Neurone Disease Research Advisory Panel from1993 to 1997.
  • Member of the Association of British Neurologists Clinical Research and Academic Committee from 1998 - 2007.
  • Guarantor of the Brain Trust from 1998 - present.
  • Advisor to the Department of Health Medicines Control Agency/ Committee on Safety of Medicines from 1997 - present.
  • Wellcome Trust / Irish Health Board New Blood Fellowship panel from 1998 - 2000.
  • External assessor for Parkinson’s Disease Society 2000.
  • Medical Advisor to the Motor Neurone Disease Association 2000 - present.
  • Member of the Neurosciences Subpanel for the 2001 Research Assessment Exercise.
  • Member of the Medical Research Society Committee from 2001 - 2004.
  • Invited expert participant in the NICE panel for the evaluation of riluzole therapy 2001.
  • Member of Council for the Association of British Neurologists from 2001 - 2007.
  • Chair of the Association of British Neurologists Clinical Research and Academic Committee from 2001 -2007.
  • Member of the Wellcome Trust Neurosciences Panel from 2001 - 2004.
  • Member of Meetings Subcommittee of the Association of British Neurologists from 2001-2003.
  • Invited external Neuroscience assessor for Universities of Glasgow and UCL 2003.
  • Member of the Research Advisory panel for the Muscular Dystrophy Campaign 2004-2007.
  • Member of the Medical Research Council College of experts 2005-2010.
  • Advisory Board for Oxford Biomedica from 2005 - 2009.
  • Member of HEFCE Clinical Senior Lecturer Appointments Panel 2006 -2009.
  • Associate Director and Chair of the Motor Neuron Disease Clinical Studies Group UKCRN Dementia and Neurodegenerative Diseases Clinical Research Network 2006 – present.
  • Member of NIHR Experimental Medicine Committee and Experimental Medicine Lead for DeNDRoN 2006 – 2010.
  • Academy of Medical Sciences Fellowship Panel 2007 – 2010.
  • Academy of Medical Sciences Clinical Academic Training Committee 2007 – 2010.
  • Wellcome Trust / Academy of Medical Sciences New Lecturer Awards panel from 2009 - 2011.
  • UKCRC/ MRC Brain Bank Strategy Advisory Committee 2007 – 2008.
  • Member of MRC strategic group for neurodegeneration 2008 - 2010.
  • Member of the Medical Research Council Neuroscience and Mental Health Board 2012 – present.
  • Academy of Medical Sciences INSPIRE Panel 2012 -2014
  • Chair of Progressive Supranuclear Palsy (PSP) Research Advisory Panel 2015 – present.
  • World Federation of Neurology Working Group on Therapeutic Trials in ALS/MND from 1996.
  • Founding Secretary to the European ALS Study Group from 1997 to 2000.
  • European ENCALS Steering Group 2002 – 2012.
  • Member of the European Neurological Society Scientific Committee on motor neurone disease from 1998 - 2006.
  • Coordinator of the Molecular/ Cell Biology Section of the European Familial ALS Group from 1997 to 2000.
  • External Assessor for the appointments committee for consultant posts in Neurology at the Beaumont Hospital, Dublin 1999.
  • Steering Committee ONO Pharmaceuticals from 2002 - 2005.
  • Chair of the Scientific Programme Committee for International MND/ALS annual scientific symposium 2004 –2010.
  • Novartis ALS/MND international advisory board, 2002 - 2003.
  • Member of the scientific panel for the European Federation of Neurological Societies (EFNS) 2004 -2006.
  • Member of the scientific panel and organising committee for the XI International Congress on Neuromuscular disorders 2004 -2006.
  • Princes Beatrijs Fonds Neuroscience Panel The Netherlands 2006.
  • Irish Health Research Board Clinician Scientist review panel 2010.
  • Member of the Executive Committee of the European Network for the Cure of ALS (ENCALS) 2012 – present.
  • Member of the Academy of Science Finland Neuroscience Grant panel 2013 – 2014. Chair 2014.
  • UK Lead for the Biogen ALS Innovation Hub 2015 – present.
  • Member of the Scientific Committee for the European Neuromuscular Centre (ENMC) 2015 - 2016
Postgraduate awards
  • 2017 Honorary Degree, University of Bradford for internationally recognized work in the field of Neurology and instrumental work in setting standards of excellence in the clinical care for patients.
  • 2017 Honorary Doctor of Medicine, University of Sussex in recognition of major contribution to the field of Neurology.
  • 2017 University of Sussex Brain Visiting Professorship
  • 2017 Kosterlitz Lecture, University of Aberdeen.
  • 2016 Croonian Lecture, UK Royal College of Physicians
  • 2015 Osler Lecture, Association of Physicians of the United Kingdom and Ireland
  • 2015 Elected Fellow of the American Association for the Advancement of Science for groundbreaking basic and translational research of relevance to the understanding and treatment of neurodegenerative diseases.
  • 2014 Dame Commander of the Order of the British Empire (DBE) for services to Neuroscience
  • 2014 Jacobson Visiting Professorship, University of Newcastle upon Tyne
  • 2013 Alfred Meyer’s Memorial Award Lecture British Neuropathological Society
  • 2013 NIHR Senior Investigator Award
  • 2013 UK ACCEA Platinum Clinical Excellence Award
  • 2012 Gary and Peggy Edwards Distinguished Visiting Professorship for ALS, Houston USA
  • 2012 Elected President of the North of England Neurological Association
  • 2012 Visiting Professorship, Association of Physicians (Kerala Chapter) India
  • 2012 Elected to membership of the Medical Pilgrims
  • 2007 The International ALS/MND Forbes Norris Award for excellence in research and compassion in clinical care
  • 2007 Fellowship of the Academy of Medical Sciences
  • 2007 Spinoza Visiting Professorship, University of Amsterdam
  • 2006 Royal College of Physicians Jean Hunter Prize for research into nervous disorders
  • 2004 Invited Fellowship of the American Neurological Association
  • 2001 American Academy of Neurology and ALS Association Sheila Essey Award for outstanding research contribution in amyotrophic lateral sclerosis/ motor neurone disease
  • 2000 Hong Kong Neurological Association Li Po Shan/ Dr Vincent Liu visiting Professorship
  • 1997 Invited Fellowship of the American Academy of Neurology
  • 1996 Renewal of Wellcome Senior Fellowship in Clinical Science
  • 1995 British Medical Association Vera Down Award
  • 1992 Poster Research prize at the Third International Symposium on ALS/MND
  • 1991 Award of Wellcome Senior Fellowship in Clinical Science
  • 1991 Association of British Neurologists Sir Charles Symonds Prize
  • 1990 North of England Neurological Association Liversedge Research Prize
  • 1985 Northern Regional Health Authority David Dickson Research Prize
  • 1985 Association of Physicians UK Dewar Research Prize
  • 1985 British Cardiac Society Young Investigator of the Year award