Dr Richard Mead

Journal articles

• Ciervo Y, Gatto N, Allen C, Grierson A, Ferraiuolo L, Mead RJ & Shaw PJ (2021) Adipose-derived stem cells protect motor neurons and reduce glial activation in both in vitro and in vivo models of ALS. Molecular Therapy — Methods & Clinical Development, 21, 413-433. View this article in WRRO
• Watkins J, Ghosh A, Keerie AFA, Alix JJP, Mead RJ & Sreedharan J (2021) Author Correction: Female sex mitigates motor and behavioural phenotypes in TDP-43^Q331K knock-in mice (Scientific Reports, (2020), 10, 1, (19220), 10.1038/s41598-020-76070-w). Scientific Reports, 11(1).
• Plesia M, Stevens OA, Lloyd GR, Kendall CA, Coldicott I, Kennerley AJ, Miller G, Shaw PJ, Mead RJ, Day JCC & Alix JJP (2021) In Vivo Fiber Optic Raman Spectroscopy of Muscle in Preclinical Models of Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy.. ACS Chem Neurosci.
• Watkins J, Ghosh A, Keerie AFA, Alix JJP, Mead RJ & Sreedharan J (2020) Female sex mitigates motor and behavioural phenotypes in TDP-43Q331K knock-in mice. Scientific Reports, 10(1).
• Myszczynska MA, Ojamies PN, Lacoste AMB, Neil D, Saffari A, Mead R, Hautbergue GM, Holbrook JD & Ferraiuolo L (2020) Applications of machine learning to diagnosis and treatment of neurodegenerative diseases. Nature Reviews Neurology, 16, 440-456. View this article in WRRO
• White MA, Lin Z, Kim E, Henstridge CM, Pena Altamira E, Hunt CK, Burchill E, Callaghan I, Loreto A, Brown-Wright H , Mead R et al (2019) Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss. Acta Neuropathologica Communications, 7. View this article in WRRO
• White MA, Kim E, Duffy A, Adalbert R, Phillips BU, Peters OM, Stephenson J, Yang S, Massenzio F, Lin Z , Andrews S et al (2018) Publisher Correction: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD. Nature Neuroscience, 21(8), 1138-1138.
• White MA, Kim E, Duffy A, Adalbert R, Phillips BU, Peters OM, Stephenson J, Yang S, Massenzio F, Lin Z , Andrews S et al (2018) TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD. Nature Neuroscience, 21, 552-563. View this article in WRRO
• Ciervo Y, Ning K, Jun X, Shaw PJ & Mead RJ (2017) Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis.. Molecular neurodegeneration, 12(1), 85. View this article in WRRO
• Bennett EJ, Mead RJ, Azzouz M, Shaw PJ & Grierson AJ (2014) Early detection of motor dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis (ALS) using home cage running wheels.. PloS one, 9(9), e107918. View this article in WRRO
• Mead RJ, Higginbottom A, Allen SP, Kirby J, Bennett E, Barber SC, Heath PR, Coluccia A, Patel N, Gardner I , Brancale A et al (2013) S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis.. Free Radic Biol Med, 61, 438-452.
• Mead RJ, Bennett EJ, Kennerley AJ, Sharp P, Sunyach C, Kasher P, Berwick J, Pettmann B, Battaglia G, Azzouz M , Grierson A et al (2011) Optimised and Rapid Pre-clinical Screening in the SOD1(G93A) Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (ALS). PLOS ONE, 6(8). View this article in WRRO
• Valori CF, Ning K, Wyles M, Mead RJ, Grierson AJ, Shaw PJ & Azzouz M (2010) Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy.. Sci Transl Med, 2(35), 35ra42.
• Ludolph AC, Bendotti C, Blaugrund E, Chio A, Greensmith L, Loeffler JP, Mead R, Niessen HG, Petri S, Pradat PF , Robberecht W et al (2010) Guidelines for preclinical animal research in ALS/MND: A consensus meeting. AMYOTROPH LATERAL SC, 11(1-2), 38-45.
• Barber SC, Higginbottom A, Mead RJ, Barber S & Shaw PJ (2009) An in vitro screening cascade to identify neuroprotective antioxidants in ALS.. Free Radic Biol Med, 46(8), 1127-1138.
• Barber SC, Mead RJ & Shaw PJ (2006) Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target.. Biochim Biophys Acta, 1762(11-12), 1051-1067.
• Wood-Allum CA, Barber SC, Kirby J, Heath P, Holden H, Mead R, Higginbottom A, Allen S, Beaujeux T, Alexson SE , Ince PG et al (2006) Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen.. Brain, 129(Pt 7), 1693-1709.
• Mead RJ, Neal JW, Griffiths MR, Linington C, Botto M, Lassmann H & Morgan BP (2004) Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis.. Lab Invest, 84(1), 21-28.
• Hanna SM, Spiller OB, Linton SM, Mead RJ & Morgan BP (2002) Rat T cells express neither CD55 nor CD59 and are dependent on Crry for protection from homologous complement.. Eur J Immunol, 32(2), 502-509.
• Mead RJ, Singhrao SK, Neal JW, Lassmann H & Morgan BP (2002) The membrane attack complex of complement causes severe demyelination associated with acute axonal injury.. J Immunol, 168(1), 458-465.
• Mead RJ, Singhrao S, Neal JW & Paul Morgan B (2000) The membrane attack complex (MAC) of complement causes severe demyelination in vivo. Evidence from C6 deficient rats. Immunopharmacology, 49(1-2), 7-7.
• Mead R, Hinchliffe SJ & Morgan BP (1999) Molecular cloning, expression and characterization of the rat analogue of human membrane cofactor protein (MCP/CD46).. Immunology, 98(1), 137-143.
• Mead R, Jack D, Pembrey M, Tyfield L & Turner M (1997) Mannose-binding lectin alleles in a prospectively recruited UK population. LANCET, 349(9066), 1669-1670.