Department of Oncology and Metabolism
Senior Lecturer in Nutritional Science
+44 114 215 9065
Full contact details
Department of Oncology and Metabolism
Human Nutrition Unit, GU29
The Medical School
Beech Hill Road
I trained in Physiology at The University of Sheffield and continued at Sheffield for my postgraduate studies investigating the role of riboflavin deficiency on gastrointestinal development. I was awarded my PhD in 1996 and was then appointed as a Postdoctoral Researcher at the MRC Dunn Nutrition Unit, Cambridge and worked at a MRC field station in The Gambia, West Africa.
On my return to the UK I was appointed as a Lecturer in Human Nutrition at Newcastle University. In 2003 I returned to Sheffield and joined the Human Nutrition Unit as a Lecturer. I was promoted to Senior Lecturer in 2010.
- Research interests
I have a long-standing research interest in diet and intestinal health and, in particular, biomarkers of colorectal cancer, and the role of butyrate and folate on colorectal carcinogenesis.
I also have a research interest in the nutrition, health and wellbeing of older adults. This includes an interest in the relationship between diet, immune function and ageing, and the assessment of dietary intake in older adults.
The work has developed through collaboration with colleagues in Sheffield (Profs Pockley, Powers and Parker) and beyond (University of St Andrews, Reading University and Bath Institute of Mechanical Engineering).
I am the Sheffield principal investigator on the NANA project. Novel assessment of Nutrition in Ageing. The NANA project is a multidisciplinary study funded by ESRC as part of the New Dynamics of Ageing (NDA) programme.
- Inadequacy of protein intake in older UK adults. Geriatrics, 5(1). View this article in WRRO
- Reply to the letter: Lycopene improves sperm motility and morphology: a promising agent for treating male infertility. European Journal of Nutrition, 59(2), 837-837.
- Effect of vitamin D supplementation on irritable bowel syndrome symptom severity and quality of life. Proceedings of the Nutrition Society, 79(OCE1).
- Protein valuation in food choice is positively associated with lean mass in older adults. The Journal of Nutrition, 149(11), 2056-2064. View this article in WRRO
- Dietary intake of people with dementia on acute hospital wards. Nursing Older People, 31(6), 16-21.
- Rate of change of circulating 25-hydroxyvitamin D following sublingual and capsular vitamin D preparations. European Journal of Clinical Nutrition. View this article in WRRO
- Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial. The Lancet, 392(10164), 2583-2594. View this article in WRRO
- Optimizing nutrition in older people. Maturitas, 112, 34-38. View this article in WRRO
- Protein for Life: Towards a focussed dietary framework for healthy ageing. Nutrition Bulletin, 43(1), 97-102. View this article in WRRO
- Computerized Self-Administered Measures of Mood and Appetite for Older Adults: The Novel Assessment of Nutrition and Ageing Toolkit. Journal of Applied Gerontology, 37(2), 157-176.
- Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what do we need to know?. European Journal of Clinical Nutrition. View this article in WRRO
- Dietary nitrate does not modify blood pressure and cardiac output at rest and during exercise in older adults : a randomised cross-over study. International Journal of Food Sciences and Nutrition, 69(1), 74-83. View this article in WRRO
- Investigating the enabling factors influencing occupational therapists’ adoption of assisted living technology. British Journal of Occupational Therapy, 80(11), 668-675. View this article in WRRO
- A comparison of food portion size estimation by older adults, young adults and nutritionists. The journal of nutrition, health & aging. View this article in WRRO
- Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid Release. Diabetes, 66(3), 674-688. View this article in WRRO
- Using the NANA toolkit at home to predict older adults’ future depression. Journal of Affective Disorders. View this article in WRRO
- Dietary nitrate does not affect physical activity outcomes in health older adults in a randomized, crossover trial. Nutrition Research, 36(12), 1361-1369. View this article in WRRO
- Feasibility study of portable technology for weight loss and HbA1c control in type 2 diabetes. BMC Medical Informatics and Decision Making, 16(1), 92-92. View this article in WRRO
- Computer-based tools for assessing micro-longitudinal patterns of cognitive function in older adults.. Age, 1-16. View this article in WRRO
- Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial. BMJ Open Gastroenterology, 2(1). View this article in WRRO
- Reduced keratin expression in colorectal neoplasia and associated fields is reversible by diet and resection. BMJ Open Gastroenterology, 2(1). View this article in WRRO
- The validation of a computer-based food record for older adults: the Novel Assessment of Nutrition and Ageing (NANA) method. British Journal of Nutrition, 113(04), 654-664. View this article in WRRO
- Validation of the NANA (Novel Assessment of Nutrition and Ageing) touch screen system for use at home by older adults. Experimental Gerontology, 60, 100-107. View this article in WRRO
- Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: a preliminary study using healthy individuals. BENEFICIAL MICROBES, 4(4), 313-317.
- Systemic folate status, rectal mucosal folate concentration and dietary intake in patients at differential risk of bowel cancer (The FAB2 Study).. Eur J Nutr, 52(7), 1801-1810.
- Improvement in nutritional status reduces the clinical impact of infections in older adults.. J Am Geriatr Soc, 60(9), 1645-1654.
- Folate, colorectal cancer and the involvement of DNA methylation.. Proc Nutr Soc, 71(4), 592-597.
- COBALT: Challenging obstacles and barriers to assistive living technologies. Gerontechnology, 11(2), 151-151. View this article in WRRO
- Quantitative profiling of CpG island methylation in human stool for colorectal cancer detection. International Journal of Colorectal Disease, 1-8.
- Effect of maternal and post-weaning folate supply on gene-specific DNA methylation in the small intestine of weaning and adult Apc and wild type mice. Frontiers in Genetics, 2(MAY). View this article in WRRO
- Correcting a marginal riboflavin deficiency improves hematologic status in young women in the United Kingdom (RIBOFEM).. Am J Clin Nutr, 93(6), 1274-1284.
- Dietary intakes in people with irritable bowel syndrome.. BMC Gastroenterol, 11, 9. View this article in WRRO
- UK Food Standards Agency Workshop Report: Diet and Immune Function. BRIT J NUTR, 103(11), 1684-1687.
- Inter-individual variation in DNA damage and base excision repair in young, healthy non-smokers: effects of dietary supplementation and genotype. BRIT J NUTR, 103(11), 1585-1593.
- Folate depletion during pregnancy and lactation reduces genomic DNA methylation in murine adult offspring. Genes and Nutrition, 1-8.
- Recruiting older people to a randomised controlled dietary intervention trial--how hard can it be?. BMC Med Res Methodol, 10, 17. View this article in WRRO
- Effects of methodological variation on assessment of riboflavin status using the erythrocyte glutathione reductase activation coefficient assay.. Br J Nutr, 102(2), 273-278.
- Inter-individual variation in nucleotide excision repair in young adults: effects of age, adiposity, micronutrient supplementation and genotype. BRIT J NUTR, 101(9), 1316-1323.
- Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. ALIMENT PHARM THER, 29(1), 97-103.
- A study protocol to investigate the relationship between dietary fibre intake and fermentation, colon cell turnover, global protein acetylation and early carcinogenesis: the FACT study.. BMC Cancer, 9, 332. View this article in WRRO
- Study Protocol: randomised controlled trial to investigate the functional significance of marginal riboflavin status in young women in the UK (RIBOFEM).. BMC Public Health, 9, 90. View this article in WRRO
- Gender-specific modulation of tumorigenesis by folic acid supply in the Apc(+/Min) mouse during early neonatal life. BRIT J NUTR, 99(3), 550-558.
- Commonly used bowel preparations have significant and different effects upon cell proliferation in the colon: a pilot study.. BMC Gastroenterol, 8, 54. View this article in WRRO
- Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study).. Cancer Epidemiol Biomarkers Prev, 16(10), 2128-2135.
- A double-blind, placebo-controlled, glutamine-supplementation trial in growth-faltering Gambian infants.. Am J Clin Nutr, 86(2), 421-427.
- A MitoTracker Green-based flow cytometric assay for natural killer cell activity: variability, the influence of platelets and a comparison of analytical approaches.. Exp Hematol, 35(3), 350-357.
- Proteomic analysis reveals field-wide changes in protein expression in the morphologically normal mucosa of patients with colorectal neoplasia. Cancer Research, 66(13), 6553-6562.
- DNA mismatch repair status may influence anti-neoplastic effects of butyrate. BIOCHEMICAL SOCIETY TRANSACTIONS, 33, 728-729.
- Foliate and DNA methylation during in utero development and aging. BIOCHEM SOC T, 32, 1006-1007.
- Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer. CANCER EPIDEM BIOMAR, 13(9), 1495-1501.
- Anti-cancer effects of butyrate: use of micro-array technology to investigate mechanisms.. Proc Nutr Soc, 62(1), 107-115.
- An investigation into the reversibility of the morphological and cytokinetic changes seen in the small intestine of riboflavin deficient rats.. Gut, 39(2), 220-225.
- Cytokinetic and structural responses of the rat small intestine to riboflavin depletion.. Br J Nutr, 75(2), 315-324.
- Morphological changes in the rat small intestine in response to riboflavin depletion.. Br J Nutr, 73(1), 141-146.
- Development of locomotion in the rat--spatiotemporal footfall patterns.. Physiol Behav, 55(1), 151-155.
- A randomized placebo-controlled trial to investigate the effect of lactolycopene on semen quality in healthy males. European Journal of Nutrition. View this article in WRRO
- Eicosapentaenoic acid and/or aspirin for preventing colorectal adenomas during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme: the seAFOod RCT. Efficacy and Mechanism Evaluation, 6(4), 1-154.
- Protein for Life: Review of Optimal Protein Intake, Sustainable Dietary Sources and the Effect on Appetite in Ageing Adults. Nutrients, 10(3), 360-360. View this article in WRRO
- NANA: a tale of ageing and technology, The New Dynamics of Ageing Volume 2 (pp. 157-176). Policy Press
Conference proceedings papers
- COBALT, TUNGSTEN, and THAW: New tools for engaging older adults as technology experts. Gerontechnology, Vol. 17(s) (pp 76-76)
- Diet advice in colorectal cancer survivors - are we doing enough?. Proceedings of the Nutrition Society, Vol. 77(OCE1)
- Efficacy and comparative uptake rates of sublingual and capsular vitamin D preparations. Proceedings of the Nutrition Society, Vol. 77(OCE4)
- Inorganic nitrate mimics exercise-stimulated muscular fibre-type switching and myokine and gamma-aminobutyric acid release. DIABETIC MEDICINE, Vol. 34 (pp 55-55)
- Wellbeing and HCI in later life – what matters?. Lecture Notes in Computer Science, Vol. 9735 (pp 455-453) View this article in WRRO
- Use of NANA, a novel method of dietary assessment, for the longitudinal capture of dietary intake in older adults. PROCEEDINGS OF THE NUTRITION SOCIETY, Vol. 72(OCE4) (pp E267-E267)
- Cross-sectional analyses show no association between fibre intake and faecal butyrate level. PROCEEDINGS OF THE NUTRITION SOCIETY, Vol. 72(OCE4) (pp E235-E235)
- Why do Patients get Metachronous Colorectal Adenomas?. JOURNAL OF PATHOLOGY, Vol. 228 (pp S3-S3)
- A comparison of younger v. older adults' ability to estimate food portion sizes. Proceedings of the Nutrition Society, Vol. 70(OCE3)
- The relationship between dietary micro and macronutrients intake and cell proliferation in the colon. Proceedings of the Nutrition Society, Vol. 70(OCE3)
- Factors associated with inflammation in older adults. Proceedings of the Nutrition Society, Vol. 69(OCE3)
- A strategy for concurrently profiling multiple parameters of human innate and adaptive immune function. IMMUNOLOGY, Vol. 125 (pp 31-31)
- A comparison between measures of innate immunity in young and old human subjects. IMMUNOLOGY, Vol. 125 (pp 83-83)
- Relationship between plasma zinc and antibacterial innate immune function in the elderly. Proceedings of the Nutrition Society, Vol. 67(OCE8)
- A MitoTracker (R) Green-based flow cytometric assay for natural killer cell activity. IMMUNOLOGY, Vol. 120 (pp 86-86)
- Reduced maternal folate supply decreases genomic DNA methylation in the offspring of C57Bl/6J mice.. P NUTR SOC, Vol. 65 (pp 114A-114A)
- Reactive oxygen species generation in mismatch repair-proficient and -deficient colorectal cancer cell lines exposed to butyrate.. P NUTR SOC, Vol. 65 (pp 66A-66A)
- Methylation of the ESR1 CpG island in the colorectal mucosa is an 'all or nothing' process in healthy human colon, and is accelerated by dietary folate supplementation in the mouse. BIOCHEMICAL SOCIETY TRANSACTIONS, Vol. 33 (pp 709-711)
- Colon mucosal folate is responsive to folic acid supplements and correlates with plasma folate. P NUTR SOC, Vol. 64 (pp 90A-90A)
- Dietary characteristics of gastroenterology patients. P NUTR SOC, Vol. 64 (pp 99A-99A)
- Effect of butyrate on induction of aneuploidy in colorectal carcinoma cell lines. P NUTR SOC, Vol. 64 (pp 70A-70A)
- Use of gene hypermethylation in stool samples for detection of colorectal cancer: early results. BRITISH JOURNAL OF SURGERY, Vol. 91 (pp 92-92)
- Validating NANA: Novel assessment of nutrition and ageing. Gerontechnology, Vol. 11(2) View this article in WRRO
- Working with older adults to develop NANA: Novel assessment of nutrition and ageing. Gerontechnology, Vol. 11(2) View this article in WRRO
Theses / Dissertations
- Teaching activities
My primary teaching responsibilities are within the Human Nutrition Unit. The Unit runs a 12-month MMedSci and a 9-month Postgraduate Diploma in Human Nutrition. The Masters programme consists of 6 taught modules and a 5-month research project. I am responsible for the design, delivery and assessment of the 15 credit Nutritional Physiology module on the course.
- Professional activities
Nutritional Genomics Theme Leader, The Nutritional Society.