Dr Munitta Muthana

Department of Oncology and Metabolism

Senior Lecturer

Munitta Muthana
m.muthana@sheffield.ac.uk
+44 114 215 9057

Full contact details

Dr Munitta Muthana
Department of Oncology and Metabolism
D Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries, please contact - om-operationalteam@sheffield.ac.uk

I joined The University of Sheffield in 2002 as a post-doctoral scientist in the Immunobiology Research Unit. From 2005 I held a research position in the Tumour Targeting Group where I was awarded funding as an independent researcher from the Prostate Cancer Charity (2007) and the Medical Research Council (2010). In 2011 I was appointed as a non-clinical lecturer.

Research interests

Our research focuses on the role of innate immune cells like macrophages in inflammatory disease including cancer. Recently, we have used our knowledge of this area to develop innovative cell-based methods to target anticancer therapies to tumours. For example, we have devised a way to use macrophages to deliver large quantities of cancer-killing virus to both primary and secondary tumours simultaneously.

We are also interested in developing innovative approaches to improve the targeting of cancer therapies only to the tumour so that healthy tissue remains unharmed. To do this we have developed a novel nanomagnetic approach.

BBC News report on Trojan-horse therapy


Current projects

  • Targeting novel oncolytic viruses to tumours
  • Using nanomagnet technology to improve tumour targeting
  • Developing novel magnetic devices for cancer
  • Characterisation of infiltrating subsets of monocytes/macrophages in diseased tissues including the arthritic joint and the tumour microenvironment
Publications

Show: Featured publications All publications

This person does not have any publications available.

All publications

Journal articles

Chapters

Conference proceedings papers

  • Danson SJ, Conner J, Edwards JG, Blyth KG, Fisher PM, Muthana M, Salawu A, Taylor F, Hodgkinson E, Joyce P , Roman J et al (2020) Oncolytic herpesvirus therapy for mesothelioma – A Phase I/IIa trial of intrapleural administration of HSV1716. Lung Cancer RIS download Bibtex download
  • AL-Janabi H, Conner J, Howard F, Hunt S, Taher Z, Staniland S & Muthana M (2019) Abstract LB-188: Breast cancer immunotherapy using magnetized HSV1716. Immunology RIS download Bibtex download
  • Pu X, AL-Janabi H, Wang N, Muthana M, Brown J & Lewis C (2019) Abstract LB-136: Targeting perivascular macrophages to prevent castration resistance in men with high-risk, localized prostate cancer. Tumor Biology RIS download Bibtex download
  • Pu X, AL-Janabi H, Wang N, Muthana M, Brown J & Lewis C (2019) Abstract LB-136: Targeting perivascular macrophages to prevent castration resistance in men with high-risk, localized prostate cancer. Tumor Biology RIS download Bibtex download
  • Moamin MR, Monk P, Cox A, Ottewell P, Saint-Pol J, Rubinstein E & Muthana M (2019) Abstract LB-036: Tetraspanin 5 expressing macrophages promote mammary tumor growth. Tumor Biology RIS download Bibtex download
  • Moamin MR, Monk P, Cox A, Ottewell P, Saint-Pol J, Rubinstein E & Muthana M (2019) Abstract LB-036: Tetraspanin 5 expressing macrophages promote mammary tumor growth. Tumor Biology RIS download Bibtex download
  • AL-Janabi H, Conner J, Howard F, Hunt S, Taher Z, Staniland S & Muthana M (2019) Abstract LB-188: Breast cancer immunotherapy using magnetized HSV1716. Immunology RIS download Bibtex download
  • Stewart G, Tazzyman ST, Lath D, Down J, Lawson M, Muthana M & Chantry A (2019) Myeloma-specific oncolytic adenovirus induces significant tumour oncolysis in vitro and in vivo and prevents cell line regrowth. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 185 (pp 97-97) RIS download Bibtex download
  • AL-Janabi H, Conner J, Taher Z, Staniland S & Muthana M (2018) Breast cancer immunotherapy using magnetised oncolytic viruses. European Journal of Cancer, Vol. 92 (pp S4-S4) RIS download Bibtex download
  • Seehra RS, Wharton S, Heath P, Ince P, Muthana M, Garwood C & Simpson J (2018) Hypoxia-induced changes in astrocytes and their role in the formation of age-associated white matter lesions. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 44 (pp 17-18) RIS download Bibtex download
  • Dorris E, Creevey K, Moylett J, Tazzyman S, Muthana M & Wilson AG (2017) The Rheumatoid Arthritis Susceptibility Gene C5orf30 Is an Immunomodulator in Macrophages. ARTHRITIS & RHEUMATOLOGY, Vol. 69 RIS download Bibtex download
  • Muthana M, Murphy E, Kwan A, Winder N & Conner J (2017) Abstract 2938: Tumour-associated macrophage polarisation and re-education with oncolytic viruses. Tumor Biology RIS download Bibtex download
  • Dorris ER, Creevey K, Moran C, Muthana M & Wilson AG (2016) OP0134 The Rheumatoid Arthritis Susceptibility Gene C5ORF30 Acts as An Immunomodulator in Macrophages. Annals of the Rheumatic Diseases, Vol. 75(Suppl 2) (pp 107.1-107) RIS download Bibtex download
  • Tazzyman S, Muthana M, Harrison J, Lewis C, Conner J & Chantry A (2015) Development of a Trojan horse oncolytic virus for treatment of myeloma.. JOURNAL OF CLINICAL ONCOLOGY, Vol. 33(15) RIS download Bibtex download
  • Hardy W, Wright F, Hawtree S, Fearon U, Veale D, Perretti M, Wilson A & Muthana M (2014) OP0296 Hypoxia-Inducible Factor 2A Regulates Macrophage Function in Rheumatoid Arthritis. Annals of the Rheumatic Diseases, Vol. 73(Suppl 2) (pp 174.2-174) RIS download Bibtex download
  • Muthana M, Davies H, Khetan S, Wright F, Hawtree S, Ciani B & Wilson A (2014) THU0515 C5orf30 A Novel Regulator of Tissue Damage in Rheumatoid Arthritis. Annals of the Rheumatic Diseases, Vol. 73(Suppl 2) (pp 361.3-361) RIS download Bibtex download
  • Hawtree S, Muthana M, Wilkinson JM & Wilson AG (2014) FRI0360 Histone Deacetylase One Contributes to the Auto-Aggressive Phenotype of Rheumatoid Arthritis Synovial Fibroblasts. Annals of the Rheumatic Diseases, Vol. 73(Suppl 2) (pp 517.2-517) RIS download Bibtex download
  • Hawtree S, Muthana M, Wilkinson JM & Wilson AG (2014) INVESTIGATION OF THE ROLE OF HISTONE DEACETYLASES IN RHEUMATOID ARTHRITIS SYNOVIAL FIBROBLASTS. RHEUMATOLOGY, Vol. 53 (pp 85-85) RIS download Bibtex download
  • Muthana M, Khetan S, Hawtree S, Davies H, Gbadebo A, Akil M, Ciani B, Wright F & Wilson AG (2014) BIOLOGICAL ROLES OF C5ORF30 IN RHEUMATOID ARTHRITIS SYNOVIAL FIBROBLASTS. RHEUMATOLOGY, Vol. 53 (pp 147-147) RIS download Bibtex download
  • Albloui FS, Muthana M, Wilson AG & Grabowski PS (2014) Acidification enhances acid sensing protein and matrix metalloproteinase expression in human rheumatoid fibroblast like synoviocytes. Annals of the Rheumatic Diseases, Vol. 73(Supplement 2) (pp 511-511) RIS download Bibtex download
  • Muthana M, Davies H, Khetan S, Adeleke G, Hawtree S, Wright F, Ciani B, Akil M & Wilson AG (2013) The biological role of C5orf30 in rheumatoid arthritis pathogenesis. IMMUNOLOGY, Vol. 140 (pp 45-45) RIS download Bibtex download
  • Muthana M, Davies H, Khetan S, Adeleke GA, Hawtree S & Wilson AG (2013) Biological Roles of C5orf30 In Rheumatoid Arthritis Synovial Fibroblasts. ARTHRITIS AND RHEUMATISM, Vol. 65 (pp S1232-S1233) RIS download Bibtex download
  • Hawtree S, Muthana M, Aynsley S, Wilkinson JM & Wilson AG (2013) Investigation Of The Role Of Histone Deacetylases In Rheumatoid Arthritis Synovial Fibroblasts. ARTHRITIS AND RHEUMATISM, Vol. 65 (pp S1035-S1036) RIS download Bibtex download
  • Hawtree S, Muthana M, Aynsley S, Wilkinson JM & Wilson AG (2013) Investigation of the role of histone deacetylases in rheumatoid arthritis synovial fibroblasts. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 94(5) (pp A3-A3) RIS download Bibtex download
  • Albloui FS, Muthana M, Wilson AG & Grabowski PS (2013) TISSUE LOCALISATION OF ACID SENSING PROTEINS IN SYNOVIAL BIOPSIES FROM PATIENTS WITH RHEUMATOID ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES, Vol. 72 (pp 812-812) RIS download Bibtex download
  • Davies H, Muthana M, Khetan S, Adeleke G, Hawtree S, Morrow F, Ciani B & Wilson AG (2013) THE ROLE OF C5ORF30 IN RHEUMATOID ARTHRITIS PATHOGENESIS. ANNALS OF THE RHEUMATIC DISEASES, Vol. 72 (pp 190-190) RIS download Bibtex download
  • Muthana M, Davies H, Khetan S, Adeleke G, Hawtree S, Tazzyman S, Morrow F, Ciani B & Wilson G (2013) BIOLOGICAL ROLES OF C5ORF30 IN RHEUMATOID ARTHRITIS. RHEUMATOLOGY, Vol. 52 (pp 50-50) RIS download Bibtex download
  • Hawtree S, Muthana M, Aynsley S, Wilkinson JM & Wilson AG (2013) INVESTIGATION OF THE ROLE OF HISTONE DEACETYLASES IN RHEUMATOID ARTHRITIS SYNOVIAL FIBROBLASTS. RHEUMATOLOGY, Vol. 52 (pp 79-80) RIS download Bibtex download
  • Aynsley S, Hardy J, Veale D, Fearon U, Wilson G & Muthana M (2013) MACROPHAGES IN HYPOXIC RHEUMATOID JOINTS PREFERENTIALLY EXPRESS HYPOXIA-INDUCIBLE TRANSCRIPTION FACTOR-2. RHEUMATOLOGY, Vol. 52 (pp 78-78) RIS download Bibtex download
  • Muthana M, Khetan S, Adeleke GA, Tazzyman S, Aynsley S, Morrow F, Hawtree S, Ciani B & Wilson AG (2012) Biological Roles of C5orf30 in Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM, Vol. 64(10) (pp S767-S767) RIS download Bibtex download
  • Aynsley S, Fearon U, Wilson AG & Muthana M (2012) Macrophages in Hypoxic Rheumatoid Joints Preferentially Express Hypoxia Inducible Transcription Factor-2. ARTHRITIS AND RHEUMATISM, Vol. 64(10) (pp S767-S767) RIS download Bibtex download
  • Grabowski PS, Muthana M & Wilson AG (2012) Acid sensing protein genes are expressed in human rheumatoid-derived synoviocytes. BONE, Vol. 50 (pp S191-S191) RIS download Bibtex download
  • Khetan S, Muthana M & Wilson AG (2011) C5orf30 a Candidate Susceptibility Gene in Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM, Vol. 63(10) (pp S719-S719) RIS download Bibtex download
  • Muthana M, Giannoudis A, Scott SD, Mistry R, Murdoch C, Coffelt S, Georgeopolous L, Hamdy F, Brown N, Maitland N & Lewis CE (2010) Engineering macrophages to synthesize recombinant adenoviruses in hypoxic areas of human prostate tumours. DRUG DISCOVERY TODAY, Vol. 15(23-24) (pp 1097-1098) RIS download Bibtex download
  • Muthana M, Giannoudis A, Scott SD, Mistry R, Murdoch C, Georgeopolous L, Hamdy F, Brown N, Maitland N & Lewis CE (2010) Engineering Macrophages to Synthesize Recombinant Adenoviruses in Hypoxic Areas of Human Prostate Tumours. HUMAN GENE THERAPY, Vol. 21(4) (pp 488-488) RIS download Bibtex download
  • Muthana M, Scott S, Farrow N, Murdoch C & Lewis C (2007) Magnetite nanoparticle-loaded macrophages enhance gene delivery to tumours. IMMUNOLOGY, Vol. 120 (pp 82-82) RIS download Bibtex download
  • Muthana M, Giannoudis A, Scott SD, Burke B, Mistry R, Hamdy F, Brown N, Maitland N & Lewis CE (2006) Engineering macrophages to synthesize recombinant adenoviruses in hypoxic areas of human prostate tumors. CANCER RESEARCH, Vol. 66(8) RIS download Bibtex download
Teaching interests

I teach on the MBChB course and am the module lead for the phase 2 immunology module. I also deliver the cell-based therapies and tumour immunology lectures for the BSc Biomedical Sciences degree course and the medical school Masters in Molecular Medicine and Translational Oncology.

Professional activities
  • American Association of Cancer Research (AACR)
  • British Society of Immunology (BSI)
  • European Macrophage and Dendritic Cell Society and British Society of Immunology