Dr Munitta Muthana

Department of Oncology and Metabolism

Senior Lecturer

Munitta Muthana
m.muthana@sheffield.ac.uk
+44 114 215 9057

Full contact details

Dr Munitta Muthana
Department of Oncology and Metabolism
D Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries, please contact - om-operational@sheffield.ac.uk

I joined The University of Sheffield in 2002 as a post-doctoral scientist in the Immunobiology Research Unit. From 2005 I held a research position in the Tumour Targeting Group where I was awarded funding as an independent researcher from the Prostate Cancer Charity (2007) and the Medical Research Council (2010). In 2011 I was appointed as a non-clinical lecturer.

Research interests

Our research focuses on the role of innate immune cells like macrophages in inflammatory disease including cancer. Recently, we have used our knowledge of this area to develop innovative cell-based methods to target anticancer therapies to tumours. For example, we have devised a way to use macrophages to deliver large quantities of cancer-killing virus to both primary and secondary tumours simultaneously.

We are also interested in developing innovative approaches to improve the targeting of cancer therapies only to the tumour so that healthy tissue remains unharmed. To do this we have developed a novel nanomagnetic approach.

BBC News report on Trojan-horse therapy


Current projects

  • Targeting novel oncolytic viruses to tumours
  • Using nanomagnet technology to improve tumour targeting
  • Developing novel magnetic devices for cancer
  • Characterisation of infiltrating subsets of monocytes/macrophages in diseased tissues including the arthritic joint and the tumour microenvironment
Publications

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Journal articles

All publications

Journal articles

Chapters

Conference proceedings papers

Teaching interests

I teach on the MBChB course and am the module lead for the phase 2 immunology module. I also deliver the cell-based therapies and tumour immunology lectures for the BSc Biomedical Sciences degree course and the medical school Masters in Molecular Medicine and Translational Oncology.

Professional activities
  • American Association of Cancer Research (AACR)
  • British Society of Immunology (BSI)
  • European Macrophage and Dendritic Cell Society and British Society of Immunology