Member Publications
Recent publications from members of the Mellanby Centre.
Publications
Journal articles
- Automatic segmentation of lower limb muscles from MR images of post-menopausal women based on deep learning and data augmentation. PLOS ONE, 19(4). View this article in WRRO
- No evidence of association between either Modic change or disc degeneration and five circulating inflammatory proteins. JOR SPINE, 7(1).
- Week-by-week changes in serum levels of bone-related circulating microRNAs and bone turnover markers. JBMR Plus, 8(5).
- REST: a preoperative tailored sleep intervention for patients undergoing total knee replacement – feasibility study for a randomised controlled trial. BMJ Open, 14(3), e078785-e078785.
- Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes. Annals of the Rheumatic Diseases. View this article in WRRO
- Asia-Pacific consensus on long-term and sequential therapy for osteoporosis. Osteoporosis and Sarcopenia.
- Fabrication and characterisation of random and aligned electrospun scaffolds to investigate hypothalamic stem/progenitor cell behaviour. Engineered Regeneration, 5(1), 11-20.
- Automatic segmentation of skeletal muscles from MR images using modified U-Net and a novel data augmentation approach. Frontiers in Bioengineering and Biotechnology, 12. View this article in WRRO
- Effectiveness and cost effectiveness of pharmacological thromboprophylaxis for medical inpatients: decision analysis modelling study. BMJ Medicine, 3(1), e000408-e000408.
- DXA-based statistical models of shape and intensity outperform aBMD hip fracture prediction: A retrospective study. Bone, 182, 117051-117051.
- Risk of Fractures and Falls in Men with Advanced or Metastatic Prostate Cancer Receiving Androgen Deprivation Therapy and Treated with Novel Androgen Receptor Signalling Inhibitors: A Systematic Review and Meta-analysis of Randomised Controlled Trials. European Urology Oncology.
- An online clinical decision tool to screen for vertebral fragility fractures (Vfrac) in older women presenting with back pain in general practice: protocol for a feasibility study in preparation for a future cluster randomised controlled trial. Archives of Osteoporosis, 19(1).
- The loading direction dramatically affects the mechanical properties of the mouse tibia. Frontiers in Bioengineering and Biotechnology, 12. View this article in WRRO
- The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis. iScience, 109288-109288.
- Combining PTH(1‐34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice. Journal of Orthopaedic Research. View this article in WRRO
- Estimating the value of future research into thromboprophylaxis for women during pregnancy and after delivery: a value of information analysis. Journal of Thrombosis and Haemostasis.
- THE METABOLIC ROLE OF IL-4 AND IL-10 IN INTERVERTEBRAL DISC DEGENERATION. Orthopaedic Proceedings, 106-B(SUPP_2), 93-93.
- Clinical Use of Trabecular Bone Score: The 2023 ISCD Official Positions. Journal of Clinical Densitometry, 27(1), 101452-101452.
- JD-312 – A novel small molecule that facilitates cartilage repair and alleviates osteoarthritis progression. Journal of Orthopaedic Translation, 44, 60-71.
- Radium-223 in women with hormone receptor-positive bone-metastatic breast cancer receiving endocrine therapy: pooled analysis of two international, phase 2, randomized, double-blind, placebo-controlled trials. Breast Cancer Research and Treatment, 204(2), 249-259.
- Cortical thickness adaptation to combined mechanical loading and parathyroid hormone treatments is site specific and synergistic in the mouse tibia model. Bone, 180, 116994-116994.
- Electrospinning polymersomes into bead-on-string polyethylene oxide fibres for the delivery of biopharmaceuticals to mucosal epithelia. Biomaterials Advances, 157. View this article in WRRO
- Biallelic CRELD1 variants cause a multisystem syndrome, including neurodevelopmental phenotypes, cardiac dysrhythmias, and frequent infections. Genetics in Medicine, 26(2), 101023-101023.
- Injectable hydrogel induces regeneration of naturally degenerate human intervertebral discs in a loaded organ culture model.. Acta Biomaterialia.
- Development and application of simulation modelling for orthopaedic elective resource planning in England. BMJ Open, 13(12), e076221-e076221.
- Abstract B109: MTHFD1/2 inhibitor TH9619 targets the DNA damage response and causes cancer-specific folate trapping with an unprecedented therapeutic window. Molecular Cancer Therapeutics, 22(12_Supplement), B109-B109.
- A new FRAX model for Brazil. Archives of Osteoporosis, 18(1). View this article in WRRO
- Protocol of a randomised trial of teriparatide followed by zoledronic acid to reduce fracture risk in adults with osteogenesis imperfecta. BMJ Open, 13(11), e078164-e078164.
- Standard Versus Modified Ipilimumab, in Combination With Nivolumab, in Advanced Renal Cell Carcinoma: A Randomized Phase II Trial (PRISM).. J Clin Oncol, JCO2300236.
- Targeting MTHFD2 to exploit cancer-specific metabolism and the DNA damage response. Cancer Research.
- Radiotherapy to regional nodes in early breast cancer: an individual patient data meta-analysis of 14 324 women in 16 trials. The Lancet, 402(10416), 1991-2003.
- Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer (UK TACT2; CRUK/05/19): quality of life results from a multicentre, phase 3, open-label, randomised, controlled trial. The Lancet Oncology, 24(12), 1359-1374.
- Diagnosis of metaphyseal fractures in infants and young children with suspected inflicted injury: a systematic review of cross-sectional imaging techniques. Clinical Radiology.
- Cost-Effectiveness Analysis of CT-Based Finite Element Modeling for Osteoporosis Screening in Secondary Fracture Prevention: An Early Health Technology Assessment in the Netherlands. MDM Policy & Practice, 8(2).
- Impact of leptin deficiency on male tibia and vertebral body
3D bone architecture independent of changes in body weight. Physiological Reports, 11(19). - PB1532 How Can We Improve Recruitment to Trials for Prevention of Venous Thromboembolism during Pregnancy and the Puerperium? A Qualitative Evaluation of the Patients' Perspective. Research and Practice in Thrombosis and Haemostasis, 7, 101939-101939.
- Adjusting Trabecular Bone Score (TBS) for Level-specific Differences Reduces FRAX®-based Treatment Reclassification in Patients with Vertebral Exclusions: The Manitoba BMD Registry. Journal of Clinical Densitometry, 101429-101429.
- FRAX® adjustment using renormalized trabecular bone score (TBS) from L1 alone may be optimal for fracture prediction: The Manitoba BMD registry. Journal of Clinical Densitometry, 26(4), 101430-101430.
- 1768MO Incidence of fracture related hospitalisations in men with de novo high risk localised and metastatic hormone sensitive prostate cancer: Analysis of routinely collected healthcare data from the STAMPEDE docetaxel and zoledronic acid comparisons. Annals of Oncology, 34, S956-S957.
- Enhanced antibacterial ability of electrospun PCL scaffolds incorporating ZnO nanowires. International Journal of Molecular Sciences, 24(19). View this article in WRRO
- Effect of muscle forces on femur during level walking using a virtual population of older women. Methods in molecular biology (Clifton, N.J.), MIMB 2716, 335-349. View this article in WRRO
- Cementing Techniques In Knee Surgery (CeTIKS): a UK expert consensus study.. Bone Jt Open, 4(9), 682-688.
- Research prioritisation on prevention and management of preterm birth in low and middle-income countries (LMICs) with a special focus on Bangladesh using the Child Health and Nutrition Research Initiative (CHNRI) method. Journal of Global Health, 13, 07004.
- Use of genome sequencing to hunt for cryptic second-hit variants: analysis of 31 cases recruited to the 100 000 Genomes Project.. J Med Genet.
- Concerns Regarding Neuroimaging of Asymptomatic Infant Siblings of Children Who Experienced Abuse—Reply. JAMA Pediatrics, 177(8), 869-869.
- SUPPORT AND TREATMENT AFTER JOINT REPLACEMENT (STAR): LONG-TERM FOLLOW-UP OF A CARE PATHWAY FOR PATIENTS WITH CHRONIC PAIN AFTER KNEE ARTHROPLASTY. Orthopaedic Proceedings, 105-B(SUPP_13), 50-50.
- HNRNPC haploinsufficiency affects alternative splicing of intellectual disability-associated genes and causes a neurodevelopmental disorder. The American Journal of Human Genetics, 110(8), 1414-1435.
- Cell clusters in intervertebral disc degeneration: An attempted repair mechanism aborted via apoptosis. Anatomy & Cell Biology.
- Engagement with a local African-Caribbean community to explore perspectives and research priorities among Black men for prostate cancer using a co-participatory approach. British Journal of General Practice, 73(suppl 1), bjgp23X733797-bjgp23X733797.
- 1st EFORT European Consensus “Medical & Scientific Research Requirements for the Clinical Introduction of Artificial Joint Arthroplasty Devices”: Background, Delphi Methodology & Consensus process. EFORT Open Reviews, 8(7), 499-508.
- The application of FRAX in Ecuador. Revista Colombiana de Reumatología (English Edition), 30(3), 199-206.
- Underserved ‘Deep End’ populations: a critical analysis addressing the power imbalance in research. British Journal of General Practice, 73(732), 326-329.
- USING CLASSIFIER NEURAL NETWORKS TO ESTIMATE PERSONALIZED PATIENT-REPORTED OUTCOME MEASURES AFTER HIP ARTHROPLASTY. Orthopaedic Proceedings, 105-B(SUPP_12), 85-85.
- "The accuracy of the EOS imaging system to assess hip abnormalities in adolescents and adults:" a systematic review and meta-analysis.. Skeletal Radiol.
- Effect of age and gender on serum growth differentiation factor 15 and its relationship to bone density and bone turnover. Bone Reports, 18, 101676-101676.
- How Much Does Paediatric Femoral Lengthening Cost? A Cost Comparison between Magnetic Lengthening Nails and External Fixators. Strategies in Trauma and Limb Reconstruction, 18(1), 16-20.
- The role of bone metastases on the mechanical competence of human vertebrae. Bone, 173, 116814-116814.
- Selenium status in very old adults: Insights from the Newcastle 85+ Study. Proceedings of the Nutrition Society, 82(OCE3).
- Trabecular Bone Score Vertebral Exclusions Affect Risk Classification and Treatment Recommendations: The Manitoba BMD Registry. Journal of Clinical Densitometry, 101415-101415.
- Osteoarthritis genetic risk acting on the galactosyltransferase gene COLGALT2 has opposing functional effects in articulating joint tissues. Arthritis Research & Therapy, 25(1).
- Estimating the future clinical and economic benefits of improving osteoporosis diagnosis and treatment among postmenopausal women across eight European countries. Archives of Osteoporosis, 18.
- Impact of pausing elective hip and knee replacement surgery during winter 2017 on subsequent service provision at a major NHS Trust: a descriptive observational study using interrupted time series. BMJ Open, 13(5), e066398-e066398.
- Biochemical Markers of Bone Fragility in Patients With Diabetes.. J Clin Endocrinol Metab.
- International Consensus Statement on the Radiological Screening of Contact Children in the Context of Suspected Child Physical Abuse. JAMA Pediatrics, 177(5), 526-526.
- Gprc5b promotes cartilage anabolism and inhibits catabolism by blocking autophagy signaling pathway. Knockout of Gprc5b suppresses cartilage anabolic factors and promotes catabolic factors. Acta Pharmaceutica Sinica B.
- Supported exercise TrAining for Men wIth prostate caNcer on Androgen deprivation therapy (STAMINA): study protocol for a randomised controlled trial of the clinical and cost-effectiveness of the STAMINA lifestyle intervention compared with optimised usual care, including internal pilot and parallel process evaluation. Trials, 25(1).
- Evaluation of venous thromboembolism risk assessment models for hospital inpatients: the VTEAM evidence synthesis. Health Technology Assessment, 1-166.
- Bisphosphonate alternative regimens for the prevention of osteoporotic fragility fractures: BLAST-OFF, a mixed-methods study. Health Technology Assessment, 1-169.
- Medical Management for Fracture Prevention in Children with Osteogenesis Imperfecta. Calcified Tissue International.
- Anti-fracture treatment efficacy by age. Journal of Bone and Mineral Research.
- Clinical and molecular characterization of patients with
YWHAG ‐related epilepsy. Epilepsia. - Evidence-Based Guideline for the management of osteoporosis in men. Nature Reviews Rheumatology.
- Potential of Notochordal Cells within Injectable Biomaterials to Promote Intervertebral Disc Regeneration. European Cells and Materials, 47, 30-50.
- ASXL3‐related disorder: Molecular phenotyping and comprehensive review providing insights into disease mechanism. Clinical Genetics.
- Sarcopenia definitions and their association with fracture risk in older Swedish women. Journal of Bone and Mineral Research.
- The implications of competing risks and direct treatment disutility in cardiovascular disease and osteoporotic fracture: risk prediction and cost effectiveness analysis. Health and Social Care Delivery Research, 1-275.
- Cabozantinib and Axitinib After Vascular Endothelial Growth Factor Therapy in Patients with Advanced Renal Cell Carcinoma: A Retrospective Cohort Study from England. Drugs - Real World Outcomes.
- A meta-analysis of previous falls and subsequent fracture risk in cohort studies. Osteoporosis International.
- Is it possible to predict which patients are most likely to benefit from intra‐articular corticosteroid injections? A systematic review. International Journal of Rheumatic Diseases.
- Adjuvant bisphosphonate therapy and bone health. Journal of Bone and Mineral Research.
- Bone remodelling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus. Journal of Bone and Mineral Research.
- FRAX predicts cardiovascular risk in women undergoing osteoporosis screening: the Manitoba BMD registry. Journal of Bone and Mineral Research.
- Efficacy of Osteoporosis Medications in Patients with Type 2 Diabetes. Current Osteoporosis Reports.
- Changes in collagen type I C-telopeptide and procollagen type I N-terminal propeptide during the menopause transition. The Journal of Clinical Endocrinology & Metabolism.
- Fracture prediction in rheumatoid arthritis: validation of FRAX with bone mineral density for incident major osteoporotic fractures. Rheumatology.
- Celebrating 50 years of Pediatric Radiology. Pediatric Radiology, 53(13), 2571-2571.
- The impact of restricted provision of publicly funded elective hip and knee joints replacement during the COVID-19 pandemic in England. PLOS ONE, 18(11), e0294304-e0294304.
- Cellular Responses to Extracellular Vesicles as Potential Markers of Colorectal Cancer Progression. International Journal of Molecular Sciences, 24(23), 16755-16755.
- Epigenomic profiling of the infrapatellar fat pad in osteoarthritis. Human Molecular Genetics.
- Changes in the immune landscape of TNBC after neoadjuvant chemotherapy: correlation with relapse. Frontiers in Immunology, 14.
- MAF amplification licenses ERα through epigenetic remodelling to drive breast cancer metastasis. Nature Cell Biology.
- Notochordal cell-derived matrix inhibits MAPK signaling in the degenerative disc environment. European Cells and Materials, 46, 57-90.
- Children with hypophosphatasia treated with asfotase alfa: analysis from the UK Patients Cohort. Endocrine Abstracts.
- Service evaluation of the metabolic bone centre primary hyperparathyroidism registry. Endocrine Abstracts.
- Antiresorptive Versus Anabolic Therapy in Managing Osteoporosis in People with Type 1 and Type 2 Diabetes. JBMR Plus.
- Sex‐ and Age Group‐Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus. JBMR Plus.
- Selenium status and its determinants in very old adults: Insights from the Newcastle 85+ Study. British Journal of Nutrition, 1-31.
- An overview of the use of the fracture risk assessment tool (FRAX) in osteoporosis. Journal of Endocrinological Investigation.
- Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research. JOR SPINE.
- Cortical bone adaptation response is region specific, but not peak load dependent: insights from $$mu$$CT image analysis and mechanostat simulations of the mouse tibia loading model. Biomechanics and Modeling in Mechanobiology.
- Disparities in paediatric radiology research publications from low- and lower middle-income countries: Pediatric Radiology editors as advocates. Pediatric Radiology.
- Effect of
BMI‐Discordant Abdominal Tissue Thickness on Fracture Probability: ARegistry‐Based Study. Journal of Bone and Mineral Research. - Disparities in paediatric radiology research publications from low- and lower middle-income countries: a time for change. Pediatric Radiology.
- Neonatal Hip Loading in Developmental Dysplasia: Finite Element Simulation of Proximal Femur Growth and Treatment. HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery.
- Cementing Techniques In Knee Surgery (CeTIKS): a UK expert consensus study. Bone & Joint Open, 4(9), 682-688.
- Adjusting FRAX Estimates of Fracture Probability Based on a Positive Vertebral Fracture Assessment. JAMA Network Open, 6(8), e2329253-e2329253.
- Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX. Osteoporosis International.
- The use of antibiotic-loaded bone cement and systemic antibiotic prophylactic use in 2,971,357 primary total knee arthroplasties from 2010 to 2020: an international register-based observational study among countries in Africa, Europe, North America, and Oceania. Acta Orthopaedica, 94, 416-425.
- Evaluating the Usefulness and Ease of Use of a Next-Generation–Connected Drug Delivery Device for Growth Hormone Therapy: Qualitative Study of Health Care Professionals’ Perceptions. JMIR Human Factors, 10, e46893-e46893.
- EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report. Purinergic Signalling.
- MiR-662 is associated with metastatic relapse in early-stage breast cancer and promotes metastasis by stimulating cancer cell stemness. British Journal of Cancer.
- Diagnosis, treatment, and survival from kidney cancer: real‐world
NHS England data between 2013‐2019. BJU International. - Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization. JOR SPINE.
- Hemoglobin levels improve fracture risk prediction in addition to FRAX® clinical risk factors and bone mineral density. The Journal of Clinical Endocrinology & Metabolism.
- Germline pathogenic variants in HNRNPU are associated with alterations in blood methylome. European Journal of Human Genetics.
- Update on the clinical use of trabecular bone score (TBS) in the management of osteoporosis: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), and the International Osteoporosis Foundation (IOF) under the auspices of WHO Collaborating Center for Epidemiology of Musculoskeletal Health and Aging. Osteoporosis International.
- Real-world evidence: new opportunities for osteoporosis research. Recommendations from a Working Group from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Osteoporosis International.
- Bioactive Protein and Peptide Release from a Mucoadhesive Electrospun Membrane. Biomedical Materials & Devices.
- What effect have commissioners’ policies for body mass index had on hip replacement surgery?: an interrupted time series analysis from the National Joint Registry for England. BMC Medicine, 21(1).
- Research priorities regarding the use of bisphosphonates for osteoporosis: a UK priority setting exercise. Osteoporosis International.
- Metastatic infiltration of nervous tissue and periosteal nerve sprouting in multiple myeloma induced bone pain in mice and human. The Journal of Neuroscience.
- Wearable sensor-based measures of step-up transfers are supplementary to patient-reported outcome measures following total joint arthroplasty. Disability and Rehabilitation, 1-8.
- One-stage hip revisions are as good as two-stage surgery to replace infected artificial hips. BMJ, p1087-p1087.
- Better post-operative prediction and management of chronic pain in adults after total knee replacement: the multidisciplinary STAR research programme including RCT. Programme Grants for Applied Research, 1-84.
- A median fin derived from the lateral plate mesoderm and the origin of paired fins. Nature.
- Metastasis prevention with bone-targeted agents: a complex interaction between the microenvironment and tumour biology. Journal of Bone and Mineral Metabolism.
- Mortality and re-revision following single-stage and two-stage revision surgery for the management of infected primary hip arthroplasty in England and Wales. Bone & Joint Research, 12(5), 321-330.
- Biochemical Markers of Bone Fragility in Patients with Diabetes. A Narrative Review by the IOF and the ECTS. The Journal of Clinical Endocrinology & Metabolism.
Conference proceedings papers
- Enhancement and Size-based Response Criteria for Evaluating Tyrosine Kinase Inhibitor Dosing Strategy in Metastatic Renal Cancer: Prospective Imaging Study from the UK STAR Trial. CLINICAL ONCOLOGY, Vol. 36(1) (pp E78-E79)
- CHD8 missense variants cause a variable neurodevelopmental disorder with incomplete penetrance. EUROPEAN JOURNAL OF HUMAN GENETICS, Vol. 32 (pp 721-721)
Reports
Other
- Figure S1. from Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response.
- Data from Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response.
- Figure S1. from Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response.
- Data from Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response.
Preprints
- Receptor activity modifying protein modulation of parathyroid hormone-1 receptor function and signalling, Cold Spring Harbor Laboratory.
- Targeting of a STING Agonist to Perivascular Macrophages in Prostate Tumors Delays Resistance to Androgen Deprivation Therapy, Cold Spring Harbor Laboratory.
- Fracture risk assessment in men with prostate cancer requiring long-term androgen deprivation therapy: a systematic scoping review using the i-PARIHS implementation framework, Research Square Platform LLC.
- Validation of homogenized finite element models of human metastatic vertebrae using digital volume correlation, arXiv.
- What influences women’s decisions to participate in trials for prevention of venous thromboembolism during pregnancy and the puerperium: a qualitative study, Research Square Platform LLC.
- The impact of HIV infection on skeletal maturity in peripubertal children in Zimbabwe: a cross sectional study, Research Square Platform LLC.
- Large-scale evaluation of outcomes following a genetic diagnosis in children with severe developmental disorders.
- POST-COVID ORTHOPAEDIC ELECTIVE RESOURCE PLANNING USING SIMULATION MODELLING, Cold Spring Harbor Laboratory.
- Epigenomic profiling of the infrapatellar fat pad in osteoarthritis, Cold Spring Harbor Laboratory.