Grants
A list of grants awarded to staff working in the Mellanby Centre.
Government (UK, Europe) and Research Councils
National Institute of Health (US)
- Title: Predicting Fast Bone Mineral Density Decline and Fracture Across the Menopause Transition,
- Grant holder: Professor Richard Eastell
- Co-applicant: Dr Albert Shieh (UCLA)
- Date: 6.5.2020-30.4.2025
- $327,420 (Sheffield contribution)
NIHR (RfPB)
- Title: Developing normative values for vertebral morphology in children: A feasibility study
- Grant holder: Dr Amaka Offiah
- Co-applicants: Nicola Crabtree N (Birmingham) and Jonathan Taylor (Sheffield Teaching Hospitals).
- Date: 1 April 2020-30 Sept 2021
- £57,054
EU Horizon 2020
- Title: Innovative Training Network: Diabetes and Bone
- Grant Holder: Professor Richard Eastell
- Date: 2 Jan 2020
- £256,000
NIHR Rare Disease Translational Research Collaboration
- Title: Establishing clinical phenotype and diagnostic crieria in adult-onset hypophosphatasia
- Grant Holder: Eastell, R
- Date: 2019
- £54,292
Charlie Veale Research Award
- Title: High bone mass Osteogenesis Imperfecta Study. Dec 2017
- Grant Holder: Balasubramanian M (PI)
- Date: 2017-2018
- £14,995
Brittle Bone Society Research Grants
- Title: Assessing the Balance of Cost and Determining the Experiences of Families in Paediatric Osteogenesis Imperfecta Healthcare (ABCD Study)
- Grant Holder: Balasubramanian M
- £9,958
- Date: 2017-2018
National Centre for replacement, refinement and reduction of animal use in research
- Title: In silico approaches for preclinical assessment of bone changes in osteoporosis and osteoarthritis studies
- Grant Holders: Dall’Ara E (PI), Bellantuono I, Viceconti M
- Dates: 2017-2020
- £353,000
Arthritis UK, Medical Technologies Proof of Concept Award
- Title: Development and Evaluation of a Functional Prototype for the Automated Identification of Osteoporotic Vertibral Fractures: VERDICT
- Grant Holder: Professor Alejandro Frangi (PI)
- Dates: 2017-2019
- £100,000
NIHR Research Capacity Funding Award 2014-15
- Grant Holders: Balasubramanian M (PI), Bexon J, Bowen J
- Dates: Aug 2014-April 2015
- £9,974.00
EPSRC
- Title: Novel Assessment of the Osteoarthritic Hip Subchondral Bone: a Combined Experimental and Computational Investigation
- Grant Holder: Enrico Dall’Ara (PI)
- Dates: Sept 2017 to Aug 2018
- £102,000
BBSRC
- Title: Targeting mechanisms of ageing to maintain musculoskeletal health
- Grant Holders: Enrico Dall’Ara, Bellantuono (PI)
- Dates: Oct 2017 to Sept 2019
- £261,000
NIHR
- Title: Establishing clinical phenotype and diagnostic criteria in adult-onset hypophosphatasia
- Grant Holders: Richard Eastell (PI), Jennie Walsh
- Dates: April 2015 to March 2017
- £200,000
MRC/NIHR EME Award
- Title: Randomised controlled trial of selenium in older women with osteopenia
- Grant Holders: Richard Eastell, Jennie Walsh (PI), Cindy Cooper
- Dates: April 2016 to May 2018
- £461,057
Health Quality Improvement Partnership
- Title: NJR Data Access Portal Development
- Grant Holder: Kadirkamanathan, Wilkinson (PI), Hills, Northgate Information Solutions
- Awarded 2015
- £140,980
Charity
Royal Osteoporosis Society (ROS)
- Title: Are advanced glycation end products (AGEs) biomarkers of long- term low bone remodelling?
- Grant Holder: Vilace T
- Dates: February 2022 – 31 January 2023
- £23,372.00
CIMA
- Title: microRNA and fracture in the OPUS Study
- Grant Holder: Eastell R
- Date: 7 June 2019
- £58,102
Newlife Foundation for Disabled Children
- Title: Identification of novel phenotypes in a cohort of children with bone fragility and autism
- Dates: June 2015-June 2016
- £15,000
The Children’s Charity, Sheffield
- Title: Exome sequencing in Osteogenesis Imperfecta
- Grant Holders: Balasubramanian M, Dalton A, Bishop NJ
- Dates: March 2015-April 2017
- £31,669.90
The Children’s Hospital Charity, Sheffield
- Title: Exploring the functionality of a new gene in bone fragility and its role in autism
- Grant Holders: Balasubramanian M, Brown S, Roehl HE and Skerry, T
- Dates: Aug 2015-Oct 2016
Newlife Foundation for Disabled Children
- Title: Digital disease phenotypig in inerited bone fragility disorders
- Grant Holders: Dr Meena Balasubramanian, Professor Damien Lacroix, Dr Margaret Paggiosi and Professor Nick Bishop
- Dates: Sept 2015-Sept 2016
The Children’s Hospital Charity, Sheffield
- Title: Phenotype based assays in Osteogenesis Imperfecta
- Grant Holders: Dr Meena Balasubramanian, Professor Damien Lacroxi, Dr Margaret Paggiosi and Professor Nick Bishop
- Dates: April 2016
- £26,954
Arthritis Research UK
- Title: Development and Evaluation of a Functional Prototype for the Automated Identification of Osteoporotic Vertebral Fractures: VERDICT
- Grant Holders: Professor Alenjandro Frangi, Dr Jose M Pozo Soler, Dr Margaret Paggiosi, Professor Richard Eastell, Dr Nicola Peel, Dr Richard Jacques
- This is a collaborative, translational research project between the following:
- Centre for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB)
- The Mellanby Centre for Bone Research, Department of Oncology and Metabolism, Faculty of Medicine, University of Sheffield
- The Metabolic Bone Centre, Musculoskeletal Directorate, Sheffield Teaching Hospitals NHS Foundation Trust
- The Medical Statistics Group, School of Health and Related Research (ScHARR), University of Sheffield
- Dates: 1 April 2017-31 March 2019
- £98,735.09
Weston Park Hospital Cancer Charity Louise Victoria Craddock Memorial Fund
- Title: Establishing new, state-of-the-art research DXA imaging equipment in Sheffield to improve cancer patient care, clinical outcome and quality of life
- Grant Holders: Dr Margaret Paggiosi, Professor Richard Eastell, Professor Janet Brown
- Dates: 1 Nov 2016-30 April 2017
- £116,441.60
Wellcome Trust
- Title: Development of selective Adrenomedullin-2 receptor antagonists for treatment of pancreatic cancer
- Grant Holders: Tim Skerry (PI), Gareth Richards
- Dates: To continue from current grant from August 2017, end dates currently being negotiated
- £2 million
Weston Park Cancer Charity
- Title: Validating the roles of IL-1B and IL-1RA as novel predictors of breast cancer bone metastisis
- Grant Holder: Ottewell, Holen, Wilkinson
- Awarded 2015
- £98,663
Arthritis Research UK
- Development of a Personalized Health Forecasting Tool for Patients Undergoing Hip or Knee Replacement
- Grant Holder: Wilkinson (PI), McCloskey, Kadirkamanathan, Blom
- Awarded 2015
- £244,694
Sheffield Hospitals Charity
- OsteoPro: A Software System for Assessing Osteoporosis Progression using a Sheffield-born Innovation based on High-Spatial- Resolution Bone Densitometry with DXA Region-Free Analysis
- Grant Holder: Prof Mark Wilkinson
- Awarded 2015
- £15,715
Orthopaedic Research UK
- Title: Biological effects of tribocorrosion products on the bone micro-environment and prosthesis osseo-integration
- Grant Holder: Wilkinson (PI), Gartland, Shah
- Awarded 2015
- £93,245
Industry
Alexion Ltd
- Title: Clinical consequences of adult-presenting hypophosphatasia with special focus on gait, bone microarchitecture and cognition: the PORTRAIT Study
- Grant holder (50%): Professor Richard Eastell
- Awarded: 07.01.20
- Awarded: £269,000
Roche Diagnostics
- Title: Clinical utility of PINP: the POSE Study
- Grant holder: Professor Richard Eastell
- Awarded: 22 Nov 2019
- Award: £99,000
Genzyme
- Title: Commitment from Genzyme for high throughput RNA sequencing and TGF-B antibody work-up in cultured fibroblasts from patients with Osteogenesis Impertecta to identify novel pathways for diagnosis and intervention.
- Grant holder: M Balasubramanian,Y Sabbagh
- Award: $88,000
Alexion Ltd
- Title: Phase 1 development of a dynamic Radiological Electronic Atlas of Malformation Syndromes (dREAMS) – essentially a knowledge base and ontology for diagnosing skeletal dysplasias in collaboration with Certus Tech Ltd
- Grant holder: Dr Amaka Offiah
- Awarded 1 Sept 2017 – 28 Feb 2019
- Award: £87,440