Grants

Government (UK, Europe) and Research Councils

National Institute of Health (US)

• Title: Predicting Fast Bone Mineral Density Decline and Fracture Across the Menopause Transition, 
• Grant holder: Professor Richard Eastell
• Co-applicant: Dr Albert Shieh (UCLA)
• Date: 6.5.2020-30.4.2025
• $327,420 (Sheffield contribution)

NIHR (RfPB)

• Title: Developing normative values for vertebral morphology in children: A feasibility study 
• Grant holder: Dr Amaka Offiah
• Co-applicants: Nicola Crabtree N (Birmingham) and Jonathan Taylor (Sheffield Teaching Hospitals).
• Date: 1 April 2020-30 Sept 2021
• £57,054

EU Horizon 2020

• Title: Innovative Training Network: Diabetes and Bone
• Grant Holder: Professor Richard Eastell
• Date: 2 Jan 2020
• £256,000

NIHR Rare Disease Translational Research Collaboration

• Title: Establishing clinical phenotype and diagnostic crieria in adult-onset hypophosphatasia
• Grant Holder: Eastell, R
• Date: 2019
• £54,292

Charlie Veale Research Award   

• Title: High bone mass Osteogenesis Imperfecta Study. Dec 2017
• Grant Holder: Balasubramanian M (PI)
• Date: 2017-2018
• £14,995

Brittle Bone Society Research Grants 

• Title: Assessing the Balance of Cost and Determining the Experiences of Families in Paediatric Osteogenesis Imperfecta Healthcare (ABCD Study)
• Grant Holder: Balasubramanian M
• £9,958 
• Date: 2017-2018

National Centre for replacement, refinement and reduction of animal use in research

• Title: In silico approaches for preclinical assessment of bone changes in osteoporosis and osteoarthritis studies
• Grant Holders: Dall’Ara E (PI), Bellantuono I, Viceconti M
• Dates: 2017-2020
• £353,000

Arthritis UK, Medical Technologies Proof of Concept Award

• Title: Development and Evaluation of a Functional Prototype for the Automated Identification of Osteoporotic Vertibral Fractures: VERDICT
• Grant Holder: Professor Alejandro Frangi (PI)
• Dates: 2017-2019
• £100,000

NIHR Research Capacity Funding Award 2014-15

• Grant Holders: Balasubramanian M (PI), Bexon J, Bowen J
• Dates: Aug 2014-April 2015
• £9,974.00

EPSRC

• Title: Novel Assessment of the Osteoarthritic Hip Subchondral Bone: a Combined Experimental and Computational Investigation
• Grant Holder: Enrico Dall’Ara (PI)
• Dates: Sept 2017 to Aug 2018
• £102,000

BBSRC

• Title: Targeting mechanisms of ageing to maintain musculoskeletal health
• Grant Holders: Enrico Dall’Ara, Bellantuono (PI)
• Dates:  Oct 2017 to Sept 2019
• £261,000

NIHR 

• Title: Establishing clinical phenotype and diagnostic criteria in adult-onset hypophosphatasia
• Grant Holders: Richard Eastell (PI), Jennie Walsh
• Dates: April 2015 to March 2017
• £200,000

MRC/NIHR EME Award 

• Title: Randomised controlled trial of selenium in older women with osteopenia
• Grant Holders: Richard Eastell, Jennie Walsh (PI), Cindy Cooper
• Dates: April 2016 to May 2018
• £461,057

Health Quality Improvement Partnership                                         

• Title: NJR Data Access Portal Development
• Grant Holder: Kadirkamanathan, Wilkinson (PI), Hills, Northgate Information Solutions
• Awarded 2015            
• £140,980

Charity

Royal Osteoporosis Society (ROS)

• Title:  ​Are advanced glycation end products (AGEs) biomarkers of long- term low bone remodelling?
• Grant Holder: Vilace T
• Dates: ​February 2022 – 31 January 2023
• £23,372.00  

CIMA

• Title: microRNA and fracture in the OPUS Study
• Grant Holder: Eastell R
• Date: 7 June 2019
• £58,102

Newlife Foundation for Disabled Children

• Title: Identification of novel phenotypes in a cohort of children with bone fragility and autism
• Dates: June 2015-June 2016
• £15,000

The Children’s Charity, Sheffield

• Title: Exome sequencing in Osteogenesis Imperfecta
• Grant Holders: Balasubramanian M, Dalton A, Bishop NJ
• Dates: March 2015-April 2017
• £31,669.90

The Children’s Hospital Charity, Sheffield

• Title: Exploring the functionality of a new gene in bone fragility and its role in autism
• Grant Holders:  Balasubramanian M, Brown S, Roehl HE and Skerry, T
• Dates: Aug 2015-Oct 2016

Newlife Foundation for Disabled Children

• Title: Digital disease phenotypig in inerited bone fragility disorders
• Grant Holders: Dr Meena Balasubramanian, Professor Damien Lacroix, Dr Margaret Paggiosi and Professor Nick Bishop
• Dates: Sept 2015-Sept 2016

The Children’s Hospital Charity, Sheffield

• Title: Phenotype based assays in Osteogenesis Imperfecta
• Grant Holders: Dr Meena Balasubramanian, Professor Damien Lacroxi, Dr Margaret Paggiosi and Professor Nick Bishop
• Dates: April 2016
• £26,954

Arthritis Research UK

• Title: Development and Evaluation of a Functional Prototype for the Automated Identification of Osteoporotic Vertebral Fractures: VERDICT
• Grant Holders: Professor Alenjandro Frangi, Dr Jose M Pozo Soler, Dr Margaret Paggiosi, Professor Richard Eastell, Dr Nicola Peel, Dr Richard Jacques
• This is a collaborative, translational research project between the following:
  • Centre for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB)
  • The Mellanby Centre for Bone Research, Department of Oncology and Metabolism, Faculty of Medicine, University of Sheffield
  • The Metabolic Bone Centre, Musculoskeletal Directorate, Sheffield Teaching Hospitals NHS Foundation Trust
  • The Medical Statistics Group, School of Health and Related Research (ScHARR), University of Sheffield
• Dates: 1 April 2017-31 March 2019
• £98,735.09

Weston Park Hospital Cancer Charity Louise Victoria Craddock Memorial Fund

• Title: Establishing new, state-of-the-art research DXA imaging equipment in Sheffield to improve cancer patient care, clinical outcome and quality of life
• Grant Holders: Dr Margaret Paggiosi, Professor Richard Eastell, Professor Janet Brown
• Dates: 1 Nov 2016-30 April 2017
• £116,441.60

Wellcome Trust

• Title: Development of selective Adrenomedullin-2 receptor antagonists for treatment of pancreatic cancer
• Grant Holders: Tim Skerry (PI), Gareth Richards
• Dates: To continue from current grant from August 2017, end dates currently being negotiated
• £2 million

Weston Park Cancer Charity                                                            

• Title: Validating the roles of IL-1B and IL-1RA as novel predictors of breast cancer bone metastisis
• Grant Holder: Ottewell, Holen, Wilkinson
• Awarded 2015            
• £98,663

Arthritis Research UK                                                

• Development of a Personalized Health Forecasting Tool for Patients Undergoing Hip or Knee Replacement
• Grant Holder: Wilkinson (PI), McCloskey, Kadirkamanathan, Blom
• Awarded 2015
• £244,694

Sheffield Hospitals Charity                                                                 

• OsteoPro: A Software System for Assessing Osteoporosis Progression using a Sheffield-born Innovation based on High-Spatial- Resolution Bone Densitometry with DXA Region-Free Analysis
• Grant Holder: Prof Mark Wilkinson
• Awarded 2015            
• £15,715

Orthopaedic Research UK                                         

• Title: Biological effects of tribocorrosion products on the bone micro-environment and prosthesis osseo-integration
• Grant Holder: Wilkinson (PI), Gartland, Shah
• Awarded 2015
• £93,245

Industry

Alexion Ltd

• Title: Clinical consequences of adult-presenting hypophosphatasia with special focus on gait, bone microarchitecture and cognition: the PORTRAIT Study
• Grant holder (50%): Professor Richard Eastell
• Awarded: 07.01.20
• Awarded: £269,000

Roche Diagnostics

• Title: Clinical utility of PINP: the POSE Study
• Grant holder: Professor Richard Eastell
• Awarded: 22 Nov 2019
• Award: £99,000

Genzyme

• Title: Commitment from Genzyme for high throughput RNA sequencing and TGF-B antibody work-up in cultured fibroblasts from patients with Osteogenesis Impertecta to identify novel pathways for diagnosis and intervention.
• Grant holder: M Balasubramanian,Y  Sabbagh
• Award: $88,000

Alexion Ltd

• Title: Phase 1 development of a dynamic Radiological Electronic Atlas of Malformation Syndromes (dREAMS) – essentially a knowledge base and ontology for diagnosing skeletal dysplasias in collaboration with Certus Tech Ltd
• Grant holder: Dr Amaka Offiah
• Awarded 1 Sept 2017 – 28 Feb 2019
• Award: £87,440