Grants

A list of grants awarded to staff working in the Mellanby Centre.

On

Government (UK, Europe) and Research Councils

National Institute of Health (US)

  • Title: Predicting Fast Bone Mineral Density Decline and Fracture Across the Menopause Transition, 
  • Grant holder: Professor Richard Eastell
  • Co-applicant: Dr Albert Shieh (UCLA)
  • Date: 6.5.2020-30.4.2025
  • $327,420 (Sheffield contribution)

NIHR (RfPB)

  • Title: Developing normative values for vertebral morphology in children: A feasibility study 
  • Grant holder: Dr Amaka Offiah
  • Co-applicants: Nicola Crabtree N (Birmingham) and Jonathan Taylor (Sheffield Teaching Hospitals).
  • Date: 1 April 2020-30 Sept 2021
  • £57,054

EU Horizon 2020

  • Title: Innovative Training Network: Diabetes and Bone
  • Grant Holder: Professor Richard Eastell
  • Date: 2 Jan 2020
  • £256,000

NIHR Rare Disease Translational Research Collaboration

  • Title: Establishing clinical phenotype and diagnostic crieria in adult-onset hypophosphatasia
  • Grant Holder: Eastell, R
  • Date: 2019
  • £54,292

Charlie Veale Research Award   

  • Title: High bone mass Osteogenesis Imperfecta Study. Dec 2017
  • Grant Holder: Balasubramanian M (PI)
  • Date: 2017-2018
  • £14,995

Brittle Bone Society Research Grants 

  • Title: Assessing the Balance of Cost and Determining the Experiences of Families in Paediatric Osteogenesis Imperfecta Healthcare (ABCD Study)
  • Grant Holder: Balasubramanian M
  • £9,958 
  • Date: 2017-2018

National Centre for replacement, refinement and reduction of animal use in research

  • Title: In silico approaches for preclinical assessment of bone changes in osteoporosis and osteoarthritis studies
  • Grant Holders: Dall’Ara E (PI), Bellantuono I, Viceconti M
  • Dates: 2017-2020
  • £353,000

Arthritis UK, Medical Technologies Proof of Concept Award

  • Title: Development and Evaluation of a Functional Prototype for the Automated Identification of Osteoporotic Vertibral Fractures: VERDICT
  • Grant Holder: Professor Alejandro Frangi (PI)
  • Dates: 2017-2019
  • £100,000

NIHR Research Capacity Funding Award 2014-15

  • Grant Holders: Balasubramanian M (PI), Bexon J, Bowen J
  • Dates: Aug 2014-April 2015
  • £9,974.00

EPSRC

  • Title: Novel Assessment of the Osteoarthritic Hip Subchondral Bone: a Combined Experimental and Computational Investigation
  • Grant Holder: Enrico Dall’Ara (PI)
  • Dates: Sept 2017 to Aug 2018
  • £102,000

BBSRC

  • Title: Targeting mechanisms of ageing to maintain musculoskeletal health
  • Grant Holders: Enrico Dall’Ara, Bellantuono (PI)
  • Dates:  Oct 2017 to Sept 2019
  • £261,000

NIHR 

  • Title: Establishing clinical phenotype and diagnostic criteria in adult-onset hypophosphatasia
  • Grant Holders: Richard Eastell (PI), Jennie Walsh
  • Dates: April 2015 to March 2017
  • £200,000

MRC/NIHR EME Award 

  • Title: Randomised controlled trial of selenium in older women with osteopenia
  • Grant Holders: Richard Eastell, Jennie Walsh (PI), Cindy Cooper
  • Dates: April 2016 to May 2018
  • £461,057

Health Quality Improvement Partnership                                         

  • Title: NJR Data Access Portal Development
  • Grant Holder: Kadirkamanathan, Wilkinson (PI), Hills, Northgate Information Solutions
  • Awarded 2015            
  • £140,980

Charity

Royal Osteoporosis Society (ROS)

  • Title:  ​Are advanced glycation end products (AGEs) biomarkers of long- term low bone remodelling?
  • Grant Holder: Vilace T
  • Dates: ​February 2022 – 31 January 2023
  • £23,372.00  

CIMA

  • Title: microRNA and fracture in the OPUS Study
  • Grant Holder: Eastell R
  • Date: 7 June 2019
  • £58,102

Newlife Foundation for Disabled Children

  • Title: Identification of novel phenotypes in a cohort of children with bone fragility and autism
  • Dates: June 2015-June 2016
  • £15,000

The Children’s Charity, Sheffield

  • Title: Exome sequencing in Osteogenesis Imperfecta
  • Grant Holders: Balasubramanian M, Dalton A, Bishop NJ
  • Dates: March 2015-April 2017
  • £31,669.90

The Children’s Hospital Charity, Sheffield

  • Title: Exploring the functionality of a new gene in bone fragility and its role in autism
  • Grant Holders:  Balasubramanian M, Brown S, Roehl HE and Skerry, T
  • Dates: Aug 2015-Oct 2016

Newlife Foundation for Disabled Children

  • Title: Digital disease phenotypig in inerited bone fragility disorders
  • Grant Holders: Dr Meena Balasubramanian, Professor Damien Lacroix, Dr Margaret Paggiosi and Professor Nick Bishop
  • Dates: Sept 2015-Sept 2016

The Children’s Hospital Charity, Sheffield

  • Title: Phenotype based assays in Osteogenesis Imperfecta
  • Grant Holders: Dr Meena Balasubramanian, Professor Damien Lacroxi, Dr Margaret Paggiosi and Professor Nick Bishop
  • Dates: April 2016
  • £26,954

Arthritis Research UK

  • Title: Development and Evaluation of a Functional Prototype for the Automated Identification of Osteoporotic Vertebral Fractures: VERDICT
  • Grant Holders: Professor Alenjandro Frangi, Dr Jose M Pozo Soler, Dr Margaret Paggiosi, Professor Richard Eastell, Dr Nicola Peel, Dr Richard Jacques
  • This is a collaborative, translational research project between the following:
    • Centre for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB)
    • The Mellanby Centre for Bone Research, Department of Oncology and Metabolism, Faculty of Medicine, University of Sheffield
    • The Metabolic Bone Centre, Musculoskeletal Directorate, Sheffield Teaching Hospitals NHS Foundation Trust
    • The Medical Statistics Group, School of Health and Related Research (ScHARR), University of Sheffield
  • Dates: 1 April 2017-31 March 2019
  • £98,735.09

Weston Park Hospital Cancer Charity Louise Victoria Craddock Memorial Fund

  • Title: Establishing new, state-of-the-art research DXA imaging equipment in Sheffield to improve cancer patient care, clinical outcome and quality of life
  • Grant Holders: Dr Margaret Paggiosi, Professor Richard Eastell, Professor Janet Brown
  • Dates: 1 Nov 2016-30 April 2017
  • £116,441.60

Wellcome Trust

  • Title: Development of selective Adrenomedullin-2 receptor antagonists for treatment of pancreatic cancer
  • Grant Holders: Tim Skerry (PI), Gareth Richards
  • Dates: To continue from current grant from August 2017, end dates currently being negotiated
  • £2 million

Weston Park Cancer Charity                                                            

  • Title: Validating the roles of IL-1B and IL-1RA as novel predictors of breast cancer bone metastisis
  • Grant Holder: Ottewell, Holen, Wilkinson
  • Awarded 2015            
  • £98,663

Arthritis Research UK                                                

  • Development of a Personalized Health Forecasting Tool for Patients Undergoing Hip or Knee Replacement
  • Grant Holder: Wilkinson (PI), McCloskey, Kadirkamanathan, Blom
  • Awarded 2015
  • £244,694

Sheffield Hospitals Charity                                                                 

  • OsteoPro: A Software System for Assessing Osteoporosis Progression using a Sheffield-born Innovation based on High-Spatial- Resolution Bone Densitometry with DXA Region-Free Analysis
  • Grant Holder: Prof Mark Wilkinson
  • Awarded 2015            
  • £15,715

Orthopaedic Research UK                                         

  • Title: Biological effects of tribocorrosion products on the bone micro-environment and prosthesis osseo-integration
  • Grant Holder: Wilkinson (PI), Gartland, Shah
  • Awarded 2015
  • £93,245

Industry

Alexion Ltd

  • Title: Clinical consequences of adult-presenting hypophosphatasia with special focus on gait, bone microarchitecture and cognition: the PORTRAIT Study
  • Grant holder (50%): Professor Richard Eastell
  • Awarded: 07.01.20
  • Awarded: £269,000

Roche Diagnostics

  • Title: Clinical utility of PINP: the POSE Study
  • Grant holder: Professor Richard Eastell
  • Awarded: 22 Nov 2019
  • Award: £99,000

Genzyme

  • Title: Commitment from Genzyme for high throughput RNA sequencing and TGF-B antibody work-up in cultured fibroblasts from patients with Osteogenesis Impertecta to identify novel pathways for diagnosis and intervention.
  • Grant holder: M Balasubramanian,Y  Sabbagh
  • Award: $88,000

Alexion Ltd

  • Title: Phase 1 development of a dynamic Radiological Electronic Atlas of Malformation Syndromes (dREAMS) – essentially a knowledge base and ontology for diagnosing skeletal dysplasias in collaboration with Certus Tech Ltd
  • Grant holder: Dr Amaka Offiah
  • Awarded 1 Sept 2017 – 28 Feb 2019
  • Award: £87,440