Research within the Department of Neuroscience
Our internationally renowned research focuses on the understanding of the mechanisms of neurodegeneration and the development of new treatments for neurodegenerative diseases. The Department is home to the Sheffield Institute for Translational Neuroscience (SITraN), a centre of excellence for basic and clinical research into motor neuron disease (MND) and related neurodegenerative disorders. Our goal is to translate scientific discoveries emerging from experimental work in the laboratory into effective therapies and better outcomes for patients in the clinical care setting.
In the Research Excellence Framework 2014, we're number one in the UK for the impact and quality of our biomedical research, alongside other departments at the University of Sheffield.
Major research themes and theme leads
|Motor neuron disorders (MND)||Professor Pam Shaw|
|Spinal muscular atrophy (SMA)||Professor Mimoun Azzouz|
|Parkinson’s disease and movement disorders||Professor Oliver Bandmann|
|Cognitive decline and dementia - Neuropathology Group||Professor Paul Ince
Professor Stephen Wharton
|Cognitive decline and dementia - Translational Neuropsychology Group||Professor Annalena Venneri|
|Computational Biology and Bioinformatics||Professor Winston Hide|
|Machine Learning and Computational Biology||Professor Neil Lawrence|
|Cerebrovascular Disease||Professor Arshad Majid|
|Epilepsy||Professor Markus Reuber|
In the last five years, SITraN scientists have published more than 400 peer-reviewed original research publications in high impact research journals.
Our research is dedicated to improving the lives of people affected by Motor Neurone Disease (MND) and related conditions such as Alzheimer’s and Parkinson’s disease.
Wide-ranging expertise and a multi-disciplinary, collaborative environment
The Department offers a collaborative, multi-disciplinary environment including expertise in basic neuroscience, clinical neurology, neuropathology, translational neuropsychology, computational biology, as well as in disease modelling, pharmacology, gene therapy, and clinical trials methodology. Working together with patients and bringing back to the laboratory what we learn from our patients crucially enhances our understanding of neurodegenerative diseases.
Working towards drug discovery and development
This multidisciplinary approach provides the department with the capability of taking therapeutic leads - based both on a strong in-house programme of neurobiology and international collaborations - into appropriate pre-clinical models, and through to novel therapies in humans. This is linked to a central role in the UK in the coordination of clinical trials in the field of neurodegenerative diseases, the DeNDRoN network. In MND and SMA we have an international reputation based on integrating molecular science through to clinical studies.
Our partners from across the University of Sheffield as well as from national and international consortia bring further expertise in key areas required to speed up this critical path from the laboratory to the clinic.
Our partners in Sheffield and in our region
Staff from the Department of Neurosciences collaborate with various departments and NHS trusts across the University, City and region.