Evidence synthesis TSD series
A series of seven TSDs have been produced in the area of evidence synthesis.
Introduction to evidence synthesis for decision making (PDF, 106KB)
A general linear modelling framework for pair-wise and network meta-analysis of randomised controlled trials (last updated Sept 2016) (PDF, 1.6MB)
WinBUGS system (.odc) files (last updated Sept 2016) (.zip, 6.1MB)
Heterogeneity: subgroups, meta-regression, bias and bias-adjustment (PDF, 492KB)
WinBUGS system (.odc) files (.zip, 197KB)
Inconsistency in networks of evidence based on randomised controlled trials (last updated April 2014) (PDF, 429KB)
WinBUGS system (.odc) files (last updated March 2013) (.zip, 13KB)
Evidence synthesis in the baseline natural history model (PDF, 178KB)
WinBUGS system (.odc) files (.zip, 24KB)
Embedding evidence synthesis in probabilistic cost effectiveness analysis: software choices (PDF, 122KB)
Evidence synthesis of treatment efficacy in decision making: a reviewer’s checklist (PDF, 147KB)
This report refers to a checklist table. (Word document, 81KB)
TSDs 1 to 7 have been published as a series in Medical Decision Making (July 2013).
The intention behind the TSDs is not to be prescriptive, but rather to explain the requirements for evidence syntheses set out in the 2008 Methods Guide and to provide guidance on methods that meet these requirements.
TSDs 2, 3, 4 and 5 include an extensive set of worked examples of analyses using Bayesian Markov chain Monte Carlo methods, using WinBUGS. The WinBUGS code should not be copied and pasted from the text; users are instead advised to download the WinBUGS system (.odc) files.
When all seven documents have been completed, those already on the website will be updated in order to harmonise and complete the cross-referencing. Instructions for citing these documents can be found on page 3 of each TSD.
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