Professor Dilly Anumba Dilly Anumba
(MBBS, FWACS, MD, FRCOG, LLM Medical Law)

Chair of Obstetrics & Gynaecology
Consultant in Obstetrics & Gynaecology
Subspecialist in Fetomaternal Medicine


Academic Unit of Reproductive and Developmental Medicine
Level 4, The Jessop Wing
Tree Root Walk
Sheffield
S10 2SF
UK

Office: JW4 40

Email: d.o.c.anumba@sheffield.ac.uk
Secretary, Gill Burkinshaw: +44 (0)114 215 9674
Email: g.m.burkinshaw@sheffield.ac.uk

Biography

I joined the University of Sheffield in 2003 as Senior Clinical Lecturer and Honorary Consultant in Obstetrics and Fetal Medicine following research and clinical training in Newcastle University and hospitals in Yorkshire and the Northern region. I was accredited a specialist in Obstetrics and Gynaecology in 1999, and a subspecialist in Maternal and Fetal Medicine in 2001. Since 2003, I have maintained busy clinical (Obstetrics, Fetomaternal Medicine), research and teaching roles.

Research Interests

I investigate the physiology of human parturition, particularly the role of immunity and inflammation in term/preterm labour and pregnancy complications such as hypertension, fetal growth restriction and stillbirth. I am also investigating new techniques to predict preterm birth by the detection of cervical remodelling changes as well as changes in the vaginal microbiome and metabolome. I run specialist clinics in Prenatal Diagnosis and Fetal Therapy, Prematurity Prevention, and High-Risk Pregnancy, all of which have research spin-offs.

Teaching Interests

My main interest is postgraduate medical training and teaching. I am Faculty of Medicine and South Yorkshire Director for Clinical Academic Training. I am Undergraduate Module Lead for Phase 3A Women´s Health, and Postgraduate Lead for the Pregnancy and Fetus Module of the MSc programme in Reproductive and Developmental medicine. I am Training Programme Supervisor for the Maternal and Fetal Medicine subspecialty training programme, Sheffield and serve on the South Yorkshire Foundation Training School Board, Clinical Academic Working Group, and Specialty Training Committee in Obstetrics and Gynaecology.

Professional Activities

I am Vice Chair of the Academic Board of the Royal College of Obstetricians and Gynaecologists and serve on several other related organs. I am Lead Clinician of the Fetal Medicine Unit, Sheffield. I served on the NICE Medical Technologies Advisory Committee (MTAC).

Current Projects

• 04/2018-2021 NIHR Global Health Grant Global Health Group for Preterm birth prevention and management (PRIME), £2million, Chief Investigator and Research Group Director.
• 07/2018-2021 EPSRC Grant, Nonlinear analysis of EIS and metabolite data for preterm birth management. Co-investigator with ZQ Lang £600k
• 04/2018-2021 NIHR Health Technology Assessment 16/16/06: COPE Randomised Control Trial, Management of postpartum haemorrhage, £1.8million. Co-investigator with Professor Andrew Weeks (Liverpool) et al
• 2017- 2020 NIHR Invention for Innovation (i4i) Scheme. Developing and testing a clinical grade magnetic impedance spectroscopy device for assessment of the cervix in pregnant women to predict preterm birth. £792,753.00. Chief and Principal Investigator, with Dr T Healey, Professor S Dixon and S Walters, Mrs. M Oppenshaw
• 2017-2019 NIHR RfPB Scheme Determining the predictive utility of short-term variation (STV) of fetal heart rate (FHR) for fetal acidaemia in high-risk women during labour £116.333, Co-Investigator with Dr Habiba Kapaya (NIHR CL)
• 2015- 2016 Glazo Smith Kline International. The ZINN Randomised Controlled Trial of Retosiban for the Prevention of Preterm Birth £40,452.00, UK Chief Investigator, Sheffield PI
• 2012-2016 MRC Development Pathways Funding Scheme, DPFS. Assessing the Risk of Spontaneous Premature Birth by Electrical Impedance Spectroscopy of the Cervix (ECCLIPPx). £622,048 Chief and Principal Investigator, with Brian Brown, Simon Dixon, Georgina Jones, Graham Stafford, Craig Murdoch
• 2012-2016 MRC DPFS. The preterm birth prediction microbiome project- 2012-2016 Chief and Principal Investigator, with Graham Stafford
• 2012-2015. NIHR Invention for Innovation (i4i) grant. Potential prediction of preterm labour and birth by Magnetic Induction Spectroscopy. £320,138 Chief and Principal Investigator, with Timothy Healey, Brian Brown, Simon Dixon and Jonathan Boote.

Key Publications

    1. Anumba DOC. A guide to the RCOG Advanced Professional Module in Clinical Research. The Obstetrician & Gynaecologist. 2018; 20:201–203. https://doi.org/10.1111/tog.12492
    2. Roman S, Hillary C, Narice B, Bullock AJ, Anumba DO, MacNeil S. Visualisation of the insertion of a membrane for the treatment of preterm rupture of fetal membranes using a synthetic model of a pregnant uterus. J Biomater Appl. 2018 Aug;33(2):234-244. doi: 10.1177/0885328218786038. Epub 2018 Jul 12.
    3. Amabebe E, Chapman DR, Stern VL, Stafford G, Anumba DOC. Mid-gestational changes in cervicovaginal fluid cytokine levels in asymptomatic pregnant women are predictive markers of inflammation-associated spontaneous preterm birth. J Reprod Immunol. 2018 Apr;126:1-10. doi: 10.1016/j.jri.2018.01.001. Epub 2018 Jan 10.
    4. Rosalind Haddrill, Georgina L. Jones, Dilly Anumba, Caroline Mitchell, A tale of two pregnancies: A Critical Interpretive Synthesis of women’s perceptions about delayed initiation of antenatal care, Women and Birth, 31, Issue 3, 2018, 220-231. https://doi.org/10.1016/j.wombi.2017.09.017.
    5. Kapaya H, Dimelow ER, Anumba D. Women's experience of wearing a portable fetal-electrocardiogram device to monitor small-for-gestational age fetus in their home environment. Womens Health (Lond). 2018 Jan-Dec;14:1745506518785620. doi: 10.1177/1745506518785620
    6. Amabebe E, Anumba DOC. The Vaginal Microenvironment: The Physiologic Role of Lactobacilli. Front Med (Lausanne). 2018 Jun 13;5:181.
    7. Govinden G, Parker JL, Naylor KL, Frey AM, Anumba DOC, Stafford GP. Inhibition of sialidase activity and cellular invasion by the bacterial vaginosis pathogen Gardnerella vaginalis. Arch Microbiol. 2018 Sep;200(7):1129-1133. doi: 10.1007/s00203-018-1520-4.
    8. Stafford GP, Parker JL, Amabebe E, Kistler J, Reynolds S, Stern V, Paley M, Anumba DOC. Spontaneous Preterm Birth Is Associated with Differential Expression of Vaginal Metabolites by Lactobacilli-Dominated Microflora. Front Physiol. 2017 Aug 23;8:615. doi: 10.3389/fphys.2017.00615
    9. Al-Ofi EA, Anumba DO. Ligands of toll-like receptors 2/4 differentially alter markers of inflammation, adhesion and angiogenesis by monocytes from women with pre-eclampsia in co-culture with endothelial cells. J Reprod Immunol. 2017 Jun;121:26-33. doi: 10.1016/j.jri.2017.05.002. Epub 2017 May 25. PubMed PMID: 2855.
    10. Wang JY, Healey T, Barker A, Brown B, Monk C, Anumba D. Magnetic induction spectroscopy (MIS)-probe design for cervical tissue measurements. Physiol Meas. 2017 May;38(5):729-744. doi: 10.1088/1361-6579/aa6b4e. Epub 2017 Apr 27. PubMed PMID: 28448273.
    11. Lashkari B, Anumba DO. Estradiol alters the immune-responsiveness of cervical epithelial cells stimulated with ligands of Toll-like receptors 2 and 4. PLoS One. 2017 Mar 15;12(3):e0173646. doi: 10.1371/journal.pone.0173646.eCollection 2017. PubMed PMID: 28296959; PubMed Central PMCID: PMC5351915.
    12. Amabebe E, Reynolds S, Stern VL, Parker JL, Stafford GP, Paley, MN, & Anumba DOC. Identifying metabolite markers for preterm birth in cervicovaginal fluid by magnetic resonance spectroscopy. Metabolomics, 2016. 12(4), 1-11. doi: 10.1007/s11306-016-0985-x
    13. Lashkari BS, Shahana S, Anumba DO. Toll-like receptor 2 and 4 expression in the pregnant and non-pregnant human uterine cervix. J Reprod Immunol. 2015 Feb;107:43-51. doi: 10.1016/j.jri.2014.10.001. Epub 2014 Nov 5. PubMed PMID: 25467401
    14. Haddrill R, Jones GL, Mitchell CA, Anumba DO. Understanding delayed access to antenatal care: a qualitative interview study. BMC Pregnancy Childbirth. 2014 Jun 16;14:207. doi: 10.1186/1471-2393-14-207. PubMed PMID: 24935100; PubMed Central PMCID: PMC4072485
    15. Al-ofi E, Coffelt SB, Anumba DO. Fibrinogen, an endogenous ligand of Toll-like receptor 4, activates monocytes in pre-eclamptic patients. J Reprod Immunol. 2014 Jun;103:23-8. doi: 10.1016/j.jri.2014.02.004. Epub 2014 Mar 1. PubMed PMID: 24661950
    16. Chappell LC, Duckworth S, Seed PT, Griffin M, Myers J, Mackillop L, Simpson N, Waugh J, Anumba D, Kenny LC, Redman CW, Shennan AH. Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter study. Circulation. 2013 Nov 5;128(19):2121-31. doi: 10.1161/CIRCULATIONAHA.113.003215. PubMed PMID: 24190934.
    17. Anumba DO. Errors in prenatal diagnosis. Best Pract Res Clin Obstet Gynaecol. 2013 Aug;27(4):537-48. doi: 10.1016/j.bpobgyn.2013.04.007. Epub 2013 May 30. Review. PubMed PMID: 23725900
    18. Al-ofi E, Coffelt SB, Anumba DO. Monocyte subpopulations from pre-eclamptic patients are abnormally skewed and exhibit exaggerated responses to Toll-like receptor ligands. PLoS One 2012;7(7):e42217. Epub 2012 Jul 27
    19. Ghule, VV, Gray, C, Galimberti, A, and Anumba, DO (2012) Prostaglandin-induced cervical remodelling in humans in the first trimester is associated with increased expression of specific tight junction, but not gap junction proteins. Journal of Translational Medicine Mar 7;10:40
    20. Jones, GL, Morrell, CJ, Cooke, JM, Speier, D, Anumba, D, Stewart-Brown, S (2011) The development of two postnatal health instruments: one for mothers (M-PHI) and one for fathers (F-PHI) to measure health during the first year of parenting. Quality of Life Research 20:1011-22

    For a full list of publications please visit myPublications