Finding alternatives

We are improving the way that we carry out our animal research and actively seeking alternatives.

We've pioneered a number of initiatives to reduce the number of animals used in research around the world, including:

Shared Ageing Research Models (Sharm)

The unique research facility is helping to accelerate revolutionary studies into ageing while at the same as reducing the number of mouse models required for the leading research.

Ageing is the major risk factor for diseases such as Alzheimer's, arthritis and cancer.


Sheffield has become the UK's principal centre for In silico medicine (also known as computational medicine) which is the application of in silico research to problems involving health and medicine, using computer simulation in the diagnosis, treatment, or prevention of a disease.

More specifically, in silico medicine is characterised by modelling, simulation, and visualisation of biological and medical processes in computers with the goal of simulating real biological processes in a virtual environment.

This is almost certainly the most sophisticated application of computing technology in healthcare.

Tissue culture

We're at the forefront of exploiting tissue culture as an effective way of producing large amounts of high quality antibodies for medical research, reducing the number of animals needed.

We've received grants from the National Centre for the Replacement, Refinement and Reduction of Animals in Research to fund further antibody-related research and for other work aimed at refining existing animal models of disease.