Dr Munya Dimairo

BSc (Hons) (Statistics), MSc (Medical Statistics), PhD (Medical Statistics)

School of Health and Related Research

Senior Research Fellow/ Statistician

Munya Dimairo
m.dimairo@sheffield.ac.uk
+44 114 222 5204

Full contact details

Dr Munya Dimairo
School of Health and Related Research
3.06
The Innovation Centre
217 Portobello
Sheffield
S1 4DP
Profile

Munya leads statistical support in the design, conduct, monitoring, analysis, and reporting of studies (mostly clinical trials) within the University of Sheffield Clinical Trials Research Unit (CTRU). This includes overseeing multiple projects that are at various stages to ensure high-quality delivery. He also supports research proposal development of research for funding. In addition, Munya leads and collaborates on methodological research aimed at improving efficiency in the conduct of trials as well as the implementation of innovative and efficient designs within the unit, such as adaptive trial designs. His vast research interests are around innovative clinical trials statistical methodology and their translation into routine practice. He serves as an independent statistician on trial steering and data monitoring committees of several publicly funded clinical trials.

Munya holds a BSc (Hons) in Statistics from the University of Zimbabwe, an MSc in Medical Statistics from the London School of Hygiene and Tropical Medicine (funded by Wellcome Trust), and a PhD in Medical Statistics from the University of Sheffield (funded by the NIHR, DRF-2012-05-182). His PhD investigated the utility of adaptive designs in publicly funded confirmatory trials.

Munya is based in the Design, Trials and Statistics (DTS) section within ScHARR.

Qualifications

BSc (Hons) (Statistics), MSc (Medical Statistics), PhD (Medical Statistics)

Research interests
  • Clinical trials methodology
  • Adaptive designs, especially group sequential methods and treatment selection in multi-arm and platform trials
  • Transparency and reporting of adaptive trials
  • Statistical issues around the application of a stepped wedge trial design
  • Bayesian inference and borrowing of information in clinical trials
  • Early phase clinical trials
  • Diagnostic accuracy studies
  • Hierarchical or Multilevel modelling
  • Multiple imputation techniques in dealing with missing data
Publications

Show: Featured publications All publications

Journal articles

Conference proceedings papers

  • Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D , Hamasaki T et al (2017) Journeying through the development of an adaptive designs reporting guidance: findings from Delphi process. CEN ISBS Vienna 2017 (pp 94-94), 28 August 2017 - 1 September 2017. RIS download Bibtex download
  • Dimairo M, Todd S, Julious S, Jaki T, Wason J, Mander A, Hind D, Weir C, Koenig F, Altman D , Nicholl J et al (2017) Journeying through the development of an adaptive designs reporting guidance: preliminary findings. Evidence Live 2017 (pp 42-43), 21 June 2017 - 22 June 2017. RIS download Bibtex download
  • Dimairo M, Julious S, Todd S & Nicholl J (2015) Meandering journey towards routine trial adaptation: survey results on barriers to use of adaptive designs in confirmatory trials. Trials, Vol. 16(S2) View this article in WRRO RIS download Bibtex download
  • Dimairo M, Stevely A, Todd S, Julious S, Nicholl J, Hind D & Cooper C (2015) Investigation of the shortcomings of the consort 2010 statement for the reporting of group sequential randomised controlled trials. Trials, Vol. 16(S2) View this article in WRRO RIS download Bibtex download
  • Dimairo M, Stevely A, Julious S, Todd S, Cooper C, Hind D & Nicholl J (2015) Differential reporting of group sequential RCTs: shortcomings ofthe CONSORT 2010 statement. CPS 11: Group Sequential Methods and Interim Analysis. ARLINGTON, VIRGINIA, USA, 17 May 2015 - 20 May 2015. RIS download Bibtex download
  • Dimairo M, Bradburn M & Walters SJ (2011) Sample size determination through power simulation; practical lessons from a stepped wedge cluster randomised trial (SW CRT).. Trials, Vol. 12 Suppl 1 (pp A26) RIS download Bibtex download
  • Dimairo M, Mativenga S, Dauya E, Mungofa S, Makamure B, Mason P, Mangwanya D, Walley J & Corbett EL (2009) The Fate of Sputum Smear-negative TB Suspects Managed by Routine Clinical Services in Harare, Zimbabwe. 16th Conference on Retroviruses and Opportunistic Infections, Vol. 17(2). Montreal; Canada RIS download Bibtex download
  • MacPherson P, Dimairo M, Bandason T, Zezai A, Munyati S, Mungofa S, Rusikaniko S, Fielding K, Mason P & Corbett EL () Risk Factors and Timing of Mortality in HIV+ Smear-negative TB Suspects: 12-Month Cohort Study in Harare, Zimbabwe. 18th Conference on Retroviruses and Opportunistic Infections, Montreal. Boston, USA, 27 February 2011 - 2 March 2011. RIS download Bibtex download

Website content

Posters

  • Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D , Nicholl J et al (2017) Journeying through the development of a consensus-driven adaptive designs reporting guidance. Global Forum on Bioethics in Research. View this article in WRRO RIS download Bibtex download
  • Candlish J, Teare D, Cohen J, Dimairo M, Flight L, Mandefield L & Walters S (2017) Methods to analyse partially nested randomised controlled trials. RIS download Bibtex download

Theses / Dissertations

  • Dimairo M (2016) The Utility of Adaptive Designs in Publicly Funded Confirmatory Trials. RIS download Bibtex download

All publications

Journal articles

Conference proceedings papers

Website content

Posters

  • Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D , Nicholl J et al (2017) Journeying through the development of a consensus-driven adaptive designs reporting guidance. Global Forum on Bioethics in Research. View this article in WRRO RIS download Bibtex download
  • Candlish J, Teare D, Cohen J, Dimairo M, Flight L, Mandefield L & Walters S (2017) Methods to analyse partially nested randomised controlled trials. RIS download Bibtex download

Theses / Dissertations

  • Dimairo M (2016) The Utility of Adaptive Designs in Publicly Funded Confirmatory Trials. RIS download Bibtex download

Datasets

Grants
  • Double-blinded placebo control study of Mesenchymal Intravenous Stromal cell Infusions in children with recessive dystrophic Epidermolysis Bullosa (MissionEB). NIHR (NIHR127963). Co-applicant. £2,451,255.
  • MICA: Early Phase Dose-finding Trials: Development of reporting guidance to improve knowledge transfer. MRC (MR/T044934/1). Co-applicant. £306,579.
  • STOP-OHSS (Shaping and Trialling Outpatient Protocols for Ovarian Hyper-Stimulation Syndrome): A feasibility study and randomised controlled trial, with internal pilot, to assess the clinical and cost-effectiveness of earlier active management of OHSS. NIHR HTA (NIHR128137). Co-applicant. £1,782,753.
  • A Practical Adaptive & Novel Design and Analysis (PANDA) toolkit. NIHR CTU Support Funding (NIHR129761). Lead Investigator. £98,886.
  • Costing Adaptive Trials (CAT): developing best practice costing guidance for CTUs supporting adaptive trials. NIHR CTU Support Funding (NIHR130351). Co-applicant. £55,629.
  • Development of CONSORT guidance for adaptive clinical trials. NIHR CTU Support Funding (NIHR129671) and MRC HTMR (MR/L004933/1-R/N/P/B1). Lead Investigator in collaboration with the MRC HTMR Adaptive Designs Working Group, CONSORT Group and international researchers. £63,000.
  • Utility of adaptive designs in publicly funded trials. NIHR Doctoral Research Fellowship (DRF-2012-05-182). Lead investigator. £206,221.
  • NHS England Specialised Commissioning – NIHR 2018 Funding Call for CTUs. Co-applicant. £13 961.
  • Outcome Measures for Emergency Care after a Seizure (OMECS): NIHR CTU Support Funding. (NIHR129743). Co-applicant. £9,852.
  • Can Physiotherapy effectively treat patients with Lumbar Radicular Syndrome secondary to MRI demonstrable disc prolapse? A preliminary randomised trial of patients awaiting lumbar micro-discectomy. NIHR RfPB (PB-PG-0110-21158). Co-applicant. £197,129.
  • Nutritional Rehabilitation in Stable Chronic Obstructive Pulmonary Disease (COPD) – A randomised controlled pilot trial. CLAHRC South Yorkshire. Co-applicant. £28,170.
  • Masters Fellowship in Public Health and Tropical Medicine at LSHTM. Wellcome Trust (085840/Z/08/Z). Lead Investigator. £75,919.
Teaching interests

Supervision of postgraduate research students in areas around trials and statistical methods.

Professional activities
  • Trials Associate Editor
  • Member of the BMC Medicine Editorial Board
  • Member of the Research Square Advisory Board
  • Member of the ICTMC Scientific Committee
  • Member of the MRC/NIHR TMRP ADWG
  • Advisory board member of The Bill & Melinda Gates Foundation on adaptive trials in low- and middle-income countries
  • Reviewer of grant proposals for publicly funding bodies such as NIHR and MRC
  • Independent Trial Statistician on trial steering and data monitoring committees
  • Independent statistical reviewer for several journals including the BMJ, The Lancet, and The Lancet Infectious Diseases
  • Member of the NIHR HTA CET Funding Committee