Dr Munya Dimairo

BSc (Hons) (Statistics), MSc (Medical Statistics), PhD (Medical Statistics)

School of Health and Related Research

Research Fellow

Munya Dimairo
m.dimairo@sheffield.ac.uk
+44 114 222 5204

Full contact details

Dr Munya Dimairo
School of Health and Related Research
3.06
The Innovation Centre
217 Portobello
Sheffield
S1 4DP
Profile

My vast research interests are in innovative clinical trials statistical methodology. I joined the University of Sheffield in 2009 and have been involved in the design, monitoring, modelling and analysis of clinical trials within the Sheffield CTRU. I have also been providing statistical advice in research design for grant applications for researchers through the NIHR-RDS for Yorkshire and the Humber region as a Medical Statistician. Prior to this, I have worked in TB and HIV related research as a statistician and in data management responsible for Smear Negative and TB Diagnostic studies at the Biomedical Research and Training Institute under DETECTB Project.

I graduated with a BSc (Hons) in Statistics from the University of Zimbabwe, an MSc in Medical Statistics from the London School of Hygiene and Tropical Medicine funded by Wellcome Trust and a PhD in Medical Statistics from the University of Sheffield funded by NIHR as part of a Doctoral Research Fellowship (DRF-2012-05-182). My PhD investigated “The Utility of Adaptive Designs in Publicly Funded Confirmatory Trials” (http://etheses.whiterose.ac.uk/13981/). I am involved in proposal development, clinical trials statistical support of a number of trials within the Sheffield CTU, and research on innovative statistical methods to improve efficiency in the design and conduct of clinical trials. I am currently leading two adaptive designs projects: the development of a CONSORT extension to enhance the reporting of adaptive clinical trials in collaboration with international researchers, CONSORT Executive Group, and MRC HTMR Adaptive Designs Working Group (The ACE Project); and the development of an online practical educational platform on adaptive designs (The PANDA project).

I am based in the Design, Trials and Statistics (DTS) section within ScHARR.

Current and Previous Trials

  • The PANDA Project: Practical Adaptive & Novel Designs and Analysis Toolkit
  • The ACE Project: Adaptive Designs CONSORT Extension
  • Big CACTUS: A study to assess the clinical and cost effectiveness of aphasia computer treatment versus usual stimulation or attention control long term post stroke (CACTUS)
  • Endometrial Scratch: The Endometrial Scratch Trial
  • OPTION-DM: Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus trial
  • REPOSE: The Relative Effectiveness of Pumps over MDI and Structured Education for Type-1 Diabetes
  • Booster Trial: A randomised controlled trial and cost-effectiveness evaluation of 'booster' interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods
  • CACTUS: Evaluating the cost effectiveness of computer therapy compared with usual stimulation for people with long standing aphasia: a pilot study
  • CoSMoS: CBT Software for the treatment of depression in people with MS
Research interests
  • Clinical trials methodology
  • Adaptive designs, especially group sequential methods and treatment selection in multi-arm trials
  • Transparency and reporting of adaptive trials
  • Statistical issues around the application of a stepped wedge trial design
  • Diagnostic accuracy studies
  • Hierarchical or Multilevel modelling
  • Multiple imputation techniques in dealing with missing data
  • Bayesian inference in small clinical trials
Publications

Show: Featured publications All publications

Journal articles

Conference proceedings papers

  • Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D , Hamasaki T et al (2017) Journeying through the development of an adaptive designs reporting guidance: findings from Delphi process. CEN ISBS Vienna 2017 (pp 94-94), 28 August 2017 - 1 September 2017. RIS download Bibtex download
  • Dimairo M, Todd S, Julious S, Jaki T, Wason J, Mander A, Hind D, Weir C, Koenig F, Altman D , Nicholl J et al (2017) Journeying through the development of an adaptive designs reporting guidance: preliminary findings. Evidence Live 2017 (pp 42-43), 21 June 2017 - 22 June 2017. RIS download Bibtex download
  • Dimairo M, Julious S, Todd S & Nicholl J (2015) Meandering journey towards routine trial adaptation: survey results on barriers to use of adaptive designs in confirmatory trials. Trials, Vol. 16(S2) View this article in WRRO RIS download Bibtex download
  • Dimairo M, Stevely A, Todd S, Julious S, Nicholl J, Hind D & Cooper C (2015) Investigation of the shortcomings of the consort 2010 statement for the reporting of group sequential randomised controlled trials. Trials, Vol. 16(S2) View this article in WRRO RIS download Bibtex download
  • Dimairo M, Stevely A, Julious S, Todd S, Cooper C, Hind D & Nicholl J (2015) Differential reporting of group sequential RCTs: shortcomings ofthe CONSORT 2010 statement. CPS 11: Group Sequential Methods and Interim Analysis. ARLINGTON, VIRGINIA, USA, 17 May 2015 - 20 May 2015. RIS download Bibtex download
  • Dimairo M, Bradburn M & Walters SJ (2011) Sample size determination through power simulation; practical lessons from a stepped wedge cluster randomised trial (SW CRT).. Trials, Vol. 12 Suppl 1 (pp A26) RIS download Bibtex download
  • Dimairo M, Mativenga S, Dauya E, Mungofa S, Makamure B, Mason P, Mangwanya D, Walley J & Corbett EL (2009) The Fate of Sputum Smear-negative TB Suspects Managed by Routine Clinical Services in Harare, Zimbabwe. 16th Conference on Retroviruses and Opportunistic Infections, Vol. 17(2). Montreal; Canada RIS download Bibtex download
  • MacPherson P, Dimairo M, Bandason T, Zezai A, Munyati S, Mungofa S, Rusikaniko S, Fielding K, Mason P & Corbett EL () Risk Factors and Timing of Mortality in HIV+ Smear-negative TB Suspects: 12-Month Cohort Study in Harare, Zimbabwe. 18th Conference on Retroviruses and Opportunistic Infections, Montreal. Boston, USA, 27 February 2011 - 2 March 2011. RIS download Bibtex download

Website content

Posters

  • Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D , Nicholl J et al (2017) Journeying through the development of a consensus-driven adaptive designs reporting guidance. Global Forum on Bioethics in Research. View this article in WRRO RIS download Bibtex download
  • Candlish J, Teare D, Cohen J, Dimairo M, Flight L, Mandefield L & Walters S (2017) Methods to analyse partially nested randomised controlled trials. RIS download Bibtex download

Theses / Dissertations

  • Dimairo M (2016) The Utility of Adaptive Designs in Publicly Funded Confirmatory Trials. RIS download Bibtex download

All publications

Journal articles

Conference proceedings papers

Website content

Posters

  • Dimairo M, Todd S, Julious S, Jaki T, Wason J, Hind D, Mander A, Weir C, Koenig F, Altman D , Nicholl J et al (2017) Journeying through the development of a consensus-driven adaptive designs reporting guidance. Global Forum on Bioethics in Research. View this article in WRRO RIS download Bibtex download
  • Candlish J, Teare D, Cohen J, Dimairo M, Flight L, Mandefield L & Walters S (2017) Methods to analyse partially nested randomised controlled trials. RIS download Bibtex download

Theses / Dissertations

  • Dimairo M (2016) The Utility of Adaptive Designs in Publicly Funded Confirmatory Trials. RIS download Bibtex download

Datasets

Grants
  • NIHR CTU Support Funding: Practical Adaptive & Novel Designs and Analysis (PANDA) Toolkit (The PANDA project). Lead Investigator in collaboration with University of Sheffield colleagues, Cardiff University, Lancaster University, University College London, and the University of Western Australia (££98,886).
  • NIHR CTU Support Funding: The development of a CONSORT guidance tailored for adaptive clinical trials (The ACE Project). Lead Investigator in collaboration with the MRC HTMR Adaptive Designs Working Group, CONSORT Group and international researchers (£50,000)
  • NIHR Doctoral Research Fellowship (PDF, 58KB) (DRF-2012-05-182): Utility of adaptive designs in publicly funded trials; PI: Dimairo M; Co-applicants and supervisors: Prof Julious SA, Prof Nicholl J and Prof Todd SC. £206,221
  • Wellcome Trust: Masters Fellowship in Public Health and Tropical Medicine at LSHTM; PI: Dimairo M; Co-applicants and supervisors; Corbett EL and Fielding K. £75,919
  • NIHR RfPB: Can Physiotherapy effectively treat patients with Lumbar Radicular Syndrome secondary to MRI demonstrable disc prolapse? A preliminary randomised trial of patients awaiting lumbar micro-discectomy. Co-Principal Investigators; Newsome R and Reddington M; Co Investigators: Breakwell L, Chiverton N, Cole A, Boote J, Dimairo M. £197,129
  • CLAHRC South Yorkshire: Nutritional Rehabilitation in Stable Chronic Obstructive Pulmonary Disease (COPD) - A randomised controlled pilot trial. Kyi M, Parker S, Dimairo M. £28,170
Professional activities
  • Reviewer of grant proposals for publicly funding bodies (NIHR and MRC)
  • Trials Associate Editor
  • Independent TSC and DMEC Trial Statistician
  • Independent reviewer for a number of journals including BMJ, BMJ Open, The Lancet, The Lancet Infectious Diseases, Trials, and Pilot and Feasibility Studies
  • Member of the MRC HTMR ADWG
  • Advisory board member of The Bill & Melinda Gates Foundation on adaptive trials in low- and middle-income countries (LMIC)