DAFNEplus: Developing and trialling the DAFNEplus (Dose Adjustment for Normal Eating) intervention. A lifelong approach to promote effective self-management in adults with type 1 diabetes
CTRU and ScHARR staff have been awarded a five and half year programme grant from the NIHR (National Institute for Health Research) Programme Grants for Applied Research. The aim of this £2.7 million programme is to re-develop and evaluate the DAFNE programme to help people with type 1 diabetes to better manage their condition in line with their lifestyle.
The DAFNEplus research programme involves research groups from across the UK, and is led by Professor Simon Heller, Professor of Clinical Diabetes at the University of Sheffield and Research and Development Director at Sheffield Teaching Hospitals NHS Foundation Trust.
This project will see the introduction of a number of programmes, models and improvements to the existing DAFNE programme. By combining behaviour change techniques and a structured model of support with new technology (such as smartphones and apps), the aim is that adult sufferers will be supported and motivated to manage their own conditions as part of their everyday lives in the longer term.
Once the research has completed, the aim is to provide the full programme as a sustained model of support rather than an initial standalone course. A number of multi-disciplinary workstreams, outlined below, will develop the intervention before the pilot study with three centres, starts in March 2017:
Workstream 1: Revising the DAFNE Curriculum (Lead: Professor Simon Heller)
Workstream 2: Developing structured support (Leads: Dr David Hopkins; Dr Peter Mansell)
Workstream 3: Technology (Lead: Dr Jackie Elliott)
If the pilot is successful, this will be followed by a 14 centre cluster randomised controlled trial (RCT) starting in September 2018. The large scale trial plans to recruit 660 patients to assess the effectiveness and cost-effectiveness of DAFNEplus. The primary outcome is blood glucose control, as well as quality of life and relevant psychological outcomes. The RCT also includes a qualitative sub-study and assessment of intervention fidelity.
Central Study Staff
|Professor Simon Heller||Chief Investigator||Sheffield Teaching Hospitals NHS Foundation Trust / University of Sheffieldemail@example.com|
|Elaine Scott||Study Manager||University of Sheffieldfirstname.lastname@example.org|
|Becky Brown||Trials Support Officer||University of Sheffieldemail@example.com|
|Prof Cindy Cooper
||CTRU Oversight||University of Sheffieldfirstname.lastname@example.org|
University of Sheffield
|Senior Trial Manager||University of Sheffieldemail@example.com|
|Professor Stephanie Amiel||RD Lawrence Professor of Diabetic Medicine||King’s College London|
|Professor Wendy Baird||Professor of Health Services Research||University of Sheffield|
|Dr Mohammed Benaissa||Senior Lecturer||University of Sheffield|
|Professor Alan Brennan||Professor of Health Economics and Decision Modelling||University of Sheffield|
|Professor Michael Campbell||Professor of Medical Statistics||University of Sheffield|
|Dr Debbie Cooke||Senior Lecturer||University of Sheffield|
|Dr Jackie Elliott||Senior Lecturer / Consultant Diabetologist||University of Sheffield|
|Simon Fisher||Patient Representative||DAFNE Online|
|Dr David Hopkins||Senior Consultant Physician||King’s College Hospital NHS Foundation Trust|
|Professor Julia Lawton||Professor of Health and Social Science||University of Edinburgh|
|Dr Peter Mansell||Consultant in General Medicine, Diabetes and Endocrinology||Nottingham University Hospitals NHS Trust|
|Professor Susan Michie||Professor of Health Psychology||University College London|
|Professor Jane Speight||Professor of Behavioural and Social Research in Diabetes||Deakin University, Australia|
|Carolin Taylor||DAFNE Educator and Diabetes Specialist Nurse||Sheffield Teaching Hospitals NHS Foundation Trust|
|Gill Thompson||National DAFNE Collaborative Manager||Northumbria Healthcare NHS Foundation Trust|
|Professor Lucy Yardley||Professor of Health Psychology||University of Southampton|