Nikki TottonNikki Totton

Medical Statistician - Research Fellow

Clinical Trials Research Unit, ScHARR
University of Sheffield
Regent Court
30 Regent Street
S1 4DA

Office: Room 3.10, Innovation Centre
Tel: +44 (0) 114 22 25450
Fax: +44 (0) 114 22 20870

Email :


I joined the CTRU as a Medical Statistician in July 2017 after working for NWORTH (Bangor University's Clinical Trial Unit) as a Trial Statistician. I have a BSc in Mathematics and an MSc in Statistics and Management Science, both from the University of the West of England, Bristol.

I currently work on a number of clinical trials, as well as methodology projects and as a statistical advisor for the Research Design Service Yorkshire & Humber

Current Projects

I am currently involved with the following projects:

  • CFHealthHub Data Observatory - A Quality Improvement project and Trials within Cohort platform for Cystic Fibrosis.
  • MAGIC – Melatonin for Anxiety prior to General anaesthesia In Children): A Randomised Controlled Trial of Melatonin Versus Midazolam in the Premedication of Anxious Children Attending for Elective Dental and ENT Surgery Under General Anaesthesia.
  • DAFNEplus - Developing and trialling the DAFNEplus (Dose Adjustment for Normal Eating) intervention. A lifelong approach to promote effective self-management in adults with type 1 diabetes.
  • BRAINS - Benefit-Risk Assessment to Inform Non-Inferiority and Superiority study design: Guidance on the optimal design within different-in-kind of comparisons.  
  • PoPSTER - Patient preferences and current Practice for adults with STERoid resistant ulcerative colitis.
  • IDEA - The Invasive Dentistry – Endocarditis Association Study.

Research Interests

My main area of research interest is in the use of benefit-risk methods within publicly funded trials which includes an interest in the design and analysis of non-inferiority studies.
Other areas of research interests are: the design of pilot and feasibility studies, sample size calculations for analysis of covariate models and multi-arm studies.


I tutor on the HAR6036 - Applications of Statistics in the Medical and Health Sciences (Co-ordinated by Richard Jacques) for the Intercalated MBChB students.
I am an active MSc supervisor and am interested in proposals in the area of non-inferiority clinical trials, benefit-risk methodologies in trials or pilot/feasibility subjects.

Professional Activities

• Statistical member on four independent committees for external trials
• Peer reviewer for Emergency Medicine Journal and Journal of Pilot and Feasibility Studies
• Grant application and final report reviewer for NIHR Health Technology Assessment
• Statistical reviewer for Versus Arthritis and Association Breast Surgery grant applications

Nikki is part of Design, Trials and Statistics

Journal articles

Conference proceedings papers


  • Totton NV & White P (2011) The Ubiquitous Mythical Normal Distribution RIS download Bibtex download


  • Brand A (2017) An online tool for exploring recruitment achievability for a feasibility and pilot studies in the UK. 4th International Clinical Trials Methodology Conference (ICTM) and 38th Annual Meeting of the Socie. RIS download Bibtex download