Medical Statistician - Research Fellow
Clinical Trials Research Unit, ScHARR
University of Sheffield
30 Regent Street
Office: Room 3.10, Innovation Centre
Tel: +44 (0) 114 22 25450
Fax: +44 (0) 114 22 20870
Email : firstname.lastname@example.org
I joined the CTRU as a Medical Statistician in July 2017 after working for NWORTH (Bangor University's Clinical Trial Unit) as a Trial Statistician. I have a BSc in Mathematics and an MSc in Statistics and Management Science, both from the University of the West of England, Bristol.
I currently work on a number of clinical trials, as well as methodology projects and as a statistical advisor for the Research Design Service Yorkshire & Humber
I am currently involved with the following projects:
- CFHealthHub Data Observatory - A Quality Improvement project and Trials within Cohort platform for Cystic Fibrosis.
- MAGIC – Melatonin for Anxiety prior to General anaesthesia In Children): A Randomised Controlled Trial of Melatonin Versus Midazolam in the Premedication of Anxious Children Attending for Elective Dental and ENT Surgery Under General Anaesthesia.
- DAFNEplus - Developing and trialling the DAFNEplus (Dose Adjustment for Normal Eating) intervention. A lifelong approach to promote effective self-management in adults with type 1 diabetes.
- BRAINS - Benefit-Risk Assessment to Inform Non-Inferiority and Superiority study design: Guidance on the optimal design within different-in-kind of comparisons.
- PoPSTER - Patient preferences and current Practice for adults with STERoid resistant ulcerative colitis.
- IDEA - The Invasive Dentistry – Endocarditis Association Study.
My main area of research interest is in the use of benefit-risk methods within publicly funded trials which includes an interest in the design and analysis of non-inferiority studies.
Other areas of research interests are: the design of pilot and feasibility studies, sample size calculations for analysis of covariate models and multi-arm studies.
I tutor on the HAR6036 - Applications of Statistics in the Medical and Health Sciences (Co-ordinated by Richard Jacques) for the Intercalated MBChB students.
I am an active MSc supervisor and am interested in proposals in the area of non-inferiority clinical trials, benefit-risk methodologies in trials or pilot/feasibility subjects.
• Statistical member on four independent committees for external trials
• Peer reviewer for Emergency Medicine Journal and Journal of Pilot and Feasibility Studies
• Grant application and final report reviewer for NIHR Health Technology Assessment
• Statistical reviewer for Versus Arthritis and Association Breast Surgery grant applications
Nikki is part of Design, Trials and Statistics
- Correction to: Sample size estimation for randomised controlled trials with repeated assessment of patient-reported outcomes: what correlation between baseline and follow-up outcomes should we assume?. Trials, 20(1).
- Sample size estimation for randomised controlled trials with repeated assessment of patient-reported outcomes : what correlation between baseline and follow-up outcomes should we assume?. Trials, 20(1). View this article in WRRO
- Improved adenoma detection with Endocuff Vision: the ADENOMA randomised controlled trial. Gut, 68(2), 280-288.
- Mixed methods process evaluation of an enhanced community-based rehabilitation intervention for elderly patients with hip fracture. BMJ Open, 8(8). View this article in WRRO
- The B-ADENOMA Study: Bowelscope – Accuracy of Detection using Endocuff Optimisation of Mucosal Abnormalities: Study Protocol for randomised controlled trial. Endoscopy International Open, 06(07), E872-E877.
- Hip fracture in the elderly multidisciplinary rehabilitation (FEMuR) feasibility study: Testing the use of routinely collected data for future health economic evaluations. Pilot and Feasibility Studies, 4(1). View this article in WRRO
- Trial of Optimal Personalised Care After Treatment - Gynaecological Cancer (TOPCAT-G): A randomized feasibility trial. International Journal of Gynecological Cancer, 28(2), 401-411. View this article in WRRO
- Trial of Optimal Personalised Care After Treatment for Gynaecological cancer (TOPCAT-G): a study protocol for a randomised feasibility trial. Pilot and Feasibility Studies, 2(1). View this article in WRRO
- Fracture in the Elderly Multidisciplinary Rehabilitation (FEMuR): a phase II randomised feasibility study of a multidisciplinary rehabilitation package following hip fracture. BMJ Open, 6(10). View this article in WRRO
Conference proceedings papers
- MRC-NIHR Methodology guideline development on utilising benefit-risk assessments within clinical trials. Trials, Vol. 20(Supplement 1) (pp 93-93). Brighton, UK, 6 October 2019 - 9 October 2019. View this article in WRRO
- An online tool for exploring recruitment achievability for a feasibility and pilot studies in the UK. 4th International Clinical Trials Methodology Conference (ICTM) and 38th Annual Meeting of the Socie.