Nikki Totton

Medical Statistician

Clinical Trials Research Unit, ScHARR
University of Sheffield
Regent Court
30 Regent Street
S1 4DA

Office: Room 3.10, Innovation Centre
Tel: +44 (0) 114 22 25450
Fax: +44 (0) 114 22 20870

Email :


I joined the CTRU as a Medical Statistician in July 2017 after working for NWORTH (Bangor University's Clinical Trial Unit) as a Trial Statistician.  I have a BSc in Mathematics and an MSc in Statistics and Management Science, both from the University of the West of England, Bristol.

Current Projects

I am currently involved with the following projects:

  • CFHealthHub Data Observatory - A Quality Improvement project and Trials within Cohort platform for Cystic Fibrosis
  • IDEA – The Invasive Dentistry – Endocarditis Association Study
  • COMMEND – A feasibility study and randomised controlled trial of acceptance and COMmitment therapy for people with Motor nEuron Disease
  • MAGIC – Melatonin for Anxiety prior to General anaesthesia In Children): A Randomised Controlled Trial of Melatonin Versus Midazolam in the Premedication of Anxious Children Attending for Elective Dental and ENT Surgery Under General Anaesthesia

Research Interests

My areas of research interests are: clinical trial methodology, pilot and feasibility studies and trials for complex interventions.

Nikki is part of Design, Trials and Statistics

Journal articles


  • Totton NV & White P (2011) The Ubiquitous Mythical Normal Distribution RIS download Bibtex download


  • Brand A (2017) An online tool for exploring recruitment achievability for a feasibility and pilot studies in the UK. 4th International Clinical Trials Methodology Conference (ICTM) and 38th Annual Meeting of the Socie. RIS download Bibtex download