Professor Steven A Julious BSc(Hons) MSc PhD

Professor of Medical Statistics stevenj

Section Director

Medical Statistics Group, ScHARR
The University of Sheffield
Regent Court, 30 Regent Street

Tel: +44 (0) 114 222 0709
Fax: +44 (0) 114 222 0749



PA: Rebecca Swift

Working pattern: Tuesday and Wednesday 9.30am-4.00pm and Thursday 9.30am-3.30pm

Tel: +44(0)114 22 22988     Email:


I graduated with a BSc (Hons) in Mathematics, Statistics and Operational Research (MSOR) from the University of Manchester Institute of Science and Technology (UMIST) and an MSc in Biometry from the University of Reading. For my PhD from University College London, which I did part time while working in industry, I investigated the issue of designing clinical trials when you have imprecise estimates to base calculations on.

Statistically I have an interest in all aspects of clinical trials from molecule through to marketplace. My main research focus is clinical trial design and the development of applied methods related to clinical trials. I have a particular interest around adaptive designs and the implementation of adaptive designs into practice

The methodologies around sample size estimation are a particular interest and as well as a book I have developed a mobile app for the calculations called SampSize.

I also have an interest in asthma epidemiology and I am the Chief Investigator of the PLEASANT trial: Preventing and Lessening Exacerbations of Asthma in School-age children Associated with a New Term.

Research interests

My research interest include:

  • Clinical trials
  • Clinical trial design
  • Early phase trials
  • Non-inferiority
  • Asthma epidemiology

Teaching activities

My teaching activities include:

• ScHARR Director for the MSc in Statistics with Medical Applications
• Module co-ordinator for HAR6036 including Intercalated BMedSci Medical Students
• Module co-ordinator MAS6062 Further Clinical Trials for the MSc in Statistics with Medical Applications
• Teach on HAR6035

Professional activities

External to the university I was a Member of NICE appraisal Committee D and I am on the editorial board of the journals Pharmaceutical Statistics and Statistical Methods in Medical Research.

Within the university I am a member of the University Diversity Committee and ScHARR Research Committee.

Current projects

Chief Investigator

• NHS Health Technology Assessment Programme. Preventing and Lessening Exacerbations of Asthma in School-age children Associated with a New Term (PLEASANT). Julious SA, Horspool M, Boote J, Smithson H, Elphick H, van Staa T, Davis S, Norman P and Cooper CL. £486,500.
• NIHR Research Methods Fellowship. Adaptive designs in publicly funded research. Goodacre S and Julious SA. £91,000, 2013.


• NIHR Doctoral Fellowship. Adaptive designs in publicly funded research: Munya Dimairo. Dimairo M, Julious SA, Nicholl J and Todd SC. £194,000.
• Medical Research Council - National Prevention Research Initiative. Time to change! Using the transition from school to university to promote healthy lifestyle habits in young people (U@Uni). Norman P, Brennan A, Ciravegna F, Harris P, Julious SA, Meier PS, Naughton D, Petroczi A, Sheeran P and Webb T. £542,899.
• NHS Health Technology Assessment Programme. Clinical and cost effectiveness of aphasia computer therapy compared with usual stimulation or attention control long term post stroke (CACTUS). Palmer R, Julious S, Enderby P Latimer, N, Bowen A, Brady M and Cooper C. £1,379,481
• FP7-HEALTH-2013-INNOVATION-1: Integrated DEsign and AnaLysis of clinical trials in small population groups. Member of the Advisory Board of the main grant and pary of Work Package 6: Design of pharmacogenetic small population group trials including cross-over trials, n-of-1 trials and enrichment trials. 2,900,000 Euros
• Asthma UK Centre for Applied Research. Sheik A Griffiths C, Bang M, Campbell L, Ehrlich E, Barners Net al. £2,000,000, 2013


I am based in the Design, Trials and Statistics section.

Key publications

Key publications since 2008

Please click here for a full list of Steven A Julious' publications.


  • Julious S, Say-Beng T & Machin D (2010) An Introduction to Statistics in Early Phase Trials. Wiley-Blackwell. RIS download Bibtex download
  • Julious SA (2009) Samples Sizes for Clinical Trials. Chapman & Hall/CRC. RIS download Bibtex download

Journal articles


  • Dimairo M, Julious S, Bennett D & Palmer R (2018) Big CACTUS Statistical Analysis Plan v1.2 mar2018. RIS download Bibtex download