Publications
A full list of publications from members of the Clinical Infection Research Group
Publications
Journal articles
- Prevalence and risk factors for Staphylococcus aureus colonisation among healthy individuals in low- and middle-income countries: a systematic review and meta-analysis. Journal of Infection. View this article in WRRO
- Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. eClinicalMedicine, 81, 103080-103080.
- P-563. Low level viremia is associated with viral non-suppression within 96 weeks among adolescents with perinatally acquired HIV: a prospective cohort study. Open Forum Infectious Diseases, 12(Supplement_1).
- Characterization of an IL-8 cleavage inhibition assay to determine the functionality of anti-SpyCEP antibodies in human sera. Journal of Immunological Methods, 536, 113786-113786.
- Monkeypox virus isolation from longitudinal samples in 11 hospitalised patients. The Lancet Infectious Diseases, 25(1), e4-e5.
- A prospective cohort study to investigate the transmission and burden of Staphylococcus aureus in Sri Lanka. Microbial Genomics, 10(12).
- Greater preservation of SARS‐CoV‐2 neutralising antibody responses following the ChAdOx1‐S (AZD1222) vaccine compared with mRNA vaccines in haematopoietic cell transplant recipients. British Journal of Haematology. View this article in WRRO
- Microfluidic qPCR for detection of 21 common respiratory viruses in children with influenza-like illness. Scientific Reports, 14(1). View this article in WRRO
- John Phair. AIDS, 38(14), 1991-1991.
- Pre-clinical development of AP4B1 gene replacement therapy for hereditary spastic paraplegia type 47. EMBO Molecular Medicine. View this article in WRRO
- COVID-19 vaccines are effective at preventing symptomatic and severe infection among healthcare workers: A clinical review. Vaccine: X, 20, 100546-100546.
- 1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study. ERJ Open Research, 10(5). View this article in WRRO
- Association Between Vitamin D Insufficiency and Impaired Bone Density Among Adolescents With Perinatally Acquired HIV Infection. Open Forum Infectious Diseases, 11(9).
- Molecular characterization of Streptococcus pyogenes (StrepA) non-invasive isolates during the 2022–2023 UK upsurge. Microbial Genomics, 10(8).
- Effect of intra-partum azithromycin on gut microbiota development in early childhood: a post hoc analysis of a double-blind randomized trial. iScience, 110626-110626.
- Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK. The Lancet Psychiatry.
- Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study – PHOSP-COVID. ERJ Open Research, 10(4). View this article in WRRO
- Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study. The Lancet Microbe.
- Investigating the Pregnancy and Post-Partum Health Experiences of Women Living with HIV. Maternal and Child Health Journal, 1-8.
- Higher HIV-1 evolutionary rate is associated with cytotoxic T lymphocyte escape mutations in infants. Journal of Virology, 98(7).
- British
HIV Association guidelines on the management of opportunistic infection in people living withHIV : The clinical management of pulmonary opportunistic infections 2024. HIV Medicine, 25(S2), 3-37. - Closing the equity gap in the treatment of HIV-2 infection. The Lancet HIV.
- Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial. The Lancet Rheumatology, 6(6), e339-e351.
- High SARS-CoV-2 incidence and asymptomatic fraction during Delta and Omicron BA.1 waves in The Gambia. Nature Communications, 15(1). View this article in WRRO
- Streptococcus pyogenes carriage and infection within households in The Gambia: a longitudinal cohort study. The Lancet Microbe.
- A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity. Cell Reports Medicine, 101553-101553.
- Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease. Nature Immunology, 25(4), 607-621.
- Health-seeking behaviour and beliefs around sore throat in The Gambia: A qualitative study. PLOS Global Public Health, 4(3). View this article in WRRO
- Evaluating the relationship between ciprofloxacin prescription and non-susceptibility in Salmonella Typhi in Blantyre, Malawi: an observational study. The Lancet Microbe, 5(3), e226-e234.
- Efficacy and safety of autologous haematopoietic stem cell transplantation versus alemtuzumab, ocrelizumab, ofatumumab or cladribine in relapsing remitting multiple sclerosis (StarMS): protocol for a randomised controlled trial. BMJ Open, 14(2), e083582-e083582.
- Less is more: Uptake of recommended vaccines in a UK travel clinic. Journal of Infection, 88(3), 106109-106109.
- Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet Child & Adolescent Health, 8(3), 190-200. View this article in WRRO
- IL-15 reprogramming compensates for NK cell mitochondrial dysfunction in HIV-1 infection. JCI Insight, 9(4).
- Development and characterization of a hemolysis inhibition assay to determine functionality of anti-Streptolysin O antibodies in human sera. Journal of Immunological Methods, 526, 113618-113618.
- WHO global research priorities for antimicrobial resistance in human health. The Lancet Microbe, 100902-100902.
- Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19. The Journal of Infectious Diseases, 230(1), e17-e29.
- Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 14(1). View this article in WRRO
- 53 TRANSLATE TB: Transcriptional signatures for latent TB, Sheffield, UK. Clinical Infection in Practice, 20(Supplement 1). View this article in WRRO
- 44 Quantitative PCR demonstrates the underestimated burden of Streptococcus pyogenes as a cause of paediatric pyoderma in The Gambia. Clinical Infection in Practice, 20, 100304-100304.
- DC-targeting lentivectors for cancer immunotherapy. Immunotherapy Advances, 3(1).
- Human infection challenge in the pandemic era and beyond, HIC-Vac annual meeting report, 2022. Immunotherapy Advances, 3(1), ltad024.
- Streptococcus pyogenes carriage acquisition, persistence and transmission dynamics within households in The Gambia (SpyCATS): protocol for a longitudinal household cohort study. Wellcome Open Research, 8. View this article in WRRO
- Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet Diabetes & Endocrinology. View this article in WRRO
- Long COVID research: an update from the PHOSP-COVID Scientific Summit. The Lancet Respiratory Medicine, 11(11), e93-e94.
- Immunogenicity and safety of AZD2816, a beta (B.1.351) variant COVID-19 vaccine, and AZD1222 (ChAdOx1 nCoV-19) as third-dose boosters for previously vaccinated adults: a multicentre, randomised, partly double-blinded, phase 2/3 non-inferiority immunobridging study in the UK and Poland. The Lancet Microbe, 4(11), e863-e874.
- The immune evasion roles of Staphylococcus aureus protein A and impact on vaccine development. Frontiers in Cellular and Infection Microbiology, 13. View this article in WRRO
- Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study. The Lancet Respiratory Medicine.
- Early transcriptional responses to human enteric fever challenge. Infection and Immunity, 19(10). View this article in WRRO
- The effect of a comprehensive typhoid conjugate vaccine campaign on antimicrobial prescribing in children in Harare, Zimbabwe: a mixed methods study. The Lancet Global Health, 11(9), e1422-e1431.
- Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history. Nature Communications, 14(1). View this article in WRRO
- SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease. Nature Medicine, 29(7), 1760-1774. View this article in WRRO
- Repurposing an integrated national influenza platform for genomic surveillance of SARS-CoV-2 in Ghana: a molecular epidemiological analysis. The Lancet Global Health, 11(7), e1075-e1085.
- Bacterial shedding and serologic responses following an outbreak of Salmonella Typhi in an endemic cohort. BMC Infectious Diseases, 23(1).
- Omicron BA.1-containing mRNA-1273 boosters compared with the original COVID-19 vaccine in the UK: a randomised, observer-blind, active-controlled trial. The Lancet Infectious Diseases.
- Evaluating the cost implications of integrating SARS-CoV-2 genome sequencing for infection prevention and control investigation of nosocomial transmission within hospitals. Journal of Hospital Infection.
- Establishing SARS-CoV-2 membrane protein-specific antibodies as a valuable serological target via high-content microscopy. iScience, 26(7), 107056-107056.
- Streptococcus pyogenes colonization in children aged 24–59 months in the Gambia: impact of live attenuated influenza vaccine and associated serological responses. The Journal of Infectious Diseases, 228(7), 957-965. View this article in WRRO
- Rapid escape of new SARS-CoV-2 Omicron variants from BA.2-directed antibody responses. Cell Reports, 42(4).
- Persistence of immune response in heterologous COVID vaccination schedules in the Com-COV2 study – a single-blind, randomised trial incorporating mRNA, viral-vector and protein-adjuvant vaccines. Journal of Infection.
- Transitioning between clinical and academic practice from the perspectives of clinical academic trainees, academic training programme directors and academic supervisors: a mixed methods study. BMC Medical Education, 25(1).
- Reduced peri-pubertal bone density accrual among Zimbabwean males living with HIV: a longitudinal study. AIDS.
- Dynamics of the blood plasma proteome during hyperacute HIV-1 infection. Nature Communications, 15(1).
- Role of circulating T follicular helper subsets following Ty21a immunization and oral challenge with wild type S. Typhi in humans. Frontiers in Immunology, 15, 1384642.
- Changes in monocyte subsets in volunteers who received an oral wild-type Salmonella Typhi challenge and reached typhoid diagnosis criteria. Frontiers in Immunology, 15, 1454857.
- Update: Vitamin D3 and calcium carbonate supplementation for adolescents with HIV to reduce musculoskeletal morbidity and immunopathology (VITALITY trial): study protocol for a randomised placebo-controlled trial. Trials, 25(1).
- Molecular methods enhance the detection of pyoderma-related Streptococcus pyogenes and emm-type distribution in children. The Journal of Infectious Diseases.
- Rethinking pDCs: a questionable ally in immunity?. Nature Reviews Immunology.
- Characterization of bacterial and viral pathogens in the respiratory tract of children with HIV-associated chronic lung disease: a case–control study. BMC Infectious Diseases, 24(1).
- Efficient overexpression and purification of SARS-CoV-2 Nucleocapsid proteins in Escherichia coli. Biochemical Journal.
- Obesity differs from diabetes mellitus in antibody and T-cell responses post-COVID-19 recovery. Clinical and Experimental Immunology.
- Toward the elimination of hepatitis B: networking to promote the prevention of vertical transmission of hepatitis B virus through population-based interventions and multidisciplinary groups in Africa. Frontiers in Public Health, 12.
- Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 15(1).
- HLA-A*23 is Associated with Lower Odds of Acute Retroviral Syndrome in HIV-1 Infection: A Multicentre Sub-Saharan African Study. Open Forum Infectious Diseases.
- Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Nature Communications, 15(1).
- Unsupervised machine learning to investigate trajectory patterns of COVID-19 symptoms and physical activity measured via the MyHeart Counts App and smart devices. npj Digital Medicine, 6(1).
- Seasonal Azithromycin Use in Paediatric Protracted Bacterial Bronchitis Does Not Promote Antimicrobial Resistance but Does Modulate the Nasopharyngeal Microbiome. International Journal of Molecular Sciences, 24(22), 16053-16053.
- Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1. Scientific Reports, 13(1).
- Exhaled nitric oxide is associated with inflammatory biomarkers and risk of acute respiratory exacerbations in children with
HIV ‐associated chronic lung disease. HIV Medicine. - The Challenge Non-Typhoidal Salmonella (CHANTS) Consortium: Development of a non-typhoidal Salmonella controlled human infection model: Report from a consultation group workshop, 05 July 2022, London, UK. Wellcome Open Research, 8, 111-111.
- CD4+ and CD8+ T cells and antibodies are associated with protection against Delta vaccine breakthrough infection: a nested case-control study within the PITCH study. mBio.
- Direct inference and control of genetic population structure from RNA sequencing data. Communications Biology, 6(1).
- Acquisition and carriage of genetically diverse multi-drug resistant gram-negative bacilli in hospitalised newborns in The Gambia. Communications Medicine, 3(1).
- Perforin 2 mediates endosomal antigen export for cross-presentation. Nature Reviews Immunology.
- Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study. The Lancet Respiratory Medicine.
- Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet. View this article in WRRO
Conference proceedings papers
- Impaired xenon gas transfer observed one year after hospitalisation due to COVID-19 in patients with signs of interstitial lung disease.. ISMRM Annual Meeting, 3 June 2023 - 8 June 2023.
Presentations
- Exploring students’ and examiners’ perceptions of the sequential OSCE: A qualitative study. Basel, Switzerland.
Preprints
- serojump: A Bayesian tool for inferring infection timing and antibody kinetics from longitudinal serological data, Cold Spring Harbor Laboratory.
- Early life serological profiles and the development of natural protective humoral immunity toStreptococcus pyogenesin a high burden setting, Cold Spring Harbor Laboratory.
- Integrative Mapping of Pre-existing Immune Landscapes for Vaccine Response Prediction, Cold Spring Harbor Laboratory.
- Typhoid toxin ofSalmonellaTyphi elicits host antimicrobial response during acute typhoid fever, Cold Spring Harbor Laboratory.
- Interplay Between the Gut Microbiome and Typhoid Fever: Insights from Endemic Countries and a Controlled Human Infection Model, Cold Spring Harbor Laboratory.
- Molecular characterisation ofStreptococcus pyogenes(StrepA) non-invasive isolates during the 2022-23 UK upsurge, Cold Spring Harbor Laboratory.
- Dynamics of the blood plasma proteome during hyperacute HIV-1 infection, Cold Spring Harbor Laboratory.
- Molecular methods enhance the detection of pyoderma-related Streptococcus pyogenes and emm-type distribution in children, Cold Spring Harbor Laboratory.
- Efficient overexpression and purification of SARS-CoV-2 Nucleocapsid proteins in Escherichia coli, Cold Spring Harbor Laboratory.
- Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease after COVID-19 hospitalisation, Research Square Platform LLC.
- Obesity Differs from Diabetes Mellitus in Antibody and T Cell Responses Post COVID-19 Recovery, Cold Spring Harbor Laboratory.
- Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease, Cold Spring Harbor Laboratory.
- Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID), Cold Spring Harbor Laboratory.