Dr Matthew Franklin
BA, MSc, PhD
Population Health, School of Medicine and Population Health
Senior Research Fellow
+44 114 222 4226
Full contact details
Population Health, School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
- Profile
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Director of HEDM email: scharr-hedm-director@sheffield.ac.uk
I joined ScHARR in 2014 as a Health Economist Research Associate for HEDS, working as part of the National Institute for Health Research (NIHR) funded Collaboration for Leadership in Applied Health Research and Care for Yorkshire and Humber (CLAHRC YH). Since the end of the CLAHRC in 2019, I now work alongside the NIHR funded Applied Research Collaboration for Yorkshire and Humber (ARC YH).
As of January 2017, I have been promoted to the position of Research Fellow. As of July 2018, I am the current Director of the MSc Health Economics and Decision Modelling (HEDM) course. As of January 2020, I have been promoted to the position of Senior Research Fellow and I am the current HEDS section lead for Knowledge Exchange (KE).
I completed my BA in Economics and MSc in Economics and Health Economics at the University of Sheffield in 2007 and 2008, respectively. I then moved to the University of Nottingham in 2008, working as a Health Economist Research Associate, as well as starting my PhD in Health Economics in 2010.
I completed and passed my Viva for my PhD thesis, titled "The role of utility, health, and capabilities in economic evaluation: a case study in frail older people", as of December 2014.
During my time as a health economist I have provided health economic support for at least seven completed Randomised Controlled Trials (RCTs), as well as a number of cohort, pilot and feasibility studies.
Although I specialise in the use of routinely collected healthcare data and outcome measures for the purpose of economic evaluations alongside clinical trials, I also have an interest in: (1) the psychometric assessment and statistical analysis of health, well-being and capability-based measures; and (2) the use of routinely collected healthcare resource-use information from large observational datasets or directly from the health or social care service for the purpose of economic analyses, developing economic models, and costing exercises.
- Research interests
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- Trial-based economic evaluation and outcome measurement
- Cost-effectiveness analysis and Markov modelling methodology
- Use of routinely collected care data for trial-based economic analyses and economic modelling
- Application of economic evaluation and costing methods specific to the decision-maker and problem
- Statistical methods for the psychometric assessment of preference-based measures
- The capability approach to quality of life measurement and valuation
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Enabling QALY estimation in mental health trials and care settings: mapping from the PHQ-9 and GAD-7 to the ReQoL-UI or EQ-5D-5L using mixture models. Quality of Life Research.
- Estimating cost-effectiveness using alternative preference-based scores and within-trial methods : exploring the dynamics of the Quality-Adjusted Life-Year using the EQ-5D 5-level version and Recovering Quality of Life Utility Index. Value in Health.
- Psychometric assessment of EQ-5D-5L and ReQoL measures in patients with anxiety and depression : construct validity and responsiveness. Quality of Life Research.
- Conducting value for money analyses for non-randomised interventional studies including service evaluations : an educational review with recommendations. PharmacoEconomics. View this article in WRRO
- A modelling-based economic evaluation of primary-care-based fall-risk screening followed by fall-prevention intervention : a cohort-based Markov model stratified by older age groups. Age and Ageing. View this article in WRRO
- Measuring the Burden of Schizophrenia Using Clinician and Patient-Reported Measures: An Exploratory Analysis of Construct Validity. The Patient - Patient-Centered Outcomes Research, 1-13. View this article in WRRO
- An Educational Review About Using Cost Data for the Purpose of Cost-Effectiveness Analysis. PharmacoEconomics, 37(5), 631-643. View this article in WRRO
- Self-reported and routinely collected electronic healthcare resource-use data for trial-based economic evaluations: the current state of play in England and considerations for the future. BMC Medical Research Methodology, 19. View this article in WRRO
- Quantifying the Relationship between Capability and Health in Older People: Can’t Map, Won’t Map. Medical Decision Making, 38(1), 79-94. View this article in WRRO
- Economic Evaluations Alongside Efficient Study Designs Using Large Observational Datasets: the PLEASANT Trial Case Study. PharmacoEconomics, 35(5), 561-573. View this article in WRRO
- The Cost-Effectiveness of Antibiotic Prophylaxis for Patients at Risk of Infective Endocarditis. Circulation, 134(20), 1568-1578. View this article in WRRO
- Identifying patient-level health and social care costs for older people discharged from acute medical units in England. Age and Ageing, 43(5), 703-707.
- How Much Should be Invested in Lung Care Across the WHO European Region? Applying a Monetary Value to Disability-Adjusted Life-Years Within the International Respiratory Coalition’s Lung Facts. Applied Health Economics and Health Policy.
Chapters
- Cost Utility Analysis, Mental Health Economics (pp. 89-119). Springer International Publishing
- Introduction to Statistics and Modeling Methods Applied in Health Economics, Mental Health Economics (pp. 121-153). Springer International Publishing
Reports
All publications
Journal articles
- Enabling QALY estimation in mental health trials and care settings: mapping from the PHQ-9 and GAD-7 to the ReQoL-UI or EQ-5D-5L using mixture models. Quality of Life Research.
- Covariates of success in quitting smoking: a systematic review of studies from 2008 to 2021 conducted to inform the statistical analyses of quitting outcomes of a hospital-based tobacco dependence treatment service in the United Kingdom. NIHR Open Research, 3.
- Structure and Content of a Taxonomy to Support the Use of Real-World Evidence by Health Technology Assessment Practitioners and Healthcare Decision Makers. Value in Health.
- Sharing real-world data for public benefit: a qualitative exploration of stakeholder views and perceptions. BMC Public Health, 23(1).
- The Real-World Evidence Workstream In EUreccA 2025: How the task was addressed. Value in Health.
- Economic evaluation evidence for resource-allocation decision making: bridging the gap for local decision makers using English case studies. Applied Health Economics and Health Policy.
- Systematic review and critical methodological appraisal of community-based falls prevention economic models. Cost Effectiveness and Resource Allocation, 20(1).
- Health inequalities: to what extent are decision-makers and economic evaluations on the same page? An English case study. Applied Health Economics and Health Policy.
- Creating a Real-World Linked Research Platform for Analyzing the Urgent and Emergency Care System.. Med Decis Making, 272989X221098699.
- Economic evaluation of community-based falls prevention interventions for older populations : a systematic methodological overview of systematic reviews. BMC Health Services Research, 22(1). View this article in WRRO
- Economic models of community-based falls prevention: a systematic review with subsequent commissioning and methodological recommendations. BMC Health Services Research, 22(1).
- Estimating cost-effectiveness using alternative preference-based scores and within-trial methods : exploring the dynamics of the Quality-Adjusted Life-Year using the EQ-5D 5-level version and Recovering Quality of Life Utility Index. Value in Health.
- Correspondence on "How can we estimate QALYs based on PHQ-9 scores? Equipercentile linking analysis of PHQ-9 and EQ-5D" by Furukawa et al. Evidence Based Mental Health.
- Psychometric assessment of EQ-5D-5L and ReQoL measures in patients with anxiety and depression : construct validity and responsiveness. Quality of Life Research.
- Patient-reported and clinician-rated outcome measures: Complementary evidence from two different perspectives. Journal of Affective Disorders, 276, 848-849.
- A pragmatic randomized waitlist-controlled effectiveness and cost-effectiveness trial of digital interventions for depression and anxiety. npj Digital Medicine, 3(1). View this article in WRRO
- Conducting value for money analyses for non-randomised interventional studies including service evaluations : an educational review with recommendations. PharmacoEconomics. View this article in WRRO
- A modelling-based economic evaluation of primary-care-based fall-risk screening followed by fall-prevention intervention : a cohort-based Markov model stratified by older age groups. Age and Ageing. View this article in WRRO
- Quality of life is substantially worse for community-dwelling older people living with frailty: systematic review and meta-analysis. Quality of Life Research. View this article in WRRO
- Measuring the Burden of Schizophrenia Using Clinician and Patient-Reported Measures: An Exploratory Analysis of Construct Validity. The Patient - Patient-Centered Outcomes Research, 1-13. View this article in WRRO
- An Educational Review About Using Cost Data for the Purpose of Cost-Effectiveness Analysis. PharmacoEconomics, 37(5), 631-643. View this article in WRRO
- Self-reported and routinely collected electronic healthcare resource-use data for trial-based economic evaluations: the current state of play in England and considerations for the future. BMC Medical Research Methodology, 19. View this article in WRRO
- Open-label, cluster randomised controlled trial and economic evaluation of a brief letter from a GP on unscheduled medical contacts associated with the start of the school year: The PLEASANT trial. BMJ Open, 8(4). View this article in WRRO
- Digital IAPT: the effectiveness & cost-effectiveness of internet-delivered interventions for depression and anxiety disorders in the Improving Access to Psychological Therapies programme: study protocol for a randomised control trial. BMC Psychiatry, 18(1). View this article in WRRO
- The feasibility of early pulmonary rehabilitation and activity after COPD exacerbations: external pilot randomised controlled trial, qualitative case study and exploratory economic evaluation. Health Technology Assessment, 22(11), 1-204. View this article in WRRO
- Quantifying the Relationship between Capability and Health in Older People: Can’t Map, Won’t Map. Medical Decision Making, 38(1), 79-94. View this article in WRRO
- Economic Evaluations Alongside Efficient Study Designs Using Large Observational Datasets: the PLEASANT Trial Case Study. PharmacoEconomics, 35(5), 561-573. View this article in WRRO
- PLEASANT: Preventing and Lessening Exacerbations of Asthma in School-age children Associated with a New Term - a cluster randomised controlled trial and economic evaluation.. Health Technology Assessment, 20(93), 1-154. View this article in WRRO
- The Cost-Effectiveness of Antibiotic Prophylaxis for Patients at Risk of Infective Endocarditis. Circulation, 134(20), 1568-1578. View this article in WRRO
- Economic Evaluation of a General Hospital Unit for Older People with Delirium and Dementia (TEAM Randomised Controlled Trial). PLOS ONE, 10(12), e0140662-e0140662.
- Cost-Effectiveness of a Specialist Geriatric Medical Intervention for Frail Older People Discharged from Acute Medical Units: Economic Evaluation in a Two-Centre Randomised Controlled Trial (AMIGOS). PLoS ONE, 10(5), e0121340.
- Identifying patient-level health and social care costs for older people discharged from acute medical units in England. Age and Ageing, 43(5), 703-707.
- Cost Effectiveness of a Pharmacist-Led Information Technology Intervention for Reducing Rates of Clinically Important Errors in Medicines Management in General Practices (PINCER). PharmacoEconomics, 32(6), 573-590.
- Health status of UK care home residents: a cohort study. Age and Ageing, 43(1), 97-103.
- The Identification of Seniors at Risk (ISAR) score to predict clinical outcomes and health service costs in older people discharged from UK acute medical units. Age and Ageing, 42(6), 747-753.
- The predictive properties of frailty-rating scales in the acute medical unit. Age and Ageing, 42(6), 776-781.
- Specialist geriatric medical assessment for patients discharged from hospital acute assessment units: randomised controlled trial. BMJ, 347(oct08 2), f5874-f5874.
- A pharmacist-led information technology intervention for medication errors (PINCER): a multicentre, cluster randomised, controlled trial and cost-effectiveness analysis. The Lancet, 379(9823), 1310-1319.
- Persistent frequent attenders in primary care: costs, reasons for attendance, organisation of care and potential for cognitive behavioural therapeutic intervention. BMC Family Practice, 13(1).
- Acute medical unit comprehensive geriatric assessment intervention study (AMIGOS). Trials, 12(1).
- PB2708: SYMPTOM BURDEN AND ITS IMPACT ON DAILY LIFE IN PATIENTS WITH IDIOPATHIC MULTICENTRIC CASTLEMAN’S DISEASE (IMCD): AN EXPLORATORY ANALYSIS OF THE SURVEY’S INTERNAL CONSTRUCT VALIDITY. HemaSphere, 7, e69432f9-e69432f9.
- Perspectives on an enhanced ‘Improving Access to Psychological Therapies’ (IAPT) service addressing the wider determinants of mental health: a qualitative study. BMC Health Services Research, 23(1).
- How Much Should be Invested in Lung Care Across the WHO European Region? Applying a Monetary Value to Disability-Adjusted Life-Years Within the International Respiratory Coalition’s Lung Facts. Applied Health Economics and Health Policy.
- Medical Crises in Older People: cohort study of older people attending acute medical units, developmental work and randomised controlled trial of a specialist geriatric medical intervention for high-risk older people; cohort study of older people with mental health problems admitted to hospital, developmental work and randomised controlled trial of a specialist medical and mental health unit for general hospital patients with delirium and dementia; and cohort study of residents of care homes and interview study of health-care provision to residents of care homes. Programme Grants for Applied Research, 3(4), 1-410.
Chapters
- Cost Utility Analysis, Mental Health Economics (pp. 89-119). Springer International Publishing
- Introduction to Statistics and Modeling Methods Applied in Health Economics, Mental Health Economics (pp. 121-153). Springer International Publishing
Conference proceedings papers
- Exploratory Validation of a Bespoke International Patient Symptom Survey in Idiopathic Multicentric Castleman's Disease Using Psychometric Testing: Implications for Clinical Practice and Routine Data Collection. Blood, Vol. 140(Supplement 1) (pp 10885-10886)
- The Economic Impact of Schizophrenia from an English NHS Perspective Based on Estimates from Electronic and Self-Reported Methods of Data Collection. Value in Health, Vol. 19(7) (pp A608-A608)
- LATE-BREAKING ABSTRACT: PLEASANT: Preventing and lessening exacerbations of asthma in school-age children associated with a new term. 1.6 General Practice and Primary Care
- Investigating the Impact of Mental Health Status on Health and Social Care Costs of Older People after Acute Hospital Admission. Value in Health, Vol. 16(7) (pp A335-A335)
- Comparison of Alternative Methods of Resource-Use Data Collection for the Economic Evaluation of Health Care Interventions: A Case Study in Frail Older People. Value in Health, Vol. 16(7) (pp A578-A578)
- Testing the construct validity of the icecap-o as a measure of capability in frail older people. Value in Health, Vol. 16(3) (pp A196-A196)
- Identifying accurate patient-based health and social care costs of older people for trial-based economic evaluation: Is it really worth it?. Value in Health, Vol. 16(3) (pp A20-A20)
- Determining Economic Impact Of A Pharmacist-Led It-Based Intervention With Simple Feedback In Reducing Rates Of Clinically Important Errors In Medicines Management In General Practices (PINCER). Value in Health, Vol. 16(3) (pp A206-A206)
Reports
- Unlocking Data to Inform Public Health Policy and Practice: The Whole Collection
- Data sharing between the NHS and councils to improve the health of local people
- Unlocking Data to Inform Public Health Policy and Practice
- View this article in WRRO
- View this article in WRRO
Datasets
- Unlocking Data to Inform Public Health Policy and Practice: WP1 Mapping Review Supplementary Excel S1.
Other
- Author Correction: A pragmatic randomized waitlist-controlled effectiveness and cost-effectiveness trial of digital interventions for depression and anxiety.. NPJ Digit Med, 3(1), 91-91.
Preprints
- Combining causal inference and within-trial economic evaluation methods to assess comparative cost-effectiveness using real-world data: a tutorial with recommendations based on the quasi-experimental ADAPT study of a redesigned mental health service.
- Covariates of success in quitting smoking in the community and secondary acute or mental health care services: a rapid systematic review, Cold Spring Harbor Laboratory.
- Perspectives on an enhanced ‘Improving Access to Psychological Therapies’ (IAPT) service addressing the wider determinants of mental health: a qualitative study., Research Square Platform LLC.
- Economic Models of Community-Based Falls Prevention: A Systematic Review With Subsequent Commissioning And Methodological Recommendations, Research Square Platform LLC.
- Economic Evaluation of Community-Based Falls Prevention Interventions: A Systematic Methodological Overview of Systematic Reviews, Research Square Platform LLC.
- Economic Evaluation of Community-based Falls Prevention Interventions: a Systematic Methodological Overview of Systematic Reviews, Research Square Platform LLC.
- Enabling QALY estimation in mental health trials and care settings: mapping from the PHQ-9 and GAD-7 to the ReQoL-UI or EQ-5D-5L using mixture models. Quality of Life Research.
- Professional activities and memberships
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Administrative roles
- Course Director for MSc Health Economics and Decision Modelling (HEDM)
- HEDS section lead for Knowledge Exchange (KE)
- Member of the ScHARR Outcomes group