Dr Tobias Moll

PhD

School of Medicine and Population Health

MND Association Lady Edith Wolfson Research Fellow

tobias.moll@sheffield.ac.uk

B27, Sheffield Institute for Translational Neuroscience (SITraN)

Full contact details

Dr Tobias Moll
School of Medicine and Population Health
B27
Sheffield Institute for Translational Neuroscience (SITraN)
385a Glossop Road
Sheffield
S10 2HQ

Profile: I was awarded my PhD from the University of Sheffield in 2020 for my thesis describing novel genetic drivers of amyotrophic lateral sclerosis (ALS), conducted under the supervision of Professor Dame Pamela Shaw and Dr. Johnathan Cooper-Knock. I undertook postdoctoral training in the same lab to build upon my PhD research which included a period of study in California, USA. I was then awarded a Lady Edith Wolfson MND Association Fellowship in 2024 to investigate disruption of membrane lipid raft homeostasis and localised neurotrophin signalling impairments in ALS.

Publications

Journal articles

Demaegd KC, Kernan A, Cooper-Knock J, van Vugt JJFA, Harvey C, Moll T, O’Brien D, Gornall S, Drury L, Farhan SMK , Dion PA et al (2025) An observational study of pleiotropy and penetrance of amyotrophic lateral sclerosis associated with CAG-repeat expansion of ATXN2. European Journal of Human Genetics. View this article in WRRO
Harvey C, Weinreich M, Lee JAK, Shaw AC, Ferraiuolo L, Mortiboys H, Zhang S, Hop PJ, Zwamborn RAJ, van Eijk K , Julian TH et al (2024) Rare and common genetic determinants of mitochondrial function determine severity but not risk of amyotrophic lateral sclerosis. Heliyon, 10(3). View this article in WRRO
Moll T, Odon V, Harvey C, Collins MO, Peden A, Franklin J, Graves E, Marshall JNG, dos Santos Souza C, Zhang S , Castelli L et al (2023) Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication. Life Science Alliance, 6(1). View this article in WRRO
Cooper‐Knock J, Julian TH, Feneberg E, Highley JR, Sidra M, Turner MR, Talbot K, Ansorge O, Allen SP, Moll T , Shelkovnikova T et al (2023) Atypical TDP-43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP. Brain Pathology, 33(1). View this article in WRRO
Boddy S, Islam M, Moll T, Kurz J, Burrows D, McGown A, Bhargava A, Julian TH, Harvey C, Marshall JNG , Hall BPC et al (2022) Unbiased metabolome screen leads to personalized medicine strategy for amyotrophic lateral sclerosis. Brain Communications, 4(2). View this article in WRRO
Zhang S, Cooper-Knock J, Weimer AK, Shi M, Moll T, Marshall JNG, Harvey C, Nezhad HG, Franklin J, Souza CDS , Ning K et al (2022) Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis. Neuron, 110(6), 992-1008. View this article in WRRO
Julian TH, Boddy S, Islam M, Kurz J, Whittaker KJ, Moll T, Harvey C, Zhang S, Snyder MP, McDermott C , Cooper-Knock J et al (2022) A review of Mendelian randomization in amyotrophic lateral sclerosis. Brain, 145(3), 832-842. View this article in WRRO
Moll T, Marshall JNG, Soni N, Zhang S, Cooper-Knock J & Shaw PJ (2021) Membrane lipid raft homeostasis is directly linked to neurodegeneration. Essays in Biochemistry, 65(7), 999-1011. View this article in WRRO
Cooper-Knock J, Harvey C, Zhang S, Moll T, Timpanaro IS, Kenna KP, Iacoangeli A & Veldink JH (2021) Advances in the genetic classification of amyotrophic lateral sclerosis. Current Opinion in Neurology, 34(5), 756-764. View this article in WRRO
Julian TH, Glascow N, Barry ADF, Moll T, Harvey C, Klimentidis YC, Newell M, Zhang S, Snyder MP, Cooper-Knock J & Shaw PJ (2021) Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes. EBioMedicine, 68. View this article in WRRO
Cooper-Knock J, Zhang S, Kenna KP, Moll T, Franklin JP, Allen S, Nezhad HG, Iacoangeli A, Yacovzada NY, Eitan C , Hornstein E et al (2021) Rare variant burden analysis within enhancers identifies CAV1 as an ALS risk gene.. Cell Rep, 34(5), 108730.
Ghahremani Nezhad H, Franklin JP, Alix JJP, Moll T, Pattrick M, Cooper-Knock J, Shanmugarajah P, Beauchamp NJ, Hadjivissiliou M, Paling D , Mcdermott C et al (2020) Simultaneous ALS and SCA2 associated with an intermediate-length ATXN2 CAG-repeat expansion. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 22(7-8), 579-582. View this article in WRRO
Cooper-Knock J, Zhang S, Kenna KP, Moll T, Franklin JP, Allen S, Nezhad HG, Iacoangeli A, Yacovzada NY, Eitan C , Hornstein E et al (2020) Rare Variant Burden Analysis within Enhancers Identifies CAV1 as an ALS Risk Gene. Cell Reports, 33(9). View this article in WRRO
Shabir O, Moll TA, Matuszyk MM, Eyre B, Dake MD, Berwick J & Francis SE (2020) Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia. Mechanisms of Ageing and Development, 192, 111361-111361.
Franklin JP, Cooper-Knock J, Baheerathan A, Moll T, Männikkö R, Heverin M, Hardiman O, Shaw PJ & Hanna MG (2020) Concurrent sodium channelopathies and amyotrophic lateral sclerosis supports shared pathogenesis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 21(7-8), 627-630. View this article in WRRO
Moll T, Shaw PJ & Cooper-Knock J (2020) Disrupted glycosylation of lipids and proteins is a cause of neurodegeneration. Brain, 143(5), 1332-1340. View this article in WRRO
Cooper-Knock J, Moll T, Ramesh T, Castelli L, Beer A, Robins H, Fox I, Niedermoser I, Van Damme P, Moisse M , Robberecht W et al (2019) Mutations in the glycosyltransferase domain of GLT8D1 are associated with familial amyotrophic lateral sclerosis. Cell Reports, 26(9), 2298-2306.e5. View this article in WRRO

Conference proceedings papers

Cooper-Knock J, Moll T, Ramesh T, Castelli L, Shaw C, Al-Chalabi A, McDermott C, Hautbergue G & Shaw P (2019) 11.30 Mutations in the glycosyltransferase domain of GLT8D1 cause ALS. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 90(12) (pp e10.3-e11)
Cooper-Knock J, Moll T, Ramesh T, Castelli L, Shaw C, Al-Chalabi A, McDermott C, Hautbergue G & Shaw P (2019) MUTATIONS IN THE GLYCOSYLTRANSFERASE DOMAIN OF GLT8D1 CAUSE ALS. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 90(12) (pp E20-E21)

Preprints

Cooper-Knock J, Demaegd K, Kernan A, Vugt JV, Harvey C, Moll T, O'Brien D, Gornall S, Drury L, Farhan S , Dion P et al (2024) An observational study of pleiotropy and penetrance of amyotrophic lateral sclerosis associated with CAG-repeat expansion of ATXN2, Springer Science and Business Media LLC.
Moll T, Graves E, Urbanek A, Soni N, Ranganathan R, Higginbottom A, Wang S, Head BP, Cooper-Knock J & Shaw PJ (2022) GLT8D1 mutations cause amyotrophic lateral sclerosis via disruption of neurotrophin signalling within membrane lipid rafts, Cold Spring Harbor Laboratory.
Moll T, Odon V, Harvey C, Collins MO, Peden A, Franklin J, Graves E, Marshall JNG, Santos Souza CD, Zhang S , Azzouz M et al (2022) Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication, Cold Spring Harbor Laboratory.
Zhang S, Cooper-Knock J, Weimer AK, Shi M, Moll T, Harvey C, Nezhad HG, Franklin J, dos Santos Souza C, Wang C , Li J et al (2020) Genome-wide Identification of the Genetic Basis of Amyotrophic Lateral Sclerosis, Cold Spring Harbor Laboratory.
Julian TH, Glascow N, Fisher Barry AD, Moll T, Harvey C, Klimentidis YC, Newell M, Zhang S, Snyder MP, Cooper-Knock J & Shaw PJ () Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from mendelian randomisation, transcriptomics and risk genotypes.
Zhang S, Cooper-Knock J, Weimer AK, Shi M, Moll T, Harvey C, Nezhad HG, Franklin J, Souza CDS, Wang C , Li J et al () Genome-Wide Identification of the Genetic Basis of Amyotrophic Lateral Sclerosis.
Cooper-Knock J, Zhang S, Kenna KP, Moll T, Franklin J, Allen S, Nezhad HG, Yacovzada NS, Eitan C, Hornstein E , Ehilak E et al () Rare Variant Burden Analysis within Enhancers Identifies <i>CAV1</i> as a New ALS Risk Gene.
Cooper-Knock J, Moll T, Ramesh T, Castelli L, Beer A, Robins H, Fox I, Niedermoser I, Van Damme P, Robberecht W , Hardiman O et al () Mutations in the Glycosyltransferase Domain of GLT8D1 Cause Amyotrophic Lateral Sclerosis.

Research group

Connie Treanor (PhD student)
Akanksha Jangid (Research Assistant)